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VarSite: disease variants and protein structure.

Laskowski RA, Stephenson JD, Sillitoe I, Orengo CA, Thornton JM.

Protein Sci. 2019 Oct 13. doi: 10.1002/pro.3746. [Epub ahead of print]


Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster.

Siddiq MA, Thornton JW.

Proc Natl Acad Sci U S A. 2019 Oct 8. pii: 201909216. doi: 10.1073/pnas.1909216116. [Epub ahead of print]


Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor.

Bohm-Levine N, Goldberg AR, Mariani M, Frankfurt M, Thornton J.

Horm Behav. 2019 Oct 5:104590. doi: 10.1016/j.yhbeh.2019.104590. [Epub ahead of print]


Polio returns to the Philippines.

Thornton J.

Lancet. 2019 Oct 5;394(10205):1217. doi: 10.1016/S0140-6736(19)32263-9. No abstract available.


PDBe-KB: a community-driven resource for structural and functional annotations.

PDBe-KB consortium .

Nucleic Acids Res. 2019 Oct 4. pii: gkz853. doi: 10.1093/nar/gkz853. [Epub ahead of print]


N2O5 reactive uptake kinetics and chlorine activation on authentic biomass-burning aerosol.

Goldberger LA, Jahl LG, Thornton JA, Sullivan RC.

Environ Sci Process Impacts. 2019 Oct 3. doi: 10.1039/c9em00330d. [Epub ahead of print]


Multispecialty Opioid Risk Reduction Program Targeting Chronic Pain and Addiction Management in Veterans.

Vaughn IA, Beyth R, Ayers ML, Thornton JE, Tandon R, Gingrich T, Mudra SA.

Fed Pract. 2019 Sep;36(9):406-411.


Molecular identification of organic vapors driving atmospheric nanoparticle growth.

Mohr C, Thornton JA, Heitto A, Lopez-Hilfiker FD, Lutz A, Riipinen I, Hong J, Donahue NM, Hallquist M, Petäjä T, Kulmala M, Yli-Juuti T.

Nat Commun. 2019 Sep 30;10(1):4442. doi: 10.1038/s41467-019-12473-2.


Improving quality of care and outcome at very preterm birth: the Preterm Birth research programme, including the Cord pilot RCT.

Duley L, Dorling J, Ayers S, Oliver S, Yoxall CW, Weeks A, Megone C, Oddie S, Gyte G, Chivers Z, Thornton J, Field D, Sawyer A, McGuire W.

Southampton (UK): NIHR Journals Library; 2019 Sep.


EvoChromo: towards a synthesis of chromatin biology and evolution.

Drinnenberg IA, Berger F, Elsässer SJ, Andersen PR, Ausió J, Bickmore WA, Blackwell AR, Erwin DH, Gahan JM, Gaut BS, Harvey ZH, Henikoff S, Kao JY, Kurdistani SK, Lemos B, Levine MT, Luger K, Malik HS, Martín-Durán JM, Peichel CL, Renfree MB, Rutowicz K, Sarkies P, Schmitz RJ, Technau U, Thornton JW, Warnecke T, Wolfe KH.

Development. 2019 Sep 26;146(19). pii: dev178962. doi: 10.1242/dev.178962.


Polyamine Synthesis Effects Capsule Expression by Reduction of Precursors in Streptococcus pneumoniae.

Ayoola MB, Shack LA, Nakamya MF, Thornton JA, Swiatlo E, Nanduri B.

Front Microbiol. 2019 Aug 29;10:1996. doi: 10.3389/fmicb.2019.01996. eCollection 2019.


Review of external referrals to a regional stroke centre: it is not just about thrombectomy.

Adams NC, Griffin E, Motyer R, Farrell T, Carmody E, O'Shea A, Murphy B, O'Hare A, Looby S, Power S, Brennan P, Doyle KM, Thornton J.

