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Items: 1 to 50 of 134

1.

The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function.

Bancroft AJ, Levy CW, Jowitt TA, Hayes KS, Thompson S, Mckenzie EA, Ball MD, Dubaissi E, France AP, Bellina B, Sharpe C, Mironov A, Brown SL, Cook PC, S MacDonald A, Thornton DJ, Grencis RK.

Nat Commun. 2019 May 28;10(1):2344. doi: 10.1038/s41467-019-09996-z.

2.

A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus.

Fernandez-Petty CM, Hughes GW, Bowers HL, Watson JD, Rosen BH, Townsend SM, Santos C, Ridley CE, Chu KK, Birket SE, Li Y, Leung HM, Mazur M, Garcia BA, Evans TIA, Libby EF, Hathorne H, Hanes J, Tearney GJ, Clancy JP, Engelhardt JF, Swords WE, Thornton DJ, Wiesmann WP, Baker SM, Rowe SM.

JCI Insight. 2019 Apr 18;4(8). pii: 125954. doi: 10.1172/jci.insight.125954. eCollection 2019 Apr 18.

3.

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation.

Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS.

Nat Immunol. 2019 May;20(5):571-580. doi: 10.1038/s41590-019-0352-y. Epub 2019 Apr 1.

PMID:
30936493
4.

Dropping acid: why is cystic fibrosis mucus abnormal?

Rubin BK, Thornton DJ.

Eur Respir J. 2018 Dec 6;52(6). pii: 1802057. doi: 10.1183/13993003.02057-2018. Print 2018 Dec. No abstract available.

PMID:
30523208
5.

Intracellular Processing of Human Secreted Polymeric Airway Mucins.

Thornton DJ, Sharpe C, Ridley C.

Ann Am Thorac Soc. 2018 Nov;15(Supplement_3):S154-S158. doi: 10.1513/AnnalsATS.201802-143AW.

6.

Mucins: the frontline defence of the lung.

Ridley C, Thornton DJ.

Biochem Soc Trans. 2018 Oct 19;46(5):1099-1106. doi: 10.1042/BST20170402. Epub 2018 Aug 28. Review.

7.

Extracellular vesicles induce protective immunity against Trichuris muris.

Shears RK, Bancroft AJ, Hughes GW, Grencis RK, Thornton DJ.

Parasite Immunol. 2018 Jul;40(7):e12536. doi: 10.1111/pim.12536. Epub 2018 May 23.

8.

Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner.

Melo-Gonzalez F, Fenton TM, Forss C, Smedley C, Goenka A, MacDonald AS, Thornton DJ, Travis MA.

J Biol Chem. 2018 Jun 1;293(22):8543-8553. doi: 10.1074/jbc.M117.789305. Epub 2018 Mar 26.

9.

Vaccination Against Whipworm: Identification of Potential Immunogenic Proteins in Trichuris muris Excretory/Secretory Material.

Shears RK, Bancroft AJ, Sharpe C, Grencis RK, Thornton DJ.

Sci Rep. 2018 Mar 14;8(1):4508. doi: 10.1038/s41598-018-22783-y.

10.

Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.

Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC.

J Biol Chem. 2018 Apr 13;293(15):5746-5754. doi: 10.1074/jbc.RA117.001014. Epub 2018 Feb 13.

11.

A sticky end for gastrointestinal helminths; the role of the mucus barrier.

Sharpe C, Thornton DJ, Grencis RK.

Parasite Immunol. 2018 Apr;40(4):e12517. doi: 10.1111/pim.12517. Epub 2018 Mar 4. Review.

12.

A detection and quantification label-free tool to speed up downstream processing of model mucins.

Carvalho SB, Moreira AS, Gomes J, Carrondo MJT, Thornton DJ, Alves PM, Costa J, Peixoto C.

PLoS One. 2018 Jan 9;13(1):e0190974. doi: 10.1371/journal.pone.0190974. eCollection 2018.

13.

Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface.

