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Autoantibodies in chronic obstructive pulmonary disease: A systematic review.

Byrne R, Todd I, Tighe PJ, Fairclough LC.

Immunol Lett. 2019 Oct;214:8-15. doi: 10.1016/j.imlet.2019.08.007. Epub 2019 Aug 28. Review.


Primer on machine learning: utilization of large data set analyses to individualize pain management.

Rashidi P, Edwards DA, Tighe PJ.

Curr Opin Anaesthesiol. 2019 Oct;32(5):653-660. doi: 10.1097/ACO.0000000000000779.


Cigarette smoking differentially affects immunoglobulin class levels in serum and saliva: An investigation and review.

Tarbiah N, Todd I, Tighe PJ, Fairclough LC.

Basic Clin Pharmacol Toxicol. 2019 Jun 20. doi: 10.1111/bcpt.13278. [Epub ahead of print]


Intelligent ICU for Autonomous Patient Monitoring Using Pervasive Sensing and Deep Learning.

Davoudi A, Malhotra KR, Shickel B, Siegel S, Williams S, Ruppert M, Bihorac E, Ozrazgat-Baslanti T, Tighe PJ, Bihorac A, Rashidi P.

Sci Rep. 2019 May 29;9(1):8020. doi: 10.1038/s41598-019-44004-w.


Patients with tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) are hypersensitive to Toll-like receptor 9 stimulation.

Negm OH, Singh S, Abduljabbar W, Hamed MR, Radford P, McDermott EM, Drewe E, Fairclough L, Todd I, Tighe PJ.

Clin Exp Immunol. 2019 Sep;197(3):352-360. doi: 10.1111/cei.13306. Epub 2019 May 22.


Engulfment, persistence and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential.

Raghunathan D, Radford PM, Gell C, Negus D, Moore C, Till R, Tighe PJ, Wheatley SP, Martinez-Pomares L, Sockett RE, Tyson J.

Sci Rep. 2019 Mar 12;9(1):4293. doi: 10.1038/s41598-019-40223-3.


The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Diagnostic Criteria for Acute Pain Conditions: An Introduction.

Kent ML, Tighe PJ, Bruehl S, Turk DC, Dworkin RH.

J Pain. 2019 Jul;20(7):743-745. doi: 10.1016/j.jpain.2018.12.002. Epub 2019 Jan 11. No abstract available.


Emergency Department Airway Management Responsibilities in the United States.

Chiaghana C, Giordano C, Cobb D, Vasilopoulos T, Tighe PJ, Sappenfield JW.

Anesth Analg. 2019 Feb;128(2):296-301. doi: 10.1213/ANE.0000000000003851.


Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells.

Alkhattabi N, Todd I, Negm O, Tighe PJ, Fairclough LC.

Toxicol Lett. 2018 Dec 15;299:40-46. doi: 10.1016/j.toxlet.2018.09.002. Epub 2018 Sep 15.


Deep EHR: A Survey of Recent Advances in Deep Learning Techniques for Electronic Health Record (EHR) Analysis.

Shickel B, Tighe PJ, Bihorac A, Rashidi P.

IEEE J Biomed Health Inform. 2018 Sep;22(5):1589-1604. doi: 10.1109/JBHI.2017.2767063. Epub 2017 Oct 27. Review.


Characterization of Behavioral, Signaling and Cytokine Alterations in a Rat Neurodevelopmental Model for Schizophrenia, and Their Reversal by the 5-HT6 Receptor Antagonist SB-399885.

Shortall SE, Negm OH, Fowler M, Fairclough LC, Tighe PJ, Wigmore PM, King MV.

Mol Neurobiol. 2018 Sep;55(9):7413-7430. doi: 10.1007/s12035-018-0940-0. Epub 2018 Feb 8.


Economic Considerations of Acute Pain Medicine Programs.

Gray CF, Smith C, Zasimovich Y, Tighe PJ.

Tech Orthop. 2017 Dec;32(4):217-225. doi: 10.1097/BTO.0000000000000241.


IgE autoantibodies and their association with the disease activity and phenotype in bullous pemphigoid: a systematic review.

Saniklidou AH, Tighe PJ, Fairclough LC, Todd I.

Arch Dermatol Res. 2018 Jan;310(1):11-28. doi: 10.1007/s00403-017-1789-1. Epub 2017 Oct 25. Review.


Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease.

