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Items: 1 to 50 of 126


Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.

Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J.

Cell Metab. 2020 Feb 4;31(2):284-300.e7. doi: 10.1016/j.cmet.2019.11.002. Epub 2019 Dec 5.


Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism.

Wisidagama DR, Thummel CS.

G3 (Bethesda). 2019 Nov 5;9(11):3623-3630. doi: 10.1534/g3.119.400633.


Functional analysis of Aarf domain-containing kinase 1 in Drosophila melanogaster.

Wisidagama DR, Thomas SM, Lam G, Thummel CS.

Dev Dyn. 2019 Sep;248(9):762-770. doi: 10.1002/dvdy.66. Epub 2019 Jun 19.


Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood.

Storelli G, Nam HJ, Simcox J, Villanueva CJ, Thummel CS.

Dev Cell. 2019 Jan 28;48(2):200-214.e6. doi: 10.1016/j.devcel.2018.11.030. Epub 2018 Dec 13.


For Intestinal Homeostasis, You Are What You Eat.

Beebe K, Thummel CS.

Dev Cell. 2018 Oct 8;47(1):1-2. doi: 10.1016/j.devcel.2018.09.018.


Adult functions for the Drosophila DHR78 nuclear receptor.

Marxreiter S, Thummel CS.

Dev Dyn. 2018 Feb;247(2):315-322. doi: 10.1002/dvdy.24608. Epub 2017 Dec 12.


Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J.

Nat Cell Biol. 2017 Sep;19(9):1027-1036. doi: 10.1038/ncb3593. Epub 2017 Aug 14.


Parental obesity leads to metabolic changes in the F2 generation in Drosophila.

Palu RAS, Praggastis SA, Thummel CS.

Mol Metab. 2017 Apr 26;6(7):631-639. doi: 10.1016/j.molmet.2017.03.012. eCollection 2017 Jul.


Metabolomic Studies in Drosophila.

Cox JE, Thummel CS, Tennessen JM.

Genetics. 2017 Jul;206(3):1169-1185. doi: 10.1534/genetics.117.200014. Review.


Right time, right place: the temporal regulation of developmental gene expression.

Praggastis SA, Thummel CS.

Genes Dev. 2017 May 1;31(9):847-848. doi: 10.1101/gad.301002.117.


An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion.

McCommis KS, Hodges WT, Bricker DK, Wisidagama DR, Compan V, Remedi MS, Thummel CS, Finck BN.

Mol Metab. 2016 Jul 7;5(8):602-614. doi: 10.1016/j.molmet.2016.06.016. eCollection 2016 Aug.


Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila.

Palu RA, Thummel CS.

PLoS Genet. 2016 Apr 8;12(4):e1005978. doi: 10.1371/journal.pgen.1005978. eCollection 2016 Apr.


Linking Nutrients to Growth through a Positive Feedback Loop.

Palu RA, Thummel CS.

Dev Cell. 2015 Nov 9;35(3):265-6. doi: 10.1016/j.devcel.2015.10.026.


The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase.

Na U, Yu W, Cox J, Bricker DK, Brockmann K, Rutter J, Thummel CS, Winge DR.

Cell Metab. 2014 Aug 5;20(2):253-66. doi: 10.1016/j.cmet.2014.05.014. Epub 2014 Jun 19.


SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration.

Van Vranken JG, Bricker DK, Dephoure N, Gygi SP, Cox JE, Thummel CS, Rutter J.

Cell Metab. 2014 Aug 5;20(2):241-52. doi: 10.1016/j.cmet.2014.05.012. Epub 2014 Jun 19.


Epigenetic inheritance of metabolic state.

Somer RA, Thummel CS.

Curr Opin Genet Dev. 2014 Aug;27:43-7. doi: 10.1016/j.gde.2014.03.008. Epub 2014 May 19. Review.


Methods for studying metabolism in Drosophila.

Tennessen JM, Barry WE, Cox J, Thummel CS.

Methods. 2014 Jun 15;68(1):105-15. doi: 10.1016/j.ymeth.2014.02.034. Epub 2014 Mar 12. Review.


Coordinated metabolic transitions during Drosophila embryogenesis and the onset of aerobic glycolysis.

Tennessen JM, Bertagnolli NM, Evans J, Sieber MH, Cox J, Thummel CS.

G3 (Bethesda). 2014 Mar 12;4(5):839-50. doi: 10.1534/g3.114.010652.


Will branch for food-nutrient-dependent tracheal remodeling in Drosophila.

Marxreiter S, Thummel CS.

EMBO J. 2014 Feb 3;33(3):179-80. doi: 10.1002/embj.201387412. Epub 2014 Jan 17. No abstract available.


Constitutive activation of the Nrf2/Keap1 pathway in insecticide-resistant strains of Drosophila.

Misra JR, Lam G, Thummel CS.

Insect Biochem Mol Biol. 2013 Dec;43(12):1116-24. doi: 10.1016/j.ibmb.2013.09.005. Epub 2013 Oct 5.


A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.

Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J.

Science. 2012 Jul 6;337(6090):96-100. doi: 10.1126/science.1218099. Epub 2012 May 24.


The circadian clock, light, and cryptochrome regulate feeding and metabolism in Drosophila.

Seay DJ, Thummel CS.

J Biol Rhythms. 2011 Dec;26(6):497-506. doi: 10.1177/0748730411420080.


