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A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies.

Skokos D, Waite JC, Haber L, Crawford A, Hermann A, Ullman E, Slim R, Godin S, Ajithdoss D, Ye X, Wang B, Wu Q, Ramos I, Pawashe A, Canova L, Vazzana K, Ram P, Herlihy E, Ahmed H, Oswald E, Golubov J, Poon P, Havel L, Chiu D, Lazo M, Provoncha K, Yu K, Kim J, Warsaw JJ, Stokes Oristian N, Siao CJ, Dudgeon D, Huang T, Potocky T, Martin J, MacDonald D, Oyejide A, Rafique A, Poueymirou W, Kirshner JR, Smith E, Olson W, Lin J, Thurston G, Sleeman MA, Murphy AJ, Yancopoulos GD.

Sci Transl Med. 2020 Jan 8;12(525). pii: eaaw7888. doi: 10.1126/scitranslmed.aaw7888.


Genome-scale CRISPR activation screen uncovers tumor-intrinsic modulators of CD3 bispecific antibody efficacy.

Decker CE, Young T, Pasnikowski E, Chiu J, Song H, Wei Y, Thurston G, Daly C.

Sci Rep. 2019 Dec 27;9(1):20068. doi: 10.1038/s41598-019-56670-x.


A Biparatopic Antibody That Modulates MET Trafficking Exhibits Enhanced Efficacy Compared with Parental Antibodies in MET-Driven Tumor Models.

DaSilva JO, Yang K, Perez Bay AE, Andreev J, Ngoi P, Pyles E, Franklin MC, Dudgeon D, Rafique A, Dore A, Delfino FJ, Potocky TB, Babb R, Chen G, MacDonald D, Olson WC, Thurston G, Daly C.

Clin Cancer Res. 2019 Dec 17. doi: 10.1158/1078-0432.CCR-19-2428. [Epub ahead of print]


The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells.

Deckelbaum RA, Lobov IB, Cheung E, Halasz G, Rajamani S, Lerner J, Tong C, Li Z, Boland P, Dominguez M, Hughes V, Yancopoulos GD, Murphy AJ, Thurston G, Cao J, Romano C, Gale NW.

Angiogenesis. 2019 Nov 21. doi: 10.1007/s10456-019-09696-8. [Epub ahead of print]


Vibrationally resolved photoelectron spectroscopy of oligothiophene radical anions.

Thurston GK, Sagan CR, Garand E.

J Chem Phys. 2019 Oct 28;151(16):164301. doi: 10.1063/1.5124925.


Air Pollution Monitoring for Health Research and Patient Care. An Official American Thoracic Society Workshop Report.

Cromar KR, Duncan BN, Bartonova A, Benedict K, Brauer M, Habre R, Hagler GSW, Haynes JA, Khan S, Kilaru V, Liu Y, Pawson S, Peden DB, Quint JK, Rice MB, Sasser EN, Seto E, Stone SL, Thurston GD, Volckens J.

Ann Am Thorac Soc. 2019 Oct;16(10):1207-1214. doi: 10.1513/AnnalsATS.201906-477ST.


A land use regression model of nitrogen dioxide and fine particulate matter in a complex urban core in Lanzhou, China.

Jin L, Berman JD, Warren JL, Levy JI, Thurston G, Zhang Y, Xu X, Wang S, Zhang Y, Bell ML.

Environ Res. 2019 Oct;177:108597. doi: 10.1016/j.envres.2019.108597. Epub 2019 Jul 22.


Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia.

Gao J, Van Meter M, Hernandez Lopez S, Chen G, Huang Y, Ren S, Zhao Q, Rojas J, Gurer C, Thurston G, Kuhnert F.

Dis Model Mech. 2019 Sep 16;12(9). pii: dmm040931. doi: 10.1242/dmm.040931.


Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human PD-1xLAG-3-Knockin Mice.

Burova E, Hermann A, Dai J, Ullman E, Halasz G, Potocky T, Hong S, Liu M, Allbritton O, Woodruff A, Pei J, Rafique A, Poueymirou W, Martin J, MacDonald D, Olson WC, Murphy A, Ioffe E, Thurston G, Mohrs M.

