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Intravenous or Oral Acetaminophen for Analgesia After Cesarean Section: Exposure Drives Pain Relief.

Mian P, Dallmann A, van den Anker JN, Tibboel D, Allegaert K.

Pain Med. 2019 Jun 18. pii: pnz136. doi: 10.1093/pm/pnz136. [Epub ahead of print] No abstract available.


Lung function in school-aged congenital diaphragmatic hernia patients; a longitudinal evaluation.

Toussaint-Duyster LCC, van der Cammen-van Zijp MHM, Spoel M, Tiddens HAWM, Tibboel D, Wijnen RMH, van Rosmalen J, IJsselstijn H.

Pediatr Pulmonol. 2019 Jun 13. doi: 10.1002/ppul.24375. [Epub ahead of print]


Pediatric Perceived Cognitive Functioning: Psychometric Properties and Normative Data of the Dutch Item Bank and Short Form.

Marchal JP, de Vries M, Conijn J, Rietman AB, IJsselstijn H, Tibboel D, Haverman L, Maurice-Stam H, Oostrom KJ, Grootenhuis MA.

J Int Neuropsychol Soc. 2019 Jun 10:1-12. doi: 10.1017/S1355617719000572. [Epub ahead of print]


Light at the Horizon? Predicting Mortality in Infants With Congenital Diaphragmatic Hernia.

Cochius-den Otter SCM, Tibboel D.

Pediatr Crit Care Med. 2019 Jun;20(6):575-577. doi: 10.1097/PCC.0000000000001962. No abstract available.


A comprehensive analysis of ontogeny of renal drug transporters: mRNA analyses, quantitative proteomics and localization.

Wun Kathy Cheung K, van Groen BD, Spaans E, van Borselen MD, C J M de Bruijn A, Simons-Oosterhuis Y, Tibboel D, Samsom JN, Verdijk RM, Smeets B, Zhang L, Huang SM, Giacomini KM, de Wildt SN.

Clin Pharmacol Ther. 2019 May 25. doi: 10.1002/cpt.1516. [Epub ahead of print]


Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats.

van den Hoogen NJ, Patijn J, Tibboel D, Joosten EA.

Pediatr Res. 2019 May 13. doi: 10.1038/s41390-019-0420-x. [Epub ahead of print]


Lung function, exercise tolerance, and physical growth of children with congenital lung malformations at 8 years of age.

Hijkoop A, van Schoonhoven MM, van Rosmalen J, Tibboel D, van der Cammen-van Zijp MHM, Pijnenburg MW, Cohen-Overbeek TE, Schnater JM, IJsselstijn H.

Pediatr Pulmonol. 2019 Apr 22. doi: 10.1002/ppul.24345. [Epub ahead of print]


Actual body weight-based vancomycin dosing in neonates.

Pokorná P, Šíma M, Černá O, Allegaert K, Tibboel D, Slanař O.

J Chemother. 2019 Apr 14:1-6. doi: 10.1080/1120009X.2019.1599574. [Epub ahead of print]


Narcotic-Sparing Approaches and the Shift Toward Paracetamol in Neonatal Intensive Care.

Allegaert K, Tibboel D, van den Anker J.

Handb Exp Pharmacol. 2019 Mar 17. doi: 10.1007/164_2019_207. [Epub ahead of print]


Implementation of a nurse-driven ventilation weaning protocol in critically ill children: Can it improve patient outcome?

Duyndam A, Houmes RJ, van Rosmalen J, Tibboel D, van Dijk M, Ista E.

Aust Crit Care. 2019 Mar 12. pii: S1036-7314(18)30112-7. doi: 10.1016/j.aucc.2019.01.005. [Epub ahead of print]


Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method.

Calvier EAM, Krekels EHJ, Johnson TN, Rostami-Hodjegan A, Tibboel D, Knibbe CAJ.

AAPS J. 2019 Mar 8;21(3):38. doi: 10.1208/s12248-019-0295-0.


Non-inferiority double-blind randomised controlled trial comparing gabapentin versus tramadol for the treatment of chronic neuropathic or mixed pain in children and adolescents: the GABA-1 trial-a study protocol.

Kaguelidou F, Le Roux E, Mangiarini L, Lundin R, de Leeuw TG, Della Pasqua O, Felisi M, Bonifazi D, Tibboel D, Ceci A, de Wildt SN, Alberti C; GAPP consortium.

BMJ Open. 2019 Feb 20;9(2):e023296. doi: 10.1136/bmjopen-2018-023296.


Congenital diaphragmatic hernia and exercise capacity, a longitudinal evaluation.

Toussaint-Duyster LCC, van der Cammen-van Zijp MHM, de Jongste JC, Tibboel D, Wijnen RMH, Gischler SJ, van Rosmalen J, IJsselstijn H.

