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Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy.

Welc SS, Flores I, Wehling-Henricks M, Ramos J, Wang Y, Bertoni C, Tidball JG.

Nat Commun. 2019 Jun 26;10(1):2788. doi: 10.1038/s41467-019-10614-1.


Myeloid cell-derived tumor necrosis factor-alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers.

Wang Y, Welc SS, Wehling-Henricks M, Tidball JG.

Aging Cell. 2018 Dec;17(6):e12828. doi: 10.1111/acel.12828. Epub 2018 Sep 6.


Immunobiology of Inherited Muscular Dystrophies.

Tidball JG, Welc SS, Wehling-Henricks M.

Compr Physiol. 2018 Sep 14;8(4):1313-1356. doi: 10.1002/cphy.c170052. Review.


Aging of the immune system causes reductions in muscle stem cell populations, promotes their shift to a fibrogenic phenotype, and modulates sarcopenia.

Wang Y, Wehling-Henricks M, Welc SS, Fisher AL, Zuo Q, Tidball JG.

FASEB J. 2019 Jan;33(1):1415-1427. doi: 10.1096/fj.201800973R. Epub 2018 Aug 21.


Macrophages escape Klotho gene silencing in the mdx mouse model of Duchenne muscular dystrophy and promote muscle growth and increase satellite cell numbers through a Klotho-mediated pathway.

Wehling-Henricks M, Welc SS, Samengo G, Rinaldi C, Lindsey C, Wang Y, Lee J, Kuro-O M, Tidball JG.

Hum Mol Genet. 2018 Jan 1;27(1):14-29. doi: 10.1093/hmg/ddx380.


Regulation of muscle growth and regeneration by the immune system.

Tidball JG.

Nat Rev Immunol. 2017 Mar;17(3):165-178. doi: 10.1038/nri.2016.150. Epub 2017 Feb 6. Review.


Myeloid cells are capable of synthesizing aldosterone to exacerbate damage in muscular dystrophy.

Chadwick JA, Swager SA, Lowe J, Welc SS, Tidball JG, Gomez-Sanchez CE, Gomez-Sanchez EP, Rafael-Fortney JA.

Hum Mol Genet. 2016 Dec 1;25(23):5167-5177. doi: 10.1093/hmg/ddw331.


Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy.

Wehling-Henricks M, Li Z, Lindsey C, Wang Y, Welc SS, Ramos JN, Khanlou N, Kuro-O M, Tidball JG.

Hum Mol Genet. 2016 Jun 15;25(12):2465-2482. Epub 2016 May 6.


Shifts in macrophage cytokine production drive muscle fibrosis.

Tidball JG, Wehling-Henricks M.

Nat Med. 2015 Jul;21(7):665-6. doi: 10.1038/nm.3896. No abstract available.


Macrophage-Derived IGF-1 Is a Potent Coordinator of Myogenesis and Inflammation in Regenerating Muscle.

Tidball JG, Welc SS.

Mol Ther. 2015 Jul;23(7):1134-1135. doi: 10.1038/mt.2015.97. No abstract available.


Increases of M2a macrophages and fibrosis in aging muscle are influenced by bone marrow aging and negatively regulated by muscle-derived nitric oxide.

Wang Y, Wehling-Henricks M, Samengo G, Tidball JG.

Aging Cell. 2015 Aug;14(4):678-88. doi: 10.1111/acel.12350. Epub 2015 May 25.


Purloined mechanisms of bacterial immunity can cure muscular dystrophy.

Tidball JG, Bertoni C.

Cell Metab. 2014 Dec 2;20(6):927-9. doi: 10.1016/j.cmet.2014.11.011.


Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy.

Villalta SA, Rosenthal W, Martinez L, Kaur A, Sparwasser T, Tidball JG, Margeta M, Spencer MJ, Bluestone JA.

Sci Transl Med. 2014 Oct 15;6(258):258ra142. doi: 10.1126/scitranslmed.3009925.


Nitric oxide synthase deficiency and the pathophysiology of muscular dystrophy.

Tidball JG, Wehling-Henricks M.

J Physiol. 2014 Nov 1;592(21):4627-38. doi: 10.1113/jphysiol.2014.274878. Epub 2014 Sep 5. Review.


