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Items: 39


PEGylated peptide to TIP1 is a novel targeting agent that binds specifically to various cancers in vivo.

Kapoor V, Singh AK, Rogers BE, Thotala D, Hallahan DE.

J Control Release. 2019 Mar 28;298:194-201. doi: 10.1016/j.jconrel.2019.02.008. Epub 2019 Feb 11.


Post-operative radiation effects on lymphopenia, neutrophil to lymphocyte ratio, and clinical outcomes in palatine tonsil cancers.

Lin AJ, Rao YJ, Chin RI, Campian J, Mullen D, Thotala D, Daly M, Gay H, Oppelt P, Hallahan D, Adkins D, Thorstad W.

Oral Oncol. 2018 Nov;86:1-7. doi: 10.1016/j.oraloncology.2018.08.008. Epub 2018 Sep 7.


PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance.

Dadey DYA, Kapoor V, Khudanyan A, Thotala D, Hallahan DE.

Mol Cancer Res. 2018 Oct;16(10):1447-1453. doi: 10.1158/1541-7786.MCR-18-0224. Epub 2018 Jul 10.


Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells.

Riehl TE, Alvarado D, Ee X, Zuckerman A, Foster L, Kapoor V, Thotala D, Ciorba MA, Stenson WF.

Gut. 2019 Jun;68(6):1003-1013. doi: 10.1136/gutjnl-2018-316226. Epub 2018 Jun 22.


Effect of Radiation Treatment Volume Reduction on Lymphopenia in Patients Receiving Chemoradiotherapy for Glioblastoma.

Rudra S, Hui C, Rao YJ, Samson P, Lin AJ, Chang X, Tsien C, Fergus S, Mullen D, Yang D, Thotala D, Hallahan D, Campian JL, Huang J.

Int J Radiat Oncol Biol Phys. 2018 May 1;101(1):217-225. doi: 10.1016/j.ijrobp.2018.01.069. Epub 2018 Feb 1.


Injectable Hydrogels for Localized Chemotherapy and Radiotherapy in Brain Tumors.

Puente P, Fettig N, Luderer MJ, Jin A, Shah S, Muz B, Kapoor V, Goddu SM, Salama NN, Tsien C, Thotala D, Shoghi K, Rogers B, Azab AK.

J Pharm Sci. 2018 Mar;107(3):922-933. doi: 10.1016/j.xphs.2017.10.042. Epub 2017 Nov 21.


Impact of concurrent versus adjuvant chemotherapy on the severity and duration of lymphopenia in glioma patients treated with radiation therapy.

Lin AJ, Campian JL, Hui C, Rudra S, Rao YJ, Thotala D, Hallahan D, Huang J.

J Neurooncol. 2018 Jan;136(2):403-411. doi: 10.1007/s11060-017-2668-5. Epub 2017 Nov 16.


Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models.

Dadey DYA, Kapoor V, Hoye K, Khudanyan A, Collins A, Thotala D, Hallahan DE.

Clin Cancer Res. 2017 May 15;23(10):2556-2564. doi: 10.1158/1078-0432.CCR-16-1935. Epub 2016 Nov 4.


Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers.

Kapoor V, Dadey DY, Nguyen K, Wildman SA, Hoye K, Khudanyan A, Bandara N, Rogers BE, Thotala D, Hallahan DE.

J Nucl Med. 2016 Dec;57(12):1991-1997. Epub 2016 Jul 21.


A Hypoxia-Targeted Boron Neutron Capture Therapy Agent for the Treatment of Glioma.

Luderer MJ, Muz B, de la Puente P, Chavalmane S, Kapoor V, Marcelo R, Biswas P, Thotala D, Rogers B, Azab AK.

Pharm Res. 2016 Oct;33(10):2530-9. doi: 10.1007/s11095-016-1977-2. Epub 2016 Jul 11.


Anti-tax interacting protein-1 (TIP-1) monoclonal antibody targets human cancers.

Yan H, Kapoor V, Nguyen K, Akers WJ, Li H, Scott J, Laforest R, Rogers B, Thotala D, Hallahan D.

Oncotarget. 2016 Jul 12;7(28):43352-43362. doi: 10.18632/oncotarget.9713.


The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.

Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE.

Oncotarget. 2016 Jan 12;7(2):2080-92. doi: 10.18632/oncotarget.6712.


A Gamma-Knife-Enabled Mouse Model of Cerebral Single-Hemisphere Delayed Radiation Necrosis.