Pediatr Pulmonol. 2019 May;54(5):628-636. doi: 10.1002/ppul.24264. Epub 2019 Feb 11.


Antenatal therapy with sildenafil: don't throw the baby out with the bathwater.

Russo FM, Hooper S, Tibboel D, DeKoninck P, Benachi A, Tréluyer JM, Allegaert K, Kumar S, Deprest J.

Ultrasound Obstet Gynecol. 2019 Feb;53(2):274-275. doi: 10.1002/uog.20201. No abstract available.


Gabapentin as add-on to morphine for severe neuropathic or mixed pain in children from age 3 months to 18 years - evaluation of the safety, pharmacokinetics, and efficacy of a new gabapentin liquid formulation: study protocol for a randomized controlled trial.

de Leeuw TG, Mangiarini L, Lundin R, Kaguelidou F, van der Zanden T, Pasqua OD, Tibboel D, Ceci A, de Wildt SN; GAPP consortium.

Trials. 2019 Jan 15;20(1):49. doi: 10.1186/s13063-018-3169-3.


Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass.

Mian P, Valkenburg AJ, Allegaert K, Koch BCP, Breatnach CV, Knibbe CAJ, Tibboel D, Krekels EHJ.

J Clin Pharmacol. 2019 Jun;59(6):847-855. doi: 10.1002/jcph.1373. Epub 2019 Jan 11.


Validation of the Rotterdam Elderly Pain Observation Scale in the Hospital Setting.

Boerlage AA, van Rosmalen J, Cheuk-Alam-Balrak JM, Goudzwaard JA, Tibboel D, van Dijk M.

Pain Pract. 2019 Apr;19(4):407-417. doi: 10.1111/papr.12756. Epub 2019 Jan 13.


A systematic review and narrative synthesis on the histological and neurobehavioral long-term effects of dexmedetomidine.

van Hoorn CE, Hoeks SE, Essink H, Tibboel D, de Graaff JC.

Paediatr Anaesth. 2019 Feb;29(2):125-136. doi: 10.1111/pan.13553. Epub 2019 Jan 15. Review.


Validation of the SOS-PD scale for assessment of pediatric delirium: a multicenter study.

Ista E, van Beusekom B, van Rosmalen J, Kneyber MCJ, Lemson J, Brouwers A, Dieleman GC, Dierckx B, de Hoog M, Tibboel D, van Dijk M.

Crit Care. 2018 Nov 20;22(1):309. doi: 10.1186/s13054-018-2238-z.


Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability.

Mian P, van Esdonk MJ, Olkkola KT, de Winter BCM, Liukas A, Spriet I, Tibboel D, Petrovic M, Koch BCP, Allegaert K.

Br J Clin Pharmacol. 2019 Jan;85(1):126-135. doi: 10.1111/bcp.13770. Epub 2018 Oct 25.


Analgesics and Sedatives in Critically Ill Newborns and Infants: The Impact on Long-Term Neurodevelopment.

Schiller RM, Allegaert K, Hunfeld M, van den Bosch GE, van den Anker J, Tibboel D.

J Clin Pharmacol. 2018 Oct;58 Suppl 10:S140-S150. doi: 10.1002/jcph.1139.


Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory.

Calvier EAM, Nguyen TT, Johnson TN, Rostami-Hodjegan A, Tibboel D, Krekels EHJ, Knibbe CAJ.

Pharm Res. 2018 Sep 14;35(11):209. doi: 10.1007/s11095-018-2487-1.


Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial.

de Hoogd S, Valkenburg AJ, van Dongen EPA, Daeter EJ, van Rosmalen J, Dahan A, Tibboel D, Knibbe CAJ.

Eur J Anaesthesiol. 2019 Jan;36(1):32-39. doi: 10.1097/EJA.0000000000000887.


Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants.

van Groen BD, van de Steeg E, Mooij MG, van Lipzig MMH, de Koning BAE, Verdijk RM, Wortelboer HM, Gaedigk R, Bi C, Leeder JS, van Schaik RHN, van Rosmalen J, Tibboel D, Vaes WH, de Wildt SN.

Eur J Pharm Sci. 2018 Nov 1;124:217-227. doi: 10.1016/j.ejps.2018.08.042. Epub 2018 Aug 30.


Congenital pulmonary airway malformation: advances and controversies.

Wong KKY, Flake AW, Tibboel D, Rottier RJ, Tam PKH.

Lancet Child Adolesc Health. 2018 Apr;2(4):290-297. doi: 10.1016/S2352-4642(18)30035-X. Epub 2018 Feb 17. Review.


Memory deficits following neonatal critical illness: a common neurodevelopmental pathway.

Schiller R, IJsselstijn H, Hoskote A, White T, Verhulst F, van Heijst A, Tibboel D.

