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Diffusion Mapping of Eosinophil-Activation State.

Piasecka J, Thornton CA, Rees P, Summers HD.

Cytometry A. 2019 Aug 31. doi: 10.1002/cyto.a.23884. [Epub ahead of print]


Label-Free Identification of White Blood Cells Using Machine Learning.

Nassar M, Doan M, Filby A, Wolkenhauer O, Fogg DK, Piasecka J, Thornton CA, Carpenter AE, Summers HD, Rees P, Hennig H.

Cytometry A. 2019 Aug;95(8):836-842. doi: 10.1002/cyto.a.23794. Epub 2019 May 13.


Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation.

Jones N, Vincent EE, Cronin JG, Panetti S, Chambers M, Holm SR, Owens SE, Francis NJ, Finlay DK, Thornton CA.

Nat Commun. 2019 May 3;10(1):2042. doi: 10.1038/s41467-019-10023-4.


Maternal Serum, an Isolation and Expansion Tool for Umbilical Cord Matrix Mesenchymal Stromal Cells.

Davies LB, Jones RH, Thornton CA.

Tissue Eng Part C Methods. 2019 Apr;25(4):213-221. doi: 10.1089/ten.TEC.2019.0008.


Mechanical shear stress and leukocyte phenotype and function: Implications for ventricular assist device development and use.

Radley G, Ali S, Pieper IL, Thornton CA.

Int J Artif Organs. 2019 Mar;42(3):133-142. doi: 10.1177/0391398818817326. Epub 2018 Dec 26. Review.


Artificial shear stress effects on leukocytes at a biomaterial interface.

Radley G, Laura Pieper I, Thomas BR, Hawkins K, Thornton CA.

Artif Organs. 2019 Jul;43(7):E139-E151. doi: 10.1111/aor.13409. Epub 2019 Jan 8.


The Inflammatory Response to Ventricular Assist Devices.

Radley G, Pieper IL, Ali S, Bhatti F, Thornton CA.

Front Immunol. 2018 Nov 15;9:2651. doi: 10.3389/fimmu.2018.02651. eCollection 2018. Review.


Evaluation of Sterilisation Techniques for Regenerative Medicine Scaffolds Fabricated with Polyurethane Nonbiodegradable and Bioabsorbable Nanocomposite Materials.

Griffin M, Naderi N, Kalaskar DM, Malins E, Becer R, Thornton CA, Whitaker IS, Mosahebi A, Butler PEM, Seifalian AM.

Int J Biomater. 2018 Oct 3;2018:6565783. doi: 10.1155/2018/6565783. eCollection 2018.


A high-throughput serum Raman spectroscopy platform and methodology for colorectal cancer diagnostics.

Jenkins CA, Jenkins RA, Pryse MM, Welsby KA, Jitsumura M, Thornton CA, Dunstan PR, Harris DA.

Analyst. 2018 Dec 3;143(24):6014-6024. doi: 10.1039/c8an01323c.


Investigating FlowSight® imaging flow cytometry as a platform to assess chemically induced micronuclei using human lymphoblastoid cells in vitro.

Verma JR, Harte DSG, Shah UK, Summers H, Thornton CA, Doak SH, Jenkins GJS, Rees P, Wills JW, Johnson GE.

Mutagenesis. 2018 Oct 11;33(4):283-289. doi: 10.1093/mutage/gey021.


Author response: High frequency of gastrointestinal manifestations in myotonic dystrophy type 1 and type 2.

Hilbert JE, Thornton CA, Moxley RT 3rd.

Neurology. 2018 Apr 24;90(17):814. doi: 10.1212/WNL.0000000000005370. No abstract available.


Intron retention induced by microsatellite expansions as a disease biomarker.

Sznajder ŁJ, Thomas JD, Carrell EM, Reid T, McFarland KN, Cleary JD, Oliveira R, Nutter CA, Bhatt K, Sobczak K, Ashizawa T, Thornton CA, Ranum LPW, Swanson MS.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4234-4239. doi: 10.1073/pnas.1716617115. Epub 2018 Apr 2.


Design of Bivalent Nucleic Acid Ligands for Recognition of RNA-Repeated Expansion Associated with Huntington's Disease.

Thadke SA, Perera JDR, Hridya VM, Bhatt K, Shaikh AY, Hsieh WC, Chen M, Gayathri C, Gil RR, Rule GS, Mukherjee A, Thornton CA, Ly DH.

