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Items: 40

1.

ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.

Durand-Réville TF, Guler S, Comita-Prevoir J, Chen B, Bifulco N, Huynh H, Lahiri S, Shapiro AB, McLeod SM, Carter NM, Moussa SH, Velez-Vega C, Olivier NB, McLaughlin R, Gao N, Thresher J, Palmer T, Andrews B, Giacobbe RA, Newman JV, Ehmann DE, de Jonge B, O'Donnell J, Mueller JP, Tommasi RA, Miller AA.

Nat Microbiol. 2017 Jun 30;2:17104. doi: 10.1038/nmicrobiol.2017.104.

PMID:
28665414
2.

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.

Kern G, Palmer T, Ehmann DE, Shapiro AB, Andrews B, Basarab GS, Doig P, Fan J, Gao N, Mills SD, Mueller J, Sriram S, Thresher J, Walkup GK.

J Biol Chem. 2015 Aug 21;290(34):20984-94. doi: 10.1074/jbc.M115.663534. Epub 2015 Jul 6.

3.

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC.

Lahiri SD, Walkup GK, Whiteaker JD, Palmer T, McCormack K, Tanudra MA, Nash TJ, Thresher J, Johnstone MR, Hajec L, Livchak S, McLaughlin RE, Alm RA.

J Antimicrob Chemother. 2015;70(6):1650-8. doi: 10.1093/jac/dkv004. Epub 2015 Feb 1.

PMID:
25645206
4.

Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii.

Penwell WF, Shapiro AB, Giacobbe RA, Gu RF, Gao N, Thresher J, McLaughlin RE, Huband MD, DeJonge BL, Ehmann DE, Miller AA.

Antimicrob Agents Chemother. 2015 Mar;59(3):1680-9. doi: 10.1128/AAC.04808-14. Epub 2015 Jan 5.

5.

Mechanism of action for respiratory syncytial virus inhibitor RSV604.

Challa S, Scott AD, Yuzhakov O, Zhou Y, Tiong-Yip CL, Gao N, Thresher J, Yu Q.

Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7. doi: 10.1128/AAC.04119-14. Epub 2014 Dec 1.

6.

Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors.

Murphy-Benenato KE, Olivier N, Choy A, Ross PL, Miller MD, Thresher J, Gao N, Hale MR.

ACS Med Chem Lett. 2014 Sep 23;5(11):1213-8. doi: 10.1021/ml500210x. eCollection 2014 Nov 13.

7.

Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein.

Shapiro AB, Gao N, O'Connell N, Hu J, Thresher J, Gu RF, Overman R, Hardern IM, Sproat GG.

Virol J. 2014 Nov 19;11:191. doi: 10.1186/s12985-014-0191-2.

8.

Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.

Nayar AS, Dougherty TJ, Reck F, Thresher J, Gao N, Shapiro AB, Ehmann DE.

Antimicrob Agents Chemother. 2015 Jan;59(1):331-7. doi: 10.1128/AAC.04077-14. Epub 2014 Oct 27.

9.

Overexpression of Pseudomonas aeruginosa LpxC with its inhibitors in an acrB-deficient Escherichia coli strain.

Gao N, McLeod SM, Hajec L, Olivier NB, Lahiri SD, Bryan Prince D, Thresher J, Ross PL, Whiteaker JD, Doig P, Li AH, Hill PJ, Cornebise M, Reck F, Hale MR.

Protein Expr Purif. 2014 Dec;104:57-64. doi: 10.1016/j.pep.2014.09.006. Epub 2014 Sep 18.

PMID:
25240855
10.

Fluorescence anisotropy-based measurement of Pseudomonas aeruginosa penicillin-binding protein 2 transpeptidase inhibitor acylation rate constants.

Shapiro AB, Gao N, Gu RF, Thresher J.

Anal Biochem. 2014 Oct 15;463:15-22. doi: 10.1016/j.ab.2014.06.004. Epub 2014 Jun 16.

PMID:
24945954
11.

Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening.

Shapiro AB, Plant H, Walsh J, Sylvester M, Hu J, Gao N, Livchak S, Tentarelli S, Thresher J.

J Biomol Screen. 2014 Sep;19(8):1137-46. doi: 10.1177/1087057114534981. Epub 2014 May 12.

PMID:
24820111
12.

Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.

de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J.

Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. Epub 2013 Sep 16.

13.

Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.