Shindi R, Almehairi A, Negm OH, Kalsheker N, Gale NS, Shale DJ, Harrison TW, Bolton CE, John M, Todd I, Tighe PJ, Fairclough LC.

Clin Immunol. 2017 Oct;183:344-353. doi: 10.1016/j.clim.2017.09.020. Epub 2017 Sep 23.


A signalome screening approach in the autoinflammatory disease TNF receptor associated periodic syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing.

Todd I, Negm OH, Reps J, Radford P, Figueredo G, McDermott EM, Drewe E, Powell RJ, Bainbridge S, Hamed M, Crouch S, Garibaldi J, St-Gallay S, Fairclough LC, Tighe PJ.

Pharmacol Res. 2017 Nov;125(Pt B):188-200. doi: 10.1016/j.phrs.2017.08.012. Epub 2017 Aug 30.


Transition Icons for Time-Series Visualization and Exploratory Analysis.

Nickerson PV, Baharloo R, Wanigatunga AA, Manini TM, Tighe PJ, Rashidi P.

IEEE J Biomed Health Inform. 2018 Mar;22(2):623-630. doi: 10.1109/JBHI.2017.2704608. Epub 2017 May 16.


The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.

Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC 3rd, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, Mackey S, McLean SA, Polomano R, Rahman S, Raja S, Rowbotham M, Suresh S, Schachtel B, Schreiber K, Schumacher M, Stacey B, Stanos S, Todd K, Turk DC, Weisman SJ, Wu C, Carr DB, Dworkin RH, Terman G.

J Pain. 2017 May;18(5):479-489. doi: 10.1016/j.jpain.2017.02.421.


The ACTTION-APS-AAPM Pain Taxonomy (AAAPT) Multidimensional Approach to Classifying Acute Pain Conditions.

Kent ML, Tighe PJ, Belfer I, Brennan TJ, Bruehl S, Brummett CM, Buckenmaier CC 3rd, Buvanendran A, Cohen RI, Desjardins P, Edwards D, Fillingim R, Gewandter J, Gordon DB, Hurley RW, Kehlet H, Loeser JD, Mackey S, McLean SA, Polomano R, Rahman S, Raja S, Rowbotham M, Suresh S, Schachtel B, Schreiber K, Schumacher M, Stacey B, Stanos S, Todd K, Turk DC, Weisman SJ, Wu C, Carr DB, Dworkin RH, Terman G.

Pain Med. 2017 May 1;18(5):947-958. doi: 10.1093/pm/pnx019.


Age Differences in the Time Course and Magnitude of Changes in Circulating Neuropeptides After Pain Evocation in Humans.

Riley JL 3rd, Cruz-Almeida Y, Dasilva Ribeiro MC, Simon CB, Eckert NR, Aguirre M, Sorenson HL, Tighe PJ, Edwards RR, Wallet SM.

J Pain. 2017 Sep;18(9):1078-1086. doi: 10.1016/j.jpain.2017.04.006. Epub 2017 Apr 29.


DisTeam: A decision support tool for surgical team selection.

Ebadi A, Tighe PJ, Zhang L, Rashidi P.

Artif Intell Med. 2017 Feb;76:16-26. doi: 10.1016/j.artmed.2017.02.002. Epub 2017 Feb 10.


Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction.

Tubby C, Negm OH, Harrison T, Tighe PJ, Todd I, Fairclough LC.

J Asthma. 2017 Jun;54(5):456-466. doi: 10.1080/02770903.2016.1236941. Epub 2016 Oct 13.


Locating the optimal internal jugular target site for central venous line placement.

Giordano CR, Murtagh KR, Mills J, Deitte LA, Rice MJ, Tighe PJ.

J Clin Anesth. 2016 Sep;33:198-202. doi: 10.1016/j.jclinane.2016.03.070. Epub 2016 May 1.


Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease.

Selvarajah S, Todd I, Tighe PJ, John M, Bolton CE, Harrison T, Fairclough LC.

Mediators Inflamm. 2016;2016:3604842. doi: 10.1155/2016/3604842. Epub 2016 Jul 25.


Characterizations of Temporal Postoperative Pain Signatures With Symbolic Aggregate Approximations.

Tighe PJ, Nickerson P, Fillingim RB, Rashidi P.

Clin J Pain. 2017 Jan;33(1):1-11.


On variance estimate for covariate adjustment by propensity score analysis.

Zou B, Zou F, Shuster JJ, Tighe PJ, Koch GG, Zhou H.

Stat Med. 2016 Sep 10;35(20):3537-48. doi: 10.1002/sim.6943. Epub 2016 Mar 21.


The prognostic significance of STAT3 in invasive breast cancer: analysis of protein and mRNA expressions in large cohorts.

Aleskandarany MA, Agarwal D, Negm OH, Ball G, Elmouna A, Ashankyty I, Nuglozeh E, Fazaludeen MF, Diez-Rodriguez M, Nolan CC, Tighe PJ, Green AR, Ellis IO, Rakha EA.

Breast Cancer Res Treat. 2016 Feb;156(1):9-20. doi: 10.1007/s10549-016-3709-z. Epub 2016 Feb 23.


The mannose receptor negatively modulates the Toll-like receptor 4-aryl hydrocarbon receptor-indoleamine 2,3-dioxygenase axis in dendritic cells affecting T helper cell polarization.

Salazar F, Hall L, Negm OH, Awuah D, Tighe PJ, Shakib F, Ghaemmaghami AM.

J Allergy Clin Immunol. 2016 Jun;137(6):1841-1851.e2. doi: 10.1016/j.jaci.2015.10.033. Epub 2015 Dec 17.


Clinical utility of reverse phase protein array for molecular classification of breast cancer.

Negm OH, Muftah AA, Aleskandarany MA, Hamed MR, Ahmad DA, Nolan CC, Diez-Rodriguez M, Tighe PJ, Ellis IO, Rakha EA, Green AR.

Breast Cancer Res Treat. 2016 Jan;155(1):25-35. doi: 10.1007/s10549-015-3654-2. Epub 2015 Dec 9.


Markov chain evaluation of acute postoperative pain transition states.

Tighe PJ, Bzdega M, Fillingim RB, Rashidi P, Aytug H.

Pain. 2016 Mar;157(3):717-28. doi: 10.1097/j.pain.0000000000000429.


Ising Model of the Chronification of Acute Pain.

Tighe PJ.

Pain Med. 2016 Jan;17(1):3-4. No abstract available.


Time to Onset of Sustained Postoperative Pain Relief (SuPPR): Evaluation of a New Systems-level Metric for Acute Pain Management.

Tighe PJ, King CD, Zou B, Fillingim RB.

Clin J Pain. 2016 May;32(5):371-9. doi: 10.1097/AJP.0000000000000285.


Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome.

Fairclough LC, Stoop AA, Negm OH, Radford PM, Tighe PJ, Todd I.

Eur J Immunol. 2015 Oct;45(10):2937-44. doi: 10.1002/eji.201545769. Epub 2015 Aug 17.


Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis.

Negm OH, Hamed MR, Dilnot EM, Shone CC, Marszalowska I, Lynch M, Loscher CE, Edwards LJ, Tighe PJ, Wilcox MH, Monaghan TM.

Clin Vaccine Immunol. 2015 Sep;22(9):1033-9. doi: 10.1128/CVI.00190-15. Epub 2015 Jul 15.


Teaching a Machine to Feel Postoperative Pain: Combining High-Dimensional Clinical Data with Machine Learning Algorithms to Forecast Acute Postoperative Pain.

Tighe PJ, Harle CA, Hurley RW, Aytug H, Boezaart AP, Fillingim RB.

Pain Med. 2015 Jul;16(7):1386-401. doi: 10.1111/pme.12713. Epub 2015 May 29.


The painful tweet: text, sentiment, and community structure analyses of tweets pertaining to pain.

Tighe PJ, Goldsmith RC, Gravenstein M, Bernard HR, Fillingim RB.

J Med Internet Res. 2015 Apr 2;17(4):e84. doi: 10.2196/jmir.3769.


Prognostic and biological significance of peroxisome proliferator-activated receptor-gamma in luminal breast cancer.

Abduljabbar R, Al-Kaabi MM, Negm OH, Jerjees D, Muftah AA, Mukherjee A, Lai CF, Buluwela L, Ali S, Tighe PJ, Green A, Ellis I, Rakha E.

Breast Cancer Res Treat. 2015 Apr;150(3):511-22. doi: 10.1007/s10549-015-3348-9. Epub 2015 Mar 21.


Clinically derived early postoperative pain trajectories differ by age, sex, and type of surgery.

Tighe PJ, Le-Wendling LT, Patel A, Zou B, Fillingim RB.

