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Items: 41


Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.

Kim SH, Stiles SG, Feichtmeier JM, Ramesh N, Zhan L, Scalf MA, Smith LM, Pandey UB, Tibbetts RS.

Hum Mol Genet. 2018 Jan 15;27(2):322-337. doi: 10.1093/hmg/ddx403.


Tunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism.

Kim SH, Trinh AT, Larsen MC, Mastrocola AS, Jefcoate CR, Bushel PR, Tibbetts RS.

Nucleic Acids Res. 2016 Nov 16;44(20):9667-9680. Epub 2016 Jul 18.


Neurodegeneration: Problems at the nuclear pore.

Fox BW, Tibbetts RS.

Nature. 2015 Sep 3;525(7567):36-7. doi: 10.1038/nature15208. Epub 2015 Aug 26. No abstract available.


The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damage.

Mastrocola AS, Kim SH, Trinh AT, Rodenkirch LA, Tibbetts RS.

J Biol Chem. 2013 Aug 23;288(34):24731-41. doi: 10.1074/jbc.M113.497974. Epub 2013 Jul 5.


Cyclin-dependent kinase 1-dependent phosphorylation of cAMP response element-binding protein decreases chromatin occupancy.

Trinh AT, Kim SH, Chang HY, Mastrocola AS, Tibbetts RS.

J Biol Chem. 2013 Aug 16;288(33):23765-75. doi: 10.1074/jbc.M113.464057. Epub 2013 Jun 27.


Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila.

Zhan L, Hanson KA, Kim SH, Tare A, Tibbetts RS.

PLoS One. 2013;8(2):e57214. doi: 10.1371/journal.pone.0057214. Epub 2013 Feb 27.


High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity.

Kim SH, Zhan L, Hanson KA, Tibbetts RS.

Hum Mol Genet. 2012 Nov 15;21(22):4845-56. doi: 10.1093/hmg/dds321. Epub 2012 Aug 7.


RNA-binding proteins in neurodegenerative disease: TDP-43 and beyond.

Hanson KA, Kim SH, Tibbetts RS.

Wiley Interdiscip Rev RNA. 2012 Mar-Apr;3(2):265-85. doi: 10.1002/wrna.111. Epub 2011 Oct 25. Review.


Casein kinase 1-dependent phosphorylation of familial advanced sleep phase syndrome-associated residues controls PERIOD 2 stability.

Shanware NP, Hutchinson JA, Kim SH, Zhan L, Bowler MJ, Tibbetts RS.

J Biol Chem. 2011 Apr 8;286(14):12766-74. doi: 10.1074/jbc.M111.224014. Epub 2011 Feb 15.


Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1.

Hutchinson JA, Shanware NP, Chang H, Tibbetts RS.

J Biol Chem. 2011 Mar 11;286(10):8688-96. doi: 10.1074/jbc.M110.141754. Epub 2011 Jan 13.


Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress.

Shanware NP, Zhan L, Hutchinson JA, Kim SH, Williams LM, Tibbetts RS.

PLoS One. 2010 Aug 13;5(8):e12173. doi: 10.1371/journal.pone.0012173.


Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.

Kim SH, Shanware NP, Bowler MJ, Tibbetts RS.

J Biol Chem. 2010 Oct 29;285(44):34097-105. doi: 10.1074/jbc.M110.154831. Epub 2010 Aug 18.


Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.

Sakasai R, Teraoka H, Takagi M, Tibbetts RS.

J Biol Chem. 2010 May 14;285(20):15201-8. doi: 10.1074/jbc.M110.101808. Epub 2010 Mar 19.


Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).

Hanson KA, Kim SH, Wassarman DA, Tibbetts RS.

J Biol Chem. 2010 Apr 9;285(15):11068-72. doi: 10.1074/jbc.C109.078527. Epub 2010 Feb 12.


Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin.

Sakasai R, Teraoka H, Tibbetts RS.

DNA Repair (Amst). 2010 Jan 2;9(1):76-82. doi: 10.1016/j.dnarep.2009.10.008. Epub 2009 Dec 3.


Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190.

Shanware NP, Williams LM, Bowler MJ, Tibbetts RS.

BMB Rep. 2009 Mar 31;42(3):142-7.


Potentiation of amyotrophic lateral sclerosis (ALS)-associated TDP-43 aggregation by the proteasome-targeting factor, ubiquilin 1.

