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Items: 1 to 50 of 182

1.

gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population.

Konganti K, Ehrlich A, Rusyn I, Threadgill DW.

G3 (Bethesda). 2018 Jul 31;8(8):2559-2562. doi: 10.1534/g3.118.200230.

2.

Serotype Diversity and Antimicrobial Resistance among Salmonella enterica Isolates from Patients at an Equine Referral Hospital.

Leon IM, Lawhon SD, Norman KN, Threadgill DS, Ohta N, Vinasco J, Scott HM.

Appl Environ Microbiol. 2018 Jun 18;84(13). pii: e02829-17. doi: 10.1128/AEM.02829-17. Print 2018 Jul 1.

PMID:
29678910
3.

A Whole Genome Assembly of the Horn Fly, Haematobia irritans, and Prediction of Genes with Roles in Metabolism and Sex Determination.

Konganti K, Guerrero FD, Schilkey F, Ngam P, Jacobi JL, Umale PE, Perez de Leon AA, Threadgill DW.

G3 (Bethesda). 2018 May 4;8(5):1675-1686. doi: 10.1534/g3.118.200154.

4.

Tissue Level Diet and Sex-by-Diet Interactions Reveal Unique Metabolite and Clustering Profiles Using Untargeted Liquid Chromatography-Mass Spectrometry on Adipose, Skeletal Muscle, and Liver Tissue in C57BL6/J Mice.

Wells A, Barrington WT, Dearth S, May A, Threadgill DW, Campagna SR, Voy BH.

J Proteome Res. 2018 Mar 2;17(3):1077-1090. doi: 10.1021/acs.jproteome.7b00750. Epub 2018 Feb 2.

PMID:
29373032
5.

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse.

Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I.

Mamm Genome. 2018 Feb;29(1-2):168-181. doi: 10.1007/s00335-018-9734-y. Epub 2018 Jan 20.

PMID:
29353386
6.

Disruption of postnatal folliculogenesis and development of ovarian tumor in a mouse model with aberrant transforming growth factor beta signaling.

Gao Y, Fang X, Vincent DF, Threadgill DW, Bartholin L, Li Q.

Reprod Biol Endocrinol. 2017 Dec 8;15(1):94. doi: 10.1186/s12958-017-0312-z.

7.

Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice.

Maurizio PL, Ferris MT, Keele GR, Miller DR, Shaw GD, Whitmore AC, West A, Morrison CR, Noll KE, Plante KS, Cockrell AS, Threadgill DW, Pardo-Manuel de Villena F, Baric RS, Heise MT, Valdar W.

G3 (Bethesda). 2018 Feb 2;8(2):427-445. doi: 10.1534/g3.117.300438.

8.

Improving Metabolic Health Through Precision Dietetics in Mice.

Barrington WT, Wulfridge P, Wells AE, Rojas CM, Howe SYF, Perry A, Hua K, Pellizzon MA, Hansen KD, Voy BH, Bennett BJ, Pomp D, Feinberg AP, Threadgill DW.

Genetics. 2018 Jan;208(1):399-417. doi: 10.1534/genetics.117.300536. Epub 2017 Nov 20.

9.

Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Oct 1;159(2):481. doi: 10.1093/toxsci/kfx158. No abstract available.

PMID:
28962530
10.

Host genetic background influences diverse neurological responses to viral infection in mice.

Brinkmeyer-Langford CL, Rech R, Amstalden K, Kochan KJ, Hillhouse AE, Young C, Welsh CJ, Threadgill DW.

Sci Rep. 2017 Sep 22;7(1):12194. doi: 10.1038/s41598-017-12477-2.

11.

Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Sep 1;159(1):102-113. doi: 10.1093/toxsci/kfx120.

PMID:
28903486
12.

Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population.

Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I.

Environ Health Perspect. 2017 May 30;125(5):057006. doi: 10.1289/EHP788.

13.

Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition.

Feng Y, Demehri FR, Xiao W, Tsai YH, Jones JC, Brindley CD, Threadgill DW, Holst JJ, Hartmann B, Barrett TA, Teitelbaum DH, Dempsey PJ.

Cell Mol Gastroenterol Hepatol. 2017 Jan 17;3(3):447-468. doi: 10.1016/j.jcmgh.2016.12.005. eCollection 2017 May.

14.

Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism.

Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I.

Toxicol Sci. 2017 Jul 1;158(1):48-62. doi: 10.1093/toxsci/kfx065.

15.

Prevention of tumorigenesis in mice by exercise is dependent on strain background and timing relative to carcinogen exposure.

Kelly SA, Zhao L, Jung KC, Hua K, Threadgill DW, Kim Y, de Villena FP, Pomp D.

Sci Rep. 2017 Feb 22;7:43086. doi: 10.1038/srep43086.

16.

Prophylactic vaccination targeting ERBB3 decreases polyp burden in a mouse model of human colorectal cancer.

Bautz DJ, Sherpa AT, Threadgill DW.

Oncoimmunology. 2016 Dec 7;6(1):e1255395. doi: 10.1080/2162402X.2016.1255395. eCollection 2017.

17.

Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice.

Cichocki JA, Furuya S, Konganti K, Luo YS, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

J Pharmacol Exp Ther. 2017 Apr;361(1):17-28. doi: 10.1124/jpet.116.238790. Epub 2017 Feb 1.

18.

Hepatocyte ERBB3 and EGFR are required for maximal CCl4-induced liver fibrosis.

Scheving LA, Zhang X, Threadgill DW, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2016 Nov 1;311(5):G807-G816. doi: 10.1152/ajpgi.00423.2015. Epub 2016 Sep 1.

19.

R2d2 Drives Selfish Sweeps in the House Mouse.

Didion JP, Morgan AP, Yadgary L, Bell TA, McMullan RC, Ortiz de Solorzano L, Britton-Davidian J, Bult CJ, Campbell KJ, Castiglia R, Ching YH, Chunco AJ, Crowley JJ, Chesler EJ, Förster DW, French JE, Gabriel SI, Gatti DM, Garland T Jr, Giagia-Athanasopoulou EB, Giménez MD, Grize SA, Gündüz İ, Holmes A, Hauffe HC, Herman JS, Holt JM, Hua K, Jolley WJ, Lindholm AK, López-Fuster MJ, Mitsainas G, da Luz Mathias M, McMillan L, Ramalhinho Mda G, Rehermann B, Rosshart SP, Searle JB, Shiao MS, Solano E, Svenson KL, Thomas-Laemont P, Threadgill DW, Ventura J, Weinstock GM, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

Mol Biol Evol. 2016 Jun;33(6):1381-95. doi: 10.1093/molbev/msw036. Epub 2016 Feb 15.

20.

Loss of hepatocyte ERBB3 but not EGFR impairs hepatocarcinogenesis.

Scheving LA, Zhang X, Stevenson MC, Weintraub MA, Abbasi A, Clarke AM, Threadgill DW, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2015 Dec 15;309(12):G942-54. doi: 10.1152/ajpgi.00089.2015. Epub 2015 Oct 22.

21.

The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice.

Ceddia RP, Lee D, Maulis MF, Carboneau BA, Threadgill DW, Poffenberger G, Milne G, Boyd KL, Powers AC, McGuinness OP, Gannon M, Breyer RM.

Endocrinology. 2016 Jan;157(1):220-32. doi: 10.1210/en.2015-1693. Epub 2015 Oct 20.

22.

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.

Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman MB, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, Pardo-Manuel de Villena F, Baric RS.

PLoS Genet. 2015 Oct 9;11(10):e1005504. doi: 10.1371/journal.pgen.1005504. eCollection 2015 Oct.

23.

Corrigendum: analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance.

Crowley JJ, Zhabotynsky V, Sun W, Huang S, Pakatci IK, Kim Y, Wang JR, Morgan AP, Calaway JD, Aylor DL, Yun Z, Bell TA, Buus RJ, Calaway ME, Didion JP, Gooch TJ, Hansen SD, Robinson NN, Shaw GD, Spence JS, Quackenbush CR, Barrick CJ, Nonneman RJ, Kim K, Xenakis J, Xie Y, Valdar W, Lenarcic AB, Wang W, Welsh CE, Fu CP, Zhang Z, Holt J, Guo Z, Threadgill DW, Tarantino LM, Miller DR, Zou F, McMillan L, Sullivan PF, de Villena FP.

Nat Genet. 2015 Jun;47(6):690. doi: 10.1038/ng0615-690a. No abstract available.

PMID:
26018903
24.

Phosphatidylinositol 3-kinase signaling determines kidney size.

Chen JK, Nagai K, Chen J, Plieth D, Hino M, Xu J, Sha F, Ikizler TA, Quarles CC, Threadgill DW, Neilson EG, Harris RC.

J Clin Invest. 2015 Jun;125(6):2429-44. doi: 10.1172/JCI78945. Epub 2015 May 18.

25.

Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance.

