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Items: 27


Tsc1-mTORC1 signaling controls striatal dopamine release and cognitive flexibility.

Kosillo P, Doig NM, Ahmed KM, Agopyan-Miu AHCW, Wong CD, Conyers L, Threlfell S, Magill PJ, Bateup HS.

Nat Commun. 2019 Nov 28;10(1):5426. doi: 10.1038/s41467-019-13396-8.


Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior.

Hunn BHM, Vingill S, Threlfell S, Alegre-Abarrategui J, Magdelyns M, Deltheil T, Bengoa-Vergniory N, Oliver PL, Cioroch M, Doig NM, Bannerman DM, Cragg SJ, Wade-Martins R.

Cell Rep. 2019 Oct 22;29(4):920-931.e7. doi: 10.1016/j.celrep.2019.09.029.


Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.

Condon MD, Platt NJ, Zhang YF, Roberts BM, Clements MA, Vietti-Michelina S, Tseu MY, Brimblecombe KR, Threlfell S, Mann EO, Cragg SJ.

Nat Commun. 2019 Sep 19;10(1):4263. doi: 10.1038/s41467-019-12264-9.


Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration.

Pristerà A, Blomeley C, Lopes E, Threlfell S, Merlini E, Burdakov D, Cragg S, Guillemot F, Ang SL.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3817-3826. doi: 10.1073/pnas.1806820116. Epub 2019 Feb 11.


Targeted Activation of Cholinergic Interneurons Accounts for the Modulation of Dopamine by Striatal Nicotinic Receptors.

Brimblecombe KR, Threlfell S, Dautan D, Kosillo P, Mena-Segovia J, Cragg SJ.

eNeuro. 2018 Oct 30;5(5). pii: ENEURO.0397-17.2018. doi: 10.1523/ENEURO.0397-17.2018. eCollection 2018 Sep-Oct.


Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons.

Kosillo P, Zhang YF, Threlfell S, Cragg SJ.

Cereb Cortex. 2016 Oct 1;26(11):4160-4169. doi: 10.1093/cercor/bhw252.


LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.

Sloan M, Alegre-Abarrategui J, Potgieter D, Kaufmann AK, Exley R, Deltheil T, Threlfell S, Connor-Robson N, Brimblecombe K, Wallings R, Cioroch M, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Dodson PD, Wade-Martins R.

Hum Mol Genet. 2016 Mar 1;25(5):951-63. doi: 10.1093/hmg/ddv628. Epub 2016 Jan 6.


Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice.

Pristerà A, Lin W, Kaufmann AK, Brimblecombe KR, Threlfell S, Dodson PD, Magill PJ, Fernandes C, Cragg SJ, Ang SL.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4929-38. doi: 10.1073/pnas.1503911112. Epub 2015 Aug 17.


Facilitation of corticostriatal transmission following pharmacological inhibition of striatal phosphodiesterase 10A: role of nitric oxide-soluble guanylyl cyclase-cGMP signaling pathways.

Padovan-Neto FE, Sammut S, Chakroborty S, Dec AM, Threlfell S, Campbell PW, Mudrakola V, Harms JF, Schmidt CJ, West AR.

J Neurosci. 2015 Apr 8;35(14):5781-91. doi: 10.1523/JNEUROSCI.1238-14.2015.


Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse.

Taylor TN, Potgieter D, Anwar S, Senior SL, Janezic S, Threlfell S, Ryan B, Parkkinen L, Deltheil T, Cioroch M, Livieratos A, Oliver PL, Jennings KA, Davies KE, Ansorge O, Bannerman DM, Cragg SJ, Wade-Martins R.

Neurobiol Dis. 2014 Feb;62:193-207. doi: 10.1016/j.nbd.2013.10.005. Epub 2013 Oct 10.


Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model.

Janezic S, Threlfell S, Dodson PD, Dowie MJ, Taylor TN, Potgieter D, Parkkinen L, Senior SL, Anwar S, Ryan B, Deltheil T, Kosillo P, Cioroch M, Wagner K, Ansorge O, Bannerman DM, Bolam JP, Magill PJ, Cragg SJ, Wade-Martins R.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4016-25. doi: 10.1073/pnas.1309143110. Epub 2013 Sep 30.


Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

Threlfell S, Lalic T, Platt NJ, Jennings KA, Deisseroth K, Cragg SJ.

Neuron. 2012 Jul 12;75(1):58-64. doi: 10.1016/j.neuron.2012.04.038.


Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family.

Anwar S, Peters O, Millership S, Ninkina N, Doig N, Connor-Robson N, Threlfell S, Kooner G, Deacon RM, Bannerman DM, Bolam JP, Chandra SS, Cragg SJ, Wade-Martins R, Buchman VL.

J Neurosci. 2011 May 18;31(20):7264-74. doi: 10.1523/JNEUROSCI.6194-10.2011.


Nitric oxide donors enhance the frequency dependence of dopamine release in nucleus accumbens.

Hartung H, Threlfell S, Cragg SJ.

Neuropsychopharmacology. 2011 Aug;36(9):1811-22. doi: 10.1038/npp.2011.62. Epub 2011 Apr 20.


Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.

Exley R, Maubourguet N, David V, Eddine R, Evrard A, Pons S, Marti F, Threlfell S, Cazala P, McIntosh JM, Changeux JP, Maskos U, Cragg SJ, Faure P.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7577-82. doi: 10.1073/pnas.1103000108. Epub 2011 Apr 18.


Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons.

Threlfell S, Cragg SJ.

Front Syst Neurosci. 2011 Mar 3;5:11. doi: 10.3389/fnsys.2011.00011. eCollection 2011.


Using Fast-Scan Cyclic Voltammetry to Investigate Somatodendritic Dopamine Release.

Threlfell S, Cragg SJ.

In: Michael AC, Borland LM, editors. Electrochemical Methods for Neuroscience. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 8.


Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum.

Threlfell S, Clements MA, Khodai T, Pienaar IS, Exley R, Wess J, Cragg SJ.

J Neurosci. 2010 Mar 3;30(9):3398-408. doi: 10.1523/JNEUROSCI.5620-09.2010.


Nitric oxide-soluble guanylyl cyclase signaling regulates corticostriatal transmission and short-term synaptic plasticity of striatal projection neurons recorded in vivo.

Sammut S, Threlfell S, West AR.

Neuropharmacology. 2010 Mar;58(3):624-31. doi: 10.1016/j.neuropharm.2009.11.011. Epub 2009 Dec 5.


5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra.

Threlfell S, Greenfield SA, Cragg SJ.

Neuroscience. 2010 Jan 13;165(1):212-20. doi: 10.1016/j.neuroscience.2009.10.005. Epub 2009 Oct 9.


Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation.

Threlfell S, Sammut S, Menniti FS, Schmidt CJ, West AR.

J Pharmacol Exp Ther. 2009 Mar;328(3):785-95. doi: 10.1124/jpet.108.146332. Epub 2008 Dec 4.


Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra.

Threlfell S, Exley R, Cragg SJ, Greenfield SA.

J Neurochem. 2008 Nov;107(3):745-55. doi: 10.1111/j.1471-4159.2008.05646.x. Epub 2008 Aug 30.


Feed-forward excitation of striatal neuron activity by frontal cortical activation of nitric oxide signaling in vivo.

Ondracek JM, Dec A, Hoque KE, Lim SA, Rasouli G, Indorkar RP, Linardakis J, Klika B, Mukherji SJ, Burnazi M, Threlfell S, Sammut S, West AR.

Eur J Neurosci. 2008 Apr;27(7):1739-54. doi: 10.1111/j.1460-9568.2008.06157.x. Epub 2008 Mar 26.


Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata.

Threlfell S, Cragg SJ, Kalló I, Turi GF, Coen CW, Greenfield SA.

J Neurosci. 2004 Oct 6;24(40):8704-10.


An electrochemical adaptation of Ellman's test.

Nekrassova O, White PC, Threlfell S, Hignett G, Wain AJ, Lawrence NS, Davis J, Compton RG.

Analyst. 2002 Jun;127(6):797-802.


Electroanalytical exploitation of quinone-thiol interactions: application to the selective determination of cysteine.

Hignett G, Threlfell S, Wain AJ, Lawrence NS, Wilkins SJ, Davis J, Compton RG, Cardosi MF.

Analyst. 2001 Mar;126(3):353-7.


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