Biochemistry. 2018 Apr 10;57(14):2094-2108. doi: 10.1021/acs.biochem.8b00062. Epub 2018 Mar 27.


Ovine Leukocyte Microparticles Generated by the CentriMag Ventricular Assist Device In Vitro.

Pieper IL, Radley G, Christen A, Ali S, Bodger O, Thornton CA.

Artif Organs. 2018 Jun;42(6):E78-E89. doi: 10.1111/aor.13068. Epub 2018 Mar 7.


Metabolic Adaptation of Human CD4+ and CD8+ T-Cells to T-Cell Receptor-Mediated Stimulation.

Jones N, Cronin JG, Dolton G, Panetti S, Schauenburg AJ, Galloway SAE, Sewell AK, Cole DK, Thornton CA, Francis NJ.

Front Immunol. 2017 Nov 9;8:1516. doi: 10.3389/fimmu.2017.01516. eCollection 2017.


Detection of expanded RNA repeats using thermostable group II intron reverse transcriptase.

Carrell ST, Tang Z, Mohr S, Lambowitz AM, Thornton CA.

Nucleic Acids Res. 2018 Jan 9;46(1):e1. doi: 10.1093/nar/gkx867.


Expression and function of NOD-like receptors by human term gestation-associated tissues.

Bryant AH, Bevan RJ, Spencer-Harty S, Scott LM, Jones RH, Thornton CA.

Placenta. 2017 Oct;58:25-32. doi: 10.1016/j.placenta.2017.07.017. Epub 2017 Aug 2.


The effect of ventricular assist device-associated biomaterials on human blood leukocytes.

Radley G, Pieper IL, Thornton CA.

J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):1730-1738. doi: 10.1002/jbm.b.33981. Epub 2017 Sep 9.


High frequency of gastrointestinal manifestations in myotonic dystrophy type 1 and type 2.

Hilbert JE, Barohn RJ, Clemens PR, Luebbe EA, Martens WB, McDermott MP, Parkhill AL, Tawil R, Thornton CA, Moxley RT 3rd; National Registry Scientific Advisory Committee/Investigators.

Neurology. 2017 Sep 26;89(13):1348-1354. doi: 10.1212/WNL.0000000000004420. Epub 2017 Aug 30.


Shear Stress-Induced Total Blood Trauma in Multiple Species.

Chan CHH, Pieper IL, Robinson CR, Friedmann Y, Kanamarlapudi V, Thornton CA.

Artif Organs. 2017 Oct;41(10):934-947. doi: 10.1111/aor.12932. Epub 2017 Jul 26.


Production and regulation of interleukin-1 family cytokines at the materno-fetal interface.

Scott LM, Bryant AH, Rees A, Down B, Jones RH, Thornton CA.

Cytokine. 2017 Nov;99:194-202. doi: 10.1016/j.cyto.2017.07.005. Epub 2017 Jul 13.


Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 Mice.

Jauvin D, Chrétien J, Pandey SK, Martineau L, Revillod L, Bassez G, Lachon A, MacLeod AR, Gourdon G, Wheeler TM, Thornton CA, Bennett CF, Puymirat J.

Mol Ther Nucleic Acids. 2017 Jun 16;7:465-474. doi: 10.1016/j.omtn.2017.05.007. Epub 2017 May 17.


Myotonic dystrophy: approach to therapy.

Thornton CA, Wang E, Carrell EM.

Curr Opin Genet Dev. 2017 Jun;44:135-140. doi: 10.1016/j.gde.2017.03.007. Epub 2017 Apr 1. Review.


Human gestation-associated tissues express functional cytosolic nucleic acid sensing pattern recognition receptors.

Bryant AH, Menzies GE, Scott LM, Spencer-Harty S, Davies LB, Smith RA, Jones RH, Thornton CA.

Clin Exp Immunol. 2017 Jul;189(1):36-46. doi: 10.1111/cei.12960. Epub 2017 Mar 31.


Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice.

Al-Himdani S, Jessop ZM, Al-Sabah A, Combellack E, Ibrahim A, Doak SH, Hart AM, Archer CW, Thornton CA, Whitaker IS.

Front Surg. 2017 Feb 23;4:4. doi: 10.3389/fsurg.2017.00004. eCollection 2017. Review.