Hill PJ, Abibi A, Albert R, Andrews B, Gagnon MM, Gao N, Grebe T, Hajec LI, Huang J, Livchak S, Lahiri SD, McKinney DC, Thresher J, Wang H, Olivier N, Buurman ET.

J Med Chem. 2013 Sep 26;56(18):7278-88. doi: 10.1021/jm400718n. Epub 2013 Sep 17.

PMID:
23981144
14.

Kinetics of avibactam inhibition against Class A, C, and D β-lactamases.

Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Durand-Réville TF, Lahiri S, Thresher J, Livchak S, Gao N, Palmer T, Walkup GK, Fisher SL.

J Biol Chem. 2013 Sep 27;288(39):27960-71. doi: 10.1074/jbc.M113.485979. Epub 2013 Aug 2.

15.

Continuous fluorescence anisotropy-based assay of BOCILLIN FL penicillin reaction with penicillin binding protein 3.

Shapiro AB, Gu RF, Gao N, Livchak S, Thresher J.

Anal Biochem. 2013 Aug 1;439(1):37-43. doi: 10.1016/j.ab.2013.04.009. Epub 2013 Apr 16.

PMID:
23603065
16.

Exploring the UDP pocket of LpxC through amino acid analogs.

Hale MR, Hill P, Lahiri S, Miller MD, Ross P, Alm R, Gao N, Kutschke A, Johnstone M, Prince B, Thresher J, Yang W.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2362-7. doi: 10.1016/j.bmcl.2013.02.055. Epub 2013 Mar 1.

PMID:
23499237
17.

A high-throughput-compatible fluorescence anisotropy-based assay for competitive inhibitors of Escherichia coli UDP-N-acetylglucosamine acyltransferase (LpxA).

Shapiro AB, Ross PL, Gao N, Livchak S, Kern G, Yang W, Andrews B, Thresher J.

J Biomol Screen. 2013 Mar;18(3):341-7. doi: 10.1177/1087057112462062. Epub 2012 Sep 26.

PMID:
23015018
18.

The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds.

Jahić H, Liu CF, Thresher J, Livchak S, Wang H, Ehmann DE.

Biochem Pharmacol. 2012 Sep 1;84(5):654-60. doi: 10.1016/j.bcp.2012.06.017. Epub 2012 Jun 26.

PMID:
22743594
19.

A homogeneous, high-throughput-compatible, fluorescence intensity-based assay for UDP-N-acetylenolpyruvylglucosamine reductase (MurB) with nanomolar product detection.

Shapiro AB, Livchak S, Gao N, Whiteaker J, Thresher J, Jahić H, Huang J, Gu RF.

J Biomol Screen. 2012 Mar;17(3):327-38. doi: 10.1177/1087057111425188. Epub 2011 Nov 7.

PMID:
22068704
20.

A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase.

Shapiro AB, Gao N, Thresher J, Walkup GK, Whiteaker J.

J Biomol Screen. 2011 Jun;16(5):494-505. doi: 10.1177/1087057111398934. Epub 2011 Mar 14.

PMID:
21402755
21.

A homogeneous, high-throughput fluorescence anisotropy-based DNA supercoiling assay.

Shapiro A, Jahic H, Prasad S, Ehmann D, Thresher J, Gao N, Hajec L.

J Biomol Screen. 2010 Oct;15(9):1088-98. doi: 10.1177/1087057110378624.

PMID:
20930214
22.

The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation.

Komalavilas P, Penn RB, Flynn CR, Thresher J, Lopes LB, Furnish EJ, Guo M, Pallero MA, Murphy-Ullrich JE, Brophy CM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L69-78. Epub 2007 Nov 9.

23.

Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli.

Flynn CR, Smoke CC, Furnish E, Komalavilas P, Thresher J, Yi Z, Mandarino LJ, Brophy CM.

Protein Expr Purif. 2007 Mar;52(1):50-8. Epub 2006 Sep 12.

24.

Role of the small heat shock proteins in regulating vascular smooth muscle tone.

McLemore EC, Tessier DJ, Thresher J, Komalavilas P, Brophy CM.

J Am Coll Surg. 2005 Jul;201(1):30-6.

PMID:
15978441
25.

Transduction of phosphorylated heat shock-related protein 20, HSP20, prevents vasospasm of human umbilical artery smooth muscle.

Flynn CR, Brophy CM, Furnish EJ, Komalavilas P, Tessier D, Thresher J, Joshi L.