Kim SH, Shi Y, Hanson KA, Williams LM, Sakasai R, Bowler MJ, Tibbetts RS.

J Biol Chem. 2009 Mar 20;284(12):8083-92. doi: 10.1074/jbc.M808064200. Epub 2008 Dec 26.


Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.

Rimkus SA, Katzenberger RJ, Trinh AT, Dodson GE, Tibbetts RS, Wassarman DA.

Genes Dev. 2008 May 1;22(9):1205-20. doi: 10.1101/gad.1639608. Epub 2008 Apr 11.


Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies.

Shi Y, Dodson GE, Mukhopadhyay PS, Shanware NP, Trinh AT, Tibbetts RS.

J Biol Chem. 2007 Mar 23;282(12):9236-43. Epub 2007 Jan 23.


Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.

Wu ZH, Shi Y, Tibbetts RS, Miyamoto S.

Science. 2006 Feb 24;311(5764):1141-6.


DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.

Dodson GE, Tibbetts RS.

J Biol Chem. 2006 Jan 20;281(3):1692-7. Epub 2005 Nov 17.


ATR activation necessary but not sufficient for p53 induction and apoptosis in hydroxyurea-hypersensitive myeloid leukemia cells.

Kumar S, Dodson GE, Trinh A, Puchalski JR, Tibbetts RS.

Cell Cycle. 2005 Nov;4(11):1667-74. Epub 2005 Nov 13.


Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo.

Shi Y, Dodson GE, Shaikh S, Rundell K, Tibbetts RS.

J Biol Chem. 2005 Dec 2;280(48):40195-200. Epub 2005 Oct 11.


Cell biology. Guiding ATM to broken DNA.

Abraham RT, Tibbetts RS.

Science. 2005 Apr 22;308(5721):510-1. No abstract available.


The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.

Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT.

Mol Cell. 2004 Jun 4;14(5):585-98.


Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress.

Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5898-903. Epub 2004 Apr 8.


ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses.

Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF.

Nature. 2001 Jun 21;411(6840):969-74.


Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT.

Genes Dev. 2000 Dec 1;14(23):2989-3002.


Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

Sarkaria JN, Busby EC, Tibbetts RS, Roos P, Taya Y, Karnitz LM, Abraham RT.

Cancer Res. 1999 Sep 1;59(17):4375-82.


A role for ATR in the DNA damage-induced phosphorylation of p53.

Tibbetts RS, Brumbaugh KM, Williams JM, Sarkaria JN, Cliby WA, Shieh SY, Taya Y, Prives C, Abraham RT.

Genes Dev. 1999 Jan 15;13(2):152-7.


Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT.

Cancer Res. 1998 Oct 1;58(19):4375-82.


TcDJ1, a putative mitochondrial DnaJ protein in Trypanosoma cruzi.

Carreira MA, Tibbetts RS, Olson CL, Schuster C, Renz M, Engman DM, Goldenberg S.

FEMS Microbiol Lett. 1998 Sep 1;166(1):141-6.


The DnaJ family of protein chaperones in Trypanosoma cruzi.

Tibbetts RS, Jensen JL, Olson CL, Wang FD, Engman DM.

Mol Biochem Parasitol. 1998 Mar 15;91(2):319-26.


Utility of recombinant flagellar calcium-binding protein for serodiagnosis of Trypanosoma cruzi infection.

Godsel LM, Tibbetts RS, Olson CL, Chaudoir BM, Engman DM.

J Clin Microbiol. 1995 Aug;33(8):2082-5.


A rapid method for protein localization in trypanosomes.

Tibbetts RS, Klein KG, Engman DM.

Exp Parasitol. 1995 May;80(3):572-4. No abstract available.


Trypanosoma cruzi heat-shock protein 90 can functionally complement yeast.

Palmer G, Louvion JF, Tibbetts RS, Engman DM, Picard D.

Mol Biochem Parasitol. 1995 Mar;70(1-2):199-202. No abstract available.


Molecular cloning and characterization of the 78-kilodalton glucose-regulated protein of Trypanosoma cruzi.

Tibbetts RS, Kim IY, Olson CL, Barthel LM, Sullivan MA, Winquist AG, Miller SD, Engman DM.

Infect Immun. 1994 Jun;62(6):2499-507.


Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi-infected mice.

Tibbetts RS, McCormick TS, Rowland EC, Miller SD, Engman DM.

J Immunol. 1994 Feb 1;152(3):1493-9.


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