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Helios: Still Behind the Clouds.

Thornton AM, Shevach EM.

Immunology. 2019 Sep 13. doi: 10.1111/imm.13115. [Epub ahead of print] Review.


Selective deletion of Eos (Ikzf4) in T-regulatory cells leads to loss of suppressive function and development of systemic autoimmunity.

Gokhale AS, Gangaplara A, Lopez-Occasio M, Thornton AM, Shevach EM.

J Autoimmun. 2019 Jul 8:102300. doi: 10.1016/j.jaut.2019.06.011. [Epub ahead of print]


Helios Deficiency Predisposes the Differentiation of CD4+Foxp3- T Cells into Peripherally Derived Regulatory T Cells.

Skadow M, Penna VR, Galant-Swafford J, Shevach EM, Thornton AM.

J Immunol. 2019 Jul 15;203(2):370-378. doi: 10.4049/jimmunol.1900388. Epub 2019 Jun 5.


Overview and Preparation Guide for Academic Careers in Pediatric Pharmacy, Part 1: Career as a Pediatric Pharmacy Practice Faculty Member.

Siu A, Blackmer AB, Thornton AM, Johnson PN, Nichols KR, Hagemann TM.

J Pediatr Pharmacol Ther. 2019 Mar-Apr;24(2):79-89. doi: 10.5863/1551-6776-24.2.79. Review.


Helios+ and Helios- Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.

Thornton AM, Lu J, Korty PE, Kim YC, Martens C, Sun PD, Shevach EM.

Eur J Immunol. 2019 Mar;49(3):398-412. doi: 10.1002/eji.201847935. Epub 2019 Jan 15.


IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation.

Park SM, Cho H, Thornton AM, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Taggart J, Chow A, Schurer A, Gruet A, Witkin MD, Kim JH, Shevach EM, Krivtsov A, Armstrong SA, Leslie C, Kharas MG.

Cell Stem Cell. 2019 Jan 3;24(1):153-165.e7. doi: 10.1016/j.stem.2018.10.016. Epub 2018 Nov 21.


Tregs, Helios and tumor immunity: the sun has not yet risen.

Thornton AM, Shevach EM.

Transl Cancer Res. 2016 Oct;5(Suppl 4):S672-S674. doi: 10.21037/tcr.2016.10.47. No abstract available.


NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.

Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF.

Nature. 2016 Mar 10;531(7593):253-7. doi: 10.1038/nature16969. Epub 2016 Mar 2.


Helios Controls a Limited Subset of Regulatory T Cell Functions.

Sebastian M, Lopez-Ocasio M, Metidji A, Rieder SA, Shevach EM, Thornton AM.

J Immunol. 2016 Jan 1;196(1):144-55. doi: 10.4049/jimmunol.1501704. Epub 2015 Nov 18.


Current concepts in vulvodynia with a focus on pathogenesis and pain mechanisms.

Thornton AM, Drummond C.

Australas J Dermatol. 2016 Nov;57(4):253-263. doi: 10.1111/ajd.12365. Epub 2015 Jul 6. Review.


Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells.

Rieder SA, Metidji A, Glass DD, Thornton AM, Ikeda T, Morgan BA, Shevach EM.

J Immunol. 2015 Jul 15;195(2):553-63. doi: 10.4049/jimmunol.1500627. Epub 2015 Jun 10.


Inherited predisposition to breast cancer among African American women.

Churpek JE, Walsh T, Zheng Y, Moton Z, Thornton AM, Lee MK, Casadei S, Watts A, Neistadt B, Churpek MM, Huo D, Zvosec C, Liu F, Niu Q, Marquez R, Zhang J, Fackenthal J, King MC, Olopade OI.

Breast Cancer Res Treat. 2015 Jan;149(1):31-9. doi: 10.1007/s10549-014-3195-0. Epub 2014 Nov 27.


Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8.

Edwards JP, Thornton AM, Shevach EM.

J Immunol. 2014 Sep 15;193(6):2843-9. doi: 10.4049/jimmunol.1401102. Epub 2014 Aug 15.


An unexpected case of pellagra.

Thornton AM, Drummond CJ.

Med J Aust. 2014 May 19;200(9):546-8. No abstract available.


tTregs, pTregs, and iTregs: similarities and differences.

Shevach EM, Thornton AM.

Immunol Rev. 2014 May;259(1):88-102. doi: 10.1111/imr.12160. Review.


Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network.

Gulsuner S, Walsh T, Watts AC, Lee MK, Thornton AM, Casadei S, Rippey C, Shahin H; Consortium on the Genetics of Schizophrenia (COGS); PAARTNERS Study Group, Nimgaonkar VL, Go RC, Savage RM, Swerdlow NR, Gur RE, Braff DL, King MC, McClellan JM.

Cell. 2013 Aug 1;154(3):518-29. doi: 10.1016/j.cell.2013.06.049.


Modulation of Treg cells/T effector function by GITR signaling is context-dependent.

Ephrem A, Epstein AL, Stephens GL, Thornton AM, Glass D, Shevach EM.

Eur J Immunol. 2013 Sep;43(9):2421-9. doi: 10.1002/eji.201343451. Epub 2013 Jul 3.


Characteristics of women with ovarian carcinoma who have BRCA1 and BRCA2 mutations not identified by clinical testing.

Norquist BM, Pennington KP, Agnew KJ, Harrell MI, Pennil CC, Lee MK, Casadei S, Thornton AM, Garcia RL, Walsh T, Swisher EM.

Gynecol Oncol. 2013 Mar;128(3):483-7. doi: 10.1016/j.ygyno.2012.12.015. Epub 2012 Dec 19.


ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing.

Pritchard CC, Smith C, Salipante SJ, Lee MK, Thornton AM, Nord AS, Gulden C, Kupfer SS, Swisher EM, Bennett RL, Novetsky AP, Jarvik GP, Olopade OI, Goodfellow PJ, King MC, Tait JF, Walsh T.

J Mol Diagn. 2012 Jul;14(4):357-66. doi: 10.1016/j.jmoldx.2012.03.002. Epub 2012 May 30.


Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.

Kim YC, Bhairavabhotla R, Yoon J, Golding A, Thornton AM, Tran DQ, Shevach EM.

Blood. 2012 Mar 22;119(12):2810-8. doi: 10.1182/blood-2011-09-377895. Epub 2012 Jan 31.


Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.

Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King MC, Swisher EM.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18032-7. doi: 10.1073/pnas.1115052108. Epub 2011 Oct 17.


The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells.

Zhao Y, Thornton AM, Kinney MC, Ma CA, Spinner JJ, Fuss IJ, Shevach EM, Jain A.

J Biol Chem. 2011 Nov 25;286(47):40520-30. doi: 10.1074/jbc.M111.292961. Epub 2011 Sep 19.


A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease.

Killebrew JR, Perdue N, Kwan A, Thornton AM, Shevach EM, Campbell DJ.

J Immunol. 2011 Jul 15;187(2):861-9. doi: 10.4049/jimmunol.1004009. Epub 2011 Jun 20.


Store-operated Ca(2+) entry (SOCE) contributes to normal skeletal muscle contractility in young but not in aged skeletal muscle.

Thornton AM, Zhao X, Weisleder N, Brotto LS, Bougoin S, Nosek TM, Reid M, Hardin B, Pan Z, Ma J, Parness J, Brotto M.

Aging (Albany NY). 2011 Jun;3(6):621-34.


Mutations in the DBP-deficiency protein HSD17B4 cause ovarian dysgenesis, hearing loss, and ataxia of Perrault Syndrome.

Pierce SB, Walsh T, Chisholm KM, Lee MK, Thornton AM, Fiumara A, Opitz JM, Levy-Lahad E, Klevit RE, King MC.

Am J Hum Genet. 2010 Aug 13;87(2):282-8. doi: 10.1016/j.ajhg.2010.07.007. Epub 2010 Jul 30.


Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing.

Walsh T, Lee MK, Casadei S, Thornton AM, Stray SM, Pennil C, Nord AS, Mandell JB, Swisher EM, King MC.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12629-33. doi: 10.1073/pnas.1007983107. Epub 2010 Jun 28.


Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82.

Walsh T, Shahin H, Elkan-Miller T, Lee MK, Thornton AM, Roeb W, Abu Rayyan A, Loulus S, Avraham KB, King MC, Kanaan M.

Am J Hum Genet. 2010 Jul 9;87(1):90-4. doi: 10.1016/j.ajhg.2010.05.010. Epub 2010 Jun 17.


Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells.

Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y, Shevach EM.

J Immunol. 2010 Apr 1;184(7):3433-41. doi: 10.4049/jimmunol.0904028. Epub 2010 Feb 24.


CD4+CD25+ T regulatory cells limit effector T cells and favor the progression of brucellosis in BALB/c mice.

Pasquali P, Thornton AM, Vendetti S, Pistoia C, Petrucci P, Tarantino M, Pesciaroli M, Ruggeri F, Battistoni A, Shevach EM.

Microbes Infect. 2010 Jan;12(1):3-10. doi: 10.1016/j.micinf.2009.09.005. Epub 2009 Sep 17.


Combating Non-nucleoside Reverse Transcriptase Inhibitor Resistance with a Focus On Etravirine (Intelence) for HIV-1 Infection.

