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Items: 1 to 50 of 114

1.

Cryptococcal-related mortality despite fluconazole pre-emptive treatment in a cryptococcal antigen (CrAg) screen-and-treat programme.

Wake RM, Govender NP, Omar T, Nel C, Mazanderani AH, Karat AS, Ismail NA, Tiemessen CT, Jarvis JN, Harrison TS.

Clin Infect Dis. 2019 Jun 8. pii: ciz485. doi: 10.1093/cid/ciz485. [Epub ahead of print]

PMID:
31179488
2.

Partner HIV serostatus impacts viral load, genital HIV shedding and immune activation in HIV-infected individuals.

Jaumdally SZ, Liebenberg LJP, Gumbi PP, Little F, Jaspan HB, Gamieldien H, Tiemessen CT, Coetzee D, Martin DP, Williamson C, Williamson AL, Passmore JS.

J Acquir Immune Defic Syndr. 2019 May 21. doi: 10.1097/QAI.0000000000002089. [Epub ahead of print]

PMID:
31169767
3.

HIV diagnostic challenges in breast-fed infants of mothers on antiretroviral therapy.

Strehlau R, Paximadis M, Patel F, Burke M, Technau KG, Shiau S, Abrams EJ, Sherman GG, Hunt G, Ledwaba J, Mazanderani AH, Tiemessen CT, Kuhn L; LEOPARD Study Team.

AIDS. 2019 May 29. doi: 10.1097/QAD.0000000000002276. [Epub ahead of print]

PMID:
31149944
4.

Cis-regulatory genetic variants in the CCR5 gene and natural HIV-1 control in black South Africans.

Koor GW, Paximadis M, Picton ACP, Karatas F, Loubser SA, He W, Ahuja SK, Chaisson RE, Martinson N, Ebrahim O, Tiemessen CT.

Clin Immunol. 2019 May 15;205:16-24. doi: 10.1016/j.clim.2019.05.009. [Epub ahead of print]

PMID:
31100442
5.

Chronic HIV-1 Infection Alters the Cellular Distribution of FcγRIIIa and the Functional Consequence of the FcγRIIIa-F158V Variant.

Phaahla NG, Lassaunière R, Da Costa Dias B, Waja Z, Martinson NA, Tiemessen CT.

Front Immunol. 2019 Apr 10;10:735. doi: 10.3389/fimmu.2019.00735. eCollection 2019.

6.

Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.

Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, Colby DJ, Dawson L, Dong KL, Dubé K, Eron J, Frater J, Gandhi RT, Geleziunas R, Goulder P, Hanna GJ, Jefferys R, Johnston R, Kuritzkes D, Li JZ, Likhitwonnawut U, van Lunzen J, Martinez-Picado J, Miller V, Montaner LJ, Nixon DF, Palm D, Pantaleo G, Peay H, Persaud D, Salzwedel J, Salzwedel K, Schacker T, Sheikh V, Søgaard OS, Spudich S, Stephenson K, Sugarman J, Taylor J, Tebas P, Tiemessen CT, Tressler R, Weiss CD, Zheng L, Robb ML, Michael NL, Mellors JW, Deeks SG, Walker BD.

Lancet HIV. 2019 Apr;6(4):e259-e268. doi: 10.1016/S2352-3018(19)30052-9. Epub 2019 Mar 15. Review.

PMID:
30885693
7.

A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation.

Violari A, Cotton MF, Kuhn L, Schramm DB, Paximadis M, Loubser S, Shalekoff S, Da Costa Dias B, Otwombe K, Liberty A, McIntyre J, Babiker A, Gibb D, Tiemessen CT.

Nat Commun. 2019 Jan 24;10(1):412. doi: 10.1038/s41467-019-08311-0.

8.

The FCGR2C allele that modulated the risk of HIV-1 infection in the Thai RV144 vaccine trial is implicated in HIV-1 disease progression.

Lassaunière R, Paximadis M, Ebrahim O, Chaisson RE, Martinson NA, Tiemessen CT.