Mol Cancer Ther. 2019 Nov;18(11):2051-2062. doi: 10.1158/1535-7163.MCT-18-1376. Epub 2019 Aug 8.


Mapping urban air quality using mobile sampling with low-cost sensors and machine learning in Seoul, South Korea.

Lim CC, Kim H, Vilcassim MJR, Thurston GD, Gordon T, Chen LC, Lee K, Heimbinder M, Kim SY.

Environ Int. 2019 Oct;131:105022. doi: 10.1016/j.envint.2019.105022. Epub 2019 Jul 27.


Air Pollution, Oxidative Stress, and Diabetes: a Life Course Epidemiologic Perspective.

Lim CC, Thurston GD.

Curr Diab Rep. 2019 Jul 19;19(8):58. doi: 10.1007/s11892-019-1181-y. Review.


PM2.5 air pollution and cause-specific cardiovascular disease mortality.

Hayes RB, Lim C, Zhang Y, Cromar K, Shao Y, Reynolds HR, Silverman DT, Jones RR, Park Y, Jerrett M, Ahn J, Thurston GD.

Int J Epidemiol. 2019 Jul 10. pii: dyz114. doi: 10.1093/ije/dyz114. [Epub ahead of print]


A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer.

Crawford A, Haber L, Kelly MP, Vazzana K, Canova L, Ram P, Pawashe A, Finney J, Jalal S, Chiu D, Colleton CA, Garnova E, Makonnen S, Hickey C, Krueger P, DelFino F, Potocky T, Kuhnert J, Godin S, Retter MW, Duramad P, MacDonald D, Olson WC, Fairhurst J, Huang T, Martin J, Lin JC, Smith E, Thurston G, Kirshner JR.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaau7534. doi: 10.1126/scitranslmed.aau7534.


Air Pollution Exposure and Asthma Incidence in Children: Demonstrating the Value of Air Quality Standards.

Thurston GD, Rice MB.

JAMA. 2019 May 21;321(19):1875-1877. doi: 10.1001/jama.2019.5343. No abstract available.


Exposure to air pollution is associated with adverse cardiopulmonary health effects in international travellers.

Vilcassim MJR, Thurston GD, Chen LC, Lim CC, Saunders E, Yao Y, Gordon T.

J Travel Med. 2019 Jun 11;26(5). pii: taz032. doi: 10.1093/jtm/taz032.


Long-Term Exposure to Ozone and Cause-Specific Mortality Risk in the United States.

Lim CC, Hayes RB, Ahn J, Shao Y, Silverman DT, Jones RR, Garcia C, Bell ML, Thurston GD.

Am J Respir Crit Care Med. 2019 Oct 15;200(8):1022-1031. doi: 10.1164/rccm.201806-1161OC.


Advancing environmental exposure assessment science to benefit society.

Caplin A, Ghandehari M, Lim C, Glimcher P, Thurston G.

Nat Commun. 2019 Mar 15;10(1):1236. doi: 10.1038/s41467-019-09155-4. Review.


Exposure to Greater Air Pollution when Traveling Abroad Is Associated with Decreased Lung Function.

Ruzmyn Vilcassim MJ, Thurston GD, Chen LC, Lim CC, Gordon T.

Am J Respir Crit Care Med. 2019 Jun 15;199(12):1570-1572. doi: 10.1164/rccm.201811-2235LE. No abstract available.


Water Pipe (Hookah) Smoking and Cardiovascular Disease Risk: A Scientific Statement From the American Heart Association.

Bhatnagar A, Maziak W, Eissenberg T, Ward KD, Thurston G, King BA, Sutfin EL, Cobb CO, Griffiths M, Goldstein LB, Rezk-Hanna M.

Circulation. 2019 May 7;139(19):e917-e936. doi: 10.1161/CIR.0000000000000671.


Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer.

Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA.

Cell Metab. 2019 Jun 4;29(6):1390-1399.e6. doi: 10.1016/j.cmet.2019.02.001. Epub 2019 Feb 28.


Mediterranean Diet and the Association Between Air Pollution and Cardiovascular Disease Mortality Risk.

