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Items: 1 to 50 of 88

1.

Activation of Pyroptotic Cell Death Pathways in Cancer: An Alternative Therapeutic Approach.

Nagarajan K, Soundarapandian K, Thorne RF, Li D, Li D.

Transl Oncol. 2019 May 11;12(7):925-931. doi: 10.1016/j.tranon.2019.04.010. [Epub ahead of print] Review.

2.

FAT1 cadherin controls neuritogenesis during NTera2 cell differentiation.

Ahmed AF, de Bock CE, Sontag E, Hondermarck H, Lincz LF, Thorne RF.

Biochem Biophys Res Commun. 2019 May 7. pii: S0006-291X(19)30856-3. doi: 10.1016/j.bbrc.2019.04.197. [Epub ahead of print]

PMID:
31076104
3.

TP53LNC-DB, the database of lncRNAs in the p53 signalling network.

Khan MR, Bukhari I, Khan R, Hussain HMJ, Wu M, Thorne RF, Li J, Liu G.

Database (Oxford). 2019 Jan 1;2019. doi: 10.1093/database/bay136.

4.

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development.

de Bock CE, Down M, Baidya K, Sweron B, Boyd AW, Fiers M, Burns GF, Molloy TJ, Lock RB, Soulier J, Taghon T, Van Vlierberghe P, Cools J, Holst J, Thorne RF.

Haematologica. 2019 May;104(5):e204-e207. doi: 10.3324/haematol.2018.198424. Epub 2018 Dec 4. No abstract available.

5.

Dual functions for OVAAL in initiation of RAF/MEK/ERK prosurvival signals and evasion of p27-mediated cellular senescence.

Sang B, Zhang YY, Guo ST, Kong LF, Cheng Q, Liu GZ, Thorne RF, Zhang XD, Jin L, Wu M.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11661-E11670. doi: 10.1073/pnas.1805950115. Epub 2018 Nov 26.

6.

Promoter Methylation-Regulated miR-145-5p Inhibits Laryngeal Squamous Cell Carcinoma Progression by Targeting FSCN1.

Gao W, Zhang C, Li W, Li H, Sang J, Zhao Q, Bo Y, Luo H, Zheng X, Lu Y, Shi Y, Yang D, Zhang R, Li Z, Cui J, Zhang Y, Niu M, Li J, Wu Z, Guo H, Xiang C, Wang J, Hou J, Zhang L, Thorne RF, Cui Y, Wu Y, Wen S, Wang B.

Mol Ther. 2019 Feb 6;27(2):365-379. doi: 10.1016/j.ymthe.2018.09.018. Epub 2018 Sep 27.

7.

A p53-Responsive miRNA Network Promotes Cancer Cell Quiescence.

La T, Liu GZ, Farrelly M, Cole N, Feng YC, Zhang YY, Sherwin SK, Yari H, Tabatabaee H, Yan XG, Guo ST, Liu T, Thorne RF, Jin L, Zhang XD.

Cancer Res. 2018 Dec 1;78(23):6666-6679. doi: 10.1158/0008-5472.CAN-18-1886. Epub 2018 Oct 9.

PMID:
30301840
8.

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor.

Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS.

Nat Commun. 2018 Jul 9;9(1):2372. doi: 10.1038/s41467-018-04590-1.

9.

The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung.

Gao F, Griffin N, Faulkner S, Rowe CW, Williams L, Roselli S, Thorne RF, Ferdoushi A, Jobling P, Walker MM, Hondermarck H.

Sci Rep. 2018 May 25;8(1):8135. doi: 10.1038/s41598-018-26408-2.

10.

ACTN4 regulates the stability of RIPK1 in melanoma.

Zhang YY, Tabataba H, Liu XY, Wang JY, Yan XG, Farrelly M, Jiang CC, Guo ST, Liu T, Kao HY, Thorne RF, Zhang XD, Jin L.

Oncogene. 2018 Jul;37(29):4033-4045. doi: 10.1038/s41388-018-0260-x. Epub 2018 Apr 30.

PMID:
29706658
11.

Strategies for enumeration of circulating microvesicles on a conventional flow cytometer: Counting beads and scatter parameters.

Alkhatatbeh MJ, Enjeti AK, Baqar S, Ekinci EI, Liu D, Thorne RF, Lincz LF.

J Circ Biomark. 2018 Apr 5;7:1849454418766966. doi: 10.1177/1849454418766966. eCollection 2018 Jan-Dec.

12.

GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability.

Hu WL, Jin L, Xu A, Wang YF, Thorne RF, Zhang XD, Wu M.

Nat Cell Biol. 2018 Apr;20(4):492-502. doi: 10.1038/s41556-018-0066-7. Epub 2018 Mar 28.

PMID:
29593331
13.

LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect.

Xiang S, Gu H, Jin L, Thorne RF, Zhang XD, Wu M.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1465-E1474. doi: 10.1073/pnas.1711257115. Epub 2018 Jan 29.

14.

BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma.

Liu F, Jiang CC, Yan XG, Tseng HY, Wang CY, Zhang YY, Yari H, La T, Farrelly M, Guo ST, Thorne RF, Jin L, Wang Q, Zhang XD.

