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Items: 1 to 50 of 315

1.

RNA-based diagnostic and therapeutic strategies for cardiovascular disease.

Lu D, Thum T.

Nat Rev Cardiol. 2019 Jun 11. doi: 10.1038/s41569-019-0218-x. [Epub ahead of print] Review.

PMID:
31186539
2.

CircSlc8a1, breaking a vicious circle in cardiac hypertrophy.

Jahn C, Bär C, Thum T.

Cardiovasc Res. 2019 May 30. pii: cvz147. doi: 10.1093/cvr/cvz147. [Epub ahead of print] No abstract available.

PMID:
31147691
3.

Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure.

Ferreira JP, Verdonschot J, Collier T, Wang P, Pizard A, Bär C, Björkman J, Boccanelli A, Butler J, Clark A, Cleland JG, Delles C, Diez J, Girerd N, González A, Hazebroek M, Huby AC, Jukema W, Latini R, Leenders J, Levy D, Mebazaa A, Mischak H, Pinet F, Rossignol P, Sattar N, Sever P, Staessen JA, Thum T, Vodovar N, Zhang ZY, Heymans S, Zannad F.

Circ Heart Fail. 2019 May;12(5):e005897. doi: 10.1161/CIRCHEARTFAILURE.118.005897.

PMID:
31104495
4.

Effects of personalized endurance training on cellular age and vascular function in middle-aged sedentary women.

Eigendorf J, Melk A, Haufe S, Boethig D, Berliner D, Kerling A, Kueck M, Stenner H, Bara C, Stiesch M, Schippert C, Hilfiker A, Falk C, Bauersachs J, Thum T, Lichtinghagen R, Haverich A, Hilfiker-Kleiner D, Tegtbur U.

Eur J Prev Cardiol. 2019 May 13:2047487319849505. doi: 10.1177/2047487319849505. [Epub ahead of print] No abstract available.

PMID:
31084260
5.

The continuous heart failure spectrum: moving beyond an ejection fraction classification.

Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO, Chopra VK, de Boer RA, de Windt L, Hamdani N, Hasenfuss G, Heymans S, Hulot JS, Konstam M, Lee RT, Linke WA, Lunde IG, Lyon AR, Maack C, Mann DL, Mebazaa A, Mentz RJ, Nihoyannopoulos P, Papp Z, Parissis J, Pedrazzini T, Rosano G, Rouleau J, Seferovic PM, Shah AM, Starling RC, Tocchetti CG, Trochu JN, Thum T, Zannad F, Brutsaert DL, Segers VF, De Keulenaer GW.

Eur Heart J. 2019 Apr 8. pii: ehz158. doi: 10.1093/eurheartj/ehz158. [Epub ahead of print]

PMID:
30957868
6.

Identification of cell and disease specific microRNAs in glomerular pathologies.

Müller-Deile J, Dannenberg J, Liu P, Lorenzen J, Nyström J, Thum T, Schiffer M.

J Cell Mol Med. 2019 Jun;23(6):3927-3939. doi: 10.1111/jcmm.14270. Epub 2019 Apr 4.

7.

Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury.

Sonnenschein K, Fiedler J, Pfanne A, Just A, Mitzka S, Geffers RR, Pich A, Bauersachs J, Thum T.

Cardiovasc Res. 2019 Mar 7. pii: cvz063. doi: 10.1093/cvr/cvz063. [Epub ahead of print]

PMID:
30843048
8.

Identification of miR-143 as a Major Contributor for Human Stenotic Aortic Valve Disease.

Fiedler J, Park DH, Hobuß L, Anaraki PK, Pfanne A, Just A, Mitzka S, Dumler I, Weidemann F, Hilfiker A, Thum T.

J Cardiovasc Transl Res. 2019 Mar 6. doi: 10.1007/s12265-019-09880-7. [Epub ahead of print]

PMID:
30840186
9.

The Janus Face of miR-148a in Cardiac Remodeling and Heart Failure.

Hobuß L, Thum T.