Shared signaling systems in myeloid cell-mediated muscle regeneration.

Tidball JG, Dorshkind K, Wehling-Henricks M.

Development. 2014 Mar;141(6):1184-96. doi: 10.1242/dev.098285. Review.


Growth hormone plus resistance exercise attenuate structural changes in rat myotendinous junctions resulting from chronic unloading.

Curzi D, Lattanzi D, Ciuffoli S, Burattini S, Grindeland RE, Edgerton VR, Roy RR, Tidball JG, Falcieri E.

Eur J Histochem. 2013 Nov 13;57(4):e37. doi: 10.4081/ejh.2013.e37.


Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia.

Samengo G, Avik A, Fedor B, Whittaker D, Myung KH, Wehling-Henricks M, Tidball JG.

Aging Cell. 2012 Dec;11(6):1036-45. doi: 10.1111/acel.12003. Epub 2012 Oct 4.


IL-10 triggers changes in macrophage phenotype that promote muscle growth and regeneration.

Deng B, Wehling-Henricks M, Villalta SA, Wang Y, Tidball JG.

J Immunol. 2012 Oct 1;189(7):3669-80. Epub 2012 Aug 29.


p38γ activity is required for maintenance of slow skeletal muscle size.

Foster WH, Tidball JG, Wang Y.

Muscle Nerve. 2012 Feb;45(2):266-73. doi: 10.1002/mus.22289.


IFN-γ promotes muscle damage in the mdx mouse model of Duchenne muscular dystrophy by suppressing M2 macrophage activation and inhibiting muscle cell proliferation.

Villalta SA, Deng B, Rinaldi C, Wehling-Henricks M, Tidball JG.

J Immunol. 2011 Nov 15;187(10):5419-28. doi: 10.4049/jimmunol.1101267. Epub 2011 Oct 17.


Neuronal nitric oxide synthase-rescue of dystrophin/utrophin double knockout mice does not require nNOS localization to the cell membrane.

Wehling-Henricks M, Tidball JG.

PLoS One. 2011;6(10):e25071. doi: 10.1371/journal.pone.0025071. Epub 2011 Oct 7.


Mechanisms of muscle injury, repair, and regeneration.

Tidball JG.

Compr Physiol. 2011 Oct;1(4):2029-62. doi: 10.1002/cphy.c100092. Review.


Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase.

Sakellariou GK, Pye D, Vasilaki A, Zibrik L, Palomero J, Kabayo T, McArdle F, Van Remmen H, Richardson A, Tidball JG, McArdle A, Jackson MJ.

Aging Cell. 2011 Oct;10(5):749-60. doi: 10.1111/j.1474-9726.2011.00709.x. Epub 2011 May 6.


Interleukin-10 reduces the pathology of mdx muscular dystrophy by deactivating M1 macrophages and modulating macrophage phenotype.

Villalta SA, Rinaldi C, Deng B, Liu G, Fedor B, Tidball JG.

Hum Mol Genet. 2011 Feb 15;20(4):790-805. doi: 10.1093/hmg/ddq523. Epub 2010 Nov 30.


Arginine metabolism by macrophages promotes cardiac and muscle fibrosis in mdx muscular dystrophy.

Wehling-Henricks M, Jordan MC, Gotoh T, Grody WW, Roos KP, Tidball JG.

PLoS One. 2010 May 21;5(5):e10763. doi: 10.1371/journal.pone.0010763.


Regulatory interactions between muscle and the immune system during muscle regeneration.

Tidball JG, Villalta SA.

Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1173-87. doi: 10.1152/ajpregu.00735.2009. Epub 2010 Mar 10. Review.


CXCR4 enhances engraftment of muscle progenitor cells.

Perez AL, Bachrach E, Illigens BM, Jun SJ, Bagden E, Steffen L, Flint A, McGowan FX, Del Nido P, Montecino-Rodriguez E, Tidball JG, Kunkel LM.

Muscle Nerve. 2009 Oct;40(4):562-72. doi: 10.1002/mus.21317.


Loss of positive allosteric interactions between neuronal nitric oxide synthase and phosphofructokinase contributes to defects in glycolysis and increased fatigability in muscular dystrophy.