Oncotarget. 2017 May 9;8(41):69477-69492. doi: 10.18632/oncotarget.17704. eCollection 2017 Sep 19.

15.

Neurotrophin Receptors TrkA, p75NTR, and Sortilin Are Increased and Targetable in Thyroid Cancer.

Faulkner S, Jobling P, Rowe CW, Rodrigues Oliveira SM, Roselli S, Thorne RF, Oldmeadow C, Attia J, Jiang CC, Zhang XD, Walker MM, Hondermarck H.

Am J Pathol. 2018 Jan;188(1):229-241. doi: 10.1016/j.ajpath.2017.09.008. Epub 2017 Oct 14.

PMID:
29037860
16.

Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress.

Wang JY, Liu GZ, Wilmott JS, La T, Feng YC, Yari H, Yan XG, Thorne RF, Scolyer RA, Zhang XD, Jin L.

Cancer Res. 2017 Nov 15;77(22):6226-6239. doi: 10.1158/0008-5472.CAN-17-1965. Epub 2017 Sep 25.

17.

MicroRNA-645 is an oncogenic regulator in colon cancer.

Guo ST, Guo XY, Wang J, Wang CY, Yang RH, Wang FH, Li XY, Hondermarck H, Thorne RF, Wang YF, Jin L, Zhang XD, Jiang CC.

Oncogenesis. 2017 May 15;6(5):e335. doi: 10.1038/oncsis.2017.37.

18.

Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.

de Bock CE, Hughes MR, Snyder K, Alley S, Sadeqzadeh E, Dun MD, McNagny KM, Molloy TJ, Hondermarck H, Thorne RF.

FEBS Lett. 2017 Feb;591(4):667-678. doi: 10.1002/1873-3468.12569. Epub 2017 Feb 16.

19.

Bio-maleimide-stained plasma microparticles can be purified in a native state and target human proximal tubular HK2 cells.

Alkhatatbeh MJ, Lincz LF, Thorne RF.

Biomed Rep. 2017 Jan;6(1):63-68. doi: 10.3892/br.2016.806. Epub 2016 Nov 9.

20.

Cell biology: A mitochondrial brake on vascular repair.

de Bock CE, Thorne RF.

Nature. 2016 Nov 24;539(7630):503-505. doi: 10.1038/nature20476. Epub 2016 Nov 9. No abstract available.

PMID:
27828945
21.
22.

Circulating CD36+ microparticles are not altered by docosahexaenoic or eicosapentaenoic acid supplementation.

Phang M, Thorne RF, Alkhatatbeh MJ, Garg ML, Lincz LF.

Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):254-60. doi: 10.1016/j.numecd.2015.12.003. Epub 2015 Dec 18.

PMID:
26803595
23.

INPP4B is an oncogenic regulator in human colon cancer.

Guo ST, Chi MN, Yang RH, Guo XY, Zan LK, Wang CY, Xi YF, Jin L, Croft A, Tseng HY, Yan XG, Farrelly M, Wang FH, Lai F, Wang JF, Li YP, Ackland S, Scott R, Agoulnik IU, Hondermarck H, Thorne RF, Liu T, Zhang XD, Jiang CC.

Oncogene. 2016 Jun 9;35(23):3049-61. doi: 10.1038/onc.2015.361. Epub 2015 Sep 28.

24.

FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation.

Ahmed AF, de Bock CE, Lincz LF, Pundavela J, Zouikr I, Sontag E, Hondermarck H, Thorne RF.

Cell Mol Life Sci. 2015 Dec;72(23):4653-69. doi: 10.1007/s00018-015-1955-6. Epub 2015 Jun 24.

PMID:
26104008
25.

Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer.

Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, Forbes JF, Bradshaw RA, Walker MM, Jobling P, Hondermarck H.

Mol Oncol. 2015 Oct;9(8):1626-35. doi: 10.1016/j.molonc.2015.05.001. Epub 2015 May 14.

26.

Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity.

Zouikr I, Ahmed AF, Horvat JC, Beagley KW, Clifton VL, Ray A, Thorne RF, Jarnicki AG, Hansbro PM, Hodgson DM.

Brain Behav Immun. 2015 Feb;44:235-46. doi: 10.1016/j.bbi.2014.10.014. Epub 2014 Oct 31.

PMID:
25449583
27.

ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer.

Pundavela J, Demont Y, Jobling P, Lincz LF, Roselli S, Thorne RF, Bond D, Bradshaw RA, Walker MM, Hondermarck H.

Am J Pathol. 2014 Dec;184(12):3156-62. doi: 10.1016/j.ajpath.2014.08.009. Epub 2014 Oct 5.

PMID:
25285721
28.

Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma.

Oliveira CS, de Bock CE, Molloy TJ, Sadeqzadeh E, Geng XY, Hersey P, Zhang XD, Thorne RF.

BMC Cancer. 2014 Aug 29;14:630. doi: 10.1186/1471-2407-14-630.

29.

FAT1 cadherin is multiply phosphorylated on its ectodomain but phosphorylation is not catalysed by the four-jointed homologue.