Clin Radiol. 2019 Sep 11. pii: S0009-9260(19)30365-4. doi: 10.1016/j.crad.2019.07.021. [Epub ahead of print]


Acquisition of sensorimotor fMRI under general anaesthesia: Assessment of feasibility, the BOLD response and clinical utility.

Yamamoto AK, Magerkurth J, Mancini L, White MJ, Miserocchi A, McEvoy AW, Appleby I, Micallef C, Thornton JS, Price CJ, Weiskopf N, Yousry TA.

Neuroimage Clin. 2019;23:101923. doi: 10.1016/j.nicl.2019.101923. Epub 2019 Jul 2.


Somatotopic organization of corticospinal/corticobulbar motor tracts in controls and patients with tumours: A combined fMRI-DTI study.

Hazzaa NM, Mancini L, Thornton J, Yousry TA.

Neuroimage Clin. 2019;23:101910. doi: 10.1016/j.nicl.2019.101910. Epub 2019 Jun 26.


Fetal movement awareness raising: more harm than good!

Walker K, Khan K, Thornton J.

BMJ Evid Based Med. 2019 Sep 4. pii: bmjebm-2019-111246. doi: 10.1136/bmjebm-2019-111246. [Epub ahead of print] No abstract available.


Effects of Antenatal Betamethasone on Fetal Doppler Indices and Short Term Fetal Heart Rate Variation in Early Growth Restricted Fetuses.

Fratelli N, Prefumo F, Wolf H, Hecher K, Visser GHA, Giussani D, Derks JB, Shaw CJ, Frusca T, Ghi T, Ferrazzi E, Lees CC; TRUFFLE Group; TRUFFLE Group authors; TRUFFLE Group collaborating authors.

Ultraschall Med. 2019 Sep 2. doi: 10.1055/a-0972-1098. [Epub ahead of print]


Planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): a randomised controlled trial.

Chappell LC, Brocklehurst P, Green ME, Hunter R, Hardy P, Juszczak E, Linsell L, Chiocchia V, Greenland M, Placzek A, Townend J, Marlow N, Sandall J, Shennan A; PHOENIX Study Group.

Lancet. 2019 Sep 28;394(10204):1181-1190. doi: 10.1016/S0140-6736(19)31963-4. Epub 2019 Aug 28.


Reply: Current Basal and Squamous Cell Skin Cancer Management.

Mendez BM, Thornton JF.

Plast Reconstr Surg. 2019 Sep;144(3):521e-522e. doi: 10.1097/PRS.0000000000005976. No abstract available.


Ear Reconstruction after Mohs Cancer Excision: Lessons Learned from 327 Consecutive Cases.

Sanniec K, Harirah M, Thornton JF.

Plast Reconstr Surg. 2019 Sep;144(3):719-729. doi: 10.1097/PRS.0000000000005992.


Palliative care in Tajikistan.

Thornton J.

Lancet. 2019 Aug 24;394(10199):624-626. doi: 10.1016/S0140-6736(19)31968-3. No abstract available.


Most guideline organizations lack explicit guidance in how to incorporate cost considerations.

Sanabria AJ, Kotzeva A, Selva Olid A, Pequeño S, Vernooij RWM, Martínez García L, Zhang Y, Solà I, Thornton J, Alonso-Coello P.

J Clin Epidemiol. 2019 Aug 17;116:72-83. doi: 10.1016/j.jclinepi.2019.08.004. [Epub ahead of print] Review.


Emerging concepts in pseudoenzyme classification, evolution, and signaling.

Ribeiro AJM, Das S, Dawson N, Zaru R, Orchard S, Thornton JM, Orengo C, Zeqiraj E, Murphy JM, Eyers PA.

Sci Signal. 2019 Aug 13;12(594). pii: eaat9797. doi: 10.1126/scisignal.aat9797. Review.


Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1.

Martin-Herranz DE, Aref-Eshghi E, Bonder MJ, Stubbs TM, Choufani S, Weksberg R, Stegle O, Sadikovic B, Reik W, Thornton JM.

Genome Biol. 2019 Aug 14;20(1):146. doi: 10.1186/s13059-019-1753-9.


