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Items: 30

1.

Alkylphenol inverse agonists of HCN1 gating: H-bond propensity, ring saturation and adduct geometry differentially determine efficacy and potency.

Joyce RL, Beyer NP, Vasilopoulos G, Woll KA, Hall AC, Eckenhoff RG, Barman DN, Warren JD, Tibbs GR, Goldstein PA.

Biochem Pharmacol. 2019 May;163:493-508. doi: 10.1016/j.bcp.2019.02.013. Epub 2019 Feb 13.

PMID:
30768926
2.

HCN and K2P Channels in Anesthetic Mechanisms Research.

Riegelhaupt PM, Tibbs GR, Goldstein PA.

Methods Enzymol. 2018;602:391-416. doi: 10.1016/bs.mie.2018.01.015. Epub 2018 Mar 2. Review.

PMID:
29588040
3.

Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?

Tibbs GR, Posson DJ, Goldstein PA.

Trends Pharmacol Sci. 2016 Jul;37(7):522-542. doi: 10.1016/j.tips.2016.05.002. Epub 2016 May 24. Review.

PMID:
27233519
4.

cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.

Lyashchenko AK, Redd KJ, Goldstein PA, Tibbs GR.

PLoS One. 2014 Jul 1;9(7):e101236. doi: 10.1371/journal.pone.0101236. eCollection 2014.

5.

HCN1 channels as targets for anesthetic and nonanesthetic propofol analogs in the amelioration of mechanical and thermal hyperalgesia in a mouse model of neuropathic pain.

Tibbs GR, Rowley TJ, Sanford RL, Herold KF, Proekt A, Hemmings HC Jr, Andersen OS, Goldstein PA, Flood PD.

J Pharmacol Exp Ther. 2013 Jun;345(3):363-73. doi: 10.1124/jpet.113.203620. Epub 2013 Apr 2.

6.

PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons.

Ying SW, Tibbs GR, Picollo A, Abbas SY, Sanford RL, Accardi A, Hofmann F, Ludwig A, Goldstein PA.

J Neurosci. 2011 Jul 13;31(28):10412-23. doi: 10.1523/JNEUROSCI.0021-11.2011.

7.

Voltage-dependent opening of HCN channels: Facilitation or inhibition by the phytoestrogen, genistein, is determined by the activation status of the cyclic nucleotide gating ring.

Rozario AO, Turbendian HK, Fogle KJ, Olivier NB, Tibbs GR.

Biochim Biophys Acta. 2009 Sep;1788(9):1939-49. doi: 10.1016/j.bbamem.2009.06.003. Epub 2009 Jun 11.

8.

Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination.

Bell DC, Turbendian HK, Valley MT, Zhou L, Riley JH, Siegelbaum SA, Tibbs GR.

Pflugers Arch. 2009 Jun;458(2):259-72. doi: 10.1007/s00424-008-0613-3. Epub 2008 Nov 26.

9.

Ion binding in the open HCN pacemaker channel pore: fast mechanisms to shape "slow" channels.

Lyashchenko AK, Tibbs GR.

J Gen Physiol. 2008 Mar;131(3):227-43. doi: 10.1085/jgp.200709868. Epub 2008 Feb 11.

10.

Propofol inhibits HCN1 pacemaker channels by selective association with the closed states of the membrane embedded channel core.

Lyashchenko AK, Redd KJ, Yang J, Tibbs GR.

J Physiol. 2007 Aug 15;583(Pt 1):37-56. Epub 2007 Jun 14.

11.

HCN pacemaker channel activation is controlled by acidic lipids downstream of diacylglycerol kinase and phospholipase A2.

Fogle KJ, Lyashchenko AK, Turbendian HK, Tibbs GR.

J Neurosci. 2007 Mar 14;27(11):2802-14.

12.

Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.

Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA.

J Pharmacol Exp Ther. 2005 Nov;315(2):517-25. Epub 2005 Jul 20.

PMID:
16033909
13.

Molecular mechanism of cAMP modulation of HCN pacemaker channels.

Wainger BJ, DeGennaro M, Santoro B, Siegelbaum SA, Tibbs GR.

Nature. 2001 Jun 14;411(6839):805-10.

PMID:
11459060
14.

Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.

Santoro B, Chen S, Luthi A, Pavlidis P, Shumyatsky GP, Tibbs GR, Siegelbaum SA.

J Neurosci. 2000 Jul 15;20(14):5264-75.

15.

The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels.

Santoro B, Tibbs GR.

Ann N Y Acad Sci. 1999 Apr 30;868:741-64. Review.

PMID:
10414361
16.
17.

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.

Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR.

Cell. 1998 May 29;93(5):717-29.

19.

Allosteric activation and tuning of ligand efficacy in cyclic-nucleotide-gated channels.

Tibbs GR, Goulding EH, Siegelbaum SA.

Nature. 1997 Apr 10;386(6625):612-5.

PMID:
9121585
21.
22.
23.

Molecular mechanism of cyclic-nucleotide-gated channel activation.

Goulding EH, Tibbs GR, Siegelbaum SA.

Nature. 1994 Nov 24;372(6504):369-74.

PMID:
7969497
24.

A simple method for recording single-channel activity from synaptic plasma membranes.

Hall AC, Tibbs GR, Dolly JO, Lieb WR, Franks NP.

J Neurosci Methods. 1993 Aug;49(1-2):81-91.

PMID:
8271834
25.

Role of H5 domain in determining pore diameter and ion permeation through cyclic nucleotide-gated channels.

Goulding EH, Tibbs GR, Liu D, Siegelbaum SA.

Nature. 1993 Jul 1;364(6432):61-4.

PMID:
7686276
26.
27.

Repetitive action potentials in isolated nerve terminals in the presence of 4-aminopyridine: effects on cytosolic free Ca2+ and glutamate release.

Tibbs GR, Barrie AP, Van Mieghem FJ, McMahon HT, Nicholls DG.

J Neurochem. 1989 Dec;53(6):1693-9.

PMID:
2553862
30.

The discovery of a rapidly metabolized polymeric tetraphosphate derivative of adenosine in perfused rat heart.

Mowbray J, Hutchinson WL, Tibbs GR, Morris PG.

Biochem J. 1984 Nov 1;223(3):627-32.

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