Lancet Child Adolesc Health. 2018 Apr;2(4):281-289. doi: 10.1016/S2352-4642(17)30180-3. Epub 2018 Jan 10. Review.


Alveolar capillary dysplasia with misalignment of the pulmonary veins: clinical, histological, and genetic aspects.

Slot E, Edel G, Cutz E, van Heijst A, Post M, Schnater M, Wijnen R, Tibboel D, Rottier R, de Klein A.

Pulm Circ. 2018 Jul-Sep;8(3):2045894018795143. doi: 10.1177/2045894018795143. Epub 2018 Jul 30.


Combining Brain Microdialysis and Translational Pharmacokinetic Modeling to Predict Drug Concentrations in Pediatric Severe Traumatic Brain Injury: The Next Step Toward Evidence-Based Pharmacotherapy?

Ketharanathan N, Yamamoto Y, Rohlwink UK, Wildschut ED, Mathôt RAA, de Lange ECM, de Wildt SN, Argent AC, Tibboel D, Figaji AA.

J Neurotrauma. 2019 Jan 1;36(1):111-117. doi: 10.1089/neu.2017.5588. Epub 2018 Sep 6.


Improving Long-Term Outcomes After Extracorporeal Membrane Oxygenation: From Observational Follow-Up Programs Toward Risk Stratification.

IJsselstijn H, Hunfeld M, Schiller RM, Houmes RJ, Hoskote A, Tibboel D, van Heijst AFJ.

Front Pediatr. 2018 Jun 26;6:177. doi: 10.3389/fped.2018.00177. eCollection 2018. Review.


Clinically effective implementation of intravenous paracetamol as primary analgesia after major surgery in neonates and young infants.

Baarslag MA, Ista E, de Leeuw T, van Rosmalen J, Tibboel D, van Dijk M, de Wildt SN.

Arch Dis Child. 2018 Dec;103(12):1168-1169. doi: 10.1136/archdischild-2018-315379. Epub 2018 Jul 10. No abstract available.


Navigating Between Scylla and Charybdis; Sevoflurane for Difficult Sedation at the PICU.

de Graaff JC, Houmes RJ, Tibboel D.

Pediatr Crit Care Med. 2018 Jul;19(7):685-686. doi: 10.1097/PCC.0000000000001566. No abstract available.


The occurrence of adverse events in low-risk non-survivors in pediatric intensive care patients: an exploratory study.

Verlaat CW, van der Starre C, Hazelzet JA, Tibboel D, van der Hoeven J, Lemson J, Zegers M.

Eur J Pediatr. 2018 Sep;177(9):1351-1358. doi: 10.1007/s00431-018-3194-y. Epub 2018 Jun 26.


Paracetamol in Older People: Towards Evidence-Based Dosing?

Mian P, Allegaert K, Spriet I, Tibboel D, Petrovic M.

Drugs Aging. 2018 Jul;35(7):603-624. doi: 10.1007/s40266-018-0559-x. Review.


Defining outcomes following congenital diaphragmatic hernia using standardised clinical assessment and management plan (SCAMP) methodology within the CDH EURO consortium.

IJsselstijn H, Breatnach C, Hoskote A, Greenough A, Patel N, Capolupo I, Morini F, Scharbatke H, Kipfmueller F, Ertresvag K, Kraemer U, Braguglia A, Wessel L, van Heijst AFJ, Moinichen I, Emblem R, Tibboel D; CDH EURO Consortium Group.

Pediatr Res. 2018 Aug;84(2):181-189. doi: 10.1038/s41390-018-0063-3. Epub 2018 May 29. Review.


Hemodynamic Tolerance to IV Clonidine Infusion in the PICU.

Kleiber N, van Rosmalen J, Tibboel D, de Wildt SN.

Pediatr Crit Care Med. 2018 Aug;19(8):e409-e416. doi: 10.1097/PCC.0000000000001602.


Intravenous morphine versus intravenous paracetamol after cardiac surgery in neonates and infants: a study protocol for a randomized controlled trial.

Zeilmaker-Roest GA, van Rosmalen J, van Dijk M, Koomen E, Jansen NJG, Kneyber MCJ, Maebe S, van den Berghe G, Vlasselaers D, Bogers AJJC, Tibboel D, Wildschut ED.

Trials. 2018 Jun 13;19(1):318. doi: 10.1186/s13063-018-2705-5.


Potentially clinically relevant concentrations of Cefazolin, Midazolam, Propofol, and Sufentanil in auto-transfused blood in congenital cardiac surgery.

Zeilmaker-Roest GA, van Saet A, van Rosmalen J, Bahmany S, van Dijk A, Wildschut ED, Tibboel D, Bogers AJJC.

J Cardiothorac Surg. 2018 Jun 8;13(1):64. doi: 10.1186/s13019-018-0747-0.