Mol Ther. 2019 Mar 6;27(3):489-490. doi: 10.1016/j.ymthe.2019.02.004. Epub 2019 Feb 15. No abstract available.

PMID:
30777607
10.

Long Non-coding RNAs: At the Heart of Cardiac Dysfunction?

Hobuß L, Bär C, Thum T.

Front Physiol. 2019 Jan 29;10:30. doi: 10.3389/fphys.2019.00030. eCollection 2019. Review.

11.

Chronic kidney disease induces left ventricular overexpression of the pro-hypertrophic microRNA-212.

Sárközy M, Gáspár R, Zvara Á, Siska A, Kővári B, Szűcs G, Márványkövi F, Kovács MG, Diószegi P, Bodai L, Zsindely N, Pipicz M, Gömöri K, Kiss K, Bencsik P, Cserni G, Puskás LG, Földesi I, Thum T, Bátkai S, Csont T.

Sci Rep. 2019 Feb 4;9(1):1302. doi: 10.1038/s41598-018-37690-5.

12.

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology.

de Boer RA, De Keulenaer G, Bauersachs J, Brutsaert D, Cleland JG, Diez J, Du XJ, Ford P, Heinzel FR, Lipson KE, McDonagh T, Lopez-Andres N, Lunde IG, Lyon AR, Pollesello P, Prasad SK, Tocchetti CG, Mayr M, Sluijter JPG, Thum T, Tschöpe C, Zannad F, Zimmermann WH, Ruschitzka F, Filippatos G, Lindsey ML, Maack C, Heymans S.

Eur J Heart Fail. 2019 Mar;21(3):272-285. doi: 10.1002/ejhf.1406. Epub 2019 Feb 4.

13.

Circulating Long Noncoding RNA LIPCAR Predicts Heart Failure Outcomes in Patients Without Chronic Kidney Disease.

Santer L, López B, Ravassa S, Baer C, Riedel I, Chatterjee S, Moreno MU, González A, Querejeta R, Pinet F, Thum T, Díez J.

Hypertension. 2019 Apr;73(4):820-828. doi: 10.1161/HYPERTENSIONAHA.118.12261.

PMID:
30686085
14.

Circulating miRNAs as mediators in cell-to-cell communication.

Bär C, Thum T, de Gonzalo-Calvo D.

Epigenomics. 2019 Feb;11(2):111-113. doi: 10.2217/epi-2018-0183. Epub 2019 Jan 14. No abstract available.

15.

Hypoxia-Induced MicroRNA-212/132 Alter Blood-Brain Barrier Integrity Through Inhibition of Tight Junction-Associated Proteins in Human and Mouse Brain Microvascular Endothelial Cells.

Burek M, König A, Lang M, Fiedler J, Oerter S, Roewer N, Bohnert M, Thal SC, Blecharz-Lang KG, Woitzik J, Thum T, Förster CY.

Transl Stroke Res. 2019 Jan 8. doi: 10.1007/s12975-018-0683-2. [Epub ahead of print]

PMID:
30617994
16.

Vascular Smooth Muscle Cell Remodeling.

Fiedler J, Thum T.

Circ Res. 2018 Dec 7;123(12):1261-1263. doi: 10.1161/CIRCRESAHA.118.314184. No abstract available.

PMID:
30566049
17.

Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction.

Jung M, Dodsworth M, Thum T.

Basic Res Cardiol. 2018 Dec 6;114(1):4. doi: 10.1007/s00395-018-0712-z. Review.

18.

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity.

Gupta SK, Garg A, Avramopoulos P, Engelhardt S, Streckfuss-Bömeke K, Batkai S, Thum T.

Mol Ther. 2019 Jan 2;27(1):17-28. doi: 10.1016/j.ymthe.2018.11.004. Epub 2018 Nov 13.

PMID:
30527757
19.

Publisher Correction: MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure.

Dubois-Deruy E, Cuvelliez M, Fiedler J, Charrier H, Mulder P, Hebbar E, Pfanne A, Beseme O, Chwastyniak M, Amouyel P, Richard V, Bauters C, Thum T, Pinet F.

