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Items: 1 to 50 of 199

1.

LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.

Mathew D, Kremer KN, Strauch P, Tigyi G, Pelanda R, Torres RM.

Front Immunol. 2019 May 28;10:1159. doi: 10.3389/fimmu.2019.01159. eCollection 2019.

2.

Osteoclast-derived Autotaxin, a distinguishing factor for inflammatory bone loss.

Flammier S, Peyruchaud O, Bourguillault F, Duboeuf F, Davignon JL, Norman DD, Isaac S, Marotte H, Tigyi G, Machuca-Gayet I, Coury F.

Arthritis Rheumatol. 2019 Jun 4. doi: 10.1002/art.41005. [Epub ahead of print]

PMID:
31162832
3.

Optical control of sphingosine-1-phosphate formation and function.

Morstein J, Hill RZ, Novak AJE, Feng S, Norman DD, Donthamsetti PC, Frank JA, Harayama T, Williams BM, Parrill AL, Tigyi GJ, Riezman H, Isacoff EY, Bautista DM, Trauner D.

Nat Chem Biol. 2019 Jun;15(6):623-631. doi: 10.1038/s41589-019-0269-7. Epub 2019 Apr 29.

PMID:
31036923
4.

Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential.

Tigyi GJ, Johnson LR, Lee SC, Norman DD, Szabo E, Balogh A, Thompson K, Boler A, McCool WS.

J Lipid Res. 2019 Mar;60(3):464-474. doi: 10.1194/jlr.S091744. Epub 2019 Jan 28.

PMID:
30692142
5.

Prevention and treatment of secretory diarrhea by the lysophosphatidic acid analog Rx100.

Thompson KE, Ray RM, Alli S, Ge W, Boler A, Shannon McCool W, Meena AS, Shukla PK, Rao R, Johnson LR, Miller MA, Tigyi GJ.

Exp Biol Med (Maywood). 2018 Sep;243(13):1056-1065. doi: 10.1177/1535370218803349. Epub 2018 Sep 25.

PMID:
30253666
6.

Regulation of tumor cell - Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis.

Tigyi GJ, Yue J, Norman DD, Szabo E, Balogh A, Balazs L, Zhao G, Lee SC.

Adv Biol Regul. 2019 Jan;71:183-193. doi: 10.1016/j.jbior.2018.09.008. Epub 2018 Sep 16. Review.

7.

The LPA2 receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids.

Kuo B, Szabó E, Lee SC, Balogh A, Norman D, Inoue A, Ono Y, Aoki J, Tigyi G.

Cell Signal. 2018 Nov;51:23-33. doi: 10.1016/j.cellsig.2018.07.007. Epub 2018 Jul 29.

PMID:
30063964
8.

Role of autotaxin in cancer stem cells.

Lee D, Suh DS, Lee SC, Tigyi GJ, Kim JH.

Cancer Metastasis Rev. 2018 Sep;37(2-3):509-518. doi: 10.1007/s10555-018-9745-x. Review.

9.

Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells.

Banerjee S, Norman DD, Lee SC, Parrill AL, Pham TC, Baker DL, Tigyi GJ, Miller DD.

J Med Chem. 2017 Feb 23;60(4):1309-1324. doi: 10.1021/acs.jmedchem.6b01270. Epub 2017 Feb 10.

PMID:
28112925
10.

LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction.

Dancs PT, Ruisanchez É, Balogh A, Panta CR, Miklós Z, Nüsing RM, Aoki J, Chun J, Offermanns S, Tigyi G, Benyó Z.

FASEB J. 2017 Apr;31(4):1547-1555. doi: 10.1096/fj.201600735R. Epub 2017 Jan 9.

11.

Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition.

Ragle LE, Palanisamy DJ, Joe MJ, Stein RS, Norman DD, Tigyi G, Baker DL, Parrill AL.

Bioorg Med Chem. 2016 Oct 1;24(19):4660-4674. doi: 10.1016/j.bmc.2016.08.004. Epub 2016 Aug 4.

12.

Pharmacological activation of lysophosphatidic acid receptors regulates erythropoiesis.

Lin KH, Ho YH, Chiang JC, Li MW, Lin SH, Chen WM, Chiang CL, Lin YN, Yang YJ, Chen CN, Lu J, Huang CJ, Tigyi G, Yao CL, Lee H.

Sci Rep. 2016 May 31;6:27050. doi: 10.1038/srep27050.

13.

Rapid disruption of intestinal epithelial tight junction and barrier dysfunction by ionizing radiation in mouse colon in vivo: protection by N-acetyl-l-cysteine.

Shukla PK, Gangwar R, Manda B, Meena AS, Yadav N, Szabo E, Balogh A, Lee SC, Tigyi G, Rao R.

Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G705-15. doi: 10.1152/ajpgi.00314.2015. Epub 2016 Jan 28.

14.

miR-203 Functions as a Tumor Suppressor by Inhibiting Epithelial to Mesenchymal Transition in Ovarian Cancer.

Zhao G, Guo Y, Chen Z, Wang Y, Yang C, Dudas A, Du Z, Liu W, Zou Y, Szabo E, Lee SC, Sims M, Gu W, Tillmanns T, Pfeffer LM, Tigyi G, Yue J.

J Cancer Sci Ther. 2015;7(2):34-43.

15.

A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research.

Pyne NJ, Tigyi GJ.

Prog Lipid Res. 2016 Jan;61:19-29. doi: 10.1016/j.plipres.2015.10.003. Epub 2015 Nov 14. Review.

16.

Novel Inhibitory Effect of a Lysophosphatidic Acid 2 Agonist on Allergen-Driven Airway Inflammation.

Knowlden SA, Hillman SE, Chapman TJ, Patil R, Miller DD, Tigyi G, Georas SN.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):402-9. doi: 10.1165/rcmb.2015-0124OC.

17.

The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair.

Balogh A, Shimizu Y, Lee SC, Norman DD, Gangwar R, Bavaria M, Moon C, Shukla P, Rao R, Ray R, Naren AP, Banerjee S, Miller DD, Balazs L, Pelus L, Tigyi G.

Cell Signal. 2015 Sep;27(9):1751-62. doi: 10.1016/j.cellsig.2015.05.015. Epub 2015 May 28. Erratum in: Cell Signal. 2015 Oct;27(10):2137. Banerje, Souvik [corrected to Banerjee, Souvik].

18.

Uncovering unique roles of LPA receptors in the tumor microenvironment.

Lee SC, Fujiwara Y, Tigyi GJ.

Receptors Clin Investig. 2015;2(1). pii: e440.

19.

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis.

Parham KA, Zebol JR, Tooley KL, Sun WY, Moldenhauer LM, Cockshell MP, Gliddon BL, Moretti PA, Tigyi G, Pitson SM, Bonder CS.

FASEB J. 2015 Sep;29(9):3638-53. doi: 10.1096/fj.14-261289. Epub 2015 May 18.

20.

Mitigation of the hematopoietic and gastrointestinal acute radiation syndrome by octadecenyl thiophosphate, a small molecule mimic of lysophosphatidic acid.

Deng W, Kimura Y, Gududuru V, Wu W, Balogh A, Szabo E, Thompson KE, Yates CR, Balazs L, Johnson LR, Miller DD, Strobos J, McCool WS, Tigyi GJ.

Radiat Res. 2015 Apr;183(4):465-75. doi: 10.1667/RR13830.1. Epub 2015 Mar 25.

21.

In honor of Robert Bittman 1942-2014.

Tigyi G.

Biochim Biophys Acta. 2014 Dec;1841(12):1752-3. No abstract available.

PMID:
25713875
22.

Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.

Patil R, Szabó E, Fells JI, Balogh A, Lim KG, Fujiwara Y, Norman DD, Lee SC, Balazs L, Thomas F, Patil S, Emmons-Thompson K, Boler A, Strobos J, McCool SW, Yates CR, Stabenow J, Byrne GI, Miller DD, Tigyi GJ.

Chem Biol. 2015 Feb 19;22(2):206-16. doi: 10.1016/j.chembiol.2014.12.009. Epub 2015 Jan 22.

23.

Asymmetrical macromolecular complex formation of lysophosphatidic acid receptor 2 (LPA2) mediates gradient sensing in fibroblasts.

Ren A, Moon C, Zhang W, Sinha C, Yarlagadda S, Arora K, Wang X, Yue J, Parthasarathi K, Heil-Chapdelaine R, Tigyi G, Naren AP.

J Biol Chem. 2014 Dec 26;289(52):35757-69. doi: 10.1074/jbc.M114.595512. Epub 2014 Nov 5.

24.

Opposing regulation of megakaryopoiesis by LPA receptors 2 and 3 in K562 human erythroleukemia cells.

Ho YH, Yao CL, Lin KH, Hou FH, Chen WM, Chiang CL, Lin YN, Li MW, Lin SH, Yang YJ, Lin CC, Lu J, Tigyi G, Lee H.

