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Items: 36

1.

MCLA-117, a CLEC12AxCD3 bispecific antibody targeting a leukaemic stem cell antigen, induces T cell-mediated AML blast lysis.

van Loo PF, Hangalapura BN, Thordardottir S, Gibbins JD, Veninga H, Hendriks LJA, Kramer A, Roovers RC, Leenders M, de Kruif J, Doornbos RP, Sirulnik A, Throsby M, Logtenberg T, Dolstra H, Bakker ABH.

Expert Opin Biol Ther. 2019 Jul;19(7):721-733. doi: 10.1080/14712598.2019.1623200.

PMID:
31286786
2.

Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade.

Geuijen CAW, De Nardis C, Maussang D, Rovers E, Gallenne T, Hendriks LJA, Visser T, Nijhuis R, Logtenberg T, de Kruif J, Gros P, Throsby M.

Cancer Cell. 2018 May 14;33(5):922-936.e10. doi: 10.1016/j.ccell.2018.04.003.

3.

Translational PK-PD modeling analysis of MCLA-128, a HER2/HER3 bispecific monoclonal antibody, to predict clinical efficacious exposure and dose.

de Vries Schultink AHM, Doornbos RP, Bakker ABH, Bol K, Throsby M, Geuijen C, Maussang D, Schellens JHM, Beijnen JH, Huitema ADR.

Invest New Drugs. 2018 Dec;36(6):1006-1015. doi: 10.1007/s10637-018-0593-x. Epub 2018 May 5.

4.

Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.

Leto SM, Sassi F, Catalano I, Torri V, Migliardi G, Zanella ER, Throsby M, Bertotti A, Trusolino L.

Clin Cancer Res. 2015 Dec 15;21(24):5519-31. doi: 10.1158/1078-0432.CCR-14-3066. Epub 2015 Aug 21.

5.
6.

A common solution to group 2 influenza virus neutralization.

Friesen RH, Lee PS, Stoop EJ, Hoffman RM, Ekiert DC, Bhabha G, Yu W, Juraszek J, Koudstaal W, Jongeneelen M, Korse HJ, Ophorst C, Brinkman-van der Linden EC, Throsby M, Kwakkenbos MJ, Bakker AQ, Beaumont T, Spits H, Kwaks T, Vogels R, Ward AB, Goudsmit J, Wilson IA.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):445-50. doi: 10.1073/pnas.1319058110. Epub 2013 Dec 11.

7.

Phage display generation of a novel human anti-CD1A monoclonal antibody with potent cytolytic activity.

Bechan GI, Lee DW, Zajonc DM, Heckel D, Xian R, Throsby M, van Meijer M, Germeraad WT, Kruisbeek AM, Egeler RM, Arceci RJ.

Br J Haematol. 2012 Nov;159(3):299-310. doi: 10.1111/bjh.12033. Epub 2012 Aug 30.

PMID:
22934889
8.

Qualitative and semiquantitative analysis of composite mixtures of antibodies by native mass spectrometry.

Rosati S, Thompson NJ, Barendregt A, Hendriks LJ, Bakker AB, de Kruif J, Throsby M, van Duijn E, Heck AJ.

Anal Chem. 2012 Aug 21;84(16):7227-32. doi: 10.1021/ac301611d. Epub 2012 Aug 10.

PMID:
22882109
9.

Generation of stable cell clones expressing mixtures of human antibodies.

de Kruif J, Kramer A, Nijhuis R, van der Zande V, den Blanken R, Clements C, Visser T, Keehnen R, den Hartog M, Throsby M, Logtenberg T.

Biotechnol Bioeng. 2010 Aug 1;106(5):741-50. doi: 10.1002/bit.22763.

PMID:
20564612
10.

Construction of phage antibody repertoires from the blood of West Nile virus-infected donors.

Throsby M, de Kruif J.

Methods Mol Biol. 2009;562:45-60. doi: 10.1007/978-1-60327-302-2_4.

PMID:
19554286
11.

Human monoclonal antibodies against West Nile virus induced by natural infection neutralize at a postattachment step.

Vogt MR, Moesker B, Goudsmit J, Jongeneelen M, Austin SK, Oliphant T, Nelson S, Pierson TC, Wilschut J, Throsby M, Diamond MS.

