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A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1.

Le Nours J, Gherardin NA, Ramarathinam SH, Awad W, Wiede F, Gully BS, Khandokar Y, Praveena T, Wubben JM, Sandow JJ, Webb AI, von Borstel A, Rice MT, Redmond SJ, Seneviratna R, Sandoval-Romero ML, Li S, Souter MNT, Eckle SBG, Corbett AJ, Reid HH, Liu L, Fairlie DP, Giles EM, Westall GP, Tothill RW, Davey MS, Berry R, Tiganis T, McCluskey J, Pellicci DG, Purcell AW, Uldrich AP, Godfrey DI, Rossjohn J.

Science. 2019 Dec 20;366(6472):1522-1527. doi: 10.1126/science.aav3900.


PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours.

Wiede F, Lu KH, Du X, Liang S, Hochheiser K, Dodd GT, Goh PK, Kearney C, Meyran D, Beavis PA, Henderson MA, Park SL, Waithman J, Zhang S, Zhang ZY, Oliaro J, Gebhardt T, Darcy PK, Tiganis T.

EMBO J. 2020 Jan 15;39(2):e103637. doi: 10.15252/embj.2019103637. Epub 2019 Dec 5.


Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity.

Dodd GT, Xirouchaki CE, Eramo M, Mitchell CA, Andrews ZB, Henry BA, Cowley MA, Tiganis T.

Cell Rep. 2019 Sep 10;28(11):2905-2922.e5. doi: 10.1016/j.celrep.2019.08.019.


Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice.

Balland E, Chen W, Tiganis T, Cowley MA.

Neuroendocrinology. 2019;109(4):374-390. doi: 10.1159/000500201. Epub 2019 Apr 16.


T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities.

Wiede F, Brodnicki TC, Goh PK, Leong YA, Jones GW, Yu D, Baxter AG, Jones SA, Kay TWH, Tiganis T.

Diabetes. 2019 Jun;68(6):1251-1266. doi: 10.2337/db18-1362. Epub 2019 Apr 1.


Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells.

Twohig JP, Cardus Figueras A, Andrews R, Wiede F, Cossins BC, Derrac Soria A, Lewis MJ, Townsend MJ, Millrine D, Li J, Hill DG, Uceda Fernandez J, Liu X, Szomolay B, Pepper CJ, Taylor PR, Pitzalis C, Tiganis T, Williams NM, Jones GW, Jones SA.

Nat Immunol. 2019 Apr;20(4):458-470. doi: 10.1038/s41590-019-0350-0. Epub 2019 Mar 19.


Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465.

Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT.

Diabetes. 2019 Mar;68(3):676. doi: 10.2337/db19-er03a. Epub 2019 Jan 11. No abstract available.


Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice.

Balland E, Chen W, Dodd GT, Conductier G, Coppari R, Tiganis T, Cowley MA.

Cell Rep. 2019 Jan 8;26(2):346-355.e3. doi: 10.1016/j.celrep.2018.12.061.


Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.

Svensson MN, Doody KM, Schmiedel BJ, Bhattacharyya S, Panwar B, Wiede F, Yang S, Santelli E, Wu DJ, Sacchetti C, Gujar R, Seumois G, Kiosses WB, Aubry I, Kim G, Mydel P, Sakaguchi S, Kronenberg M, Tiganis T, Tremblay ML, Ay F, Vijayanand P, Bottini N.

J Clin Invest. 2019 Mar 1;129(3):1193-1210. doi: 10.1172/JCI123267. Epub 2019 Feb 11.


Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus.

Kyriakou E, Schmidt S, Dodd GT, Pfuhlmann K, Simonds SE, Lenhart D, Geerlof A, Schriever SC, De Angelis M, Schramm KW, Plettenburg O, Cowley MA, Tiganis T, Tschöp MH, Pfluger PT, Sattler M, Messias AC.

J Med Chem. 2018 Dec 27;61(24):11144-11157. doi: 10.1021/acs.jmedchem.8b01224. Epub 2018 Dec 7.


NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development.