Hypoxia inducible factor 2α (HIF2α/EPAS1) is associated with development of pulmonary hypertension in severe congenital diaphragmatic hernia patients.

Huang Y, Boerema-de Munck A, Buscop-van Kempen M, Sluiter I, de Krijger R, Tibboel D, Rottier RJ.

Pulm Circ. 2018 Jul-Sep;8(3):2045894018783734. doi: 10.1177/2045894018783734. Epub 2018 Jun 1.


Phenobarbital pharmacokinetics in neonates and infants during extracorporeal membrane oxygenation.

Pokorná P, Šíma M, Vobruba V, Tibboel D, Slanař O.

Perfusion. 2018 May;33(1_suppl):80-86. doi: 10.1177/0267659118766444.


How often do we perform painful and stressful procedures in the paediatric intensive care unit? A prospective observational study.

Baarslag MA, Jhingoer S, Ista E, Allegaert K, Tibboel D, van Dijk M.

Aust Crit Care. 2019 Jan;32(1):4-10. doi: 10.1016/j.aucc.2018.04.003. Epub 2018 May 17.


Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag's active compound, at the pseudoglandular stage improves lung vasculature.

Mous DS, Kool HM, Burgisser PE, Buscop-van Kempen MJ, Nagata K, Boerema-de Munck A, van Rosmalen J, Dzyubachyk O, Wijnen RMH, Tibboel D, Rottier RJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L276-L285. doi: 10.1152/ajplung.00392.2017. Epub 2018 May 10.


An international survey of management of pain and sedation after paediatric cardiac surgery.

Zeilmaker-Roest GA, Wildschut ED, van Dijk M, Anderson BJ, Breatnach C, Bogers AJJC, Tibboel D; Paediatric Analgesia after Cardiac Surgery consortium.

BMJ Paediatr Open. 2017 Jul 5;1(1):e000046. doi: 10.1136/bmjpo-2017-000046. eCollection 2017.


Working Memory Training Following Neonatal Critical Illness: A Randomized Controlled Trial.

Schiller RM, Madderom MJ, van Rosmalen J, van Heijst AFJ, de Blaauw I, Utens E, Rietman AB, Verhulst F, Tibboel D, White T, IJsselstijn H.

Crit Care Med. 2018 Jul;46(7):1158-1166. doi: 10.1097/CCM.0000000000003151.


Large differences in neonatal drug use between NICUs are common practice: time for consensus?

Flint RB, van Beek F, Andriessen P, Zimmermann LJ, Liem KD, Reiss IKM, de Groot R, Tibboel D, Burger DM, Simons SHP; DINO Research group.

Br J Clin Pharmacol. 2018 Jun;84(6):1313-1323. doi: 10.1111/bcp.13563. Epub 2018 Apr 17.


Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients.

Zeilmaker GA, Pokorna P, Mian P, Wildschut ED, Knibbe CAJ, Krekels EHJ, Allegaert K, Tibboel D.

Expert Opin Drug Metab Toxicol. 2018 Apr;14(4):417-428. doi: 10.1080/17425255.2018.1461836. Epub 2018 Apr 11. Review.


Cerebellar Growth Impairment Characterizes School-Aged Children Born Preterm without Perinatal Brain Lesions.

Pieterman K, White TJ, van den Bosch GE, Niessen WJ, Reiss IKM, Tibboel D, Hoebeek FE, Dudink J.

AJNR Am J Neuroradiol. 2018 May;39(5):956-962. doi: 10.3174/ajnr.A5589. Epub 2018 Mar 22.


Omphalocele: from diagnosis to growth and development at 2 years of age.

Hijkoop A, Peters NCJ, Lechner RL, van Bever Y, van Gils-Frijters APJM, Tibboel D, Wijnen RMH, Cohen-Overbeek TE, IJsselstijn H.

Arch Dis Child Fetal Neonatal Ed. 2019 Jan;104(1):F18-F23. doi: 10.1136/archdischild-2017-314700. Epub 2018 Mar 21.


Repeated touch and needle-prick stimulation in the neonatal period increases the baseline mechanical sensitivity and postinjury hypersensitivity of adult spinal sensory neurons.

van den Hoogen NJ, Patijn J, Tibboel D, Joosten BA, Fitzgerald M, Kwok CHT.

Pain. 2018 Jun;159(6):1166-1175. doi: 10.1097/j.pain.0000000000001201.


Pain Experience is Somatotopically Organized and Overlaps with Pain Anticipation in the Human Cerebellum.

Michelle Welman FHS, Smit AE, Jongen JLM, Tibboel D, van der Geest JN, Holstege JC.

Cerebellum. 2018 Aug;17(4):447-460. doi: 10.1007/s12311-018-0930-9.

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