Sci Rep. 2018 Nov 29;8(1):17584. doi: 10.1038/s41598-018-35955-7.

20.

Noncoding RNAs: potential regulators in cardioncology.

Chatterjee S, Gupta SK, Bär C, Thum T.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H160-H168. doi: 10.1152/ajpheart.00418.2018. Epub 2018 Nov 9.

PMID:
30412441
21.

Remote Welfare Monitoring of Rodents Using Thermal Imaging.

Pereira CB, Kunczik J, Zieglowski L, Tolba R, Abdelrahman A, Zechner D, Vollmar B, Janssen H, Thum T, Czaplik M.

Sensors (Basel). 2018 Oct 28;18(11). pii: E3653. doi: 10.3390/s18113653.

22.

Blood-based microRNA profiling in patients with cardiac amyloidosis.

Derda AA, Pfanne A, Bär C, Schimmel K, Kennel PJ, Xiao K, Schulze PC, Bauersachs J, Thum T.

PLoS One. 2018 Oct 17;13(10):e0204235. doi: 10.1371/journal.pone.0204235. eCollection 2018.

23.

Circulating miR-1254 predicts ventricular remodeling in patients with ST-Segment-Elevation Myocardial Infarction: A cardiovascular magnetic resonance study.

de Gonzalo-Calvo D, Cediel G, Bär C, Núñez J, Revuelta-Lopez E, Gavara J, Ríos-Navarro C, Llorente-Cortes V, Bodí V, Thum T, Bayes-Genis A.

Sci Rep. 2018 Oct 11;8(1):15115. doi: 10.1038/s41598-018-33491-y.

24.

Corrigendum: Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis-Normalization After Liver Transplantation and Implications for Future Research.

Proskynitopoulos PJ, Rhein M, Jäckel E, Manns MP, Frieling H, Bleich S, Thum T, Hillemacher T, Glahn A.

Alcohol Alcohol. 2018 Nov 1;53(6):760. doi: 10.1093/alcalc/agy062. No abstract available.

PMID:
30169583
25.

Circulating non-coding RNAs as biomarkers to predict and monitor the response to exercise: chances and hurdles.

de Gonzalo-Calvo D, Thum T.

Eur Heart J. 2018 Oct 7;39(38):3552. doi: 10.1093/eurheartj/ehy457. No abstract available.

PMID:
30060047
26.

Leukocyte telomere length correlates with hypertrophic cardiomyopathy severity.

Chatterjee S, de Gonzalo-Calvo D, Derda AA, Schimmel K, Sonnenschein K, Bavendiek U, Bauersachs J, Bär C, Thum T.

Sci Rep. 2018 Jul 25;8(1):11227. doi: 10.1038/s41598-018-29072-8.

27.

Translational Opportunities and Challenges of Long Noncoding RNAs in Cardiac Regeneration.

Thum T.

J Am Coll Cardiol. 2018 Jul 31;72(5):551-552. doi: 10.1016/j.jacc.2018.05.039. Epub 2018 Jun 23. No abstract available.

PMID:
29945752
28.

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.

van der Velden J, Tocchetti CG, Varricchi G, Bianco A, Sequeira V, Hilfiker-Kleiner D, Hamdani N, Leite-Moreira AF, Mayr M, Falcão-Pires I, Thum T, Dawson DK, Balligand JL, Heymans S.

Cardiovasc Res. 2018 Aug 1;114(10):1273-1280. doi: 10.1093/cvr/cvy147.

29.

Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis-Normalization After Liver Transplantation and Implications for Future Research.

Proskynitopoulos PJ, Rhein M, Jäckel E, Manns MP, Frieling H, Bleich S, Thum T, Hillemacher T, Glahn A.

Alcohol Alcohol. 2018 Sep 1;53(5):511-517. doi: 10.1093/alcalc/agy038. Erratum in: Alcohol Alcohol. 2018 Nov 1;53(6):760.

PMID:
29912265
30.

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.