Coordination of triacylglycerol and cholesterol homeostasis by DHR96 and the Drosophila LipA homolog magro.

Sieber MH, Thummel CS.

Cell Metab. 2012 Jan 4;15(1):122-7. doi: 10.1016/j.cmet.2011.11.011. Epub 2011 Dec 22.


Coordinating growth and maturation - insights from Drosophila.

Tennessen JM, Thummel CS.

Curr Biol. 2011 Sep 27;21(18):R750-7. doi: 10.1016/j.cub.2011.06.033. Review.


Transcriptional regulation of xenobiotic detoxification in Drosophila.

Misra JR, Horner MA, Lam G, Thummel CS.

Genes Dev. 2011 Sep 1;25(17):1796-806. doi: 10.1101/gad.17280911.


The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth.

Tennessen JM, Baker KD, Lam G, Evans J, Thummel CS.

Cell Metab. 2011 Feb 2;13(2):139-48. doi: 10.1016/j.cmet.2011.01.005.


The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage.

Ruaud AF, Lam G, Thummel CS.

Mol Endocrinol. 2011 Jan;25(1):83-91. doi: 10.1210/me.2010-0337. Epub 2010 Nov 17.


Med24 and Mdh2 are required for Drosophila larval salivary gland cell death.

Wang L, Lam G, Thummel CS.

Dev Dyn. 2010 Mar;239(3):954-64. doi: 10.1002/dvdy.22213.


The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos.

Ruaud AF, Lam G, Thummel CS.

Development. 2010 Jan;137(1):123-31. doi: 10.1242/dev.042036.


The Drosophila DHR96 nuclear receptor binds cholesterol and regulates cholesterol homeostasis.

Horner MA, Pardee K, Liu S, King-Jones K, Lajoie G, Edwards A, Krause HM, Thummel CS.

Genes Dev. 2009 Dec 1;23(23):2711-6. doi: 10.1101/gad.1833609.


The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila.

Sieber MH, Thummel CS.

Cell Metab. 2009 Dec;10(6):481-90. doi: 10.1016/j.cmet.2009.10.010.


Drosophila HNF4 regulates lipid mobilization and beta-oxidation.

Palanker L, Tennessen JM, Lam G, Thummel CS.

Cell Metab. 2009 Mar;9(3):228-39. doi: 10.1016/j.cmet.2009.01.009.


Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion.

Kozlova T, Lam G, Thummel CS.

Dev Dyn. 2009 Mar;238(3):701-7. doi: 10.1002/dvdy.21860.


A genetic screen identifies new regulators of steroid-triggered programmed cell death in Drosophila.

Wang L, Evans J, Andrews HK, Beckstead RB, Thummel CS, Bashirullah A.

Genetics. 2008 Sep;180(1):269-81. doi: 10.1534/genetics.108.092478. Epub 2008 Aug 30.


Developmental timing: let-7 function conserved through evolution.

Tennessen JM, Thummel CS.

Curr Biol. 2008 Aug 26;18(16):R707-8. doi: 10.1016/j.cub.2008.07.013.


Serotonin and insulin signaling team up to control growth in Drosophila.

Ruaud AF, Thummel CS.

Genes Dev. 2008 Jul 15;22(14):1851-5. doi: 10.1101/gad.1700708.


Prothoracicotropic hormone regulates developmental timing and body size in Drosophila.

McBrayer Z, Ono H, Shimell M, Parvy JP, Beckstead RB, Warren JT, Thummel CS, Dauphin-Villemant C, Gilbert LI, O'Connor MB.

Dev Cell. 2007 Dec;13(6):857-71.


Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila.

Baker KD, Thummel CS.

Cell Metab. 2007 Oct;6(4):257-66. Review.


Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death.

Yin VP, Thummel CS, Bashirullah A.

J Cell Biol. 2007 Jul 2;178(1):85-92. Epub 2007 Jun 25.


Specific transcriptional responses to juvenile hormone and ecdysone in Drosophila.

Beckstead RB, Lam G, Thummel CS.

Insect Biochem Mol Biol. 2007 Jun;37(6):570-8. Epub 2007 Mar 12.


To die or not to die--a role for Fork head.

Thummel CS.

J Cell Biol. 2007 Mar 12;176(6):737-9. Epub 2007 Mar 5.


Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila.

Baker KD, Beckstead RB, Mangelsdorf DJ, Thummel CS.

Genes Dev. 2007 Feb 15;21(4):450-64.


Dynamic regulation of Drosophila nuclear receptor activity in vivo.

Palanker L, Necakov AS, Sampson HM, Ni R, Hu C, Thummel CS, Krause HM.

Development. 2006 Sep;133(18):3549-62. Epub 2006 Aug 16.


The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila.

King-Jones K, Horner MA, Lam G, Thummel CS.

Cell Metab. 2006 Jul;4(1):37-48.


Indicted: worms caught using steroids.

Beckstead RB, Thummel CS.

Cell. 2006 Mar 24;124(6):1137-40. Review.


The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis.

Beckstead RB, Lam G, Thummel CS.

Genome Biol. 2005;6(12):R99. Epub 2005 Nov 21.


Developmental biology. Less steroids make bigger flies.

King-Jones K, Thummel CS.

Science. 2005 Oct 28;310(5748):630-1. No abstract available.


Powered by gas--a ligand for a fruit fly nuclear receptor.

Thummel CS.

Cell. 2005 Jul 29;122(2):151-3.

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