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Items: 28

1.

The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans.

Thorneloe KS, Sepp A, Zhang S, Galinanes-Garcia L, Galette P, Al-Azzam W, Vugts DJ, van Dongen G, Elsinga P, Wiegers J, Glaudemans AWJM, Vincent V, Renaux J, Szapacs M, Birchler M, Cleveland M, Bergstrom M, Davies M.

EJNMMI Res. 2019 May 21;9(1):45. doi: 10.1186/s13550-019-0514-9.

2.

PROPERTIES OF THE TRPV4 AGONIST GSK1016790A AND the TRPV4 ANTAGONIST GSK2193874.

Thorneloe KS, Cheung M, Holt DA, Willette RN.

Physiol Rev. 2017 Oct 1;97(4):1231-1232. doi: 10.1152/physrev.00019.2017. No abstract available.

3.

Development of Focal Segmental Glomerulosclerosis Patient-Reported Outcome Measures: Symptom Diary and Symptom Impact Questionnaire.

Mathias SD, Vallow S, Gipson DS, Thorneloe KS, Sprecher D.

Am J Kidney Dis. 2017 Oct;70(4):532-540. doi: 10.1053/j.ajkd.2017.04.023. Epub 2017 Jun 26.

PMID:
28663063
4.

Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4.

Cheung M, Bao W, Behm DJ, Brooks CA, Bury MJ, Dowdell SE, Eidam HS, Fox RM, Goodman KB, Holt DA, Lee D, Roethke TJ, Willette RN, Xu X, Ye G, Thorneloe KS.

ACS Med Chem Lett. 2017 Mar 20;8(5):549-554. doi: 10.1021/acsmedchemlett.7b00094. eCollection 2017 May 11.

5.

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.

Balakrishna S, Song W, Achanta S, Doran SF, Liu B, Kaelberer MM, Yu Z, Sui A, Cheung M, Leishman E, Eidam HS, Ye G, Willette RN, Thorneloe KS, Bradshaw HB, Matalon S, Jordt SE.

Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15;307(2):L158-72. doi: 10.1152/ajplung.00065.2014. Epub 2014 May 16.

6.

Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema.

Hilfiker MA, Hoang TH, Cornil J, Eidam HS, Matasic DS, Roethke TJ, Klein M, Thorneloe KS, Cheung M.

ACS Med Chem Lett. 2013 Jan 27;4(2):293-6. doi: 10.1021/ml300449k. eCollection 2013 Feb 14.

7.

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.

Thorneloe KS, Cheung M, Bao W, Alsaid H, Lenhard S, Jian MY, Costell M, Maniscalco-Hauk K, Krawiec JA, Olzinski A, Gordon E, Lozinskaya I, Elefante L, Qin P, Matasic DS, James C, Tunstead J, Donovan B, Kallal L, Waszkiewicz A, Vaidya K, Davenport EA, Larkin J, Burgert M, Casillas LN, Marquis RW, Ye G, Eidam HS, Goodman KB, Toomey JR, Roethke TJ, Jucker BM, Schnackenberg CG, Townsley MI, Lepore JJ, Willette RN.

Sci Transl Med. 2012 Nov 7;4(159):159ra148. doi: 10.1126/scitranslmed.3004276.

8.

A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice.

Huh D, Leslie DC, Matthews BD, Fraser JP, Jurek S, Hamilton GA, Thorneloe KS, McAlexander MA, Ingber DE.

Sci Transl Med. 2012 Nov 7;4(159):159ra147. doi: 10.1126/scitranslmed.3004249. Erratum in: Sci Transl Med. 2018 Jul 11;10(449):.

9.

Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.

Clouse AK, Jugus MJ, Eisennagel SH, Laping NJ, Westfall TD, Thorneloe KS.

Urology. 2012 Jun;79(6):1410.e1-6. doi: 10.1016/j.urology.2012.02.016. Epub 2012 Apr 11.

PMID:
22497980
10.

Enhanced sensitivity to afferent stimulation and impact of overactive bladder therapies in the conscious, spontaneously hypertensive rat.

Patra PB, Thorneloe KS.

J Pharmacol Exp Ther. 2011 Jul;338(1):392-9. doi: 10.1124/jpet.111.180885. Epub 2011 Apr 26.

PMID:
21521774
11.

Ion Channels as Therapeutic Targets--CHI's Fourth Annual Conference.

Thorneloe KS.

IDrugs. 2010 Jan;13(1):16-9.

PMID:
20024841
12.

Effect of estrogen and progesterone on urodynamics in the conscious rat.

Patra PB, Thorneloe KS, Laping NJ.

Urology. 2009 Aug;74(2):463-6. doi: 10.1016/j.urology.2008.12.046. Epub 2009 Jul 2.