Sadeqzadeh E, de Bock CE, O'Donnell MR, Timofeeva A, Burns GF, Thorne RF.

FEBS Lett. 2014 Sep 17;588(18):3511-7. doi: 10.1016/j.febslet.2014.08.014. Epub 2014 Aug 19.

30.
31.

A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding.

Wojtalewicz N, Sadeqzadeh E, Weiß JV, Tehrani MM, Klein-Scory S, Hahn S, Schmiegel W, Warnken U, Schnölzer M, de Bock CE, Thorne RF, Schwarte-Waldhoff I.

PLoS One. 2014 Mar 13;9(3):e90461. doi: 10.1371/journal.pone.0090461. eCollection 2014.

32.

Furin processing dictates ectodomain shedding of human FAT1 cadherin.

Sadeqzadeh E, de Bock CE, Wojtalewicz N, Holt JE, Smith ND, Dun MD, Schwarte-Waldhoff I, Thorne RF.

Exp Cell Res. 2014 Apr 15;323(1):41-55. doi: 10.1016/j.yexcr.2014.02.012. Epub 2014 Feb 18.

PMID:
24560745
33.

Sleeping giants: emerging roles for the fat cadherins in health and disease.

Sadeqzadeh E, de Bock CE, Thorne RF.

Med Res Rev. 2014 Jan;34(1):190-221. doi: 10.1002/med.21286. Epub 2013 May 29. Review.

PMID:
23720094
34.

PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma.

Ye Y, Jin L, Wilmott JS, Hu WL, Yosufi B, Thorne RF, Liu T, Rizos H, Yan XG, Dong L, Tay KH, Tseng HY, Guo ST, de Bock CE, Jiang CC, Wang CY, Wu M, Zhang LJ, Hersey P, Scolyer RA, Zhang XD.

Nat Commun. 2013;4:1508. doi: 10.1038/ncomms2489.

35.

Fat1 cadherin provides a novel minimal residual disease marker in acute lymphoblastic leukemia.

Ardjmand A, de Bock CE, Shahrokhi S, Lincz LF, Boyd AW, Burns GF, Thorne RF.

Hematology. 2013 Nov;18(6):315-22. doi: 10.1179/1607845413Y.0000000080. Epub 2013 Feb 20.

PMID:
23433465
36.

The origin of circulating CD36 in type 2 diabetes.

Alkhatatbeh MJ, Enjeti AK, Acharya S, Thorne RF, Lincz LF.

Nutr Diabetes. 2013 Feb 4;3:e59. doi: 10.1038/nutd.2013.1.

37.

Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress.

Tay KH, Jin L, Tseng HY, Jiang CC, Ye Y, Thorne RF, Liu T, Guo ST, Verrills NM, Hersey P, Zhang XD.

Cell Death Dis. 2012 Jun 28;3:e337. doi: 10.1038/cddis.2012.79.

38.

MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer.

Guo ST, Jiang CC, Wang GP, Li YP, Wang CY, Guo XY, Yang RH, Feng Y, Wang FH, Tseng HY, Thorne RF, Jin L, Zhang XD.

Oncogene. 2013 Apr 11;32(15):1910-20. doi: 10.1038/onc.2012.214. Epub 2012 Jun 18.

39.

The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia.

de Bock CE, Ardjmand A, Molloy TJ, Bone SM, Johnstone D, Campbell DM, Shipman KL, Yeadon TM, Holst J, Spanevello MD, Nelmes G, Catchpoole DR, Lincz LF, Boyd AW, Burns GF, Thorne RF.

Leukemia. 2012 May;26(5):918-26. doi: 10.1038/leu.2011.319. Epub 2011 Nov 25.

PMID:
22116550
40.

Altholactone induces apoptotic cell death in human colorectal cancer cells.

Mhaidat NM, Abdul-Razzak KK, Alkofahi AS, Alsarhan AM, Aldaher AN, Thorne RF.

Phytother Res. 2012 Jun;26(6):926-31. doi: 10.1002/ptr.3666. Epub 2011 Nov 22.

PMID:
22105918
41.

MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma.

Jin L, Hu WL, Jiang CC, Wang JX, Han CC, Chu P, Zhang LJ, Thorne RF, Wilmott J, Scolyer RA, Hersey P, Zhang XD, Wu M.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15840-5. doi: 10.1073/pnas.1019312108. Epub 2011 Sep 6.

42.

Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products.

Sadeqzadeh E, de Bock CE, Zhang XD, Shipman KL, Scott NM, Song C, Yeadon T, Oliveira CS, Jin B, Hersey P, Boyd AW, Burns GF, Thorne RF.

J Biol Chem. 2011 Aug 12;286(32):28181-91. doi: 10.1074/jbc.M111.234419. Epub 2011 Jun 16.

43.

Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress.

Dong L, Jiang CC, Thorne RF, Croft A, Yang F, Liu H, de Bock CE, Hersey P, Zhang XD.

Oncogene. 2011 Aug 25;30(34):3716-26. doi: 10.1038/onc.2011.87. Epub 2011 Mar 21.

44.

Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS.

Jiang CC, Lai F, