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Items: 26


Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.

Bäumer N, Krause A, Köhler G, Lettermann S, Evers G, Hascher A, Bäumer S, Berdel WE, Müller-Tidow C, Tickenbrock L.

PLoS One. 2014 Apr 16;9(4):e94993. doi: 10.1371/journal.pone.0094993. eCollection 2014.


DNA methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting polycomb target genes.

Hascher A, Haase AK, Hebestreit K, Rohde C, Klein HU, Rius M, Jungen D, Witten A, Stoll M, Schulze I, Ogawa S, Wiewrodt R, Tickenbrock L, Berdel WE, Dugas M, Thoennissen NH, Müller-Tidow C.

Clin Cancer Res. 2014 Feb 15;20(4):814-26. doi: 10.1158/1078-0432.CCR-13-1483. Epub 2013 Dec 13.


Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling.

Bäumer N, Tickenbrock L, Tschanter P, Lohmeyer L, Diederichs S, Bäumer S, Skryabin BV, Zhang F, Agrawal-Singh S, Köhler G, Berdel WE, Serve H, Koschmieder S, Müller-Tidow C.

J Biol Chem. 2011 Aug 12;286(32):28210-22. doi: 10.1074/jbc.M110.203471. Epub 2011 May 3.


Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival.

Tickenbrock L, Klein HU, Trento C, Hascher A, Göllner S, Bäumer N, Kuss R, Agrawal S, Bug G, Serve H, Thiede C, Ehninger G, Stadt UZ, McClelland M, Wang Y, Becker A, Koschmieder S, Berdel WE, Dugas M, Müller-Tidow C; Study Alliance Leukemia Group.

Leuk Res. 2011 May;35(5):620-5. doi: 10.1016/j.leukres.2010.11.006. Epub 2010 Dec 22.


Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia.

Müller-Tidow C, Klein HU, Hascher A, Isken F, Tickenbrock L, Thoennissen N, Agrawal-Singh S, Tschanter P, Disselhoff C, Wang Y, Becker A, Thiede C, Ehninger G, zur Stadt U, Koschmieder S, Seidl M, Müller FU, Schmitz W, Schlenke P, McClelland M, Berdel WE, Dugas M, Serve H; Study Alliance Leukemia.

Blood. 2010 Nov 4;116(18):3564-71. doi: 10.1182/blood-2009-09-240978. Epub 2010 May 24.


Pim2 cooperates with PML-RARalpha to induce acute myeloid leukemia in a bone marrow transplantation model.

Agrawal-Singh S, Koschmieder S, Gelsing S, Stocking C, Stehling M, Thiede C, Thoennissen NH, Köhler G, Valk PJ, Delwel R, Mills K, Bäumer N, Tickenbrock L, Hansen K, Berdel WE, Müller-Tidow C, Serve H.

Blood. 2010 Jun 3;115(22):4507-16. doi: 10.1182/blood-2009-03-210070. Epub 2010 Mar 9.


BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells.

Schemionek M, Elling C, Steidl U, Bäumer N, Hamilton A, Spieker T, Göthert JR, Stehling M, Wagers A, Huettner CS, Tenen DG, Tickenbrock L, Berdel WE, Serve H, Holyoake TL, Müller-Tidow C, Koschmieder S.

Blood. 2010 Apr 22;115(16):3185-95. doi: 10.1182/blood-2009-04-215376. Epub 2010 Jan 6.


E3 ligase-defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease.

Bandi SR, Brandts C, Rensinghoff M, Grundler R, Tickenbrock L, Köhler G, Duyster J, Berdel WE, Müller-Tidow C, Serve H, Sargin B; Study Alliance Leukemias.

Blood. 2009 Nov 5;114(19):4197-208. doi: 10.1182/blood-2008-12-190934. Epub 2009 Sep 4.


Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4.

Tickenbrock L, Hehn S, Sargin B, Choudhary C, Bäumer N, Buerger H, Schulte B, Müller O, Berdel WE, Müller-Tidow C, Serve H.

Int J Oncol. 2008 Dec;33(6):1215-21.


Activation of Wnt signaling in cKit-ITD mediated transformation and imatinib sensitivity in acute myeloid leukemia.

Tickenbrock L, Hehn S, Sargin B, Evers G, Ng PR, Choudhary C, Berdel WE, Müller-Tidow C, Serve H.

Int J Hematol. 2008 Sep;88(2):174-180. doi: 10.1007/s12185-008-0141-0. Epub 2008 Jul 31.


Flt3-dependent transformation by inactivating c-Cbl mutations in AML.

Sargin B, Choudhary C, Crosetto N, Schmidt MHH, Grundler R, Rensinghoff M, Thiessen C, Tickenbrock L, Schwäble J, Brandts C, August B, Koschmieder S, Bandi SR, Duyster J, Berdel WE, Müller-Tidow C, Dikic I, Serve H.

Blood. 2007 Aug 1;110(3):1004-12. Epub 2007 Apr 19.


Activation mechanisms of STAT5 by oncogenic Flt3-ITD.

Choudhary C, Brandts C, Schwable J, Tickenbrock L, Sargin B, Ueker A, Böhmer FD, Berdel WE, Müller-Tidow C, Serve H.

Blood. 2007 Jul 1;110(1):370-4. Epub 2007 Mar 13.


Lipocalin 24p3 is regulated by the Wnt pathway independent of regulation by iron.

Ziegler S, Röhrs S, Tickenbrock L, Langerak A, Chu ST, Feldmann I, Jakubowski N, Müller O.

Cancer Genet Cytogenet. 2007 Apr 1;174(1):16-23.


Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer.

Becker JC, Müller-Tidow C, Stolte M, Fujimori T, Tidow N, Ilea AM, Brandts C, Tickenbrock L, Serve H, Berdel WE, Domschke W, Pohle T.

Int J Oncol. 2006 Sep;29(3):615-23.


Wnt signaling regulates transendothelial migration of monocytes.

Tickenbrock L, Schwäble J, Strey A, Sargin B, Hehn S, Baas M, Choudhary C, Gerke V, Berdel WE, Müller-Tidow C, Serve H.

J Leukoc Biol. 2006 Jun;79(6):1306-13. Epub 2006 Mar 24.


Emerging Flt3 kinase inhibitors in the treatment of leukaemia.

Tickenbrock L, Müller-Tidow C, Berdel WE, Serve H.

Expert Opin Emerg Drugs. 2006 Mar;11(1):153-65. Review.


Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation.

Ziegler S, Röhrs S, Tickenbrock L, Möröy T, Klein-Hitpass L, Vetter IR, Müller O.

FEBS J. 2005 Apr;272(7):1600-15.


AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations.

Choudhary C, Schwäble J, Brandts C, Tickenbrock L, Sargin B, Kindler T, Fischer T, Berdel WE, Müller-Tidow C, Serve H.

Blood. 2005 Jul 1;106(1):265-73. Epub 2005 Mar 15.


Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signal transduction.

Tickenbrock L, Schwäble J, Wiedehage M, Steffen B, Sargin B, Choudhary C, Brandts C, Berdel WE, Müller-Tidow C, Serve H.

Blood. 2005 May 1;105(9):3699-706. Epub 2005 Jan 13.


RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation.

Schwäble J, Choudhary C, Thiede C, Tickenbrock L, Sargin B, Steur C, Rehage M, Rudat A, Brandts C, Berdel WE, Müller-Tidow C, Serve H.

Blood. 2005 Mar 1;105(5):2107-14. Epub 2004 Nov 9.


The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells.

Worch J, Tickenbrock L, Schwäble J, Steffen B, Cauvet T, Mlody B, Buerger H, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C.

Oncogene. 2004 Dec 9;23(57):9162-72.


S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer.

Diederichs S, Bulk E, Steffen B, Ji P, Tickenbrock L, Lang K, Zänker KS, Metzger R, Schneider PM, Gerke V, Thomas M, Berdel WE, Serve H, Müller-Tidow C.

Cancer Res. 2004 Aug 15;64(16):5564-9.


Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.

Müller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Köhler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H.

Mol Cell Biol. 2004 Apr;24(7):2890-904.


Structure of the amino-terminal nuclear export domain of the APC tumor suppressor protein.

Tickenbrock L, Cramer J, Vetter I, Muller O.

Ann N Y Acad Sci. 2002 Nov;973:109-11. No abstract available.


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