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Items: 22

1.

An Alternative Focus for Route Design for the Synthesis of Antibody-Drug Conjugate Payloads.

Tiberghien AC, Howard PW, Goundry WRF, McCormick M, Parker JS.

J Org Chem. 2019 Jan 11. doi: 10.1021/acs.joc.8b02876. [Epub ahead of print]

PMID:
30602115
2.

SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads.

Kinneer K, Meekin J, Tiberghien AC, Tai YT, Phipps S, Kiefer CM, Rebelatto MC, Dimasi N, Moriarty A, Papadopoulos KP, Sridhar S, Gregson SJ, Wick MJ, Masterson L, Anderson KC, Herbst R, Howard PW, Tice DA.

Clin Cancer Res. 2018 Dec 15;24(24):6570-6582. doi: 10.1158/1078-0432.CCR-18-1300. Epub 2018 Aug 21.

PMID:
30131388
3.

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine.

Hartley JA, Flynn MJ, Bingham JP, Corbett S, Reinert H, Tiberghien A, Masterson LA, Antonow D, Adams L, Chowdhury S, Williams DG, Mao S, Harper J, Havenith CEG, Zammarchi F, Chivers S, van Berkel PH, Howard PW.

Sci Rep. 2018 Jul 11;8(1):10479. doi: 10.1038/s41598-018-28533-4.

4.

ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies.

Zammarchi F, Corbett S, Adams L, Tyrer PC, Kiakos K, Janghra N, Marafioti T, Britten CE, Havenith CEG, Chivers S, D'Hooge F, Williams DG, Tiberghien A, Howard PW, Hartley JA, van Berkel PH.

Blood. 2018 Mar 8;131(10):1094-1105. doi: 10.1182/blood-2017-10-813493. Epub 2018 Jan 3.

5.

Assessment of executive functions in children and adolescents with acquired brain injury (ABI) using a novel complex multi-tasking computerised task: The Jansari assessment of Executive Functions for Children (JEF-C©).

Gilboa Y, Jansari A, Kerrouche B, Uçak E, Tiberghien A, Benkhaled O, Aligon D, Mariller A, Verdier V, Mintegui A, Abada G, Canizares C, Goldstein A, Chevignard M.

Neuropsychol Rehabil. 2017 Dec 28:1-24. doi: 10.1080/09602011.2017.1411819. [Epub ahead of print]

PMID:
29283024
6.

Fractionated Dosing Improves Preclinical Therapeutic Index of Pyrrolobenzodiazepine-Containing Antibody Drug Conjugates.

Hinrichs MJM, Ryan PM, Zheng B, Afif-Rider S, Yu XQ, Gunsior M, Zhong H, Harper J, Bezabeh B, Vashisht K, Rebelatto M, Reed M, Ryan PC, Breen S, Patel N, Chen C, Masterson L, Tiberghien A, Howard PW, Dimasi N, Dixit R.

Clin Cancer Res. 2017 Oct 1;23(19):5858-5868. doi: 10.1158/1078-0432.CCR-17-0219. Epub 2017 Jun 19.

7.

Synthesis and in vitro evaluation of SG3227, a pyrrolobenzodiazepine dimer antibody-drug conjugate payload based on sibiromycin.

Kemp GC, Tiberghien AC, Patel NV, D'Hooge F, Nilapwar SM, Adams LR, Corbett S, Williams DG, Hartley JA, Howard PW.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1154-1158. doi: 10.1016/j.bmcl.2017.01.074. Epub 2017 Jan 30.

PMID:
28188066
8.

Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload.

Tiberghien AC, Levy JN, Masterson LA, Patel NV, Adams LR, Corbett S, Williams DG, Hartley JA, Howard PW.

ACS Med Chem Lett. 2016 May 24;7(11):983-987. eCollection 2016 Nov 10.

9.

Long-term motor, functional, and academic outcome following childhood ischemic and hemorrhagic stroke: A large rehabilitation center-based retrospective study.

Yvon E, Lamotte D, Tiberghien A, Godard I, Mardaye A, Laurent-Vannier A, Agostini M, Chevignard M.

Dev Neurorehabil. 2018 Feb;21(2):83-90. doi: 10.1080/17518423.2016.1247923. Epub 2016 Nov 14.

PMID:
27841719
10.

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer-Containing Antibody-Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies.

Flynn MJ, Zammarchi F, Tyrer PC, Akarca AU, Janghra N, Britten CE, Havenith CE, Levy JN, Tiberghien A, Masterson LA, Barry C, D'Hooge F, Marafioti T, Parren PW, Williams DG, Howard PW, van Berkel PH, Hartley JA.

Mol Cancer Ther. 2016 Nov;15(11):2709-2721. Epub 2016 Aug 17.