J Appl Physiol (1985). 2005 May;98(5):1836-45.

26.

Transducible recombinant small heat shock-related protein, HSP20, inhibits vasospasm and platelet aggregation.

McLemore EC, Tessier DJ, Flynn CR, Furnish EJ, Komalavilas P, Thresher JS, Joshi L, Stone WM, Fowl RJ, Brophy CM.

Surgery. 2004 Sep;136(3):573-8.

PMID:
15349104
27.

Inactivity-induced modulation of Hsp20 and Hsp25 content in rat hindlimb muscles.

Huey KA, Thresher JS, Brophy CM, Roy RR.

Muscle Nerve. 2004 Jul;30(1):95-101.

PMID:
15221884
28.

Transduction of peptide analogs of the small heat shock-related protein HSP20 inhibits intimal hyperplasia.

Tessier DJ, Komalavilas P, Liu B, Kent CK, Thresher JS, Dreiza CM, Panitch A, Joshi L, Furnish E, Stone W, Fowl R, Brophy CM.

J Vasc Surg. 2004 Jul;40(1):106-14.

29.

Sildenafil-induced vasorelaxation is associated with increases in the phosphorylation of the heat shock-related protein 20 (HSP20).

Tessier DJ, Komalavilas P, McLemore E, Thresher J, Brophy CM.

J Surg Res. 2004 May 1;118(1):21-5.

PMID:
15093712
30.

Transduction of biologically active motifs of the small heat shock-related protein HSP20 leads to relaxation of vascular smooth muscle.

Flynn CR, Komalavilas P, Tessier D, Thresher J, Niederkofler EE, Dreiza CM, Nelson RW, Panitch A, Joshi L, Brophy CM.

FASEB J. 2003 Jul;17(10):1358-60. Epub 2003 May 8.

PMID:
12738803
31.

Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats.

Commerford SR, Ferniza JB, Bizeau ME, Thresher JS, Willis WT, Pagliassotti MJ.

Am J Physiol Endocrinol Metab. 2002 Sep;283(3):E545-55.

32.

Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance.

Pagliassotti MJ, Kang J, Thresher JS, Sung CK, Bizeau ME.

Am J Physiol Endocrinol Metab. 2002 Jan;282(1):E170-6.

33.

Sucrose diets increase glucose-6-phosphatase and glucose release and decrease glucokinase in hepatocytes.

Bizeau ME, Thresher JS, Pagliassotti MJ.

J Appl Physiol (1985). 2001 Nov;91(5):2041-6.

34.

Hyperglycemia compensates for diet-induced insulin resistance in liver and skeletal muscle of rats.

Commerford SR, Bizeau ME, McRae H, Jampolis A, Thresher JS, Pagliassotti MJ.

Am J Physiol Regul Integr Comp Physiol. 2001 Nov;281(5):R1380-9.

35.

Increased pyruvate flux capacities account for diet-induced increases in gluconeogenesis in vitro.

Bizeau ME, Short C, Thresher JS, Commerford SR, Willis WT, Pagliassotti MJ.

Am J Physiol Regul Integr Comp Physiol. 2001 Aug;281(2):R427-33.

36.

A high-sucrose diet increases gluconeogenic capacity in isolated periportal and perivenous rat hepatocytes.

Bizeau ME, Thresher JS, Pagliassotti MJ.

Am J Physiol Endocrinol Metab. 2001 May;280(5):E695-702.

37.

Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance.

Thresher JS, Podolin DA, Wei Y, Mazzeo RS, Pagliassotti MJ.

Am J Physiol Regul Integr Comp Physiol. 2000 Oct;279(4):R1334-40.

38.

Menhaden oil prevents but does not reverse sucrose-induced insulin resistance in rats.

Podolin DA, Gayles EC, Wei Y, Thresher JS, Pagliassotti MJ.

Am J Physiol. 1998 Mar;274(3):R840-8. doi: 10.1152/ajpregu.1998.274.3.R840.

PMID:
9530253
39.

Science education for mentally retarded children: a rationale.

THRESHER JM.

Ment Retard. 1963 Jun;1(3):152-60. No abstract available.

PMID:
13981289
40.

A problem for educators: arithmetical concept formation in the mentally retarded child.

THRESHER JM.

Am J Ment Defic. 1962 Mar;66:766-73. No abstract available.

PMID:
13921075

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