Harrison IP, Vinh A, Johnson IRD, Luong R, Drummond GR, Sobey CG, Tiganis T, Williams ED, O' Leary JJ, Brooks DA, Selemidis S.

Oncotarget. 2018 Oct 23;9(83):35378-35393. doi: 10.18632/oncotarget.26237. eCollection 2018 Oct 23.


Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.

Grohmann M, Wiede F, Dodd GT, Gurzov EN, Ooi GJ, Butt T, Rasmiena AA, Kaur S, Gulati T, Goh PK, Treloar AE, Archer S, Brown WA, Muller M, Watt MJ, Ohara O, McLean CA, Tiganis T.

Cell. 2018 Nov 15;175(5):1289-1306.e20. doi: 10.1016/j.cell.2018.09.053. Epub 2018 Oct 25.


Insulin regulates POMC neuronal plasticity to control glucose metabolism.

Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT, Munder AC, Simonds SE, Brüning JC, Zhang ZY, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T.

Elife. 2018 Sep 19;7. pii: e38704. doi: 10.7554/eLife.38704.


Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.

Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT.

Diabetes. 2018 Nov;67(11):2456-2465. doi: 10.2337/db18-0146. Epub 2018 Aug 28. Erratum in: Diabetes. 2019 Mar;68(3):676.


Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells.

Quinn KM, Fox A, Harland KL, Russ BE, Li J, Nguyen THO, Loh L, Olshanksy M, Naeem H, Tsyganov K, Wiede F, Webster R, Blyth C, Sng XYX, Tiganis T, Powell D, Doherty PC, Turner SJ, Kedzierska K, La Gruta NL.

Cell Rep. 2018 Jun 19;23(12):3512-3524. doi: 10.1016/j.celrep.2018.05.057.


TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding.

Dodd GT, Lee-Young RS, Brüning JC, Tiganis T.

Diabetes. 2018 Jul;67(7):1246-1257. doi: 10.2337/db17-1485. Epub 2018 Apr 30.


Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signaling Pathway in Drosophila.

Henstridge MA, Aulsebrook L, Koyama T, Johnson TK, Whisstock JC, Tiganis T, Mirth CK, Warr CG.

Genetics. 2018 Apr;208(4):1523-1533. doi: 10.1534/genetics.117.300601. Epub 2018 Feb 13.


Isolation and Characterization of Mouse Intrahepatic Lymphocytes by Flow Cytometry.

Wiede F, Tiganis T.

Methods Mol Biol. 2018;1725:301-311. doi: 10.1007/978-1-4939-7568-6_23.


PTPN2: a tumor suppressor you want deleted?

Wiede F, Tiganis T.

Immunol Cell Biol. 2017 Nov;95(10):859-861. doi: 10.1038/icb.2017.70. Epub 2017 Oct 10. No abstract available.


A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.

Dodd GT, Andrews ZB, Simonds SE, Michael NJ, DeVeer M, Brüning JC, Spanswick D, Cowley MA, Tiganis T.

Cell Metab. 2017 Sep 5;26(3):577. doi: 10.1016/j.cmet.2017.08.001. No abstract available.


PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

Wiede F, Dudakov JA, Lu KH, Dodd GT, Butt T, Godfrey DI, Strasser A, Boyd RL, Tiganis T.

J Exp Med. 2017 Sep 4;214(9):2733-2758. doi: 10.1084/jem.20161903. Epub 2017 Aug 10.


A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding.

Dodd GT, Andrews ZB, Simonds SE, Michael NJ, DeVeer M, Brüning JC, Spanswick D, Cowley MA, Tiganis T.

Cell Metab. 2017 Aug 1;26(2):375-393.e7. doi: 10.1016/j.cmet.2017.07.013. Erratum in: Cell Metab. 2017 Sep 5;26(3):577.


Insulin action in the brain: Roles in energy and glucose homeostasis.

Dodd GT, Tiganis T.

J Neuroendocrinol. 2017 Oct;29(10). doi: 10.1111/jne.12513. Review.


Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants.

Willoughby LF, Manent J, Allan K, Lee H, Portela M, Wiede F, Warr C, Meng TC, Tiganis T, Richardson HE.