11.

Describing the attention profile of children and adolescents with acquired brain injury using the Virtual Classroom.

Gilboa Y, Kerrouche B, Longaud-Vales A, Kieffer V, Tiberghien A, Aligon D, Mariller A, Mintegui A, Canizares C, Abada G, Paule Chevignard M.

Brain Inj. 2015;29(13-14):1691-700. doi: 10.3109/02699052.2015.1075148. Epub 2015 Sep 23.

PMID:
26399584
12.

Genetically Encoded Azide Containing Amino Acid in Mammalian Cells Enables Site-Specific Antibody-Drug Conjugates Using Click Cycloaddition Chemistry.

VanBrunt MP, Shanebeck K, Caldwell Z, Johnson J, Thompson P, Martin T, Dong H, Li G, Xu H, D'Hooge F, Masterson L, Bariola P, Tiberghien A, Ezeadi E, Williams DG, Hartley JA, Howard PW, Grabstein KH, Bowen MA, Marelli M.

Bioconjug Chem. 2015 Nov 18;26(11):2249-60. doi: 10.1021/acs.bioconjchem.5b00359. Epub 2015 Sep 11.

PMID:
26332743
13.

Metamemory following childhood brain injury: A consequence of executive impairment.

Geurten M, Chevignard M, Kerrouche B, Tiberghien A, Meulemans T.

Child Neuropsychol. 2017 Jan;23(1):67-82. Epub 2015 Aug 21.

14.

A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.

Jeffrey SC, Burke PJ, Lyon RP, Meyer DW, Sussman D, Anderson M, Hunter JH, Leiske CI, Miyamoto JB, Nicholas ND, Okeley NM, Sanderson RJ, Stone IJ, Zeng W, Gregson SJ, Masterson L, Tiberghien AC, Howard PW, Thurston DE, Law CL, Senter PD.

Bioconjug Chem. 2013 Jul 17;24(7):1256-63. doi: 10.1021/bc400217g. Epub 2013 Jun 28.

PMID:
23808985
15.

SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activity.

Hartley JA, Hamaguchi A, Coffils M, Martin CR, Suggitt M, Chen Z, Gregson SJ, Masterson LA, Tiberghien AC, Hartley JM, Pepper C, Lin TT, Fegan C, Thurston DE, Howard PW.

Cancer Res. 2010 Sep 1;70(17):6849-58. doi: 10.1158/0008-5472.CAN-10-0790. Epub 2010 Jul 26.

16.

Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents.

Antonow D, Kaliszczak M, Kang GD, Coffils M, Tiberghien AC, Cooper N, Barata T, Heidelberger S, James CH, Zloh M, Jenkins TC, Reszka AP, Neidle S, Guichard SM, Jodrell DI, Hartley JA, Howard PW, Thurston DE.

J Med Chem. 2010 Apr 8;53(7):2927-41. doi: 10.1021/jm901722v.

PMID:
20218628
17.

Synthesis of a novel C2/C2'-aryl-substituted pyrrolo[2,1-c][1,4]benzodiazepine dimer prodrug with improved water solubility and reduced DNA reaction rate.

Howard PW, Chen Z, Gregson SJ, Masterson LA, Tiberghien AC, Cooper N, Fang M, Coffils MJ, Klee S, Hartley JA, Thurston DE.

Bioorg Med Chem Lett. 2009 Nov 15;19(22):6463-6. doi: 10.1016/j.bmcl.2009.09.012. Epub 2009 Sep 9.

PMID:
19811912
18.

An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.

Tiberghien AC, Evans DA, Kiakos K, Martin CR, Hartley JA, Thurston DE, Howard PW.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2073-7. doi: 10.1016/j.bmcl.2008.01.096. Epub 2008 Jan 30.

PMID:
18272367
19.

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.

Wells G, Martin CR, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE.

J Med Chem. 2006 Sep 7;49(18):5442-61.

PMID:
16942018
20.

[Hormonal regulatory influence in tear film].

Oprea L, Tiberghien A, Creuzot-Garcher C, Baudouin C.

J Fr Ophtalmol. 2004 Oct;27(8):933-41. Review. French.

21.

Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).

Tiberghien AC, Hagan D, Howard PW, Thurston DE.

Bioorg Med Chem Lett. 2004 Oct 18;14(20):5041-4.

PMID:
15380195
22.

Synthesis of novel C2-aryl pyrrolobenzodiazepines (PBDs) as potential antitumour agents.

Cooper N, Hagan DR, Tiberghien A, Ademefun T, Matthews CS, Howard PW, Thurston DE.

Chem Commun (Camb). 2002 Aug 21;(16):1764-5.

PMID:
12196988

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