Skeletal muscle MRI differentiates SBMA and ALS and correlates with disease severity.

Klickovic U, Zampedri L, Sinclair CDJ, Wastling SJ, Trimmel K, Howard RS, Malaspina A, Sharma N, Sidle K, Emira A, Shah S, Yousry TA, Hanna MG, Greensmith L, Morrow JM, Thornton JS, Fratta P.

Neurology. 2019 Aug 27;93(9):e895-e907. doi: 10.1212/WNL.0000000000008009. Epub 2019 Aug 7.


Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial.

Chappell LC, Bell JL, Smith A, Linsell L, Juszczak E, Dixon PH, Chambers J, Hunter R, Dorling J, Williamson C, Thornton JG; PITCHES study group.

Lancet. 2019 Sep 7;394(10201):849-860. doi: 10.1016/S0140-6736(19)31270-X. Epub 2019 Aug 1.


The quantitative neuroradiology initiative framework: application to dementia.

Goodkin O, Pemberton H, Vos SB, Prados F, Sudre CH, Moggridge J, Cardoso MJ, Ourselin S, Bisdas S, White M, Yousry T, Thornton J, Barkhof F.

Br J Radiol. 2019 Sep;92(1101):20190365. doi: 10.1259/bjr.20190365. Epub 2019 Aug 1. Review.


Ear Reconstruction after Mohs Cancer Excision: Lessons Learned from 327 Consecutive Cases.

Sanniec K, Harirah M, Thornton JF.

Plast Reconstr Surg. 2019 Jun 7. doi: 10.1097/PRS.0000000000005992. [Epub ahead of print]


Increasing Isoprene Epoxydiol-to-Inorganic Sulfate Aerosol Ratio Results in Extensive Conversion of Inorganic Sulfate to Organosulfur Forms: Implications for Aerosol Physicochemical Properties.

Riva M, Chen Y, Zhang Y, Lei Z, Olson NE, Boyer HC, Narayan S, Yee LD, Green HS, Cui T, Zhang Z, Baumann K, Fort M, Edgerton E, Budisulistiorini SH, Rose CA, Ribeiro IO, E Oliveira RL, Dos Santos EO, Machado CMD, Szopa S, Zhao Y, Alves EG, de Sá SS, Hu W, Knipping EM, Shaw SL, Duvoisin Junior S, de Souza RAF, Palm BB, Jimenez JL, Glasius M, Goldstein AH, Pye HOT, Gold A, Turpin BJ, Vizuete W, Martin ST, Thornton JA, Dutcher CS, Ault AP, Surratt JD.

Environ Sci Technol. 2019 Aug 6;53(15):8682-8694. doi: 10.1021/acs.est.9b01019. Epub 2019 Jul 23.


A Standardized Aspiration-First Approach for Thrombectomy to Increase Speed and Improve Recanalization Rates.

O'Neill D, Griffin E, Doyle KM, Power S, Brennan P, Sheehan M, O'Hare A, Looby S, da Silva Santos AM, Rossi R, Thornton J.

AJNR Am J Neuroradiol. 2019 Aug;40(8):1335-1341. doi: 10.3174/ajnr.A6117. Epub 2019 Jul 18.


Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy.

Koczo A, Marino A, Jeyabalan A, Elkayam U, Cooper LT, Fett J, Briller J, Hsich E, Blauwet L, McTiernan C, Morel PA, Hanley-Yanez K, McNamara DM; IPAC Investigators.

JACC Basic Transl Sci. 2019 Jun 24;4(3):291-300. doi: 10.1016/j.jacbts.2019.01.010. eCollection 2019 Jun.


Medicaid Expansion May Give Us Room to Breathe.

Thornton JD.

Ann Am Thorac Soc. 2019 Jul;16(7):824-825. doi: 10.1513/AnnalsATS.201903-223ED. No abstract available.


"Doctors need to step up"-why are there still so few medical chief executives in the NHS?

Thornton J.

