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129Xenon Gas Exchange MRI as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis.

Rankine LJ, Wang Z, Wang JM, He M, McAdams P, Mammarappallil J, Rackley CR, Driehuys B, Tighe RM.

Ann Am Thorac Soc. 2019 Oct 8. doi: 10.1513/AnnalsATS.201905-413RL. [Epub ahead of print] No abstract available.


Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.

Cyphert-Daly JM, Yang Z, Ingram JL, Tighe RM, Que LG.

J Allergy Clin Immunol. 2019 Jul 29. pii: S0091-6749(19)30968-6. doi: 10.1016/j.jaci.2019.07.019. [Epub ahead of print] No abstract available.


Improving the Quality and Reproducibility of Flow Cytometry in the Lung. An Official American Thoracic Society Workshop Report.

Tighe RM, Redente EF, Yu YR, Herold S, Sperling AI, Curtis JL, Duggan R, Swaminathan S, Nakano H, Zacharias WJ, Janssen WJ, Freeman CM, Brinkman RR, Singer BD, Jakubzick CV, Misharin AV.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):150-161. doi: 10.1165/rcmb.2019-0191ST.


Management of Idiopathic Pulmonary Fibrosis.

Pleasants R, Tighe RM.

Ann Pharmacother. 2019 Dec;53(12):1238-1248. doi: 10.1177/1060028019862497. Epub 2019 Jul 7.


Immediate Release of Gastrin-Releasing Peptide Mediates Delayed Radiation-Induced Pulmonary Fibrosis.

Tighe RM, Heck K, Soderblom E, Zhou S, Birukova A, Young K, Rouse D, Vidas J, Komforti MK, Toomey CB, Cuttitta F, Sunday ME.

Am J Pathol. 2019 May;189(5):1029-1040. doi: 10.1016/j.ajpath.2019.01.017. Epub 2019 Mar 18.


Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses.

Birukova A, Cyphert-Daly J, Cumming RI, Yu YR, Gowdy KM, Que LG, Tighe RM.

Toxicol Sci. 2019 Jun 1;169(2):499-510. doi: 10.1093/toxsci/kfz056.


Factors affecting adenoma detection rate in a national flexible sigmoidoscopy screening programme: a retrospective analysis.

Bevan R, Blanks RG, Nickerson C, Saunders BP, Stebbing J, Tighe R, Veitch AM, Garrett W, Rees CJ.

Lancet Gastroenterol Hepatol. 2019 Mar;4(3):239-247. doi: 10.1016/S2468-1253(18)30387-X. Epub 2019 Jan 15.


Isolation and Characterization of Human Lung Myeloid Cells.

Yu YA, Tighe RM.

Methods Mol Biol. 2018;1809:111-119. doi: 10.1007/978-1-4939-8570-8_9.


Flow Cytometry for the Immunotoxicologist.

Espenschied ST, Tighe RM, Gowdy KM.

Methods Mol Biol. 2018;1803:183-197. doi: 10.1007/978-1-4939-8549-4_12.


Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.

Que LG, Yang Z, Lugogo NL, Katial RK, Shoemaker SA, Troha JM, Rodman DM, Tighe RM, Kraft M.

Immun Inflamm Dis. 2018 Jun;6(2):322-331. doi: 10.1002/iid3.220. Epub 2018 Apr 11.


Inflammation Gets on the Lung's Nerves: IL-17 and Neuroendocrine Cells Mediate Ozone Responses in Obesity.

Garantziotis S, Tighe RM.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):284-285. doi: 10.1165/rcmb.2017-0363ED. No abstract available.


Euthanasia- and Lavage-mediated Effects on Bronchoalveolar Measures of Lung Injury and Inflammation.

Tighe RM, Birukova A, Yaeger MJ, Reece SW, Gowdy KM.

Am J Respir Cell Mol Biol. 2018 Aug;59(2):257-266. doi: 10.1165/rcmb.2017-0357OC.


Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation.

Kilburg-Basnyat B, Reece SW, Crouch MJ, Luo B, Boone AD, Yaeger M, Hodge M, Psaltis C, Hannan JL, Manke J, Armstrong ML, Reisdorph N, Tighe RM, Shaikh SR, Gowdy KM.

Toxicol Sci. 2018 Jun 1;163(2):466-477. doi: 10.1093/toxsci/kfy040.