FEBS J. 2017 Jul;284(14):2231-2250. doi: 10.1111/febs.14118. Epub 2017 Jun 30.


Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.

Gras S, Chadderton J, Del Campo CM, Farenc C, Wiede F, Josephs TM, Sng XYX, Mirams M, Watson KA, Tiganis T, Quinn KM, Rossjohn J, La Gruta NL.

Immunity. 2016 Oct 18;45(4):749-760. doi: 10.1016/j.immuni.2016.09.007. Epub 2016 Oct 4.


Erratum to: Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.

Merry TL, Tran M, Dodd GT, Mangiafico SP, Wiede F, Kaur S, McLean CL, Andrikopoulos S, Tiganis T.

Diabetologia. 2016 Dec;59(12):2729. No abstract available.


RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.

Yi Lo JC, O'Connor AE, Andrews ZB, Lo C, Tiganis T, Watt MJ, O'Bryan MK.

Endocrinology. 2016 Dec;157(12):4732-4743. Epub 2016 Oct 12.


PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity.

Wiede F, Sacirbegovic F, Leong YA, Yu D, Tiganis T.

J Autoimmun. 2017 Jan;76:85-100. doi: 10.1016/j.jaut.2016.09.004. Epub 2016 Sep 19.


Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice.

Merry TL, Tran M, Dodd GT, Mangiafico SP, Wiede F, Kaur S, McLean CL, Andrikopoulos S, Tiganis T.

Diabetologia. 2016 Dec;59(12):2632-2644. Epub 2016 Sep 15. Erratum in: Diabetologia. 2016 Dec;59(12 ):2729.


T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.

Beringer DX, Kleijwegt FS, Wiede F, van der Slik AR, Loh KL, Petersen J, Dudek NL, Duinkerken G, Laban S, Joosten A, Vivian JP, Chen Z, Uldrich AP, Godfrey DI, McCluskey J, Price DA, Radford KJ, Purcell AW, Nikolic T, Reid HH, Tiganis T, Roep BO, Rossjohn J.

Nat Immunol. 2015 Nov;16(11):1153-61. doi: 10.1038/ni.3271. Epub 2015 Oct 5.


Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.

Zhang ZY, Dodd GT, Tiganis T.

Trends Pharmacol Sci. 2015 Oct;36(10):661-674. doi: 10.1016/ Review.


The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.

Ooms LM, Binge LC, Davies EM, Rahman P, Conway JR, Gurung R, Ferguson DT, Papa A, Fedele CG, Vieusseux JL, Chai RC, Koentgen F, Price JT, Tiganis T, Timpson P, McLean CA, Mitchell CA.

Cancer Cell. 2015 Aug 10;28(2):155-69. doi: 10.1016/j.ccell.2015.07.003.


Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets.

Stanley WJ, Litwak SA, Quah HS, Tan SM, Kay TW, Tiganis T, de Haan JB, Thomas HE, Gurzov EN.

Diabetes. 2015 Jul;64(7):2489-96. doi: 10.2337/db14-1575. Epub 2015 Mar 2.


Leptin and insulin act on POMC neurons to promote the browning of white fat.

Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T.

Cell. 2015 Jan 15;160(1-2):88-104. doi: 10.1016/j.cell.2014.12.022.


Pioneer of Eph biology and therapeutics: Martin Lackmann (1956-2014).

Scott AM, Tiganis T.

Growth Factors. 2014 Dec;32(6):171-3. doi: 10.3109/08977194.2014.983226. Epub 2014 Nov 17. No abstract available.


Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice.

Xi Y, Liu S, Bettaieb A, Matsuo K, Matsuo I, Hosein E, Chahed S, Wiede F, Zhang S, Zhang ZY, Kulkarni RN, Tiganis T, Haj FG.

Diabetologia. 2015 Jan;58(1):122-31. doi: 10.1007/s00125-014-3413-7. Epub 2014 Oct 23.


Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration.

Davies EM, Kong AM, Tan A, Gurung R, Sriratana A, Bukczynska PE, Ooms LM, McLean CA, Tiganis T, Mitchell CA.