Lim CC, Hayes RB, Ahn J, Shao Y, Silverman DT, Jones RR, Thurston GD.

Circulation. 2019 Apr 9;139(15):1766-1775. doi: 10.1161/CIRCULATIONAHA.118.035742.


Recent spatial gradients and time trends in Dhaka, Bangladesh, air pollution and their human health implications.

Rahman MM, Mahamud S, Thurston GD.

J Air Waste Manag Assoc. 2019 Apr;69(4):478-501. doi: 10.1080/10962247.2018.1548388. Epub 2019 Jan 22.


Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 2: Air Pollution and Organ Systems.

Schraufnagel DE, Balmes JR, Cowl CT, De Matteis S, Jung SH, Mortimer K, Perez-Padilla R, Rice MB, Riojas-Rodriguez H, Sood A, Thurston GD, To T, Vanker A, Wuebbles DJ.

Chest. 2019 Feb;155(2):417-426. doi: 10.1016/j.chest.2018.10.041. Epub 2018 Nov 9. Review.


Air Pollution and Noncommunicable Diseases: A Review by the Forum of International Respiratory Societies' Environmental Committee, Part 1: The Damaging Effects of Air Pollution.

Schraufnagel DE, Balmes JR, Cowl CT, De Matteis S, Jung SH, Mortimer K, Perez-Padilla R, Rice MB, Riojas-Rodriguez H, Sood A, Thurston GD, To T, Vanker A, Wuebbles DJ.

Chest. 2019 Feb;155(2):409-416. doi: 10.1016/j.chest.2018.10.042. Epub 2018 Nov 9. Review.


Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter.

Burnett R, Chen H, Szyszkowicz M, Fann N, Hubbell B, Pope CA 3rd, Apte JS, Brauer M, Cohen A, Weichenthal S, Coggins J, Di Q, Brunekreef B, Frostad J, Lim SS, Kan H, Walker KD, Thurston GD, Hayes RB, Lim CC, Turner MC, Jerrett M, Krewski D, Gapstur SM, Diver WR, Ostro B, Goldberg D, Crouse DL, Martin RV, Peters P, Pinault L, Tjepkema M, van Donkelaar A, Villeneuve PJ, Miller AB, Yin P, Zhou M, Wang L, Janssen NAH, Marra M, Atkinson RW, Tsang H, Quoc Thach T, Cannon JB, Allen RT, Hart JE, Laden F, Cesaroni G, Forastiere F, Weinmayr G, Jaensch A, Nagel G, Concin H, Spadaro JV.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9592-9597. doi: 10.1073/pnas.1803222115. Epub 2018 Sep 4.


The perils posed by the US Environmental Protection Agency's transparency rule.

Thurston GD.

Lancet Respir Med. 2018 Aug;6(8):e40-e41. doi: 10.1016/S2213-2600(18)30281-9. No abstract available.


Air pollution health research priorities for India: Perspectives of the Indo-U.S. Communities of Researchers.

Gordon T, Balakrishnan K, Dey S, Rajagopalan S, Thornburg J, Thurston G, Agrawal A, Collman G, Guleria R, Limaye S, Salvi S, Kilaru V, Nadadur S.

Environ Int. 2018 Oct;119:100-108. doi: 10.1016/j.envint.2018.06.013. Epub 2018 Jun 23. Review. No abstract available.


Photoelectron spectroscopy of anthracene and fluoranthene radical anions.

Kregel SJ, Thurston GK, Garand E.

J Chem Phys. 2018 Jun 21;148(23):234306. doi: 10.1063/1.5036757.


Association between long-term exposure to ambient air pollution and diabetes mortality in the US.

Lim CC, Hayes RB, Ahn J, Shao Y, Silverman DT, Jones RR, Garcia C, Thurston GD.

Environ Res. 2018 Aug;165:330-336. doi: 10.1016/j.envres.2018.04.011. Epub 2018 May 17.


ImmunoPET Imaging of Endogenous and Transfected Prolactin Receptor Tumor Xenografts.

Cheal SM, Ruan S, Veach DR, Longo VA, Punzalan BJ, Wu J, Fung EK, Kelly MP, Kirshner JR, Giurleo JT, Ehrlich G, Han AQ, Thurston G, Olson WC, Zanzonico PB, Larson SM, Carrasquillo JA.