Eraikhuemen N, Thornton AM, Branch E, Huynh ST, Farley C.

P T. 2008 Aug;33(8):445-91. No abstract available.


CD25high T cells with a prolonged survival inhibit development of diabetes.

Yan Y, Xiong Z, Zhang S, Song J, Huang Y, Thornton AM, Wang H, Yang XF.

Int J Immunopathol Pharmacol. 2008 Oct-Dec;21(4):767-80.


Proliferative assays for T cell function.

Kruisbeek AM, Shevach E, Thornton AM.

Curr Protoc Immunol. 2004 May;Chapter 3:Unit 3.12. doi: 10.1002/0471142735.im0312s60. Review.


Fractionation of T and B cells using magnetic beads.

Thornton AM.

Curr Protoc Immunol. 2003 Nov;Chapter 3:Unit 3.5A. doi: 10.1002/0471142735.im0305as57.


Cutting edge: CD4 T cell-mast cell interactions alter IgE receptor expression and signaling.

Kashyap M, Thornton AM, Norton SK, Barnstein B, Macey M, Brenzovich J, Shevach E, Leonard WJ, Ryan JJ.

J Immunol. 2008 Feb 15;180(4):2039-43.


Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome.

Adriani M, Aoki J, Horai R, Thornton AM, Konno A, Kirby M, Anderson SM, Siegel RM, Candotti F, Schwartzberg PL.

Clin Immunol. 2007 Jul;124(1):41-8. Epub 2007 May 18.


CD4+ CD25+ [corrected] regulatory T cells render naive CD4+ CD25- T cells anergic and suppressive.

Qiao M, Thornton AM, Shevach EM.

Immunology. 2007 Apr;120(4):447-55. Epub 2007 Jan 17. Erratum in: Immunology. 2007 May;121(1):146.


The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cells.

Shevach EM, DiPaolo RA, Andersson J, Zhao DM, Stephens GL, Thornton AM.

Immunol Rev. 2006 Aug;212:60-73. Review.


Activated CD4+CD25+ T cells selectively kill B lymphocytes.

Zhao DM, Thornton AM, DiPaolo RJ, Shevach EM.

Blood. 2006 May 15;107(10):3925-32. Epub 2006 Jan 17.


Signal transduction in CD4+CD25+ regulatory T cells: CD25 and IL-2.

Thornton AM.

Front Biosci. 2006 Jan 1;11:921-7. Review.


T regulatory cells.

Thornton AM.

Curr Biol. 2005 Aug 9;15(15):R582. Review. No abstract available.


Subtractive cloning: new genes for studying inflammatory disorders.

Rebrikov D, Desai S, Kogan YN, Thornton AM, Diatchenko L.

Ann Periodontol. 2002 Dec;7(1):17-28. Review.


Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells.

Piccirillo CA, Thornton AM.

Trends Immunol. 2004 Jul;25(7):374-80. Review. No abstract available.


Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function.

Thornton AM, Donovan EE, Piccirillo CA, Shevach EM.

J Immunol. 2004 Jun 1;172(11):6519-23.


Activation requirements for the induction of CD4+CD25+ T cell suppressor function.

Thornton AM, Piccirillo CA, Shevach EM.

Eur J Immunol. 2004 Feb;34(2):366-76.


Control of T cell activation by CD4+CD25+ suppressor T cells.

Shevach EM, Piccirillo CA, Thornton AM, McHugh RS.

Novartis Found Symp. 2003;252:24-36; discussion 36-44, 106-14. Review.


CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness.

Piccirillo CA, Letterio JJ, Thornton AM, McHugh RS, Mamura M, Mizuhara H, Shevach EM.

J Exp Med. 2002 Jul 15;196(2):237-46.


Control of T-cell activation by CD4+ CD25+ suppressor T cells.

Shevach EM, McHugh RS, Piccirillo CA, Thornton AM.

Immunol Rev. 2001 Aug;182:58-67. Review.


Control of organ-specific autoimmunity by immunoregulatory CD4(+)CD25(+) T cells.

McHugh RS, Shevach EM, Thornton AM.

Microbes Infect. 2001 Sep;3(11):919-27. Review.


Control of autoimmunity by regulatory T cells.

Shevach EM, McHugh RS, Thornton AM, Piccirillo C, Natarajan K, Margulies DH.

Adv Exp Med Biol. 2001;490:21-32. Review. No abstract available.


An IFN regulatory factor-2 DNA-binding domain dominant negative mutant exhibits altered cell growth and gene expression.

Rubinstein YR, Driggers PH, Ogryzko VV, Thornton AM, Ozato K, Pontzer CH.

Oncogene. 2000 Mar 9;19(11):1411-8.

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