Biochim Biophys Acta. 2015 Feb;1851(2):172-83. doi: 10.1016/j.bbalip.2014.11.009. Epub 2014 Nov 21. Erratum in: Biochim Biophys Acta. 2015 Sep;1851(9):1284.

PMID:
25463482
25.

Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone.

Leblanc R, Lee SC, David M, Bordet JC, Norman DD, Patil R, Miller D, Sahay D, Ribeiro J, Clézardin P, Tigyi GJ, Peyruchaud O.

Blood. 2014 Nov 13;124(20):3141-50. doi: 10.1182/blood-2014-04-568683. Epub 2014 Oct 2.

26.

Autotaxin and LPA1 and LPA5 receptors exert disparate functions in tumor cells versus the host tissue microenvironment in melanoma invasion and metastasis.

Lee SC, Fujiwara Y, Liu J, Yue J, Shimizu Y, Norman DD, Wang Y, Tsukahara R, Szabo E, Patil R, Banerjee S, Miller DD, Balazs L, Ghosh MC, Waters CM, Oravecz T, Tigyi GJ.

Mol Cancer Res. 2015 Jan;13(1):174-85. doi: 10.1158/1541-7786.MCR-14-0263. Epub 2014 Aug 26.

27.

Doxycycline inducible Krüppel-like factor 4 lentiviral vector mediates mesenchymal to epithelial transition in ovarian cancer cells.

Chen Z, Wang Y, Liu W, Zhao G, Lee S, Balogh A, Zou Y, Guo Y, Zhang Z, Gu W, Li C, Tigyi G, Yue J.

PLoS One. 2014 Aug 19;9(8):e105331. doi: 10.1371/journal.pone.0105331. eCollection 2014.

28.

Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.

Patil R, Fells JI, Szabó E, Lim KG, Norman DD, Balogh A, Patil S, Strobos J, Miller DD, Tigyi GJ.

J Med Chem. 2014 Aug 28;57(16):7136-40. doi: 10.1021/jm5007116. Epub 2014 Aug 12.

29.

Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs.

Morales-Lázaro SL, Serrano-Flores B, Llorente I, Hernández-García E, González-Ramírez R, Banerjee S, Miller D, Gududuru V, Fells J, Norman D, Tigyi G, Escalante-Alcalde D, Rosenbaum T.

J Biol Chem. 2014 Aug 29;289(35):24079-90. doi: 10.1074/jbc.M114.572503. Epub 2014 Jul 17. Erratum in: J Biol Chem. 2014 Dec 5;289(49):33876.

30.

Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response.

Hu J, Oda SK, Shotts K, Donovan EE, Strauch P, Pujanauski LM, Victorino F, Al-Shami A, Fujiwara Y, Tigyi G, Oravecz T, Pelanda R, Torres RM.

J Immunol. 2014 Jul 1;193(1):85-95. doi: 10.4049/jimmunol.1300429. Epub 2014 Jun 2.

31.

Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.

Oda SK, Strauch P, Fujiwara Y, Al-Shami A, Oravecz T, Tigyi G, Pelanda R, Torres RM.

Cancer Immunol Res. 2013 Oct;1(4):245-55. doi: 10.1158/2326-6066.CIR-13-0043-T.

32.

Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.

Fells JI, Lee SC, Norman DD, Tsukahara R, Kirby JR, Nelson S, Seibel W, Papoian R, Patil R, Miller DD, Parrill AL, Pham TC, Baker DL, Bittman R, Tigyi G.

FEBS J. 2014 Feb;281(4):1017-28. doi: 10.1111/febs.12674. Epub 2014 Jan 15.

33.

Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase.

Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z.

FASEB J. 2014 Feb;28(2):880-90. doi: 10.1096/fj.13-234997. Epub 2013 Nov 18.

34.

The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis.

Kotla S, Singh NK, Heckle MR, Tigyi GJ, Rao GN.

Sci Signal. 2013 Sep 17;6(293):ra83. doi: 10.1126/scisignal.2004214.

35.

Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.

Fells JI, Lee SC, Fujiwara Y, Norman DD, Lim KG, Tsukahara R, Liu J, Patil R, Miller DD, Kirby RJ, Nelson S, Seibel W, Papoian R, Parrill AL, Baker DL, Bittman R, Tigyi G.

Mol Pharmacol. 2013 Sep;84(3):415-24. doi: 10.1124/mol.113.087080. Epub 2013 Jun 21.

36.

Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells.

Schwingshackl A, Teng B, Ghosh M, Lim KG, Tigyi G, Narayanan D, Jaggar JH, Waters CM.

