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Items: 1 to 50 of 333

1.

Whole-plant optimality predicts changes in leaf nitrogen under variable CO2 and nutrient availability.

Caldararu S, Thum T, Yu L, Zaehle S.

New Phytol. 2019 Nov 18. doi: 10.1111/nph.16327. [Epub ahead of print]

PMID:
31737904
2.

Living myocardial slices: a novel multicellular model for cardiac translational research.

Perbellini F, Thum T.

Eur Heart J. 2019 Nov 11. pii: ehz779. doi: 10.1093/eurheartj/ehz779. [Epub ahead of print]

PMID:
31711161
3.

In peripartum cardiomyopathy Plasminogen Activator Inhibitor-1 is a potential new biomarker with controversial roles.

Ricke-Hoch M, Hoes MF, Pfeffer TJ, Schlothauer S, Nonhoff J, Haidari S, Bomer N, Scherr M, Stapel B, Stelling E, Kiyan Y, Falk C, Haghikia A, Binah O, Arany Z, Thum T, Bauersachs J, van der Meer P, Hilfiker-Kleiner D.

Cardiovasc Res. 2019 Nov 11. pii: cvz300. doi: 10.1093/cvr/cvz300. [Epub ahead of print]

PMID:
31711127
4.

Circulating microRNAs in Fabry Disease.

Xiao K, Lu D, Hoepfner J, Santer L, Gupta S, Pfanne A, Thum S, Lenders M, Brand E, Nordbeck P, Thum T.

Sci Rep. 2019 Oct 24;9(1):15277. doi: 10.1038/s41598-019-51805-6.

5.

Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis.

Kenneweg F, Bang C, Xiao K, Boulanger CM, Loyer X, Mazlan S, Schroen B, Hermans-Beijnsberger S, Foinquinos A, Hirt MN, Eschenhagen T, Funcke S, Stojanovic S, Genschel C, Schimmel K, Just A, Pfanne A, Scherf K, Dehmel S, Raemon-Buettner SM, Fiedler J, Thum T.

Mol Ther Nucleic Acids. 2019 Sep 13;18:363-374. doi: 10.1016/j.omtn.2019.09.003. [Epub ahead of print]

6.

Studying Interactions between 2'-O-Me-Modified Inhibitors and MicroRNAs Utilizing Microscale Thermophoresis.

Herkt M, Batkai S, Thum T.

Mol Ther Nucleic Acids. 2019 Aug 28;18:259-268. doi: 10.1016/j.omtn.2019.08.019. [Epub ahead of print]

7.

A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs.

Kunz M, Wolf B, Fuchs M, Christoph J, Xiao K, Thum T, Atlan D, Prokosch HU, Dandekar T.

Brief Bioinform. 2019 Oct 3. pii: bbz066. doi: 10.1093/bib/bbz066. [Epub ahead of print]

PMID:
31578571
8.

A novel multi-parametric analysis of non-invasive methods to assess animal distress during chronic pancreatitis.

Abdelrahman A, Kumstel S, Zhang X, Liebig M, Wendt EHU, Eichberg J, Palme R, Thum T, Vollmar B, Zechner D.

Sci Rep. 2019 Oct 1;9(1):14084. doi: 10.1038/s41598-019-50682-3.

9.

Elevated levels of miR-181c and miR-633 in the CSF of patients with MS: A validation study.

Kramer S, Haghikia A, Bang C, Scherf K, Pfanne A, Duscha A, Kaisler J, Gisevius B, Gold R, Thum T, Haghikia A.

Neurol Neuroimmunol Neuroinflamm. 2019 Oct 1;6(6):e623. doi: 10.1212/NXI.0000000000000623. Print 2019 Nov.

10.

Remote vitals monitoring in rodents using video recordings.

Kunczik J, Barbosa Pereira C, Zieglowski L, Tolba R, Wassermann L, Häger C, Bleich A, Janssen H, Thum T, Czaplik M.

Biomed Opt Express. 2019 Aug 5;10(9):4422-4436. doi: 10.1364/BOE.10.004422. eCollection 2019 Sep 1.

11.

Letter by Pinet et al Regarding Article, "Comparative Analysis of Circulating Noncoding RNAs Versus Protein Biomarkers in the Detection of Myocardial Injury".