Genes Immun. 2018 Dec 19. doi: 10.1038/s41435-018-0053-9. [Epub ahead of print]

PMID:
30563969
9.

Living donor liver transplant from an HIV-positive mother to her HIV-negative child: opening up new therapeutic options.

Botha J, Conradie F, Etheredge H, Fabian J, Duncan M, Haeri Mazanderani A, Paximadis M, Maher H, Britz R, Loveland J, Ströbele B, Rambarran S, Mahomed A, Terblanche A, Beretta M, Brannigan L, Pienaar M, Archibald-Durham L, Lang A, Tiemessen CT.

AIDS. 2018 Oct 23;32(16):F13-F19. doi: 10.1097/QAD.0000000000002000.

10.

Identification and sequence analysis of two novel cryptic plasmids isolated from the vaginal mucosa of South African women.

Harris L, van Zyl LJ, Kirby-McCullough BM, Damelin LH, Tiemessen CT, Trindade M.

Plasmid. 2018 Jun;98:56-62. doi: 10.1016/j.plasmid.2018.09.008. Epub 2018 Sep 18.

PMID:
30240699
11.

Common Variation in NLRP3 Is Associated With Early Death and Elevated Inflammasome Biomarkers Among Advanced HIV/TB Co-infected Patients in Botswana.

Ravimohan S, Nfanyana K, Tamuhla N, Tiemessen CT, Weissman D, Bisson GP.

Open Forum Infect Dis. 2018 Apr 11;5(5):ofy075. doi: 10.1093/ofid/ofy075. eCollection 2018 May.

12.

Age at antiretroviral therapy initiation and cell-associated HIV-1 DNA levels in HIV-1-infected children.

Kuhn L, Paximadis M, Da Costa Dias B, Loubser S, Strehlau R, Patel F, Shiau S, Coovadia A, Abrams EJ, Tiemessen CT.

PLoS One. 2018 Apr 12;13(4):e0195514. doi: 10.1371/journal.pone.0195514. eCollection 2018.

13.

Prevalence and outcomes of HIV-1 diagnostic challenges during universal birth testing - an urban South African observational cohort.

Technau KG, Mazanderani AH, Kuhn L, Hans L, Strehlau R, Abrams EJ, Conradie M, Coovadia A, Mbete N, Murnane PM, Patel F, Shiau S, Tiemessen CT, Sherman GG.

J Int AIDS Soc. 2017 Aug 29;20(Suppl 6):21761. doi: 10.7448/IAS.20.7.21761.

14.

Killer-cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) class I genetic diversity in four South African populations.

Gentle NL, Loubser S, Paximadis M, Puren A, Tiemessen CT.

Hum Immunol. 2017 Jul - Aug;78(7-8):503-509. doi: 10.1016/j.humimm.2017.05.006. Epub 2017 May 29.

PMID:
28571758
15.

Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Indian population.

Loubser S, Paximadis M, Tiemessen CT.

Hum Immunol. 2017 Jul - Aug;78(7-8):468-470. doi: 10.1016/j.humimm.2017.04.010. Epub 2017 May 2.

PMID:
28465172
16.

Human leukocyte antigen class I (A, B and C) allele and haplotype variation in a South African Mixed ancestry population.

Loubser S, Paximadis M, Tiemessen CT.

Hum Immunol. 2017 May - Jun;78(5-6):399-400. doi: 10.1016/j.humimm.2017.04.006. Epub 2017 Apr 21.

17.

CXCR6 gene characterization in two ethnically distinct South African populations and association with viraemic disease control in HIV-1-infected black South African individuals.

Picton ACP, Paximadis M, Chaisson RE, Martinson NA, Tiemessen CT.

Clin Immunol. 2017 Jul;180:69-79. doi: 10.1016/j.clim.2017.04.006. Epub 2017 Apr 18.

18.

CCR5 expression, haplotype and immune activation in protection from infection in HIV-exposed uninfected individuals in HIV-serodiscordant relationships.