Mol Pharm. 2018 Jun 4;15(6):2133-2141. doi: 10.1021/acs.molpharmaceut.7b01133. Epub 2018 Apr 30.


Realizing the Paris Climate Agreement to Improve Cardiopulmonary Health. Where Science Meets Policy.

Rice MB, Motto Malea N, Pinkerton KE, Schwartz J, Nadeau KC, Browner CM, Whitehouse S, Thurston GD.

Ann Am Thorac Soc. 2018 Jul;15(7):791-798. doi: 10.1513/AnnalsATS.201803-203PS. Review. No abstract available.


Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids.

Nittoli T, Kelly MP, Delfino F, Rudge J, Kunz A, Markotan T, Spink J, Chen Z, Shan J, Navarro E, Tait M, Provoncha K, Giurleo J, Zhao F, Jiang X, Hylton D, Makonnen S, Hickey C, Kirshner JR, Thurston G, Papadopoulos N.

Bioorg Med Chem. 2018 May 15;26(9):2271-2279. doi: 10.1016/j.bmc.2018.02.025. Epub 2018 Feb 21.


Hard-sphere-like dynamics in highly concentrated alpha-crystallin suspensions.

Vodnala P, Karunaratne N, Lurio L, Thurston GM, Vega M, Gaillard E, Narayanan S, Sandy A, Zhang Q, Dufresne EM, Foffi G, Grybos P, Kmon P, Maj P, Szczygiel R.

Phys Rev E. 2018 Feb;97(2-1):020601. doi: 10.1103/PhysRevE.97.020601.


Maximizing the Public Health Benefits from Climate Action.

Thurston GD, De Matteis S, Murray K, Scheelbeek P, Scovronick N, Budolfson M, Spears D, Vineis P.

Environ Sci Technol. 2018 Apr 3;52(7):3852-3853. doi: 10.1021/acs.est.8b00859. Epub 2018 Mar 7. No abstract available.


Single-Cell Transcriptome Analyses Reveal Endothelial Cell Heterogeneity in Tumors and Changes following Antiangiogenic Treatment.

Zhao Q, Eichten A, Parveen A, Adler C, Huang Y, Wang W, Ding Y, Adler A, Nevins T, Ni M, Wei Y, Thurston G.

Cancer Res. 2018 May 1;78(9):2370-2382. doi: 10.1158/0008-5472.CAN-17-2728. Epub 2018 Feb 15.


Model for screened, charge-regulated electrostatics of an eye lens protein: Bovine gammaB-crystallin.

Wahle CW, Martini KM, Hollenbeck DM, Langner A, Ross DS, Hamilton JF, Thurston GM.

Phys Rev E. 2017 Sep;96(3-1):032415. doi: 10.1103/PhysRevE.96.032415. Epub 2017 Sep 25.


Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor.

Daly C, Qian X, Castanaro C, Pasnikowski E, Jiang X, Thomson BR, Quaggin SE, Papadopoulos N, Wei Y, Rudge JS, Thurston G, Yancopoulos GD, Davis S.

Sci Rep. 2018 Jan 11;8(1):505. doi: 10.1038/s41598-017-18912-8.


Association between Exposure to Ambient Air Particulates and Metabolic Syndrome Components in a Saudi Arabian Population.

Shamy M, Alghamdi M, Khoder MI, Mohorjy AM, Alkhatim AA, Alkhalaf AK, Brocato J, Chen LC, Thurston GD, Lim CC, Costa M.

Int J Environ Res Public Health. 2017 Dec 25;15(1). pii: E27. doi: 10.3390/ijerph15010027.


Walking to a pathway for cardiovascular effects of air pollution.

Thurston GD, Newman JD.

Lancet. 2018 Jan 27;391(10118):291-292. doi: 10.1016/S0140-6736(17)33078-7. Epub 2017 Dec 5. No abstract available.


A multi-plate velocity-map imaging design for high-resolution photoelectron spectroscopy.

Kregel SJ, Thurston GK, Zhou J, Garand E.

J Chem Phys. 2017 Sep 7;147(9):094201. doi: 10.1063/1.4996011.