Oncogene. 2015 Jul;34(28):3711-27. doi: 10.1038/onc.2014.303. Epub 2014 Sep 22.


PTPN2 restrains CD8⁺ T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice.

Wiede F, Ziegler A, Zehn D, Tiganis T.

J Autoimmun. 2014 Sep;53:105-14. doi: 10.1016/j.jaut.2014.05.008. Epub 2014 Jul 2.


Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.

Gurzov EN, Tran M, Fernandez-Rojo MA, Merry TL, Zhang X, Xu Y, Fukushima A, Waters MJ, Watt MJ, Andrikopoulos S, Neel BG, Tiganis T.

Cell Metab. 2014 Jul 1;20(1):85-102. doi: 10.1016/j.cmet.2014.05.011. Epub 2014 Jun 19.


Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis.

Bettaieb A, Xi Y, Hosein E, Coggins N, Bachaalany S, Wiede F, Perez S, Griffey SM, Sastre J, Tiganis T, Haj FG.

Cell Commun Signal. 2014 Mar 10;12:13. doi: 10.1186/1478-811X-12-13.


PTPN2 attenuates T-cell lymphopenia-induced proliferation.

Wiede F, La Gruta NL, Tiganis T.

Nat Commun. 2014;5:3073. doi: 10.1038/ncomms4073.


High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage.

Merry TL, Tran M, Stathopoulos M, Wiede F, Fam BC, Dodd GT, Clarke I, Watt MJ, Andrikopoulos S, Tiganis T.

Antioxid Redox Signal. 2014 May 10;20(14):2114-29. doi: 10.1089/ars.2013.5428. Epub 2014 Mar 11.


Characterization of PTPN2 and its use as a biomarker.

Bussières-Marmen S, Hutchins AP, Schirbel A, Rebert N, Tiganis T, Fiocchi C, Miranda-Saavedra D, Tremblay ML.

Methods. 2014 Jan 15;65(2):239-46. doi: 10.1016/j.ymeth.2013.08.020. Epub 2013 Aug 30.


Special issue--signalling. Introduction: Frontiers in cell signalling.

Daly R, Tiganis T.

FEBS J. 2013 Nov;280(21):5163. doi: 10.1111/febs.12508. Epub 2013 Sep 23.


The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity.

Buszard BJ, Johnson TK, Meng TC, Burke R, Warr CG, Tiganis T.

Mol Cell Biol. 2013 Apr;33(7):1345-56. doi: 10.1128/MCB.01411-12. Epub 2013 Jan 22.


TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.

Shields BJ, Wiede F, Gurzov EN, Wee K, Hauser C, Zhu HJ, Molloy TJ, O'Toole SA, Daly RJ, Sutherland RL, Mitchell CA, McLean CA, Tiganis T.

Mol Cell Biol. 2013 Feb;33(3):557-70. doi: 10.1128/MCB.01016-12. Epub 2012 Nov 19.


Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase.

Pagnon J, Matzaris M, Stark R, Meex RC, Macaulay SL, Brown W, O'Brien PE, Tiganis T, Watt MJ.

Endocrinology. 2012 Sep;153(9):4278-89. doi: 10.1210/en.2012-1127. Epub 2012 Jun 25.


Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.

Wiede F, Chew SH, van Vliet C, Poulton IJ, Kyparissoudis K, Sasmono T, Loh K, Tremblay ML, Godfrey DI, Sims NA, Tiganis T.

PLoS One. 2012;7(5):e36703. doi: 10.1371/journal.pone.0036703. Epub 2012 May 8.


The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity.

Visinoni S, Khalid NF, Joannides CN, Shulkes A, Yim M, Whitehead J, Tiganis T, Lamont BJ, Favaloro JM, Proietto J, Andrikopoulos S, Fam BC.

Diabetes. 2012 May;61(5):1122-32. doi: 10.2337/db11-1511.


PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis.

Tiganis T.

FEBS J. 2013 Jan;280(2):445-58. doi: 10.1111/j.1742-4658.2012.08563.x. Epub 2012 Apr 18. Review.

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