Jaumdally SZ, Picton A, Tiemessen CT, Paximadis M, Jaspan HB, Gamieldien H, Masson L, Coetzee D, Williamson AL, Little F, Gumbi PP, Passmore JS.

Immunology. 2017 Aug;151(4):464-473. doi: 10.1111/imm.12743. Epub 2017 May 24.

19.

Mechanisms of HIV persistence in HIV reservoirs.

Mzingwane ML, Tiemessen CT.

Rev Med Virol. 2017 Mar;27(2). doi: 10.1002/rmv.1924. Epub 2017 Jan 27. Review.

PMID:
28128885
20.

RICH2 is implicated in viraemic control of HIV-1 in black South African individuals.

Paximadis M, Ngqobe RN, Chaisson RE, Martinson NA, Tiemessen CT.

Infect Genet Evol. 2017 Apr;49:78-87. doi: 10.1016/j.meegid.2017.01.007. Epub 2017 Jan 6.

21.

Pre-treatment minority HIV-1 drug resistance mutations and long term virological outcomes: is prediction possible?

Mzingwane ML, Tiemessen CT, Richter KL, Mayaphi SH, Hunt G, Bowyer SM.

Virol J. 2016 Oct 12;13(1):170.

22.

Perinatal HIV-1 transmission: Fc gamma receptor variability associates with maternal infectiousness and infant susceptibility.

Lassaunière R, Musekiwa A, Gray GE, Kuhn L, Tiemessen CT.

Retrovirology. 2016 Jun 10;13(1):40. doi: 10.1186/s12977-016-0272-y.

23.

Variability at the FCGR locus: characterization in Black South Africans and evidence for ethnic variation in and out of Africa.

Lassaunière R, Tiemessen CT.

Genes Immun. 2016 Mar;17(2):93-104. doi: 10.1038/gene.2015.60. Epub 2015 Dec 17.

PMID:
26673965
24.

Serum levels of inflammatory cytokines in Rift Valley fever patients are indicative of severe disease.

Jansen van Vuren P, Shalekoff S, Grobbelaar AA, Archer BN, Thomas J, Tiemessen CT, Paweska JT.

Virol J. 2015 Oct 6;12:159. doi: 10.1186/s12985-015-0392-3.

25.

Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor.

Gornalusse GG, Mummidi S, Gaitan AA, Jimenez F, Ramsuran V, Picton A, Rogers K, Manoharan MS, Avadhanam N, Murthy KK, Martinez H, Molano Murillo A, Chykarenko ZA, Hutt R, Daskalakis D, Shostakovich-Koretskaya L, Abdool Karim S, Martin JN, Deeks SG, Hecht F, Sinclair E, Clark RA, Okulicz J, Valentine FT, Martinson N, Tiemessen CT, Ndung'u T, Hunt PW, He W, Ahuja SK.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4762-71. doi: 10.1073/pnas.1423228112. Epub 2015 Aug 11.

26.

Alginate microbead-encapsulated silver complexes for selective delivery of broad-spectrum silver-based microbicides.

Damelin LH, Fernandes MA, Tiemessen CT.

Int J Antimicrob Agents. 2015 Oct;46(4):394-400. doi: 10.1016/j.ijantimicag.2015.05.016. Epub 2015 Jun 29.

PMID:
26184337
27.

Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed.

Kuhn L, Schramm DB, Shiau S, Strehlau R, Pinillos F, Technau K, Coovadia A, Abrams EJ, Puren A, Tiemessen CT.

AIDS. 2015 Jun 1;29(9):1053-60. doi: 10.1097/QAD.0000000000000677.

28.

Maternal human leukocyte antigen-G (HLA-G) genetic variants associate with in utero mother-to-child transmission of HIV-1 in Black South Africans.

Hong HA, Paximadis M, Gray GE, Kuhn L, Tiemessen CT.

Infect Genet Evol. 2015 Mar;30:147-158. doi: 10.1016/j.meegid.2014.12.021. Epub 2014 Dec 23.

29.