Wehling-Henricks M, Oltmann M, Rinaldi C, Myung KH, Tidball JG.

Hum Mol Genet. 2009 Sep 15;18(18):3439-51. doi: 10.1093/hmg/ddp288. Epub 2009 Jun 19.


NO may prompt calcium leakage in dystrophic muscle.

Tidball JG, Villalta SA.

Nat Med. 2009 Mar;15(3):243-4. doi: 10.1038/nm0309-243. No abstract available.


Nitric oxide generated by muscle corrects defects in hippocampal neurogenesis and neural differentiation caused by muscular dystrophy.

Deng B, Glanzman D, Tidball JG.

J Physiol. 2009 Apr 15;587(Pt 8):1769-78. doi: 10.1113/jphysiol.2008.166256. Epub 2009 Feb 23.


Shifts in macrophage phenotypes and macrophage competition for arginine metabolism affect the severity of muscle pathology in muscular dystrophy.

Villalta SA, Nguyen HX, Deng B, Gotoh T, Tidball JG.

Hum Mol Genet. 2009 Feb 1;18(3):482-96. doi: 10.1093/hmg/ddn376. Epub 2008 Nov 7.


Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy.

Wehling-Henricks M, Sokolow S, Lee JJ, Myung KH, Villalta SA, Tidball JG.

Hum Mol Genet. 2008 Aug 1;17(15):2280-92. doi: 10.1093/hmg/ddn129. Epub 2008 Apr 21.


Patient survival by Hsp70 membrane phenotype: association with different routes of metastasis.

Pfister K, Radons J, Busch R, Tidball JG, Pfeifer M, Freitag L, Feldmann HJ, Milani V, Issels R, Multhoff G.

Cancer. 2007 Aug 15;110(4):926-35.


Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.

Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC.

J Clin Invest. 2007 Apr;117(4):889-901. Epub 2007 Mar 22.


The role of free radicals in the pathophysiology of muscular dystrophy.

Tidball JG, Wehling-Henricks M.

J Appl Physiol (1985). 2007 Apr;102(4):1677-86. Epub 2006 Nov 9. Review.


Damage and inflammation in muscular dystrophy: potential implications and relationships with autoimmune myositis.

Tidball JG, Wehling-Henricks M.

Curr Opin Rheumatol. 2005 Nov;17(6):707-13. Review.


Cardiomyopathy in dystrophin-deficient hearts is prevented by expression of a neuronal nitric oxide synthase transgene in the myocardium.

Wehling-Henricks M, Jordan MC, Roos KP, Deng B, Tidball JG.

Hum Mol Genet. 2005 Jul 15;14(14):1921-33. Epub 2005 May 25.


Mechanical signal transduction in skeletal muscle growth and adaptation.

Tidball JG.

J Appl Physiol (1985). 2005 May;98(5):1900-8. Review.


Inflammatory processes in muscle injury and repair.

Tidball JG.

Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R345-53. Review.


Evolving therapeutic strategies for Duchenne muscular dystrophy: targeting downstream events.

Tidball JG, Wehling-Henricks M.

Pediatr Res. 2004 Dec;56(6):831-41. Epub 2004 Nov 5. Review.


Defects in neuromuscular junction structure in dystrophic muscle are corrected by expression of a NOS transgene in dystrophin-deficient muscles, but not in muscles lacking alpha- and beta1-syntrophins.

Shiao T, Fond A, Deng B, Wehling-Henricks M, Adams ME, Froehner SC, Tidball JG.

Hum Mol Genet. 2004 Sep 1;13(17):1873-84. Epub 2004 Jul 6.


Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro.

Kramerova I, Kudryashova E, Tidball JG, Spencer MJ.

Hum Mol Genet. 2004 Jul 1;13(13):1373-88. Epub 2004 May 11.


Null mutation of gp91phox reduces muscle membrane lysis during muscle inflammation in mice.

Nguyen HX, Tidball JG.

J Physiol. 2003 Dec 15;553(Pt 3):833-41. Epub 2003 Oct 10.


Skipping to new gene therapies for muscular dystrophy.

Tidball JG, Spencer MJ.

Nat Med. 2003 Aug;9(8):997-8. No abstract available.


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