Bondue A, Arbustini E, Bianco A, Ciccarelli M, Dawson D, De Rosa M, Hamdani N, Hilfiker-Kleiner D, Meder B, Leite-Moreira AF, Thum T, Tocchetti CG, Varricchi G, Van der Velden J, Walsh R, Heymans S.

Cardiovasc Res. 2018 Aug 1;114(10):1287-1303. doi: 10.1093/cvr/cvy122.

PMID:
29800419
31.

Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.

Fiedler J, Baker AH, Dimmeler S, Heymans S, Mayr M, Thum T.

Cardiovasc Res. 2018 Aug 1;114(10):1281-1286. doi: 10.1093/cvr/cvy121.

PMID:
29800267
32.

Circulating non-coding RNAs in biomarker-guided cardiovascular therapy: a novel tool for personalized medicine?

de Gonzalo-Calvo D, Vea A, Bär C, Fiedler J, Couch LS, Brotons C, Llorente-Cortes V, Thum T.

Eur Heart J. 2019 May 21;40(20):1643-1650. doi: 10.1093/eurheartj/ehy234.

33.

Epigenetic modulation of vascular diseases: Assessing the evidence and exploring the opportunities.

Schiattarella GG, Madonna R, Van Linthout S, Thum T, Schulz R, Ferdinandy P, Perrino C.

Vascul Pharmacol. 2018 Mar 14. pii: S1537-1891(17)30468-8. doi: 10.1016/j.vph.2018.02.009. [Epub ahead of print] Review.

PMID:
29548901
34.

Overexpression of preeclampsia induced microRNA-26a-5p leads to proteinuria in zebrafish.

Müller-Deile J, Schröder P, Beverly-Staggs L, Hiss R, Fiedler J, Nyström J, Thum T, Haller H, Schiffer M.

Sci Rep. 2018 Feb 26;8(1):3621. doi: 10.1038/s41598-018-22070-w.

35.

Long non-coding RNAs: A crucial part of the vasculature puzzle.

Garg A, Gupta SK, Thum T.

Vascul Pharmacol. 2019 Mar;114:131-138. doi: 10.1016/j.vph.2018.02.008. Epub 2018 Feb 24. Review.

PMID:
29481972
36.

Hypoxia-induced long non-coding RNA Malat1 is dispensable for renal ischemia/reperfusion-injury.

Kölling M, Genschel C, Kaucsar T, Hübner A, Rong S, Schmitt R, Sörensen-Zender I, Haddad G, Kistler A, Seeger H, Kielstein JT, Fliser D, Haller H, Wüthrich R, Zörnig M, Thum T, Lorenzen J.

Sci Rep. 2018 Feb 21;8(1):3438. doi: 10.1038/s41598-018-21720-3.

37.

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.

Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, Döhner K, Mätzig T, Ng M, Reinhardt D, Döhner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F, Klusmann JH.

J Clin Oncol. 2018 Apr 1;36(10):1007-1016. doi: 10.1200/JCO.2017.75.2204. Epub 2018 Feb 12.

PMID:
29432078
38.

The innate immune system in chronic cardiomyopathy: a European Society of Cardiology (ESC) scientific statement from the Working Group on Myocardial Function of the ESC.

Frantz S, Falcao-Pires I, Balligand JL, Bauersachs J, Brutsaert D, Ciccarelli M, Dawson D, de Windt LJ, Giacca M, Hamdani N, Hilfiker-Kleiner D, Hirsch E, Leite-Moreira A, Mayr M, Thum T, Tocchetti CG, van der Velden J, Varricchi G, Heymans S.

Eur J Heart Fail. 2018 Mar;20(3):445-459. doi: 10.1002/ejhf.1138. Epub 2018 Jan 15. Review.

39.

Refractory angina revisited: stem cells for a growing unmet clinical need?

Thum T.

Eur Heart J. 2018 Jun 14;39(23):2217-2219. doi: 10.1093/eurheartj/ehx793. No abstract available.

PMID:
29315372
40.

[Non-coding RNA : Innovative regulators with therapeutic perspective].