Frequencies of immune hypersensitivity reaction-associated HLA class I alleles in healthy South African Indian and mixed ancestry populations determined by a novel real-time PCR assay.

Loubser S, Paximadis M, Gentle N, Puren A, Gray CM, Tiemessen CT.

Tissue Antigens. 2014 Oct;84(4):389-97. doi: 10.1111/tan.12414. Epub 2014 Aug 25.

PMID:
25154892
30.

Comparison of a quantitative Real-Time PCR assay and droplet digital PCR for copy number analysis of the CCL4L genes.

Bharuthram A, Paximadis M, Picton AC, Tiemessen CT.

Infect Genet Evol. 2014 Jul;25:28-35. doi: 10.1016/j.meegid.2014.03.028. Epub 2014 Apr 12.

PMID:
24727646
31.

Prevalence of premalignant cervical lesions in women with a long-term nonprogressor or HIV controller phenotype.

McLeod KE, Omar T, Tiemessen CT, Tshabangu N, Martinson NA.

J Acquir Immune Defic Syndr. 2014 Jan 1;65(1):e29-32. doi: 10.1097/QAI.0b013e31829ce738. No abstract available.

32.

KIR2DS4 allelic variants: Differential effects on in utero and intrapartum HIV-1 mother-to-child transmission.

Hong HA, Paximadis M, Gray GE, Kuhn L, Tiemessen CT.

Clin Immunol. 2013 Dec;149(3):498-508. doi: 10.1016/j.clim.2013.09.005. Epub 2013 Sep 25.

PMID:
24239756
33.

Genetic variability in markers of HLA-C expression in two diverse South African populations.

Gentle NL, Paximadis M, Puren A, Tiemessen CT.

PLoS One. 2013 Jul 5;8(7):e67780. doi: 10.1371/journal.pone.0067780. Print 2013.

34.

Differences are evident within the CXCR4-CXCL12 axis between ethnically divergent South African populations.

Shalekoff S, Schramm DB, Lassaunière R, Picton AC, Tiemessen CT.

Cytokine. 2013 Mar;61(3):792-800. doi: 10.1016/j.cyto.2013.01.003. Epub 2013 Feb 8.

PMID:
23395387
35.

A novel FCGR3A intragenic haplotype is associated with increased FcγRIIIa/CD16a cell surface density and population differences.

Lassaunière R, Shalekoff S, Tiemessen CT.

Hum Immunol. 2013 May;74(5):627-34. doi: 10.1016/j.humimm.2013.01.020. Epub 2013 Jan 31.

PMID:
23376083
36.

Contribution of variable CCL3L copy number to CCL3 protein production in two ethnically divergent South African populations.

Picton AC, Paximadis M, Tiemessen CT.

Infect Genet Evol. 2013 Mar;14:347-56. doi: 10.1016/j.meegid.2012.12.016. Epub 2013 Jan 5.

PMID:
23295355
37.

Influence of intragenic CCL3 haplotypes and CCL3L copy number in HIV-1 infection in a sub-Saharan African population.

Paximadis M, Schramm DB, Gray GE, Sherman G, Coovadia A, Kuhn L, Tiemessen CT.

Genes Immun. 2013 Jan;14(1):42-51. doi: 10.1038/gene.2012.51. Epub 2012 Nov 15.

38.

CCR5 promoter haplotypes differentially influence CCR5 expression on natural killer and T cell subsets in ethnically divergent HIV-1 uninfected South African populations.

Picton AC, Paximadis M, Tiemessen CT.

Immunogenetics. 2012 Nov;64(11):795-806. doi: 10.1007/s00251-012-0642-0. Epub 2012 Aug 15.

PMID:
22893032
39.

Marked differences in CCR5 expression and activation levels in two South African populations.

Picton AC, Shalekoff S, Paximadis M, Tiemessen CT.

Immunology. 2012 Aug;136(4):397-407. doi: 10.1111/j.1365-2567.2012.03592.x.

40.

Human leukocyte antigen class I (A, B, C) and II (DRB1) diversity in the black and Caucasian South African population.