Dubaissi E, Rousseau K, Hughes GW, Ridley C, Grencis RK, Roberts IS, Thornton DJ.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):726-731. doi: 10.1073/pnas.1713539115. Epub 2018 Jan 8.

14.

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin.

Ermund A, Meiss LN, Rodriguez-Pineiro AM, Bähr A, Nilsson HE, Trillo-Muyo S, Ridley C, Thornton DJ, Wine JJ, Hebert H, Klymiuk N, Hansson GC.

Biochem Biophys Res Commun. 2017 Oct 21;492(3):331-337. doi: 10.1016/j.bbrc.2017.08.113. Epub 2017 Aug 30.

15.

MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma.

Welsh KG, Rousseau K, Fisher G, Bonser LR, Bradding P, Brightling CE, Thornton DJ, Gaillard EA.

Chest. 2017 Oct;152(4):771-779. doi: 10.1016/j.chest.2017.07.001. Epub 2017 Jul 14.

16.

Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion.

Hasnain SZ, Dawson PA, Lourie R, Hutson P, Tong H, Grencis RK, McGuckin MA, Thornton DJ.

PLoS Pathog. 2017 Feb 13;13(2):e1006218. doi: 10.1371/journal.ppat.1006218. eCollection 2017 Feb.

17.

Aspergillosis and the role of mucins in cystic fibrosis.

Cowley AC, Thornton DJ, Denning DW, Horsley A.

Pediatr Pulmonol. 2017 Apr;52(4):548-555. doi: 10.1002/ppul.23618. Epub 2016 Nov 21. Review.

18.

Secondary Structure and Glycosylation of Mucus Glycoproteins by Raman Spectroscopies.

Davies HS, Singh P, Deckert-Gaudig T, Deckert V, Rousseau K, Ridley CE, Dowd SE, Doig AJ, Pudney PD, Thornton DJ, Blanch EW.

Anal Chem. 2016 Dec 6;88(23):11609-11615. Epub 2016 Nov 11.

19.

Biosynthesis of the polymeric gel-forming mucin MUC5B.

Ridley C, Kirkham S, Williamson SJ, Davis CW, Woodman P, Thornton DJ.

Am J Physiol Lung Cell Mol Physiol. 2016 May 15;310(10):L993-L1002. doi: 10.1152/ajplung.00046.2016. Epub 2016 Mar 18.

20.

New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection.

Wang H, Kim JJ, Denou E, Gallagher A, Thornton DJ, Shajib MS, Xia L, Schertzer JD, Grencis RK, Philpott DJ, Khan WI.

Infect Immun. 2015 Nov 2;84(1):275-85. doi: 10.1128/IAI.01187-15. Print 2016 Jan.

21.

Characterization of neopeptides in equine articular cartilage degradation.

Peffers MJ, Thornton DJ, Clegg PD.

J Orthop Res. 2016 Jan;34(1):106-20. doi: 10.1002/jor.22963. Epub 2015 Jul 7.

22.

Reorganisation of the salivary mucin network by dietary components: insights from green tea polyphenols.

Davies HS, Pudney PD, Georgiades P, Waigh TA, Hodson NW, Ridley CE, Blanch EW, Thornton DJ.

PLoS One. 2014 Sep 29;9(9):e108372. doi: 10.1371/journal.pone.0108372. eCollection 2014.

23.

Tea derived galloylated polyphenols cross-link purified gastrointestinal mucins.

Georgiades P, Pudney PD, Rogers S, Thornton DJ, Waigh TA.

PLoS One. 2014 Aug 27;9(8):e105302. doi: 10.1371/journal.pone.0105302. eCollection 2014.

24.

A combined small-angle X-ray and neutron scattering study of the structure of purified soluble gastrointestinal mucins.

Georgiades P, di Cola E, Heenan RK, Pudney PD, Thornton DJ, Waigh TA.

Biopolymers. 2014 Dec;101(12):1154-64. doi: 10.1002/bip.22523.

25.

Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin.

Ridley C, Kouvatsos N, Raynal BD, Howard M, Collins RF, Desseyn JL, Jowitt TA, Baldock C, Davis CW, Hardingham TE, Thornton DJ.