Crowley JJ, Zhabotynsky V, Sun W, Huang S, Pakatci IK, Kim Y, Wang JR, Morgan AP, Calaway JD, Aylor DL, Yun Z, Bell TA, Buus RJ, Calaway ME, Didion JP, Gooch TJ, Hansen SD, Robinson NN, Shaw GD, Spence JS, Quackenbush CR, Barrick CJ, Nonneman RJ, Kim K, Xenakis J, Xie Y, Valdar W, Lenarcic AB, Wang W, Welsh CE, Fu CP, Zhang Z, Holt J, Guo Z, Threadgill DW, Tarantino LM, Miller DR, Zou F, McMillan L, Sullivan PF, Pardo-Manuel de Villena F.

Nat Genet. 2015 Apr;47(4):353-60. doi: 10.1038/ng.3222. Epub 2015 Mar 2. Erratum in: Nat Genet. 2015 Jun;47(6):690.

26.

A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.

Didion JP, Morgan AP, Clayshulte AM, Mcmullan RC, Yadgary L, Petkov PM, Bell TA, Gatti DM, Crowley JJ, Hua K, Aylor DL, Bai L, Calaway M, Chesler EJ, French JE, Geiger TR, Gooch TJ, Garland T Jr, Harrill AH, Hunter K, McMillan L, Holt M, Miller DR, O'Brien DA, Paigen K, Pan W, Rowe LB, Shaw GD, Simecek P, Sullivan PF, Svenson KL, Weinstock GM, Threadgill DW, Pomp D, Churchill GA, Pardo-Manuel de Villena F.

PLoS Genet. 2015 Feb 13;11(2):e1004850. doi: 10.1371/journal.pgen.1004850. eCollection 2015 Feb.

27.

Identification and Characterization of a Putative Chemotaxis Protein, CheY, from the Oral Pathogen Campylobacter rectus.

LaGier MJ, Bilokopytov I, Cockerill B, Threadgill DS.

Internet J Microbiol. 2014;12(1). pii: 21300.

28.

ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas.

Song X, Fan PD, Bantikassegn A, Guha U, Threadgill DW, Varmus H, Politi K.

Cancer Res. 2015 Mar 15;75(6):1035-45. doi: 10.1158/0008-5472.CAN-13-1625. Epub 2015 Jan 16.

29.

Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice.

Church RJ, Gatti DM, Urban TJ, Long N, Yang X, Shi Q, Eaddy JS, Mosedale M, Ballard S, Churchill GA, Navarro V, Watkins PB, Threadgill DW, Harrill AH.

Food Chem Toxicol. 2015 Feb;76:19-26. doi: 10.1016/j.fct.2014.11.008. Epub 2014 Nov 28.

30.

Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice.

Scheving LA, Zhang X, Stevenson MC, Threadgill DW, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 1;308(5):G364-77. doi: 10.1152/ajpgi.00364.2014. Epub 2014 Nov 20.

31.

SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.

Didion JP, Buus RJ, Naghashfar Z, Threadgill DW, Morse HC 3rd, de Villena FP.

BMC Genomics. 2014 Oct 3;15:847. doi: 10.1186/1471-2164-15-847.

32.

A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner.

Donohoe DR, Holley D, Collins LB, Montgomery SA, Whitmore AC, Hillhouse A, Curry KP, Renner SW, Greenwalt A, Ryan EP, Godfrey V, Heise MT, Threadgill DS, Han A, Swenberg JA, Threadgill DW, Bultman SJ.

Cancer Discov. 2014 Dec;4(12):1387-97. doi: 10.1158/2159-8290.CD-14-0501. Epub 2014 Sep 29.

33.

The epidermal growth factor receptor critically regulates endometrial function during early pregnancy.

Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJ.

PLoS Genet. 2014 Jun 19;10(6):e1004451. doi: 10.1371/journal.pgen.1004451. eCollection 2014 Jun.

34.

Identification and Characterization of an Invasion Antigen B Gene from the Oral Pathogen Campylobacter rectus.

Lagier MJ, Threadgill DS.

Indian J Microbiol. 2014 Mar;54(1):33-40. doi: 10.1007/s12088-013-0406-z. Epub 2013 Apr 21.

35.

Epidermal growth factor receptor plays a role in the regulation of liver and plasma lipid levels in adult male mice.

Scheving LA, Zhang X, Garcia OA, Wang RF, Stevenson MC, Threadgill DW, Russell WE.

Am J Physiol Gastrointest Liver Physiol. 2014 Mar 1;306(5):G370-81. doi: 10.1152/ajpgi.00116.2013. Epub 2014 Jan 9.

36.

Using the emerging Collaborative Cross to probe the immune system.

Phillippi J, Xie Y, Miller DR, Bell TA, Zhang Z, Lenarcic AB, Aylor DL, Krovi SH, Threadgill DW, de Villena FP, Wang W, Valdar W, Frelinger JA.