Jiang X, Yuan L, Engelbach JA, Cates J, Perez-Torres CJ, Gao F, Thotala D, Drzymala RE, Schmidt RE, Rich KM, Hallahan DE, Ackerman JJ, Garbow JR.

PLoS One. 2015 Oct 6;10(10):e0139596. doi: 10.1371/journal.pone.0139596. eCollection 2015.


Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells.

Thotala D, Karvas RM, Engelbach JA, Garbow JR, Hallahan AN, DeWees TA, Laszlo A, Hallahan DE.

Oncotarget. 2015 Oct 27;6(33):35004-22. doi: 10.18632/oncotarget.5253.


Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth.

Zhao DY, Jacobs KM, Hallahan DE, Thotala D.

Mol Cancer Ther. 2015 Oct;14(10):2343-52. doi: 10.1158/1535-7163.MCT-14-1051. Epub 2015 Jul 23.


Stem Cell Transfusion Restores Immune Function in Radiation-Induced Lymphopenic C57BL/6 Mice.

Kapoor V, Khudanyan A, de la Puente P, Campian J, Hallahan DE, Azab AK, Thotala D.

Cancer Res. 2015 Sep 1;75(17):3442-5. doi: 10.1158/0008-5472.CAN-15-1412. Epub 2015 Jun 30.


NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells.

Kotipatruni RP, Ren X, Thotala D, Jaboin JJ.

Oncotarget. 2015 Jul 10;6(19):17594-604.


Toward distinguishing recurrent tumor from radiation necrosis: DWI and MTC in a Gamma Knife--irradiated mouse glioma model.

Perez-Torres CJ, Engelbach JA, Cates J, Thotala D, Yuan L, Schmidt RE, Rich KM, Drzymala RE, Ackerman JJ, Garbow JR.

Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):446-53. doi: 10.1016/j.ijrobp.2014.06.015. Epub 2014 Aug 4.


A GSK-3β inhibitor protects against radiation necrosis in mouse brain.

Jiang X, Perez-Torres CJ, Thotala D, Engelbach JA, Yuan L, Cates J, Gao F, Drzymala RE, Rich KM, Schmidt RE, Ackerman JJ, Hallahan DE, Garbow JR.

Int J Radiat Oncol Biol Phys. 2014 Jul 15;89(4):714-21. doi: 10.1016/j.ijrobp.2014.04.018.


Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines.

Bhave SR, Dadey DY, Karvas RM, Ferraro DJ, Kotipatruni RP, Jaboin JJ, Hallahan AN, Dewees TA, Linkous AG, Hallahan DE, Thotala D.

Front Oncol. 2013 Sep 17;3:236. doi: 10.3389/fonc.2013.00236. eCollection 2013.


Cytosolic phospholipaseA2 inhibition with PLA-695 radiosensitizes tumors in lung cancer animal models.

Thotala D, Craft JM, Ferraro DJ, Kotipatruni RP, Bhave SR, Jaboin JJ, Hallahan DE.

PLoS One. 2013 Jul 19;8(7):e69688. doi: 10.1371/journal.pone.0069688. Print 2013.


Membrane phospholipids, EML4-ALK, and Hsp90 as novel targets in lung cancer treatment.

Laszlo A, Thotala D, Hallahan DE.

Cancer J. 2013 May-Jun;19(3):238-46. doi: 10.1097/PPO.0b013e31829a68eb. Review.


High-throughput identification of putative receptors for cancer-binding peptides using biopanning and microarray analysis.

Ferraro DJ, Bhave SR, Kotipatruni RP, Hunn JC, Wildman SA, Hong C, Dadey DY, Muhoro LK, Jaboin JJ, Thotala D, Hallahan DE.

Integr Biol (Camb). 2013 Feb;5(2):342-50. doi: 10.1039/c2ib20187a.


NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas.

Kotipatruni RP, Ferraro DJ, Ren X, Vanderwaal RP, Thotala DK, Hallahan DE, Jaboin JJ.

Integr Biol (Camb). 2012 Oct;4(10):1185-97.


GSK-3β: A Bifunctional Role in Cell Death Pathways.

Jacobs KM, Bhave SR, Ferraro DJ, Jaboin JJ, Hallahan DE, Thotala D.

Int J Cell Biol. 2012;2012:930710. doi: 10.1155/2012/930710. Epub 2012 May 21.


Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature.

Schleicher SM, Thotala DK, Linkous AG, Hu R, Leahy KM, Yazlovitskaya EM, Hallahan DE.