Pinet F, Bauters C, Bär C, Thum T.

Circ Res. 2019 Aug 2;125(4):e20-e21. doi: 10.1161/CIRCRESAHA.119.315530. Epub 2019 Aug 1. No abstract available.

PMID:
31518206
12.

Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors.

Gorinski N, Bijata M, Prasad S, Wirth A, Abdel Galil D, Zeug A, Bazovkina D, Kondaurova E, Kulikova E, Ilchibaeva T, Zareba-Koziol M, Papaleo F, Scheggia D, Kochlamazashvili G, Dityatev A, Smyth I, Krzystyniak A, Wlodarczyk J, Richter DW, Strekalova T, Sigrist S, Bang C, Hobuß L, Fiedler J, Thum T, Naumenko VS, Pandey G, Ponimaskin E.

Nat Commun. 2019 Sep 2;10(1):3924. doi: 10.1038/s41467-019-11876-5.

13.

TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation.

Grund A, Szaroszyk M, Korf-Klingebiel M, Malek Mohammadi M, Trogisch FA, Schrameck U, Gigina A, Tiedje C, Gaestel M, Kraft T, Hegermann J, Batkai S, Thum T, Perrot A, Remedios CD, Riechert E, Völkers M, Doroudgar S, Jungmann A, Bauer R, Yin X, Mayr M, Wollert KC, Pich A, Xiao H, Katus HA, Bauersachs J, Müller OJ, Heineke J.

EMBO Mol Med. 2019 Oct;11(10):e10018. doi: 10.15252/emmm.201810018. Epub 2019 Aug 30.

14.

Selective Heart Irradiation Induces Cardiac Overexpression of the Pro-hypertrophic miR-212.

Sárközy M, Gáspár R, Zvara Á, Kiscsatári L, Varga Z, Kővári B, Kovács MG, Szűcs G, Fábián G, Diószegi P, Cserni G, Puskás LG, Thum T, Kahán Z, Csont T, Bátkai S.

Front Oncol. 2019 Jul 16;9:598. doi: 10.3389/fonc.2019.00598. eCollection 2019.

15.

Circular RNAs: A Novel Class of Functional RNA Molecules with a Therapeutic Perspective.

Santer L, Bär C, Thum T.

Mol Ther. 2019 Aug 7;27(8):1350-1363. doi: 10.1016/j.ymthe.2019.07.001. Epub 2019 Jul 9. Review.

PMID:
31324392
16.

Non-coding RNAs: key players in cardiac disease.

Kreutzer FP, Fiedler J, Thum T.

J Physiol. 2019 Jul 10. doi: 10.1113/JP278131. [Epub ahead of print]

PMID:
31291008
17.

Perspective review of optical imaging in welfare assessment in animal-based research.

Pereira C, Kunczik J, Bleich A, Haeger C, Kiessling F, Thum T, Tolba R, Lindauer U, Treue S, Czaplik M.

J Biomed Opt. 2019 Jul;24(7):1-11. doi: 10.1117/1.JBO.24.7.070601.

18.

A new diastolic dysfunction disease-modelling platform.

Chatterjee S, Thum T.

Eur Heart J. 2019 Jul 4. pii: ehz447. doi: 10.1093/eurheartj/ehz447. [Epub ahead of print] No abstract available.

PMID:
31274156
19.

RNA-based diagnostic and therapeutic strategies for cardiovascular disease.

Lu D, Thum T.

Nat Rev Cardiol. 2019 Nov;16(11):661-674. doi: 10.1038/s41569-019-0218-x. Epub 2019 Jun 11. Review.

PMID:
31186539
20.

CircSlc8a1, breaking a vicious circle in cardiac hypertrophy.

Jahn C, Bär C, Thum T.

Cardiovasc Res. 2019 May 30. pii: cvz147. doi: 10.1093/cvr/cvz147. [Epub ahead of print] No abstract available.

PMID:
31147691
21.

Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure.