Genes Immun. 2014 Jan;15(1):38-46. doi: 10.1038/gene.2013.59. Epub 2013 Nov 7.

37.

Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response.

Desimone MC, Rathmell WK, Threadgill DW.

J Natl Cancer Inst. 2013 Sep 18;105(18):1355-64. doi: 10.1093/jnci/djt226. Epub 2013 Aug 29.

39.

Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK.

Neufert C, Becker C, Türeci Ö, Waldner MJ, Backert I, Floh K, Atreya I, Leppkes M, Jefremow A, Vieth M, Schneider-Stock R, Klinger P, Greten FR, Threadgill DW, Sahin U, Neurath MF.

J Clin Invest. 2013 Apr;123(4):1428-43. doi: 10.1172/JCI63748. Epub 2013 Mar 15.

40.

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.

Ferris MT, Aylor DL, Bottomly D, Whitmore AC, Aicher LD, Bell TA, Bradel-Tretheway B, Bryan JT, Buus RJ, Gralinski LE, Haagmans BL, McMillan L, Miller DR, Rosenzweig E, Valdar W, Wang J, Churchill GA, Threadgill DW, McWeeney SK, Katze MG, Pardo-Manuel de Villena F, Baric RS, Heise MT.

PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.

41.

Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones.

Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill D, Okada Y, Toyama Y, Sato K.

PLoS One. 2013;8(1):e54853. doi: 10.1371/journal.pone.0054853. Epub 2013 Jan 18.

42.

Mapping six new susceptibility to colon cancer (Scc) loci using a mouse interspecific backcross.

Eversley CD, Yuying X, Pearsall RS, Threadgill DW.

G3 (Bethesda). 2012 Dec;2(12):1577-84. doi: 10.1534/g3.112.002253. Epub 2012 Dec 1.

43.

EGF receptor is required for KRAS-induced pancreatic tumorigenesis.

Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT.

Cancer Cell. 2012 Sep 11;22(3):304-17. doi: 10.1016/j.ccr.2012.07.024.

44.

Status and access to the Collaborative Cross population.

Welsh CE, Miller DR, Manly KF, Wang J, McMillan L, Morahan G, Mott R, Iraqi FA, Threadgill DW, de Villena FP.

Mamm Genome. 2012 Oct;23(9-10):706-12. doi: 10.1007/s00335-012-9410-6. Epub 2012 Jul 31. Erratum in: Mamm Genome. 2014 Apr;25(3-4):192.

45.

Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts.

Mustafi R, Dougherty U, Shah H, Dehghan H, Gliksberg A, Wu J, Zhu H, Joseph L, Hart J, Dive C, Fichera A, Threadgill D, Bissonnette M.

Carcinogenesis. 2012 Oct;33(10):1930-9. doi: 10.1093/carcin/bgs231. Epub 2012 Jul 12.

46.

Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials.

Rinella ES, Threadgill DW.

PLoS One. 2012;7(6):e39552. doi: 10.1371/journal.pone.0039552. Epub 2012 Jun 25.

47.

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation.

Franzke CW, Cobzaru C, Triantafyllopoulou A, Löffek S, Horiuchi K, Threadgill DW, Kurz T, van Rooijen N, Bruckner-Tuderman L, Blobel CP.

J Exp Med. 2012 Jun 4;209(6):1105-19. doi: 10.1084/jem.20112258. Epub 2012 May 7. Erratum in: J Exp Med. 2012 Dec 17;209(13):2517.

48.

Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice.

Bottomly D, Ferris MT, Aicher LD, Rosenzweig E, Whitmore A, Aylor DL, Haagmans BL, Gralinski LE, Bradel-Tretheway BG, Bryan JT, Threadgill DW, de Villena FP, Baric RS, Katze MG, Heise M, McWeeney SK.

G3 (Bethesda). 2012 Feb;2(2):213-21. doi: 10.1534/g3.111.001800. Epub 2012 Feb 1.

49.

Genetic analysis of hematological parameters in incipient lines of the collaborative cross.

Kelada SN, Aylor DL, Peck BC, Ryan JF, Tavarez U, Buus RJ, Miller DR, Chesler EJ, Threadgill DW, Churchill GA, Pardo-Manuel de Villena F, Collins FS.

G3 (Bethesda). 2012 Feb;2(2):157-65. doi: 10.1534/g3.111.001776. Epub 2012 Feb 1.

50.

Ten years of the collaborative cross.

Threadgill DW, Churchill GA.

G3 (Bethesda). 2012 Feb;2(2):153-6. doi: 10.1534/g3.111.001891. Epub 2012 Feb 1.

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