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Items: 1 to 50 of 62

1.

Crystal Structure of the Marburg Virus VP35 Oligomerization Domain.

Bruhn JF, Kirchdoerfer RN, Urata SM, Li S, Tickle IJ, Bricogne G, Saphire EO.

J Virol. 2017 Jan 3;91(2). pii: e01085-16. doi: 10.1128/JVI.01085-16. Print 2017 Jan 15.

2.

XModeScore: a novel method for accurate protonation/tautomer-state determination using quantum-mechanically driven macromolecular X-ray crystallographic refinement.

Borbulevych O, Martin RI, Tickle IJ, Westerhoff LM.

Acta Crystallogr D Struct Biol. 2016 Apr;72(Pt 4):586-98. doi: 10.1107/S2059798316002837. Epub 2016 Mar 30.

3.

Detection of secondary binding sites in proteins using fragment screening.

Ludlow RF, Verdonk ML, Saini HK, Tickle IJ, Jhoti H.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15910-5. doi: 10.1073/pnas.1518946112. Epub 2015 Dec 11.

4.

Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.

Cleasby A, Yon J, Day PJ, Richardson C, Tickle IJ, Williams PA, Callahan JF, Carr R, Concha N, Kerns JK, Qi H, Sweitzer T, Ward P, Davies TG.

PLoS One. 2014 Jun 4;9(6):e98896. doi: 10.1371/journal.pone.0098896. eCollection 2014.

5.

Statistical quality indicators for electron-density maps.

Tickle IJ.

Acta Crystallogr D Biol Crystallogr. 2012 Apr;68(Pt 4):454-67. doi: 10.1107/S0907444911035918. Epub 2012 Mar 16.

6.

A new generation of crystallographic validation tools for the protein data bank.

Read RJ, Adams PD, Arendall WB 3rd, Brunger AT, Emsley P, Joosten RP, Kleywegt GJ, Krissinel EB, Lütteke T, Otwinowski Z, Perrakis A, Richardson JS, Sheffler WH, Smith JL, Tickle IJ, Vriend G, Zwart PH.

Structure. 2011 Oct 12;19(10):1395-412. doi: 10.1016/j.str.2011.08.006.

7.

Fragment screening using X-ray crystallography.

Davies TG, Tickle IJ.

Top Curr Chem. 2012;317:33-59. doi: 10.1007/128_2011_179. Review.

PMID:
21678136
8.

PDB_REDO: automated re-refinement of X-ray structure models in the PDB.

Joosten RP, Salzemann J, Bloch V, Stockinger H, Berglund AC, Blanchet C, Bongcam-Rudloff E, Combet C, Da Costa AL, Deleage G, Diarena M, Fabbretti R, Fettahi G, Flegel V, Gisel A, Kasam V, Kervinen T, Korpelainen E, Mattila K, Pagni M, Reichstadt M, Breton V, Tickle IJ, Vriend G.

J Appl Crystallogr. 2009 Jun 1;42(Pt 3):376-384. Epub 2009 Apr 3.

9.

Crystal structure of human CDK4 in complex with a D-type cyclin.

Day PJ, Cleasby A, Tickle IJ, O'Reilly M, Coyle JE, Holding FP, McMenamin RL, Yon J, Chopra R, Lengauer C, Jhoti H.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4166-70. doi: 10.1073/pnas.0809645106. Epub 2009 Feb 23.

10.

Experimental determination of optimal root-mean-square deviations of macromolecular bond lengths and angles from their restrained ideal values.

Tickle IJ.

Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1274-81; author reply 1282-3. Epub 2007 Nov 16.

PMID:
18084075
11.

Automated protein-ligand crystallography for structure-based drug design.

Mooij WT, Hartshorn MJ, Tickle IJ, Sharff AJ, Verdonk ML, Jhoti H.

ChemMedChem. 2006 Aug;1(8):827-38.

PMID:
16902937
12.

Fragment-based lead discovery using X-ray crystallography.

Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H.

J Med Chem. 2005 Jan 27;48(2):403-13.

PMID:
15658854
13.

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone.

Williams PA, Cosme J, Vinkovic DM, Ward A, Angove HC, Day PJ, Vonrhein C, Tickle IJ, Jhoti H.

Science. 2004 Jul 30;305(5684):683-6. Epub 2004 Jul 15.

14.

Estimation of weights and validation: a marginal likelihood approach.

Lebedev AA, Tickle IJ, Laskowski RA, Moss DS.

Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1557-66. Epub 2003 Aug 19.

PMID:
12925785
15.

Sensitivity of molecular docking to induced fit effects in influenza virus neuraminidase.

Birch L, Murray CW, Hartshorn MJ, Tickle IJ, Verdonk ML.

J Comput Aided Mol Des. 2002 Dec;16(12):855-69.

PMID:
12825619
16.

Engineering of an intersubunit disulfide bridge in the iron-superoxide dismutase of Mycobacterium tuberculosis.