Ferreira JP, Verdonschot J, Collier T, Wang P, Pizard A, Bär C, Björkman J, Boccanelli A, Butler J, Clark A, Cleland JG, Delles C, Diez J, Girerd N, González A, Hazebroek M, Huby AC, Jukema W, Latini R, Leenders J, Levy D, Mebazaa A, Mischak H, Pinet F, Rossignol P, Sattar N, Sever P, Staessen JA, Thum T, Vodovar N, Zhang ZY, Heymans S, Zannad F.

Circ Heart Fail. 2019 May;12(5):e005897. doi: 10.1161/CIRCHEARTFAILURE.118.005897.

PMID:
31104495
22.

Effects of personalized endurance training on cellular age and vascular function in middle-aged sedentary women.

Eigendorf J, Melk A, Haufe S, Boethig D, Berliner D, Kerling A, Kueck M, Stenner H, Bara C, Stiesch M, Schippert C, Hilfiker A, Falk C, Bauersachs J, Thum T, Lichtinghagen R, Haverich A, Hilfiker-Kleiner D, Tegtbur U.

Eur J Prev Cardiol. 2019 Nov;26(17):1903-1906. doi: 10.1177/2047487319849505. Epub 2019 May 13. No abstract available.

PMID:
31084260
23.

The continuous heart failure spectrum: moving beyond an ejection fraction classification.

Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO, Chopra VK, de Boer RA, de Windt L, Hamdani N, Hasenfuss G, Heymans S, Hulot JS, Konstam M, Lee RT, Linke WA, Lunde IG, Lyon AR, Maack C, Mann DL, Mebazaa A, Mentz RJ, Nihoyannopoulos P, Papp Z, Parissis J, Pedrazzini T, Rosano G, Rouleau J, Seferovic PM, Shah AM, Starling RC, Tocchetti CG, Trochu JN, Thum T, Zannad F, Brutsaert DL, Segers VF, De Keulenaer GW.

Eur Heart J. 2019 Jul 1;40(26):2155-2163. doi: 10.1093/eurheartj/ehz158.

PMID:
30957868
24.

Identification of cell and disease specific microRNAs in glomerular pathologies.

Müller-Deile J, Dannenberg J, Liu P, Lorenzen J, Nyström J, Thum T, Schiffer M.

J Cell Mol Med. 2019 Jun;23(6):3927-3939. doi: 10.1111/jcmm.14270. Epub 2019 Apr 4.

25.

Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury.

Sonnenschein K, Fiedler J, Pfanne A, Just A, Mitzka S, Geffers R, Pich A, Bauersachs J, Thum T.

Cardiovasc Res. 2019 Oct 1;115(12):1804-1810. doi: 10.1093/cvr/cvz063.

26.

Identification of miR-143 as a Major Contributor for Human Stenotic Aortic Valve Disease.

Fiedler J, Park DH, Hobuß L, Anaraki PK, Pfanne A, Just A, Mitzka S, Dumler I, Weidemann F, Hilfiker A, Thum T.

J Cardiovasc Transl Res. 2019 Oct;12(5):447-458. doi: 10.1007/s12265-019-09880-7. Epub 2019 Mar 6.

PMID:
30840186
27.

The Janus Face of miR-148a in Cardiac Remodeling and Heart Failure.

Hobuß L, Thum T.

Mol Ther. 2019 Mar 6;27(3):489-490. doi: 10.1016/j.ymthe.2019.02.004. Epub 2019 Feb 15. No abstract available.

PMID:
30777607
28.

Long Non-coding RNAs: At the Heart of Cardiac Dysfunction?

Hobuß L, Bär C, Thum T.

Front Physiol. 2019 Jan 29;10:30. doi: 10.3389/fphys.2019.00030. eCollection 2019. Review.

29.

Chronic kidney disease induces left ventricular overexpression of the pro-hypertrophic microRNA-212.

Sárközy M, Gáspár R, Zvara Á, Siska A, Kővári B, Szűcs G, Márványkövi F, Kovács MG, Diószegi P, Bodai L, Zsindely N, Pipicz M, Gömöri K, Kiss K, Bencsik P, Cserni G, Puskás LG, Földesi I, Thum T, Bátkai S, Csont T.

Sci Rep. 2019 Feb 4;9(1):1302. doi: 10.1038/s41598-018-37690-5.

30.

