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Items: 14


Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions.

Thyme SB, Pieper LM, Li EH, Pandey S, Wang Y, Morris NS, Sha C, Choi JW, Herrera KJ, Soucy ER, Zimmerman S, Randlett O, Greenwood J, McCarroll SA, Schier AF.

Cell. 2019 Apr 4;177(2):478-491.e20. doi: 10.1016/j.cell.2019.01.048. Epub 2019 Mar 28.


Kctd13 deletion reduces synaptic transmission via increased RhoA.

Escamilla CO, Filonova I, Walker AK, Xuan ZX, Holehonnur R, Espinosa F, Liu S, Thyme SB, López-García IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM.

Nature. 2017 Nov 9;551(7679):227-231. doi: 10.1038/nature24470. Epub 2017 Nov 1.


Internal guide RNA interactions interfere with Cas9-mediated cleavage.

Thyme SB, Akhmetova L, Montague TG, Valen E, Schier AF.

Nat Commun. 2016 Jun 10;7:11750. doi: 10.1038/ncomms11750.


Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development.

Thyme SB, Schier AF.

Cell Rep. 2016 May 17;15(7):1611-1613. doi: 10.1016/j.celrep.2016.04.089. Epub 2016 May 21. No abstract available.


CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering.

Labun K, Montague TG, Gagnon JA, Thyme SB, Valen E.

Nucleic Acids Res. 2016 Jul 8;44(W1):W272-6. doi: 10.1093/nar/gkw398. Epub 2016 May 16.


Polq-Mediated End Joining Is Essential for Surviving DNA Double-Strand Breaks during Early Zebrafish Development.

Thyme SB, Schier AF.

Cell Rep. 2016 Apr 26;15(4):707-714. doi: 10.1016/j.celrep.2016.03.072. Epub 2016 Apr 14. Erratum in: Cell Rep. 2016 May 17;15(7):1611-1613.


Massively parallel determination and modeling of endonuclease substrate specificity.

Thyme SB, Song Y, Brunette TJ, Szeto MD, Kusak L, Bradley P, Baker D.

Nucleic Acids Res. 2014 Dec 16;42(22):13839-52. doi: 10.1093/nar/gku1096. Epub 2014 Nov 11.


Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs.

Gagnon JA, Valen E, Thyme SB, Huang P, Akhmetova L, Pauli A, Montague TG, Zimmerman S, Richter C, Schier AF.

PLoS One. 2014 May 29;9(5):e98186. doi: 10.1371/journal.pone.0098186. eCollection 2014. Erratum in: PLoS One. 2014;9(8):e106396. Ahkmetova, Laila [corrected to Akhmetova, Laila].


Reprogramming homing endonuclease specificity through computational design and directed evolution.

Thyme SB, Boissel SJ, Arshiya Quadri S, Nolan T, Baker DA, Park RU, Kusak L, Ashworth J, Baker D.

Nucleic Acids Res. 2014 Feb;42(4):2564-76. doi: 10.1093/nar/gkt1212. Epub 2013 Nov 21.


Improved modeling of side-chain--base interactions and plasticity in protein--DNA interface design.

Thyme SB, Baker D, Bradley P.

J Mol Biol. 2012 Jun 8;419(3-4):255-74. doi: 10.1016/j.jmb.2012.03.005. Epub 2012 Mar 15.


Mining endonuclease cleavage determinants in genomic sequence data.

Szeto MD, Boissel SJ, Baker D, Thyme SB.

J Biol Chem. 2011 Sep 16;286(37):32617-27. doi: 10.1074/jbc.M111.259572. Epub 2011 Jul 21.


A synthetic homing endonuclease-based gene drive system in the human malaria mosquito.

Windbichler N, Menichelli M, Papathanos PA, Thyme SB, Li H, Ulge UY, Hovde BT, Baker D, Monnat RJ Jr, Burt A, Crisanti A.

Nature. 2011 May 12;473(7346):212-5. doi: 10.1038/nature09937. Epub 2011 Apr 20.


Exploitation of binding energy for catalysis and design.

Thyme SB, Jarjour J, Takeuchi R, Havranek JJ, Ashworth J, Scharenberg AM, Stoddard BL, Baker D.

Nature. 2009 Oct 29;461(7268):1300-4. doi: 10.1038/nature08508.


Mechanistic study of competitive sp(3)-sp(3) and sp(2)-sp(3) carbon-carbon reductive elimination from a platinum (IV) center and the isolation of a C-C agostic complex.

Madison BL, Thyme SB, Keene S, Williams BS.

J Am Chem Soc. 2007 Aug 8;129(31):9538-9. Epub 2007 Jul 13. No abstract available. Erratum in: J Am Chem Soc. 2007 Nov 21;129(46):14523.


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