BMJ. 2019 Jun 25;365:l4341. doi: 10.1136/bmj.l4341. No abstract available.


Deep brain stimulation has state-dependent effects on motor connectivity in Parkinson's disease.

Kahan J, Mancini L, Flandin G, White M, Papadaki A, Thornton J, Yousry T, Zrinzo L, Hariz M, Limousin P, Friston K, Foltynie T.

Brain. 2019 Aug 1;142(8):2417-2431. doi: 10.1093/brain/awz164.


Lack of training in eating disorders is contributing to avoidable deaths, MPs conclude.

Thornton J.

BMJ. 2019 Jun 18;365:l4279. doi: 10.1136/bmj.l4279. No abstract available.


Natural history of limb girdle muscular dystrophy R9 over 6 years: searching for trial endpoints.

Murphy AP, Morrow J, Dahlqvist JR, Stojkovic T, Willis TA, Sinclair CDJ, Wastling S, Yousry T, Hanna MS, James MK, Mayhew A, Eagle M, Lee LE, Hogrel JY, Carlier PG, Thornton JS, Vissing J, Hollingsworth KG, Straub V.

Ann Clin Transl Neurol. 2019 May 16;6(6):1033-1045. doi: 10.1002/acn3.774. eCollection 2019 Jun. Erratum in: Ann Clin Transl Neurol. 2019 Jul;6(7):1358.


Reply to Letter: Current Basal and Squamous Cell Skin Cancer Management.

Mendez BM, Thornton JF.

Plast Reconstr Surg. 2019 Jun 13. doi: 10.1097/PRS.0000000000005976. [Epub ahead of print] No abstract available.


Athlete autonomy, supportive interpersonal environments and clinicians' duty of care; as leaders in sport and sports medicine, the onus is on us: the clinicians.

Thornton JS.

Br J Sports Med. 2019 Jun 13. pii: bjsports-2019-100783. doi: 10.1136/bjsports-2019-100783. [Epub ahead of print] No abstract available.


VarMap: a web tool for mapping genomic coordinates to protein sequence and structure and retrieving protein structural annotations.

Stephenson JD, Laskowski RA, Nightingale A, Hurles ME, Thornton JM.

Bioinformatics. 2019 Jun 13. pii: btz482. doi: 10.1093/bioinformatics/btz482. [Epub ahead of print]


The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis.

Deng L, Spencer BL, Holmes JA, Mu R, Rego S, Weston TA, Hu Y, Sanches GF, Yoon S, Park N, Nagao PE, Jenkinson HF, Thornton JA, Seo KS, Nobbs AH, Doran KS.

PLoS Pathog. 2019 Jun 10;15(6):e1007848. doi: 10.1371/journal.ppat.1007848. eCollection 2019 Jun.


Concordance of Organ Donation and Other Altruistic Behaviors Among Twins.

Huml AM, Thornton JD, Figueroa M, Cain K, Dolata J, Scott K, Sullivan C, Sehgal AR.

Prog Transplant. 2019 Sep;29(3):225-229. doi: 10.1177/1526924819853826. Epub 2019 May 30.


Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies.