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology.

de Boer RA, De Keulenaer G, Bauersachs J, Brutsaert D, Cleland JG, Diez J, Du XJ, Ford P, Heinzel FR, Lipson KE, McDonagh T, Lopez-Andres N, Lunde IG, Lyon AR, Pollesello P, Prasad SK, Tocchetti CG, Mayr M, Sluijter JPG, Thum T, Tschöpe C, Zannad F, Zimmermann WH, Ruschitzka F, Filippatos G, Lindsey ML, Maack C, Heymans S.

Eur J Heart Fail. 2019 Mar;21(3):272-285. doi: 10.1002/ejhf.1406. Epub 2019 Feb 4.

31.

Circulating Long Noncoding RNA LIPCAR Predicts Heart Failure Outcomes in Patients Without Chronic Kidney Disease.

Santer L, López B, Ravassa S, Baer C, Riedel I, Chatterjee S, Moreno MU, González A, Querejeta R, Pinet F, Thum T, Díez J.

Hypertension. 2019 Apr;73(4):820-828. doi: 10.1161/HYPERTENSIONAHA.118.12261.

PMID:
30686085
32.

Circulating miRNAs as mediators in cell-to-cell communication.

Bär C, Thum T, de Gonzalo-Calvo D.

Epigenomics. 2019 Feb;11(2):111-113. doi: 10.2217/epi-2018-0183. Epub 2019 Jan 14. No abstract available.

33.

Hypoxia-Induced MicroRNA-212/132 Alter Blood-Brain Barrier Integrity Through Inhibition of Tight Junction-Associated Proteins in Human and Mouse Brain Microvascular Endothelial Cells.

Burek M, König A, Lang M, Fiedler J, Oerter S, Roewer N, Bohnert M, Thal SC, Blecharz-Lang KG, Woitzik J, Thum T, Förster CY.

Transl Stroke Res. 2019 Dec;10(6):672-683. doi: 10.1007/s12975-018-0683-2. Epub 2019 Jan 8.

PMID:
30617994
34.

Vascular Smooth Muscle Cell Remodeling.

Fiedler J, Thum T.

Circ Res. 2018 Dec 7;123(12):1261-1263. doi: 10.1161/CIRCRESAHA.118.314184. No abstract available.

PMID:
30566049
35.

Inflammatory cells and their non-coding RNAs as targets for treating myocardial infarction.

Jung M, Dodsworth M, Thum T.

Basic Res Cardiol. 2018 Dec 6;114(1):4. doi: 10.1007/s00395-018-0712-z. Review.

36.

miR-212/132 Cluster Modulation Prevents Doxorubicin-Mediated Atrophy and Cardiotoxicity.

Gupta SK, Garg A, Avramopoulos P, Engelhardt S, Streckfuss-Bömeke K, Batkai S, Thum T.

Mol Ther. 2019 Jan 2;27(1):17-28. doi: 10.1016/j.ymthe.2018.11.004. Epub 2018 Nov 13.

PMID:
30527757
37.

Publisher Correction: MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure.

Dubois-Deruy E, Cuvelliez M, Fiedler J, Charrier H, Mulder P, Hebbar E, Pfanne A, Beseme O, Chwastyniak M, Amouyel P, Richard V, Bauters C, Thum T, Pinet F.

Sci Rep. 2018 Nov 29;8(1):17584. doi: 10.1038/s41598-018-35955-7.

38.

Noncoding RNAs: potential regulators in cardioncology.

Chatterjee S, Gupta SK, Bär C, Thum T.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H160-H168. doi: 10.1152/ajpheart.00418.2018. Epub 2018 Nov 9. Review.

PMID:
30412441
39.

Remote Welfare Monitoring of Rodents Using Thermal Imaging.

Pereira CB, Kunczik J, Zieglowski L, Tolba R, Abdelrahman A, Zechner D, Vollmar B, Janssen H, Thum T, Czaplik M.

Sensors (Basel). 2018 Oct 28;18(11). pii: E3653. doi: 10.3390/s18113653.

40.

Blood-based microRNA profiling in patients with cardiac amyloidosis.

Derda AA, Pfanne A, Bär C, Schimmel K, Kennel PJ, Xiao K, Schulze PC, Bauersachs J, Thum T.