J Biol Chem. 2014 Jun 6;289(23):16409-20. doi: 10.1074/jbc.M114.566679. Epub 2014 Apr 28.

26.

Cystic fibrosis: an inherited disease affecting mucin-producing organs.

Ehre C, Ridley C, Thornton DJ.

Int J Biochem Cell Biol. 2014 Jul;52:136-45. doi: 10.1016/j.biocel.2014.03.011. Epub 2014 Mar 28. Review.

27.

A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis.

Dubaissi E, Rousseau K, Lea R, Soto X, Nardeosingh S, Schweickert A, Amaya E, Thornton DJ, Papalopulu N.

Development. 2014 Apr;141(7):1514-25. doi: 10.1242/dev.102426. Epub 2014 Mar 5.

28.

Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.

Horsley A, Rousseau K, Ridley C, Flight W, Jones A, Waigh TA, Thornton DJ.

J Cyst Fibros. 2014 May;13(3):260-6. doi: 10.1016/j.jcf.2013.11.002. Epub 2013 Dec 12.

29.

Muc5b is required for airway defence.

Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM.

Nature. 2014 Jan 16;505(7483):412-6. doi: 10.1038/nature12807. Epub 2013 Dec 8.

30.

Particle tracking microrheology of purified gastrointestinal mucins.

Georgiades P, Pudney PD, Thornton DJ, Waigh TA.

Biopolymers. 2014 Apr;101(4):366-77. doi: 10.1002/bip.22372.

31.

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures.

Bell PA, Wagener R, Zaucke F, Koch M, Selley J, Warwood S, Knight D, Boot-Handford RP, Thornton DJ, Briggs MD.

Biol Open. 2013 Jun 18;2(8):802-11. doi: 10.1242/bio.20135280. eCollection 2013 Aug 15.

32.

The expression of mucin genes and the presence of mucin gene products in the equine endometrium.

Maischberger E, Cummins CA, Fitzpatrick E, Gallagher ME, Worrall S, Rousseau K, Thornton DJ, Meijer WG, Miranda-Casoluengo R, Duggan VE, Carrington SD, Irwin JA, Reid CJ.

Res Vet Sci. 2013 Aug;95(1):169-75. doi: 10.1016/j.rvsc.2013.03.012. Epub 2013 Apr 11.

PMID:
23583093
33.

TGF-β₂ decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells.

Harrop CA, Gore RB, Evans CM, Thornton DJ, Herrick SE.

Exp Lung Res. 2013 Feb;39(1):39-47. doi: 10.3109/01902148.2012.748854. Epub 2012 Dec 18.

PMID:
23249391
34.

A new role for mucins in immunity: insights from gastrointestinal nematode infection.

Hasnain SZ, Gallagher AL, Grencis RK, Thornton DJ.

Int J Biochem Cell Biol. 2013 Feb;45(2):364-74. doi: 10.1016/j.biocel.2012.10.011. Epub 2012 Oct 27. Review.

PMID:
23107603
35.

Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier.

Hasnain SZ, McGuckin MA, Grencis RK, Thornton DJ.

PLoS Negl Trop Dis. 2012;6(10):e1856. doi: 10.1371/journal.pntd.0001856. Epub 2012 Oct 11.

36.

Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates.

Farnell E, Rousseau K, Thornton DJ, Bowyer P, Herrick SE.

Fungal Biol. 2012 Sep;116(9):1003-12. doi: 10.1016/j.funbio.2012.07.004. Epub 2012 Jul 20.

37.

Desulfurization of mucin by Pseudomonas aeruginosa: influence of sulfate in the lungs of cystic fibrosis patients.

Robinson CV, Elkins MR, Bialkowski KM, Thornton DJ, Kertesz MA.

J Med Microbiol. 2012 Dec;61(Pt 12):1644-53. doi: 10.1099/jmm.0.047167-0. Epub 2012 Aug 23.

PMID:
22918866
38.