Isolation of Mesenchymal Stromal Cells From Peripheral Blood of ST Elevation Myocardial Infarction Patients.

Pieper IL, Smith R, Bishop JC, Aldalati O, Chase AJ, Morgan G, Thornton CA.

Artif Organs. 2017 Jul;41(7):654-666. doi: 10.1111/aor.12829. Epub 2017 Feb 28.


Interleukin 4 and interleukin 13 downregulate the lipopolysaccharide-mediated inflammatory response by human gestation-associated tissues.

Bryant AH, Spencer-Harty S, Owens SE, Jones RH, Thornton CA.

Biol Reprod. 2017 Mar 1;96(3):576-586. doi: 10.1095/biolreprod.116.145680. Epub 2017 Jan 27.


Development of an in vitro PIG-A gene mutation assay in human cells.

Rees BJ, Tate M, Lynch AM, Thornton CA, Jenkins GJ, Walmsley RM, Johnson GE.

Mutagenesis. 2017 Mar 1;32(2):283-297. doi: 10.1093/mutage/gew059.


Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells.

Verma JR, Rees BJ, Wilde EC, Thornton CA, Jenkins GJS, Doak SH, Johnson GE.

Arch Toxicol. 2017 Jul;91(7):2689-2698. doi: 10.1007/s00204-016-1903-8. Epub 2016 Dec 10.


A Trajectory toward Allergy: In Utero Uptake of Allergens Can Prime Type 2 Inflammation.

Thornton CA, Marsland BJ.

Am J Respir Crit Care Med. 2016 Oct 15;194(8):919-920. No abstract available.


Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy.

Wagner SD, Struck AJ, Gupta R, Farnsworth DR, Mahady AE, Eichinger K, Thornton CA, Wang ET, Berglund JA.

PLoS Genet. 2016 Sep 28;12(9):e1006316. doi: 10.1371/journal.pgen.1006316. eCollection 2016 Sep.


Dmpk gene deletion or antisense knockdown does not compromise cardiac or skeletal muscle function in mice.

Carrell ST, Carrell EM, Auerbach D, Pandey SK, Bennett CF, Dirksen RT, Thornton CA.

Hum Mol Genet. 2016 Oct 1;25(19):4328-4338. doi: 10.1093/hmg/ddw266. Epub 2016 Aug 13.


Quantification methods for human and large animal leukocytes using DNA dyes by flow cytometry.

Pieper IL, Radley G, Chan CH, Friedmann Y, Foster G, Thornton CA.

Cytometry A. 2016 Jun;89(6):565-74. doi: 10.1002/cyto.a.22874. Epub 2016 Jun 6. Erratum in: Cytometry A. 2017 Aug;91(8):830.


Immune biomarkers in the spectrum of childhood noncommunicable diseases.

Skevaki C, Van den Berg J, Jones N, Garssen J, Vuillermin P, Levin M, Landay A, Renz H, Calder PC, Thornton CA.

J Allergy Clin Immunol. 2016 May;137(5):1302-16. doi: 10.1016/j.jaci.2016.03.012. Review.


Signal transducer and activator of transcription-3 licenses Toll-like receptor 4-dependent interleukin (IL)-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.

Cronin JG, Kanamarlapudi V, Thornton CA, Sheldon IM.

Mucosal Immunol. 2016 Sep;9(5):1125-36. doi: 10.1038/mi.2015.131. Epub 2016 Jan 27.


Identification and characterization of modified antisense oligonucleotides targeting DMPK in mice and nonhuman primates for the treatment of myotonic dystrophy type 1.

Pandey SK, Wheeler TM, Justice SL, Kim A, Younis HS, Gattis D, Jauvin D, Puymirat J, Swayze EE, Freier SM, Bennett CF, Thornton CA, MacLeod AR.

J Pharmacol Exp Ther. 2015 Nov;355(2):329-40. doi: 10.1124/jpet.115.226969. Epub 2015 Sep 1.


Functional activity but not gene expression of toll-like receptors is decreased in the preterm versus term human placenta.

Patni S, Bryant AH, Wynen LP, Seager AL, Morgan G, Thornton CA.

Placenta. 2015 Sep;36(9):1031-8. doi: 10.1016/j.placenta.2015.06.017. Epub 2015 Jul 11.


Bioenergetic analysis of human peripheral blood mononuclear cells.

Jones N, Piasecka J, Bryant AH, Jones RH, Skibinski DO, Francis NJ, Thornton CA.

Clin Exp Immunol. 2015 Oct;182(1):69-80. doi: 10.1111/cei.12662. Epub 2015 Jul 24.


Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy.

Campbell DE, Boyle RJ, Thornton CA, Prescott SL.

Clin Exp Allergy. 2015 May;45(5):844-858. doi: 10.1111/cea.12531. Review.


Short antisense-locked nucleic acids (all-LNAs) correct alternative splicing abnormalities in myotonic dystrophy.

Wojtkowiak-Szlachcic A, Taylor K, Stepniak-Konieczna E, Sznajder LJ, Mykowska A, Sroka J, Thornton CA, Sobczak K.

Nucleic Acids Res. 2015 Mar 31;43(6):3318-31. doi: 10.1093/nar/gkv163. Epub 2015 Mar 9.


TWEAK/Fn14, a pathway and novel therapeutic target in myotonic dystrophy.

Yadava RS, Foff EP, Yu Q, Gladman JT, Kim YK, Bhatt KS, Thornton CA, Zheng TS, Mahadevan MS.

Hum Mol Genet. 2015 Apr 1;24(7):2035-48. doi: 10.1093/hmg/ddu617. Epub 2014 Dec 11.


Adipogenic differentiation of adipose-derived stem cells in 3-dimensional spheroid cultures (microtissue): implications for the reconstructive surgeon.

Naderi N, Wilde C, Haque T, Francis W, Seifalian AM, Thornton CA, Xia Z, Whitaker IS.

J Plast Reconstr Aesthet Surg. 2014 Dec;67(12):1726-34. doi: 10.1016/j.bjps.2014.08.013. Epub 2014 Aug 15.


Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease.

Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn DJ, Goodwin M, Zhang C, Sobczak K, Thornton CA, Swanson MS.

Mol Cell. 2014 Oct 23;56(2):311-322. doi: 10.1016/j.molcel.2014.08.027. Epub 2014 Sep 25.


The effect of shear stress on the size, structure, and function of human von Willebrand factor.

Chan CH, Pieper IL, Fleming S, Friedmann Y, Foster G, Hawkins K, Thornton CA, Kanamarlapudi V.

Artif Organs. 2014 Sep;38(9):741-50. doi: 10.1111/aor.12382.


The CentriMag centrifugal blood pump as a benchmark for in vitro testing of hemocompatibility in implantable ventricular assist devices.

Chan CH, Pieper IL, Hambly R, Radley G, Jones A, Friedmann Y, Hawkins KM, Westaby S, Foster G, Thornton CA.

Artif Organs. 2015 Feb;39(2):93-101. doi: 10.1111/aor.12351. Epub 2014 Jul 28.


Myotonic dystrophy.

Thornton CA.

Neurol Clin. 2014 Aug;32(3):705-19, viii. doi: 10.1016/j.ncl.2014.04.011. Epub 2014 Jun 6. Review.


Probiotics in the prevention of eczema: a randomised controlled trial.

Allen SJ, Jordan S, Storey M, Thornton CA, Gravenor MB, Garaiova I, Plummer SF, Wang D, Morgan G.

Arch Dis Child. 2014 Nov;99(11):1014-9. doi: 10.1136/archdischild-2013-305799. Epub 2014 Jun 19.


Lomofungin and dilomofungin: inhibitors of MBNL1-CUG RNA binding with distinct cellular effects.

Hoskins JW, Ofori LO, Chen CZ, Kumar A, Sobczak K, Nakamori M, Southall N, Patnaik S, Marugan JJ, Zheng W, Austin CP, Disney MD, Miller BL, Thornton CA.

Nucleic Acids Res. 2014 Jun;42(10):6591-602. doi: 10.1093/nar/gku275. Epub 2014 May 5.


Detection of slipped-DNAs at the trinucleotide repeats of the myotonic dystrophy type I disease locus in patient tissues.

Axford MM, Wang YH, Nakamori M, Zannis-Hadjopoulos M, Thornton CA, Pearson CE.

PLoS Genet. 2013;9(12):e1003866. doi: 10.1371/journal.pgen.1003866. Epub 2013 Dec 19.

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