J Virol. 2009 Jul;83(13):6494-507. doi: 10.1128/JVI.00286-09. Epub 2009 Apr 22.

12.

Human immunoglobulin repertoires against tetanus toxoid contain a large and diverse fraction of high-affinity promiscuous V(H) genes.

de Kruif J, Kramer A, Visser T, Clements C, Nijhuis R, Cox F, van der Zande V, Smit R, Pinto D, Throsby M, Logtenberg T.

J Mol Biol. 2009 Apr 3;387(3):548-58. doi: 10.1016/j.jmb.2009.02.009. Epub 2009 Feb 11.

PMID:
19361421
13.

Antibody recognition of a highly conserved influenza virus epitope.

Ekiert DC, Bhabha G, Elsliger MA, Friesen RH, Jongeneelen M, Throsby M, Goudsmit J, Wilson IA.

Science. 2009 Apr 10;324(5924):246-51. doi: 10.1126/science.1171491. Epub 2009 Feb 26.

14.

Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells.

Throsby M, van den Brink E, Jongeneelen M, Poon LL, Alard P, Cornelissen L, Bakker A, Cox F, van Deventer E, Guan Y, Cinatl J, ter Meulen J, Lasters I, Carsetti R, Peiris M, de Kruif J, Goudsmit J.

PLoS One. 2008;3(12):e3942. doi: 10.1371/journal.pone.0003942. Epub 2008 Dec 16.

15.

Induction of epitope-specific neutralizing antibodies against West Nile virus.

Oliphant T, Nybakken GE, Austin SK, Xu Q, Bramson J, Loeb M, Throsby M, Fremont DH, Pierson TC, Diamond MS.

J Virol. 2007 Nov;81(21):11828-39. Epub 2007 Aug 22.

16.

Increased transcriptional preproinsulin II beta-cell activity in neonatal nonobese diabetic mice: in situ hybridization analysis.

Throsby M, Coulaud J, Durant S, Homo-Delarche F.

Rev Diabet Stud. 2005 Summer;2(2):75-83. Epub 2005 Aug 10.

17.

Mapping and analysis of West Nile virus-specific monoclonal antibodies: prospects for vaccine development.

Throsby M, Ter Meulen J, Geuijen C, Goudsmit J, de Kruif J.

Expert Rev Vaccines. 2007 Apr;6(2):183-91. Review.

PMID:
17408368
18.

A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis.

de Kruif J, Bakker AB, Marissen WE, Kramer RA, Throsby M, Rupprecht CE, Goudsmit J.

Annu Rev Med. 2007;58:359-68. Review.

PMID:
16886905
19.

Isolation and characterization of human monoclonal antibodies from individuals infected with West Nile Virus.

Throsby M, Geuijen C, Goudsmit J, Bakker AQ, Korimbocus J, Kramer RA, Clijsters-van der Horst M, de Jong M, Jongeneelen M, Thijsse S, Smit R, Visser TJ, Bijl N, Marissen WE, Loeb M, Kelvin DJ, Preiser W, ter Meulen J, de Kruif J.

J Virol. 2006 Jul;80(14):6982-92.

20.

Affinity ranking of antibodies using flow cytometry: application in antibody phage display-based target discovery.

Geuijen CA, Clijsters-van der Horst M, Cox F, Rood PM, Throsby M, Jongeneelen MA, Backus HH, van Deventer E, Kruisbeek AM, Goudsmit J, de Kruif J.

J Immunol Methods. 2005 Jul;302(1-2):68-77.

PMID:
15992810
21.

Novel rabies virus-neutralizing epitope recognized by human monoclonal antibody: fine mapping and escape mutant analysis.

Marissen WE, Kramer RA, Rice A, Weldon WC, Niezgoda M, Faber M, Slootstra JW, Meloen RH, Clijsters-van der Horst M, Visser TJ, Jongeneelen M, Thijsse S, Throsby M, de Kruif J, Rupprecht CE, Dietzschold B, Goudsmit J, Bakker AB.

J Virol. 2005 Apr;79(8):4672-8.

22.