Wilson D, Ambler G, Lee KJ, Lim JS, Shiozawa M, Koga M, Li L, Lovelock C, Chabriat H, Hennerici M, Wong YK, Mak HKF, Prats-Sánchez L, Martínez-Domeño A, Inamura S, Yoshifuji K, Arsava EM, Horstmann S, Purrucker J, Lam BYK, Wong A, Kim YD, Song TJ, Schrooten M, Lemmens R, Eppinger S, Gattringer T, Uysal E, Tanriverdi Z, Bornstein NM, Assayag EB, Hallevi H, Tanaka J, Hara H, Coutts SB, Hert L, Polymeris A, Seiffge DJ, Lyrer P, Algra A, Kappelle J, Al-Shahi Salman R, Jäger HR, Lip GYH, Mattle HP, Panos LD, Mas JL, Legrand L, Karayiannis C, Phan T, Gunkel S, Christ N, Abrigo J, Leung T, Chu W, Chappell F, Makin S, Hayden D, Williams DJ, Kooi ME, van Dam-Nolen DHK, Barbato C, Browning S, Wiegertjes K, Tuladhar AM, Maaijwee N, Guevarra C, Yatawara C, Mendyk AM, Delmaire C, Köhler S, van Oostenbrugge R, Zhou Y, Xu C, Hilal S, Gyanwali B, Chen C, Lou M, Staals J, Bordet R, Kandiah N, de Leeuw FE, Simister R, van der Lugt A, Kelly PJ, Wardlaw JM, Soo Y, Fluri F, Srikanth V, Calvet D, Jung S, Kwa VIH, Engelter ST, Peters N, Smith EE, Yakushiji Y, Orken DN, Fazekas F, Thijs V, Heo JH, Mok V, Veltkamp R, Ay H, Imaizumi T, Gomez-Anson B, Lau KK, Jouvent E, Rothwell PM, Toyoda K, Bae HJ, Marti-Fabregas J, Werring DJ; Microbleeds International Collaborative Network.

Lancet Neurol. 2019 Jul;18(7):653-665. doi: 10.1016/S1474-4422(19)30197-8. Epub 2019 May 23. Erratum in: Lancet Neurol. 2019 Sep;18(9):e8.


Cancer screening must be made more convenient to suit busy lifestyles, says NHS report.

Thornton J.

BMJ. 2019 May 24;365:l2344. doi: 10.1136/bmj.l2344. No abstract available.


Comparative analysis of the 2-year outcomes in the GRIT and TRUFFLE trials.

Ganzevoort W, Thornton JG, Marlow N, Thilaganathan B, Arabin B, Prefumo F, Lees C, Wolf H; GRIT study group; TRUFFLE-study group.

Ultrasound Obstet Gynecol. 2019 May 24. doi: 10.1002/uog.20354. [Epub ahead of print]


A quantitative analysis of CT angiography, large vessel occlusion, and thrombectomy rates in acute ischaemic stroke.

Griffin E, Herlihy D, Hayden R, Murphy M, Walsh J, Murphy S, Shanahan J, O'Brien P, Power S, Brennan P, Motyer R, Thornton J.

Clin Radiol. 2019 Sep;74(9):731.e21-731.e25. doi: 10.1016/j.crad.2019.04.014. Epub 2019 May 21.


Government is "losing its grip" of cancer screening services, say MPs.

Thornton J.

BMJ. 2019 May 10;365:l2168. doi: 10.1136/bmj.l2168. No abstract available.


The cost-effectiveness of universal late-pregnancy screening for macrosomia in nulliparous women: a decision analysis.

Wastlund D, Moraitis AA, Thornton JG, Sanders J, White IR, Brocklehurst P, Smith G, Wilson E.

BJOG. 2019 Sep;126(10):1243-1250. doi: 10.1111/1471-0528.15809. Epub 2019 Jun 5.


What's behind reduced child obesity in Leeds?

Thornton J.

BMJ. 2019 May 3;365:l2045. doi: 10.1136/bmj.l2045. No abstract available.


Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.

Cheng S, Park Y, Kurleto JD, Jeon M, Zinn K, Thornton JW, Özkan E.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):9837-9842. doi: 10.1073/pnas.1818631116. Epub 2019 May 1.


A Frenchman in England.

Torre A, Thornton J.

J Gynecol Obstet Hum Reprod. 2019 Sep;48(7):531. doi: 10.1016/j.jogoh.2019.04.010. Epub 2019 Apr 28. No abstract available.


Per-Pass Analysis of Thrombus Composition in Patients With Acute Ischemic Stroke Undergoing Mechanical Thrombectomy.

Duffy S, McCarthy R, Farrell M, Thomas S, Brennan P, Power S, O'Hare A, Morris L, Rainsford E, MacCarthy E, Thornton J, Gilvarry M.

Stroke. 2019 May;50(5):1156-1163. doi: 10.1161/STROKEAHA.118.023419.


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