Paximadis M, Mathebula TY, Gentle NL, Vardas E, Colvin M, Gray CM, Tiemessen CT, Puren A.

Hum Immunol. 2012 Jan;73(1):80-92. doi: 10.1016/j.humimm.2011.10.013. Epub 2011 Oct 23.

PMID:
22074999
41.

Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in mice.

Jansen van Vuren P, Tiemessen CT, Paweska JT.

PLoS One. 2011;6(9):e25027. doi: 10.1371/journal.pone.0025027. Epub 2011 Sep 16.

42.

Africa: the next frontier for human disease gene discovery?

Ramsay M, Tiemessen CT, Choudhury A, Soodyall H.

Hum Mol Genet. 2011 Oct 15;20(R2):R214-20. doi: 10.1093/hmg/ddr401. Epub 2011 Sep 9. Review.

PMID:
21908518
43.

Killer-cell immunoglobulin-like receptor genotyping and HLA killer-cell immunoglobulin-like receptor-ligand identification by real-time polymerase chain reaction.

Hong HA, Loubser AS, de Assis Rosa D, Naranbhai V, Carr W, Paximadis M, Lewis DA, Tiemessen CT, Gray CM.

Tissue Antigens. 2011 Sep;78(3):185-94. doi: 10.1111/j.1399-0039.2011.01749.x.

44.

Natural killer cell responses to HIV-1 peptides are associated with more activating KIR genes and HLA-C genes of the C1 allotype.

Tiemessen CT, Paximadis M, Minevich G, Winchester R, Shalekoff S, Gray GE, Sherman GG, Coovadia AH, Kuhn L.

J Acquir Immune Defic Syndr. 2011 Jul 1;57(3):181-9. doi: 10.1097/QAI.0b013e3182174a76.

45.

KIR-HLA and maternal-infant HIV-1 transmission in sub-Saharan Africa.

Paximadis M, Minevich G, Winchester R, Schramm DB, Gray GE, Sherman GG, Coovadia AH, Kuhn L, Tiemessen CT.

PLoS One. 2011 Feb 8;6(2):e16541. doi: 10.1371/journal.pone.0016541.

46.

Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early Life.

Schramm DB, Anthony F, Mathebula B, Sherman G, Coovadia A, Gray GE, Kuhn L, Tiemessen CT.

Open AIDS J. 2010 Aug 12;4:156-65. doi: 10.2174/1874613601004010156.

47.

Identification of predominant culturable vaginal Lactobacillus species and associated bacteriophages from women with and without vaginal discharge syndrome in South Africa.

Damelin LH, Paximadis M, Mavri-Damelin D, Birkhead M, Lewis DA, Tiemessen CT.

J Med Microbiol. 2011 Feb;60(Pt 2):180-3. doi: 10.1099/jmm.0.024463-0. Epub 2010 Oct 28.

PMID:
21030503
48.

Natural killer cells that respond to human immunodeficiency virus type 1 (HIV‐1) peptides are associated with control of HIV‐1 infection.

Tiemessen CT, Shalekoff S, Meddows-Taylor S, Schramm DB, Papathanasopoulos M, Gray G, Sherman G, Coovadia A, Kuhn L.

J Infect Dis. 2010 Nov 1;202(9):1444-53. doi: 10.1086/656535.

49.

FOXP3 expression is upregulated in CD4T cells in progressive HIV-1 infection and is a marker of disease severity.

Suchard MS, Mayne E, Green VA, Shalekoff S, Donninger SL, Stevens WS, Gray CM, Tiemessen CT.

PLoS One. 2010 Jul 23;5(7):e11762. doi: 10.1371/journal.pone.0011762.

50.

Plasmid transduction using bacteriophage Phi(adh) for expression of CC chemokines by Lactobacillus gasseri ADH.

Damelin LH, Mavri-Damelin D, Klaenhammer TR, Tiemessen CT.

Appl Environ Microbiol. 2010 Jun;76(12):3878-85. doi: 10.1128/AEM.00139-10. Epub 2010 Apr 23.

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