Pain. 2015 Apr;156(4):609-17. doi: 10.1097/01.j.pain.0000460352.07836.0d.


Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer.

Abduljabbar R, Negm OH, Lai CF, Jerjees DA, Al-Kaabi M, Hamed MR, Tighe PJ, Buluwela L, Mukherjee A, Green AR, Ali S, Rakha EA, Ellis IO.

Breast Cancer Res Treat. 2015 Apr;150(2):335-46. doi: 10.1007/s10549-015-3335-1. Epub 2015 Mar 12.


Effects of pro-inflammatory cytokines on cannabinoid CB1 and CB2 receptors in immune cells.

Jean-Gilles L, Braitch M, Latif ML, Aram J, Fahey AJ, Edwards LJ, Robins RA, Tanasescu R, Tighe PJ, Gran B, Showe LC, Alexander SP, Chapman V, Kendall DA, Constantinescu CS.

Acta Physiol (Oxf). 2015 May;214(1):63-74. doi: 10.1111/apha.12474. Epub 2015 Mar 10.


The mammalian target of rapamycin complex 1 (mTORC1) in breast cancer: the impact of oestrogen receptor and HER2 pathways.

Jerjees DA, Negm OH, Alabdullah ML, Mirza S, Alkaabi M, Hameed MR, Abduljabbar R, Muftah A, Nolan CC, Green AR, Tighe PJ, Band V, Ellis IO, Rakha EA.

Breast Cancer Res Treat. 2015 Feb;150(1):91-103. doi: 10.1007/s10549-015-3308-4. Epub 2015 Feb 21.


Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFN╬│/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis.

Vilisaar J, Kawabe K, Braitch M, Aram J, Furtun Y, Fahey AJ, Chopra M, Tanasescu R, Tighe PJ, Gran B, Pothoulakis C, Constantinescu CS.

J Neuroimmune Pharmacol. 2015 Sep;10(3):457-67. doi: 10.1007/s11481-015-9589-x. Epub 2015 Feb 18.


ELISA in the multiplex era: potentials and pitfalls.

Tighe PJ, Ryder RR, Todd I, Fairclough LC.

Proteomics Clin Appl. 2015 Apr;9(3-4):406-22. doi: 10.1002/prca.201400130. Epub 2015 Mar 25. Review.


Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease.

Daffa NI, Tighe PJ, Corne JM, Fairclough LC, Todd I.

Clin Exp Immunol. 2015 Apr;180(1):155-63. doi: 10.1111/cei.12565.


Development and validation of protein microarray technology for simultaneous inflammatory mediator detection in human sera.

Selvarajah S, Negm OH, Hamed MR, Tubby C, Todd I, Tighe PJ, Harrison T, Fairclough LC.

Mediators Inflamm. 2014;2014:820304. doi: 10.1155/2014/820304. Epub 2014 Oct 14.


Sex differences in the incidence of severe pain events following surgery: a review of 333,000 pain scores.

Tighe PJ, Riley JL 3rd, Fillingim RB.

Pain Med. 2014 Aug;15(8):1390-404. doi: 10.1111/pme.12498. Epub 2014 Jul 8.


Epithelial mesenchymal transition in early invasive breast cancer: an immunohistochemical and reverse phase protein array study.

Aleskandarany MA, Negm OH, Green AR, Ahmed MA, Nolan CC, Tighe PJ, Ellis IO, Rakha EA.

Breast Cancer Res Treat. 2014 Jun;145(2):339-48. doi: 10.1007/s10549-014-2927-5. Epub 2014 Apr 26.


A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS).

Negm OH, Mannsperger HA, McDermott EM, Drewe E, Powell RJ, Todd I, Fairclough LC, Tighe PJ.

Eur J Immunol. 2014 Jul;44(7):2096-110. doi: 10.1002/eji.201344328. Epub 2014 Jun 10.


Geospatial analysis of hospital consumer assessment of healthcare providers and systems pain management experience scores in U.S. hospitals.

Tighe PJ, Fillingim RB, Hurley RW.

Pain. 2014 May;155(5):1016-26. doi: 10.1016/j.pain.2014.02.003. Epub 2014 Feb 10.


Acute pain medicine in anesthesiology.

Boezaart AP, Munro AP, Tighe PJ.

F1000Prime Rep. 2013 Dec 3;5:54. doi: 10.12703/P5-54. Review.

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