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Items: 5

1.

Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.

Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA.

Science. 2015 Feb 27;347(6225):995-8. doi: 10.1126/science.1258758.

2.

Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase.

McHardy SF, Bohmann JA, Corbett MR, Campos B, Tidwell MW, Thompson PM, Bemben CJ, Menchaca TA, Reeves TE, Cantrell WR Jr, Bauta WE, Lopez A, Maxwell DM, Brecht KM, Sweeney RE, McDonough J.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1711-4. doi: 10.1016/j.bmcl.2014.02.049. Epub 2014 Feb 28.

PMID:
24630558
3.

Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain.

Hollinshead SP, Tidwell MW, Palmer J, Guidetti R, Sanderson A, Johnson MP, Chambers MG, Oskins J, Stratford R, Astles PC.

J Med Chem. 2013 Jul 25;56(14):5722-33. doi: 10.1021/jm400305d. Epub 2013 Jul 3.

PMID:
23795771
4.

Discovery and optimization of novel purines as potent and selective CB2 agonists.

Hollinshead SP, Astles PC, Chambers MG, Johnson MP, Palmer J, Tidwell MW.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):4962-6. doi: 10.1016/j.bmcl.2012.06.035. Epub 2012 Jun 16.

PMID:
22765893
5.

Cyclization of aryl silanes with unexpected retention of silicon.

Fearnley SP, Tidwell MW.

Org Lett. 2002 Oct 31;4(22):3797-8.

PMID:
12599461

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