PLoS One. 2018 Oct 17;13(10):e0204235. doi: 10.1371/journal.pone.0204235. eCollection 2018.

41.

Circulating miR-1254 predicts ventricular remodeling in patients with ST-Segment-Elevation Myocardial Infarction: A cardiovascular magnetic resonance study.

de Gonzalo-Calvo D, Cediel G, Bär C, Núñez J, Revuelta-Lopez E, Gavara J, Ríos-Navarro C, Llorente-Cortes V, Bodí V, Thum T, Bayes-Genis A.

Sci Rep. 2018 Oct 11;8(1):15115. doi: 10.1038/s41598-018-33491-y.

42.

Corrigendum: Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis-Normalization After Liver Transplantation and Implications for Future Research.

Proskynitopoulos PJ, Rhein M, Jäckel E, Manns MP, Frieling H, Bleich S, Thum T, Hillemacher T, Glahn A.

Alcohol Alcohol. 2018 Nov 1;53(6):760. doi: 10.1093/alcalc/agy062. No abstract available.

PMID:
30169583
43.

Circulating non-coding RNAs as biomarkers to predict and monitor the response to exercise: chances and hurdles.

de Gonzalo-Calvo D, Thum T.

Eur Heart J. 2018 Oct 7;39(38):3552. doi: 10.1093/eurheartj/ehy457. No abstract available.

PMID:
30060047
44.

Leukocyte telomere length correlates with hypertrophic cardiomyopathy severity.

Chatterjee S, de Gonzalo-Calvo D, Derda AA, Schimmel K, Sonnenschein K, Bavendiek U, Bauersachs J, Bär C, Thum T.

Sci Rep. 2018 Jul 25;8(1):11227. doi: 10.1038/s41598-018-29072-8.

45.

Translational Opportunities and Challenges of Long Noncoding RNAs in Cardiac Regeneration.

Thum T.

J Am Coll Cardiol. 2018 Jul 31;72(5):551-552. doi: 10.1016/j.jacc.2018.05.039. Epub 2018 Jun 23. No abstract available.

46.

Metabolic changes in hypertrophic cardiomyopathies: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.

van der Velden J, Tocchetti CG, Varricchi G, Bianco A, Sequeira V, Hilfiker-Kleiner D, Hamdani N, Leite-Moreira AF, Mayr M, Falcão-Pires I, Thum T, Dawson DK, Balligand JL, Heymans S.

Cardiovasc Res. 2018 Aug 1;114(10):1273-1280. doi: 10.1093/cvr/cvy147. Review.

47.

Leptin Expression and Gene Methylation Patterns in Alcohol-Dependent Patients with Ethyltoxic Cirrhosis-Normalization After Liver Transplantation and Implications for Future Research.

Proskynitopoulos PJ, Rhein M, Jäckel E, Manns MP, Frieling H, Bleich S, Thum T, Hillemacher T, Glahn A.

Alcohol Alcohol. 2018 Sep 1;53(5):511-517. doi: 10.1093/alcalc/agy038. Erratum in: Alcohol Alcohol. 2018 Nov 1;53(6):760.

PMID:
29912265
48.

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.

Bondue A, Arbustini E, Bianco A, Ciccarelli M, Dawson D, De Rosa M, Hamdani N, Hilfiker-Kleiner D, Meder B, Leite-Moreira AF, Thum T, Tocchetti CG, Varricchi G, Van der Velden J, Walsh R, Heymans S.

Cardiovasc Res. 2018 Aug 1;114(10):1287-1303. doi: 10.1093/cvr/cvy122. Review.

49.

Non-coding RNAs in vascular disease - from basic science to clinical applications: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology.

Fiedler J, Baker AH, Dimmeler S, Heymans S, Mayr M, Thum T.

Cardiovasc Res. 2018 Aug 1;114(10):1281-1286. doi: 10.1093/cvr/cvy121. Review.

50.

Circulating non-coding RNAs in biomarker-guided cardiovascular therapy: a novel tool for personalized medicine?

de Gonzalo-Calvo D, Vea A, Bär C, Fiedler J, Couch LS, Brotons C, Llorente-Cortes V, Thum T.

Eur Heart J. 2019 May 21;40(20):1643-1650. doi: 10.1093/eurheartj/ehy234.

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