PLoS One. 2011;6(7):e22182. doi: 10.1371/journal.pone.0022182. Epub 2011 Jul 20.


Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.

Thotala DK, Hallahan DE, Yazlovitskaya EM.

Cell Death Differ. 2012 Mar;19(3):387-96. doi: 10.1038/cdd.2011.94. Epub 2011 Jul 8.


Glycogen synthase kinase 3beta inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons.

Yang ES, Nowsheen S, Wang T, Thotala DK, Xia F.

Neuro Oncol. 2011 May;13(5):459-70. doi: 10.1093/neuonc/nor016. Epub 2011 Mar 11.


GSK-3β inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line.

Dickey A, Schleicher S, Leahy K, Hu R, Hallahan D, Thotala DK.

J Neurooncol. 2011 Aug;104(1):145-53. doi: 10.1007/s11060-010-0491-3. Epub 2010 Dec 16.


A new class of molecular targeted radioprotectors: GSK-3beta inhibitors.

Thotala DK, Geng L, Dickey AK, Hallahan DE, Yazlovitskaya EM.

Int J Radiat Oncol Biol Phys. 2010 Feb 1;76(2):557-65. doi: 10.1016/j.ijrobp.2009.09.024.


Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis.

Thotala D, Chetyrkin S, Hudson B, Hallahan D, Voziyan P, Yazlovitskaya E.

Free Radic Biol Med. 2009 Sep 15;47(6):779-85. doi: 10.1016/j.freeradbiomed.2009.06.020. Epub 2009 Jun 21.


Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation.

Thotala DK, Hallahan DE, Yazlovitskaya EM.

Cancer Res. 2008 Jul 15;68(14):5859-68. doi: 10.1158/0008-5472.CAN-07-6327. Erratum in: Cancer Res. 2008 Oct 1;68(19):8189.


Cytosolic phospholipase A2 regulates viability of irradiated vascular endothelium.

Yazlovitskaya EM, Linkous AG, Thotala DK, Cuneo KC, Hallahan DE.

Cell Death Differ. 2008 Oct;15(10):1641-53. doi: 10.1038/cdd.2008.93. Epub 2008 Jun 20.


Bone marrow X kinase-mediated signal transduction in irradiated vascular endothelium.

Tu T, Thotala D, Geng L, Hallahan DE, Willey CD.

Cancer Res. 2008 Apr 15;68(8):2861-9. doi: 10.1158/0008-5472.CAN-07-5743. Erratum in: Cancer Res. 2008 Oct 1;68(19):8189.


Differential efficacy of combined therapy with radiation and AEE788 in high and low EGFR-expressing androgen-independent prostate tumor models.

Huamani J, Willey C, Thotala D, Niermann KJ, Reyzer M, Leavitt L, Jones C, Fleishcher A, Caprioli R, Hallahan DE, Kim DW.

Int J Radiat Oncol Biol Phys. 2008 May 1;71(1):237-46. doi: 10.1016/j.ijrobp.2007.12.049. Epub 2008 Mar 11.


Role of 16S ribosomal RNA methylations in translation initiation in Escherichia coli.

Das G, Thotala DK, Kapoor S, Karunanithi S, Thakur SS, Singh NS, Varshney U.

EMBO J. 2008 Mar 19;27(6):840-51. doi: 10.1038/emboj.2008.20. Epub 2008 Feb 21.


Lithium treatment prevents neurocognitive deficit resulting from cranial irradiation.

Yazlovitskaya EM, Edwards E, Thotala D, Fu A, Osusky KL, Whetsell WO Jr, Boone B, Shinohara ET, Hallahan DE.

Cancer Res. 2006 Dec 1;66(23):11179-86.


Structure-functional analysis of human immunodeficiency virus type 1 (HIV-1) Vpr: role of leucine residues on Vpr-mediated transactivation and virus replication.

Thotala D, Schafer EA, Tungaturthi PK, Majumder B, Janket ML, Wagner M, Srinivasan A, Watkins S, Ayyavoo V.

Virology. 2004 Oct 10;328(1):89-100. Erratum in: Virology. 2005 Feb 20;332(2):691.


Differential regulation of host cellular genes by HIV-1 viral protein R (Vpr): cDNA microarray analysis using isogenic virus.

Janket ML, Manickam P, Majumder B, Thotala D, Wagner M, Schafer EA, Collman RG, Srinivasan A, Ayyavoo V.

Biochem Biophys Res Commun. 2004 Feb 20;314(4):1126-32.


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