Am J Physiol Lung Cell Mol Physiol. 2013 Feb 15;304(4):L276-86. doi: 10.1152/ajplung.00299.2012. Epub 2012 Dec 28.

37.

Mitigation of radiation injury by selective stimulation of the LPA(2) receptor.

Kiss GN, Lee SC, Fells JI, Liu J, Valentine WJ, Fujiwara Y, Thompson KE, Yates CR, Sümegi B, Tigyi G.

Biochim Biophys Acta. 2013 Jan;1831(1):117-25. doi: 10.1016/j.bbalip.2012.08.020.

38.

New trends in lysophospholipid research.

Tigyi G.

Biochim Biophys Acta. 2013 Jan;1831(1):1. doi: 10.1016/j.bbalip.2012.09.011. Epub 2012 Sep 23. Review. No abstract available.

PMID:
23010474
39.

Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactions.

Parrill AL, Tigyi G.

Biochim Biophys Acta. 2013 Jan;1831(1):2-12. doi: 10.1016/j.bbalip.2012.09.002. Epub 2012 Sep 12. Review.

40.

Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.

Kiss GN, Fells JI, Gupte R, Lee SC, Liu J, Nusser N, Lim KG, Ray RM, Lin FT, Parrill AL, Sümegi B, Miller DD, Tigyi G.

Mol Pharmacol. 2012 Dec;82(6):1162-73. doi: 10.1124/mol.112.079699. Epub 2012 Sep 11.

41.

Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy.

Brindley DN, Lin FT, Tigyi GJ.

Biochim Biophys Acta. 2013 Jan;1831(1):74-85. doi: 10.1016/j.bbalip.2012.08.015. Epub 2012 Aug 29. Review.

42.

High-throughput assays to measure intracellular Ca²⁺ mobilization in cells that express recombinant S1P receptor subtypes.

Valentine WJ, Tigyi G.

Methods Mol Biol. 2012;874:77-87. doi: 10.1007/978-1-61779-800-9_7.

43.

DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice.

Chen Z, Wu J, Yang C, Fan P, Balazs L, Jiao Y, Lu M, Gu W, Li C, Pfeffer LM, Tigyi G, Yue J.

J Biol Chem. 2012 Jun 1;287(23):19018-28. doi: 10.1074/jbc.M112.351791. Epub 2012 Apr 17.

44.

Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.

Gotoh M, Fujiwara Y, Yue J, Liu J, Lee S, Fells J, Uchiyama A, Murakami-Murofushi K, Kennel S, Wall J, Patil R, Gupte R, Balazs L, Miller DD, Tigyi GJ.

Biochem Soc Trans. 2012 Feb;40(1):31-6. doi: 10.1042/BST20110608. Review.

45.

Lipids: LPA activates TRPV1--and it hurts.

Tigyi G.

Nat Chem Biol. 2011 Dec 15;8(1):22-3. doi: 10.1038/nchembio.738. No abstract available.

46.

FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2.

Valentine WJ, Godwin VI, Osborne DA, Liu J, Fujiwara Y, Van Brocklyn J, Bittman R, Parrill AL, Tigyi G.

J Biol Chem. 2011 Sep 2;286(35):30513-25. doi: 10.1074/jbc.M111.263442. Epub 2011 Jun 30.

47.

Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.

Gupte R, Patil R, Liu J, Wang Y, Lee SC, Fujiwara Y, Fells J, Bolen AL, Emmons-Thompson K, Yates CR, Siddam A, Panupinthu N, Pham TC, Baker DL, Parrill AL, Mills GB, Tigyi G, Miller DD.

ChemMedChem. 2011 May 2;6(5):922-35. doi: 10.1002/cmdc.201000425. Epub 2011 Apr 4.

48.

The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation.

Bolen AL, Naren AP, Yarlagadda S, Beranova-Giorgianni S, Chen L, Norman D, Baker DL, Rowland MM, Best MD, Sano T, Tsukahara T, Liliom K, Igarashi Y, Tigyi G.

J Lipid Res. 2011 May;52(5):958-70. doi: 10.1194/jlr.M013326. Epub 2011 Mar 9.

49.

Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality.

Pan Y, Balazs L, Tigyi G, Yue J.

Biochem Biophys Res Commun. 2011 May 13;408(3):369-74. doi: 10.1016/j.bbrc.2011.02.119. Epub 2011 Feb 28.

50.

Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors.

Tabchy A, Tigyi G, Mills GB.

Nat Struct Mol Biol. 2011 Feb;18(2):117-8. doi: 10.1038/nsmb0211-117.

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