Bunting KA, Cooper JB, Tickle IJ, Young DB.

Arch Biochem Biophys. 2002 Jan 1;397(1):69-76.

PMID:
11747311
17.
18.

MAD analyses of yeast 5-aminolaevulinate dehydratase: their use in structure determination and in defining the metal-binding sites.

Erskine PT, Duke EM, Tickle IJ, Senior NM, Warren MJ, Cooper JB.

Acta Crystallogr D Biol Crystallogr. 2000 Apr;56(Pt 4):421-30.

PMID:
10739915
19.

Two structural transitions in membrane pore formation by pneumolysin, the pore-forming toxin of Streptococcus pneumoniae.

Gilbert RJ, Jiménez JL, Chen S, Tickle IJ, Rossjohn J, Parker M, Andrew PW, Saibil HR.

Cell. 1999 May 28;97(5):647-55.

20.

Error estimates of protein structure coordinates and deviations from standard geometry by full-matrix refinement of gammaB- and betaB2-crystallin.

Tickle IJ, Laskowski RA, Moss DS.

Acta Crystallogr D Biol Crystallogr. 1998 Mar 1;54(Pt 2):243-52.

PMID:
9761889
21.

Rfree and the rfree ratio. I. Derivation of expected values of cross-validation residuals used in macromolecular least-squares refinement.

Tickle IJ, Laskowski RA, Moss DS.

Acta Crystallogr D Biol Crystallogr. 1998 Jul 1;54(Pt 4):547-57.

PMID:
9761849
22.

Engineering a change in metal-ion specificity of the iron-dependent superoxide dismutase from Mycobacterium tuberculosis-- X-ray structure analysis of site-directed mutants.

Bunting K, Cooper JB, Badasso MO, Tickle IJ, Newton M, Wood SP, Zhang Y, Young D.

Eur J Biochem. 1998 Feb 1;251(3):795-803.

23.

X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase.

Erskine PT, Senior N, Awan S, Lambert R, Lewis G, Tickle IJ, Sarwar M, Spencer P, Thomas P, Warren MJ, Shoolingin-Jordan PM, Wood SP, Cooper JB.

Nat Struct Biol. 1997 Dec;4(12):1025-31.

PMID:
9406553
24.

Crystallization of 5-aminolaevulinic acid dehydratase from Escherichia coli and Saccharomyces cerevisiae and preliminary X-ray characterization of the crystals.

Erskine PT, Senior N, Maignan S, Cooper J, Lambert R, Lewis G, Spencer P, Awan S, Warren M, Tickle IJ, Thomas P, Wood SP, Shoolingin-Jordan PM.

Protein Sci. 1997 Aug;6(8):1774-6.

25.

Molecular replacement using known structural information.

Tickle IJ, Driessen HP.

Methods Mol Biol. 1996;56:173-203. Review. No abstract available.

PMID:
8781246
26.
27.

X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.

Dealwis CG, Frazao C, Badasso M, Cooper JB, Tickle IJ, Driessen H, Blundell TL, Murakami K, Miyazaki H, Sueiras-Diaz J, et al.

J Mol Biol. 1994 Feb 11;236(1):342-60.

PMID:
8107115
28.

Structure of pentameric human serum amyloid P component.

Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP.

Nature. 1994 Jan 27;367(6461):338-45.

PMID:
8114934
29.

X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 A resolution of the aspartic proteinase from Mucor pusillus.

Newman M, Watson F, Roychowdhury P, Jones H, Badasso M, Cleasby A, Wood SP, Tickle IJ, Blundell TL.

J Mol Biol. 1993 Mar 5;230(1):260-83.

PMID:
8450540
30.

The use of protein homologues in the rotation function.

Aguilar CF, Newman MP, Sanz Aparicio J, Cooper JB, Tickle IJ, Blundell TL.

Acta Crystallogr A. 1993 Mar 1;49 ( Pt 2):306-15.

PMID:
8447986
31.

X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.

Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HP, Newman M, Aguilar C, et al.

Nature. 1992 Jun 11;357(6378):466-72.

PMID:
1608447
32.

Structure of oligomeric beta B2-crystallin: an application of the T2 translation function to an asymmetric unit containing two dimers.

Driessen HP, Bax B, Slingsby C, Lindley PF, Mahadevan D, Moss DS, Tickle IJ.

Acta Crystallogr B. 1991 Dec 1;47 ( Pt 6):987-97.

PMID:
1772634
33.

X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 A resolution of bovine chymosin.

Newman M, Safro M, Frazao C, Khan G, Zdanov A, Tickle IJ, Blundell TL, Andreeva N.

J Mol Biol. 1991 Oct 20;221(4):1295-309.

PMID:
1942052
34.

MOLPACK: molecular graphics for studying the packing of protein molecules in the crystallographic unit cell.

Wang DW, Driessen HP, Tickle IJ.

J Mol Graph. 1991 Mar;9(1):50-2, 38.

PMID:
2018755
35.

Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).

Webster GD, Sanderson MR, Skelly JV, Neidle S, Swann PF, Li BF, Tickle IJ.

Proc Natl Acad Sci U S A. 1990 Sep;87(17):6693-7.

36.

X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution.

Cooper JB, Khan G, Taylor G, Tickle IJ, Blundell TL.

J Mol Biol. 1990 Jul 5;214(1):199-222.

PMID:
2115088
37.

The conformation of deamino-oxytocin: X-ray analysis of the 'dry' and 'wet' forms.

Husain J, Blundell TL, Cooper S, Pitts JE, Tickle IJ, Wood SP, Hruby VJ, Buku A, Fischman AJ, Wyssbrod HR, et al.

Philos Trans R Soc Lond B Biol Sci. 1990 Apr 27;327(1243):625-54. Erratum in: Philos Trans R Soc Lond Biol 1990 Jun 30;328(1251):239.

PMID:
1972289
38.

X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin.

Blundell TL, Jenkins JA, Sewell BT, Pearl LH, Cooper JB, Tickle IJ, Veerapandian B, Wood SP.

J Mol Biol. 1990 Feb 20;211(4):919-41.

PMID:
2179568
39.

Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.

Wood SP, Tickle IJ, Treharne AM, Pitts JE, Mascarenhas Y, Li JY, Husain J, Cooper S, Blundell TL, Hruby VJ, et al.

Science. 1986 May 2;232(4750):633-6.

PMID:
3008332
40.

The crystal structures of [Met5]enkephalin and a third form of [Leu5]enkephalin: observations of a novel pleated beta-sheet.

Griffin JF, Langs DA, Smith GD, Blundell TL, Tickle IJ, Bedarkar S.

Proc Natl Acad Sci U S A. 1986 May;83(10):3272-6.

41.

Refinement of the solution structure of the B DNA hexamer 5'd(C-G-T-A-C-G)2 on the basis of inter-proton distance data.

Clore GM, Gronenborn AM, Moss DS, Tickle IJ.

J Mol Biol. 1985 Sep 5;185(1):219-26.

PMID:
2995686
42.

Anisotropic thermal motion and polypeptide secondary structure studied by X-ray analysis at 0.98A resolution.

Glover ID, Moss DS, Tickle IJ, Pitts JE, Haneef I, Wood SP, Blundell TL.

Adv Biophys. 1985;20:1-12.

PMID:
3834786
43.

Conformational studies on the pancreatic polypeptide hormone family.

Glover ID, Barlow DJ, Pitts JE, Wood SP, Tickle IJ, Blundell TL, Tatemoto K, Kimmel JR, Wollmer A, Strassburger W, et al.

Eur J Biochem. 1984 Jul 16;142(2):379-85.

44.

The crystal structures of three non-pancreatic human insulins.

Chawdhury SA, Dodson EJ, Dodson GG, Reynolds CD, Tolley SP, Blundell TL, Cleasby A, Pitts JE, Tickle IJ, Wood SP.

Diabetologia. 1983 Dec;25(6):460-4.

PMID:
6363174
45.

Adaptation of plasminogen activator sequences to known protease structures.

Strassburger W, Wollmer A, Pitts JE, Glover ID, Tickle IJ, Blundell TL, Steffens GJ, Günzler WA, Otting F, Flohé L.

FEBS Lett. 1983 Jul 4;157(2):219-23.

46.

Calculated tyrosyl circular dichroism of proteins: absence of tryptophan and cystine interferences in avian pancreatic polypeptide.

Strassburger W, Glatter U, Wollmer A, Fleischhauer J, Mercola DA, Blundell TL, Glover I, Pitts JE, Tickle IJ, Wood SP.

FEBS Lett. 1982 Mar 22;139(2):295-9. No abstract available.

47.

X-ray analysis (1. 4-A resolution) of avian pancreatic polypeptide: Small globular protein hormone.

Blundell TL, Pitts JE, Tickle IJ, Wood SP, Wu CW.

Proc Natl Acad Sci U S A. 1981 Jul;78(7):4175-9.

48.

The conformation and receptor binding of pancreatic hormones.

Blundell TL, Pitts JE, Tickle IJ, Wood SP.

Biochem Soc Trans. 1981 Feb;9(1):31-2. No abstract available.

PMID:
6260550
49.

Crystallisation and preliminary crystallographic data of a porcine neurophysin I-Tyr-Phe-NH2 complex.

Pitts JE, Wood SP, Hearn L, Tickle IJ, Wu CW, Blundell TL, Robinson IC.

FEBS Lett. 1980 Nov 17;121(1):41-3. No abstract available.

50.

Crystal structure of [Leu5]enkephalin.

Blundell TL, Hearn L, Tickle IJ, Palmer RA, Morgan BA, Smith GD, Griffin JF.

Science. 1979 Jul 13;205(4402):220. No abstract available.

PMID:
451597

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