Molecular and biological characterization of human monoclonal antibodies binding to the spike and nucleocapsid proteins of severe acute respiratory syndrome coronavirus.

van den Brink EN, Ter Meulen J, Cox F, Jongeneelen MA, Thijsse A, Throsby M, Marissen WE, Rood PM, Bakker AB, Gelderblom HR, Martina BE, Osterhaus AD, Preiser W, Doerr HW, de Kruif J, Goudsmit J.

J Virol. 2005 Feb;79(3):1635-44.

23.

A proteomic approach to tumour target identification using phage display, affinity purification and mass spectrometry.

Geuijen CA, Bijl N, Smit RC, Cox F, Throsby M, Visser TJ, Jongeneelen MA, Bakker AB, Kruisbeek AM, Goudsmit J, de Kruif J.

Eur J Cancer. 2005 Jan;41(1):178-87.

PMID:
15618003
24.

C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia.

Bakker AB, van den Oudenrijn S, Bakker AQ, Feller N, van Meijer M, Bia JA, Jongeneelen MA, Visser TJ, Bijl N, Geuijen CA, Marissen WE, Radosevic K, Throsby M, Schuurhuis GJ, Ossenkoppele GJ, de Kruif J, Goudsmit J, Kruisbeek AM.

Cancer Res. 2004 Nov 15;64(22):8443-50.

25.

Islet endocrine-cell behavior from birth onward in mice with the nonobese diabetic genetic background.

Pelegri C, Rosmalen JG, Durant S, Throsby M, Alvès V, Coulaud J, Esling A, Pléau JM, Drexhage HA, Homo-Delarche F.

Mol Med. 2001 May;7(5):311-9.

26.
27.

Thymic expression of the pancreatic endocrine hormones.

Throsby M, Pleau J, Dardenne M, Homo-Delarche F.

Neuroimmunomodulation. 1999 Jan-Apr;6(1-2):108-14. Review.

PMID:
9876241
28.

Pancreatic hormone expression in the murine thymus: localization in dendritic cells and macrophages.

Throsby M, Homo-Delarche F, Chevenne D, Goya R, Dardenne M, Pleau JM.

Endocrinology. 1998 May;139(5):2399-406.

PMID:
9564851
29.

Glucose homeostasis in the nonobese diabetic mouse at the prediabetic stage.

Amrani A, Durant S, Throsby M, Coulaud J, Dardenne M, Homo-Delarche F.

Endocrinology. 1998 Mar;139(3):1115-24.

PMID:
9492045
30.

Ontogeny of glutamic acid decarboxylase gene expression in the mouse pancreas.

Pleau JM, Throsby M, Esling A, Dardenne M.

Biochem Biophys Res Commun. 1997 Apr 7;233(1):227-30.

PMID:
9144428
31.

Localization of gamma-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse.

Saravia-Fernandez F, Faveeuw C, Blasquez-Bulant C, Tappaz M, Throsby M, Pelletier G, Vaudry H, Dardenne M, Homo-Delarche F.

Endocrinology. 1996 Aug;137(8):3497-506.

PMID:
8754779
32.

Colocalization of atrial natriuretic factor and beta-endorphin in rat thymic macrophages.

Throsby M, Yang Z, Copolov DL, Lim AT.

Peptides. 1994;15(2):291-6.

PMID:
8008634
33.

Coexpression of atrial natriuretic factor and beta-endorphin in a subpopulation of rat splenic macrophages: age-related differences.

Throsby M, Yang Z, Lee D, Huang W, Copolov DL, Lim AT.

Endocrinology. 1993 Dec;133(6):2889-96.

PMID:
8243316
34.

In vitro evidence for atrial natriuretic factor-(5-28) production by macrophages of adult rat thymi.

Throsby M, Yang Z, Lee D, Huang W, Copolov DL, Lim AT.

Endocrinology. 1993 May;132(5):2184-90.

PMID:
8477663
35.

Evidence for atrial natriuretic peptide-(5-28) production by rat placental cytotrophoblasts.

Huang W, Lee D, Yang Z, Casley D, Throsby M, Copolov DL, Johnston C, Lim AT.

Endocrinology. 1992 Aug;131(2):919-24.

PMID:
1386304
36.

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