Bührke A, Bär C, Thum T.

Herz. 2018 Mar;43(2):115-122. doi: 10.1007/s00059-017-4660-4. Review. German.

PMID:
29236145
41.

Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling.

Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, Laggerbauer B, Engelhardt S.

Nat Commun. 2017 Nov 20;8(1):1614. doi: 10.1038/s41467-017-01737-4.

42.

An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology.

Lourenço AP, Leite-Moreira AF, Balligand JL, Bauersachs J, Dawson D, de Boer RA, de Windt LJ, Falcão-Pires I, Fontes-Carvalho R, Franz S, Giacca M, Hilfiker-Kleiner D, Hirsch E, Maack C, Mayr M, Pieske B, Thum T, Tocchetti CG, Brutsaert DL, Heymans S.

Eur J Heart Fail. 2018 Feb;20(2):216-227. doi: 10.1002/ejhf.1059. Epub 2017 Nov 16. Review.

43.

miRNome Profiling of Purified Endoderm and Mesoderm Differentiated from hESCs Reveals Functions of miR-483-3p and miR-1263 for Cell-Fate Decisions.

Ishikawa D, Diekmann U, Fiedler J, Just A, Thum T, Lenzen S, Naujok O.

Stem Cell Reports. 2017 Nov 14;9(5):1588-1603. doi: 10.1016/j.stemcr.2017.10.011.

44.

Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression.

Gupta SK, Garg A, Bär C, Chatterjee S, Foinquinos A, Milting H, Streckfuß-Bömeke K, Fiedler J, Thum T.

Circ Res. 2018 Jan 19;122(2):246-254. doi: 10.1161/CIRCRESAHA.117.311335. Epub 2017 Nov 13.

45.

MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure.

Dubois-Deruy E, Cuvelliez M, Fiedler J, Charrier H, Mulder P, Hebbar E, Pfanne A, Beseme O, Chwastyniak M, Amouyel P, Richard V, Bauters C, Thum T, Pinet F.

Sci Rep. 2017 Nov 7;7(1):14747. doi: 10.1038/s41598-017-15011-6. Erratum in: Sci Rep. 2018 Nov 29;8(1):17584.

46.

A large shRNA library approach identifies lncRNA Ntep as an essential regulator of cell proliferation.

Beermann J, Kirste D, Iwanov K, Lu D, Kleemiß F, Kumarswamy R, Schimmel K, Bär C, Thum T.

Cell Death Differ. 2018 Feb;25(2):307-318. doi: 10.1038/cdd.2017.158. Epub 2017 Nov 3.

47.

Sonic hedgehog-dependent activation of adventitial fibroblasts promotes neointima formation.

Dutzmann J, Koch A, Weisheit S, Sonnenschein K, Korte L, Haertlé M, Thum T, Bauersachs J, Sedding DG, Daniel JM.

Cardiovasc Res. 2017 Nov 1;113(13):1653-1663. doi: 10.1093/cvr/cvx158.

PMID:
29088375
48.

A long way for microRNAs to become meaningful prognostic biomarkers.

Bär C, Thum T.

Eur J Heart Fail. 2018 Jan;20(1):76-77. doi: 10.1002/ejhf.1036. Epub 2017 Oct 17. No abstract available.

49.

microRNA-206 correlates with left ventricular function after transcatheter aortic valve implantation.

Kleeberger JA, Neuser J, de Gonzalo-Calvo D, Kempf T, Bauersachs J, Thum T, Widder JD.

Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1261-H1266. doi: 10.1152/ajpheart.00432.2017. Epub 2017 Oct 13.

50.

Circulating microRNA-132 levels improve risk prediction for heart failure hospitalization in patients with chronic heart failure.

Masson S, Batkai S, Beermann J, Bär C, Pfanne A, Thum S, Magnoli M, Balconi G, Nicolosi GL, Tavazzi L, Latini R, Thum T.

Eur J Heart Fail. 2018 Jan;20(1):78-85. doi: 10.1002/ejhf.961. Epub 2017 Oct 12.

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