PMID:
19573897
13.

Dual modulation of urinary bladder activity and urine flow by prostanoid EP3 receptors in the conscious rat.

Jugus MJ, Jaworski JP, Patra PB, Jin J, Morrow DM, Laping NJ, Edwards RM, Thorneloe KS.

Br J Pharmacol. 2009 Sep;158(1):372-81. doi: 10.1111/j.1476-5381.2009.00275.x. Epub 2009 May 22.

14.

Functional TRPV4 channels and an absence of capsaicin-evoked currents in freshly-isolated, guinea-pig urothelial cells.

Xu X, Gordon E, Lin Z, Lozinskaya IM, Chen Y, Thorneloe KS.

Channels (Austin). 2009 May-Jun;3(3):156-60. Epub 2009 May 24.

PMID:
19411839
15.

Urodynamic measurements by radiotelemetry in conscious, freely moving beagle dogs.

McCafferty GP, Coatney RW, Laping NJ, Thorneloe KS.

J Urol. 2009 Mar;181(3):1444-51. doi: 10.1016/j.juro.2008.10.137. Epub 2009 Jan 20.

PMID:
19157444
16.

The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction.

Ritter AM, Martin WJ, Thorneloe KS.

Neurosci Lett. 2009 Mar 6;452(1):28-32. doi: 10.1016/j.neulet.2008.12.051. Epub 2009 Jan 6.

PMID:
19146922
17.

Enhanced bladder capacity and reduced prostaglandin E2-mediated bladder hyperactivity in EP3 receptor knockout mice.

McCafferty GP, Misajet BA, Laping NJ, Edwards RM, Thorneloe KS.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F507-14. doi: 10.1152/ajprenal.00054.2008. Epub 2008 May 28.

18.

N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I.

Thorneloe KS, Sulpizio AC, Lin Z, Figueroa DJ, Clouse AK, McCafferty GP, Chendrimada TP, Lashinger ES, Gordon E, Evans L, Misajet BA, Demarini DJ, Nation JH, Casillas LN, Marquis RW, Votta BJ, Sheardown SA, Xu X, Brooks DP, Laping NJ, Westfall TD.

J Pharmacol Exp Ther. 2008 Aug;326(2):432-42. doi: 10.1124/jpet.108.139295. Epub 2008 May 22. Erratum in: J Pharmacol Exp Ther. 2011 Jul;338(1):410.

PMID:
18499743
19.

Small-conductance, Ca(2+) -activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder.

Thorneloe KS, Knorn AM, Doetsch PE, Lashinger ES, Liu AX, Bond CT, Adelman JP, Nelson MT.

Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1737-43. doi: 10.1152/ajpregu.00840.2006. Epub 2008 Mar 19.

20.

Ion channels in smooth muscle: regulators of intracellular calcium and contractility.

Thorneloe KS, Nelson MT.

Can J Physiol Pharmacol. 2005 Mar;83(3):215-42. Review.

PMID:
15870837
21.

Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder.

Thorneloe KS, Meredith AL, Knorn AM, Aldrich RW, Nelson MT.

Am J Physiol Renal Physiol. 2005 Sep;289(3):F604-10. Epub 2005 Apr 12.

22.

Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel.

Meredith AL, Thorneloe KS, Werner ME, Nelson MT, Aldrich RW.

J Biol Chem. 2004 Aug 27;279(35):36746-52. Epub 2004 Jun 7.

23.

Properties of a tonically active, sodium-permeable current in mouse urinary bladder smooth muscle.

Thorneloe KS, Nelson MT.

Am J Physiol Cell Physiol. 2004 Jun;286(6):C1246-57. Epub 2004 Jan 21.

24.

Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current.

Thorneloe KS, Nelson MT.

J Physiol. 2003 May 15;549(Pt 1):65-74. Epub 2003 Apr 4.

25.

Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B.

Thorneloe KS, Maruyama Y, Malcolm AT, Light PE, Walsh MP, Cole WC.

J Physiol. 2002 May 15;541(Pt 1):65-80.

26.

Heteromultimeric Kv1.2-Kv1.5 channels underlie 4-aminopyridine-sensitive delayed rectifier K(+) current of rabbit vascular myocytes.

Kerr PM, Clément-Chomienne O, Thorneloe KS, Chen TT, Ishii K, Sontag DP, Walsh MP, Cole WC.

Circ Res. 2001 Nov 23;89(11):1038-44.

PMID:
11717161
27.

Molecular composition of 4-aminopyridine-sensitive voltage-gated K(+) channels of vascular smooth muscle.

Thorneloe KS, Chen TT, Kerr PM, Grier EF, Horowitz B, Cole WC, Walsh MP.

Circ Res. 2001 Nov 23;89(11):1030-7.

PMID:
11717160
28.

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