We Need to "Think Different" about Particulate Matter.

Thurston G, Balmes J.

Am J Respir Crit Care Med. 2017 Jul 1;196(1):6-7. doi: 10.1164/rccm.201702-0273ED. No abstract available.


Temporal variations of fine and coarse particulate matter sources in Jeddah, Saudi Arabia.

Lim CC, Thurston GD, Shamy M, Alghamdi M, Khoder M, Mohorjy AM, Alkhalaf AK, Brocato J, Chen LC, Costa M.

J Air Waste Manag Assoc. 2018 Feb;68(2):123-138. doi: 10.1080/10962247.2017.1344158. Epub 2018 Jan 16.


Preclinical Activity of the Novel Anti-Prolactin Receptor (PRLR) Antibody-Drug Conjugate REGN2878-DM1 in PRLR-Positive Breast Cancers.

Kelly MP, Hickey C, Makonnen S, Coetzee S, Jalal S, Wang Y, Delfino F, Shan J, Potocky TB, Chatterjee I, Andreev J, Kunz A, D'Souza C, Giurleo JT, Nittoli T, Trail PA, Thurston G, Kirshner JR.

Mol Cancer Ther. 2017 Jul;16(7):1299-1311. doi: 10.1158/1535-7163.MCT-16-0839. Epub 2017 Apr 4.


Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice.

Burova E, Hermann A, Waite J, Potocky T, Lai V, Hong S, Liu M, Allbritton O, Woodruff A, Wu Q, D'Orvilliers A, Garnova E, Rafique A, Poueymirou W, Martin J, Huang T, Skokos D, Kantrowitz J, Popke J, Mohrs M, MacDonald D, Ioffe E, Olson W, Lowy I, Murphy A, Thurston G.

Mol Cancer Ther. 2017 May;16(5):861-870. doi: 10.1158/1535-7163.MCT-16-0665. Epub 2017 Mar 6.


An evaluation of the health benefits achieved at the time of an air quality intervention in three Israeli cities.

Yinon L, Thurston G.

Environ Int. 2017 May;102:66-73. doi: 10.1016/j.envint.2016.12.025. Epub 2017 Feb 23.


Statistical-thermodynamic model for light scattering from eye lens protein mixtures.

Bell MM, Ross DS, Bautista MP, Shahmohamad H, Langner A, Hamilton JF, Lahnovych CN, Thurston GM.

J Chem Phys. 2017 Feb 7;146(5):055101. doi: 10.1063/1.4974155.


Bispecific Antibodies and Antibody-Drug Conjugates (ADCs) Bridging HER2 and Prolactin Receptor Improve Efficacy of HER2 ADCs.

Andreev J, Thambi N, Perez Bay AE, Delfino F, Martin J, Kelly MP, Kirshner JR, Rafique A, Kunz A, Nittoli T, MacDonald D, Daly C, Olson W, Thurston G.

Mol Cancer Ther. 2017 Apr;16(4):681-693. doi: 10.1158/1535-7163.MCT-16-0658. Epub 2017 Jan 20.


A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework.

Thurston GD, Kipen H, Annesi-Maesano I, Balmes J, Brook RD, Cromar K, De Matteis S, Forastiere F, Forsberg B, Frampton MW, Grigg J, Heederik D, Kelly FJ, Kuenzli N, Laumbach R, Peters A, Rajagopalan ST, Rich D, Ritz B, Samet JM, Sandstrom T, Sigsgaard T, Sunyer J, Brunekreef B.

Eur Respir J. 2017 Jan 11;49(1). pii: 1600419. doi: 10.1183/13993003.00419-2016. Print 2017 Jan.


Basis for calculating cross sections for nuclear magnetic resonance spin-modulated polarized neutron scattering.

Kotlarchyk M, Thurston GM.

J Chem Phys. 2016 Dec 28;145(24):244201. doi: 10.1063/1.4972994.


Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer.

Wu FT, Paez-Ribes M, Xu P, Man S, Bogdanovic E, Thurston G, Kerbel RS.

Sci Rep. 2016 Nov 14;6:36694. doi: 10.1038/srep36694.

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