Detecting, visualising, and quantifying mucins.

Harrop CA, Thornton DJ, McGuckin MA.

Methods Mol Biol. 2012;842:49-66. doi: 10.1007/978-1-61779-513-8_3.

PMID:
22259129
39.

Gel-forming and cell-associated mucins: preparation for structural and functional studies.

Davies JR, Wickström C, Thornton DJ.

Methods Mol Biol. 2012;842:27-47. doi: 10.1007/978-1-61779-513-8_2.

PMID:
22259128
40.

Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation.

Bell PA, Piróg KA, Fresquet M, Thornton DJ, Boot-Handford RP, Briggs MD.

Arthritis Rheum. 2012 May;64(5):1529-39. doi: 10.1002/art.33486.

41.

Electronic memorandum decreases unnecessary antimicrobial use for asymptomatic bacteriuria and culture-negative pyuria.

Linares LA, Thornton DJ, Strymish J, Baker E, Gupta K.

Infect Control Hosp Epidemiol. 2011 Jul;32(7):644-8. doi: 10.1086/660764.

PMID:
21666393
42.

Muc5b is the major polymeric mucin in mucus from thoroughbred horses with and without airway mucus accumulation.

Rousseau K, Cardwell JM, Humphrey E, Newton R, Knight D, Clegg P, Thornton DJ.

PLoS One. 2011;6(5):e19678. doi: 10.1371/journal.pone.0019678. Epub 2011 May 13.

43.

Muc5ac: a critical component mediating the rejection of enteric nematodes.

Hasnain SZ, Evans CM, Roy M, Gallagher AL, Kindrachuk KN, Barron L, Dickey BF, Wilson MS, Wynn TA, Grencis RK, Thornton DJ.

J Exp Med. 2011 May 9;208(5):893-900. doi: 10.1084/jem.20102057. Epub 2011 Apr 18.

44.

Changes in the mucosal barrier during acute and chronic Trichuris muris infection.

Hasnain SZ, Thornton DJ, Grencis RK.

Parasite Immunol. 2011 Jan;33(1):45-55. doi: 10.1111/j.1365-3024.2010.01258.x.

45.

Nerves are living structures whose injury requires urgent repair.

Kay SP, Wiberg M, Thornton DJ.

J Plast Reconstr Aesthet Surg. 2010 Dec;63(12):1939-40. doi: 10.1016/j.bjps.2010.05.014. No abstract available.

PMID:
21095601
46.

An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia.

Nundlall S, Rajpar MH, Bell PA, Clowes C, Zeeff LA, Gardner B, Thornton DJ, Boot-Handford RP, Briggs MD.

Cell Stress Chaperones. 2010 Nov;15(6):835-49. doi: 10.1007/s12192-010-0193-y. Epub 2010 Apr 30.

47.

Autologous augmentation-mastopexy after bariatric surgery: waste not want not!

Thornton DJ, Fourie le R.

Aesthetic Plast Surg. 2010 Aug;34(4):519-24. doi: 10.1007/s00266-010-9479-9. Epub 2010 Mar 13.

PMID:
20229112
48.

Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection.

Hasnain SZ, Wang H, Ghia JE, Haq N, Deng Y, Velcich A, Grencis RK, Thornton DJ, Khan WI.

Gastroenterology. 2010 May;138(5):1763-71. doi: 10.1053/j.gastro.2010.01.045. Epub 2010 Feb 4.

49.

Targeted induction of endoplasmic reticulum stress induces cartilage pathology.

Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, Heeran M, Thornton DJ, Wilson R, Bateman JF, Poulsom R, Arvan P, Kadler KE, Briggs MD, Boot-Handford RP.

PLoS Genet. 2009 Oct;5(10):e1000691. doi: 10.1371/journal.pgen.1000691. Epub 2009 Oct 16.

50.

Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii.

Kesimer M, Kiliç N, Mehrotra R, Thornton DJ, Sheehan JK.

BMC Microbiol. 2009 Aug 11;9:163. doi: 10.1186/1471-2180-9-163.

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