Hyaluronan interactions with innate immunity in lung biology.

Tighe RM, Garantziotis S.

Matrix Biol. 2019 May;78-79:84-99. doi: 10.1016/j.matbio.2018.01.027. Epub 2018 Feb 2. Review.



Potts-Kant EN, Li Z, Tighe RM, Lindsey JY, Frush BW, Foster WM, Hollingsworth JW.

Free Radic Biol Med. 2017 Dec;113:580. doi: 10.1016/j.freeradbiomed.2017.06.007. No abstract available.


Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.

Suwanpradid J, Shih M, Pontius L, Yang B, Birukova A, Guttman-Yassky E, Corcoran DL, Que LG, Tighe RM, MacLeod AS.

J Immunol. 2017 Sep 1;199(5):1827-1834. doi: 10.4049/jimmunol.1700739. Epub 2017 Jul 26.


Combination Therapy with NHS-muIL12 and Avelumab (anti-PD-L1) Enhances Antitumor Efficacy in Preclinical Cancer Models.

Xu C, Zhang Y, Rolfe PA, Hernández VM, Guzman W, Kradjian G, Marelli B, Qin G, Qi J, Wang H, Yu H, Tighe R, Lo KM, English JM, Radvanyi L, Lan Y.

Clin Cancer Res. 2017 Oct 1;23(19):5869-5880. doi: 10.1158/1078-0432.CCR-17-0483. Epub 2017 Jul 5.


A novel role for primary cilia in airway remodeling.

Trempus CS, Song W, Lazrak A, Yu Z, Creighton JR, Young BM, Heise RL, Yu YR, Ingram JL, Tighe RM, Matalon S, Garantziotis S.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L328-L338. doi: 10.1152/ajplung.00284.2016. Epub 2017 May 4.


Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling.

Pinilla-Vera M, Xiong Z, Zhao Y, Zhao J, Donahoe MP, Barge S, Horne WT, Kolls JK, McVerry BJ, Birukova A, Tighe RM, Foster WM, Hollingsworth J, Ray A, Mallampalli R, Ray P, Lee JS.

PLoS One. 2016 Jul 19;11(7):e0159329. doi: 10.1371/journal.pone.0159329. eCollection 2016.


Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects.

Frush BW, Li Z, Stiles JV, Cotter SF, Shofer SL, Foster WM, Hollingsworth JW, Tighe RM.

J Allergy Clin Immunol. 2016 Oct;138(4):1213-1215.e1. doi: 10.1016/j.jaci.2016.03.052. Epub 2016 May 13. No abstract available.


Systemic Immunotherapy of Non-Muscle Invasive Mouse Bladder Cancer with Avelumab, an Anti-PD-L1 Immune Checkpoint Inhibitor.

Vandeveer AJ, Fallon JK, Tighe R, Sabzevari H, Schlom J, Greiner JW.

Cancer Immunol Res. 2016 May;4(5):452-62. doi: 10.1158/2326-6066.CIR-15-0176. Epub 2016 Feb 26.


Correction: Ozone Inhalation Promotes CX3CR1-Dependent Maturation of Resident Lung Macrophages That Limit Oxidative Stress and Inflammation.

Tighe RM, Li Z, Potts EN, Frush S, Liu N, Gunn MD, Foster WM, Noble PW, Hollingsworth JW.

J Immunol. 2016 Mar 1;196(5):2424. doi: 10.4049/jimmunol.1600002. No abstract available.


ATS Core Curriculum 2015. Part I: Adult Pulmonary Medicine.

Michaud GC, Channick CL, Marion CR, Tighe RM, Town JA, Luks AM, Richards JB, Kher S, Mota P, Hong G, West NE, Rackley C, Neilans L, Rodriguez-Lopez J, DuBrock H, Kennedy CC, Kelm DJ, Thomson CC.

Ann Am Thorac Soc. 2015 Sep;12(9):1387-97. doi: 10.1513/AnnalsATS.201504-194CME. No abstract available.


Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues.

Yu YR, Hotten DF, Malakhau Y, Volker E, Ghio AJ, Noble PW, Kraft M, Hollingsworth JW, Gunn MD, Tighe RM.

Am J Respir Cell Mol Biol. 2016 Jan;54(1):13-24. doi: 10.1165/rcmb.2015-0146OC.


Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation.

Schilbach K, Alkhaled M, Welker C, Eckert F, Blank G, Ziegler H, Sterk M, Müller F, Sonntag K, Wieder T, Braumüller H, Schmitt J, Eyrich M, Schleicher S, Seitz C, Erbacher A, Pichler BJ, Müller H, Tighe R, Lim A, Gillies SD, Strittmatter W, Röcken M, Handgretinger R.

Oncoimmunology. 2015 Mar 19;4(7):e1014760. eCollection 2015 Jul.


Defining the Pharmacodynamic Profile and Therapeutic Index of NHS-IL12 Immunocytokine in Dogs with Malignant Melanoma.

Paoloni M, Mazcko C, Selting K, Lana S, Barber L, Phillips J, Skorupski K, Vail D, Wilson H, Biller B, Avery A, Kiupel M, LeBlanc A, Bernhardt A, Brunkhorst B, Tighe R, Khanna C.

PLoS One. 2015 Jun 19;10(6):e0129954. doi: 10.1371/journal.pone.0129954. eCollection 2015.


NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy.

van den Heuvel MM, Verheij M, Boshuizen R, Belderbos J, Dingemans AM, De Ruysscher D, Laurent J, Tighe R, Haanen J, Quaratino S.

J Transl Med. 2015 Jan 27;13:32. doi: 10.1186/s12967-015-0397-0.


NAP5 and consent.

Tighe R.

Anaesthesia. 2015 Feb;70(2):236. doi: 10.1111/anae.12985. No abstract available.


Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.

Waight JD, Takai S, Marelli B, Qin G, Hance KW, Zhang D, Tighe R, Lan Y, Lo KM, Sabzevari H, Hofmeister R, Wilson NS.

J Immunol. 2015 Feb 1;194(3):878-82. doi: 10.4049/jimmunol.1402725. Epub 2014 Dec 29.


Enterohemorrhagic Escherichia coli colonization of human colonic epithelium in vitro and ex vivo.

Lewis SB, Cook V, Tighe R, Schüller S.

Infect Immun. 2015 Mar;83(3):942-9. doi: 10.1128/IAI.02928-14. Epub 2014 Dec 22.


The immunocytokine NHS-IL12 as a potential cancer therapeutic.

Fallon J, Tighe R, Kradjian G, Guzman W, Bernhardt A, Neuteboom B, Lan Y, Sabzevari H, Schlom J, Greiner JW.

Oncotarget. 2014 Apr 15;5(7):1869-84.


Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium.

Reynolds A, Wharton N, Parris A, Mitchell E, Sobolewski A, Kam C, Bigwood L, El Hadi A, Münsterberg A, Lewis M, Speakman C, Stebbings W, Wharton R, Sargen K, Tighe R, Jamieson C, Hernon J, Kapur S, Oue N, Yasui W, Williams MR.

Gut. 2014 Apr;63(4):610-21. doi: 10.1136/gutjnl-2012-304067. Epub 2013 Jul 5.


Teaching corner: Regional anaesthesia for ophthalmic surgery.

Tighe R, Burgess PI, Msukwa G.

Malawi Med J. 2012 Dec;24(4):89-94.


Identification of myeloid cell subsets in murine lungs using flow cytometry.

Zaynagetdinov R, Sherrill TP, Kendall PL, Segal BH, Weller KP, Tighe RM, Blackwell TS.

Am J Respir Cell Mol Biol. 2013 Aug;49(2):180-9. doi: 10.1165/rcmb.2012-0366MA.


Genes of innate immunity and the biological response to inhaled ozone.

Li Z, Tighe RM, Feng F, Ledford JG, Hollingsworth JW.

J Biochem Mol Toxicol. 2013 Jan;27(1):3-16. doi: 10.1002/jbt.21453. Epub 2012 Nov 20. Review.


Screen-detected colorectal cancers show improved cancer-specific survival when compared with cancers diagnosed via the 2-week suspected colorectal cancer referral guidelines.

Courtney ED, Chong D, Tighe R, Easterbrook JR, Stebbings WS, Hernon J.

Colorectal Dis. 2013 Feb;15(2):177-82. doi: 10.1111/j.1463-1318.2012.03131.x.


The opprobrium of Big Tobacco.

Piantadosi CA, Bartz RR, Carraway MS, Ghio AJ, McMahon TJ, Murdoch DM, Roggli VL, Shofer SL, Tighe RM, Welty-Wolf KE, Young SL.

Am J Respir Crit Care Med. 2012 May 1;185(9):1030. No abstract available.


A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury.

Liang J, Jung Y, Tighe RM, Xie T, Liu N, Leonard M, Gunn MD, Jiang D, Noble PW.

Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L933-40. doi: 10.1152/ajplung.00256.2011. Epub 2012 Jan 27.


RETRACTED: NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice.

Potts-Kant EN, Li Z, Tighe RM, Lindsey JY, Frush BW, Foster WM, Hollingsworth JW.

Free Radic Biol Med. 2012 Feb 1;52(3):705-715. doi: 10.1016/j.freeradbiomed.2011.11.027. Epub 2011 Dec 16. Retraction in: Free Radic Biol Med. 2017 Dec;113:580.


Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation.

Tighe RM, Li Z, Potts EN, Frush S, Liu N, Gunn MD, Foster WM, Noble PW, Hollingsworth JW.

J Immunol. 2011 Nov 1;187(9):4800-8. doi: 10.4049/jimmunol.1101312. Epub 2011 Sep 19. Erratum in: J Immunol. 2016 Mar 1;196(5):2424.


Extracellular Matrix Protein Mindin is Required for the Complete Allergic Response to Fungal-Associated Proteinase.

Tighe RM, Potts EN, Feng F, Li Z, Frush B, He YW, Corry DB, Noble PW, Hollingsworth JW.

J Allergy Ther. 2011 Sep 20;2011(Suppl 1). pii: 001.


Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury.

Tighe RM, Liang J, Liu N, Jung Y, Jiang D, Gunn MD, Noble PW.

Am J Respir Cell Mol Biol. 2011 Oct;45(4):781-8. doi: 10.1165/rcmb.2010-0471OC. Epub 2011 Feb 17.


Ambient ozone and pulmonary innate immunity.

Al-Hegelan M, Tighe RM, Castillo C, Hollingsworth JW.

Immunol Res. 2011 Apr;49(1-3):173-91. doi: 10.1007/s12026-010-8180-z. Review.


Quality in endoscopy: highlight report from the annual meeting of the BSG, Liverpool 2010.

Tighe R.

Frontline Gastroenterol. 2010 Jul;1(2):68-69. doi: 10.1136/fg.2010.001651. Epub 2010 Jun 15. No abstract available.


Intralipid reverses coma associated with zopiclone and venlafaxine overdose.

Hillyard SG, Barrera-Groba C, Tighe R.

Eur J Anaesthesiol. 2010 Jun;27(6):582-3. doi: 10.1097/EJA.0b013e3283357049. No abstract available.


Antibiotic prophylaxis in gastrointestinal endoscopy.

Allison MC, Sandoe JA, Tighe R, Simpson IA, Hall RJ, Elliott TS; Endoscopy Committee of the British Society of Gastroenterology.

Gut. 2009 Jun;58(6):869-80. doi: 10.1136/gut.2007.136580. No abstract available.


Guidelines for the management of anticoagulant and antiplatelet therapy in patients undergoing endoscopic procedures.

Veitch AM, Baglin TP, Gershlick AH, Harnden SM, Tighe R, Cairns S; British Society of Gastroenterology; British Committee for Standards in Haematology; British Cardiovascular Intervention Society.

Gut. 2008 Sep;57(9):1322-9. doi: 10.1136/gut.2007.142497. Epub 2008 May 9. Review. No abstract available.


Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium.

Reynolds A, Parris A, Evans LA, Lindqvist S, Sharp P, Lewis M, Tighe R, Williams MR.

J Physiol. 2007 Jul 15;582(Pt 2):507-24. Epub 2007 May 3.


Prospective randomized trial of laparoscopic gastrojejunostomy versus duodenal stenting for malignant gastric outflow obstruction.

Mehta S, Hindmarsh A, Cheong E, Cockburn J, Saada J, Tighe R, Lewis MP, Rhodes M.

Surg Endosc. 2006 Feb;20(2):239-42. Epub 2005 Dec 9.


Prevention of murine erythropoietic protoporphyria-associated skin photosensitivity and liver disease by dermal and hepatic ferrochelatase.

Pawliuk R, Tighe R, Wise RJ, Mathews-Roth MM, Leboulch P.

J Invest Dermatol. 2005 Jan;124(1):256-62.

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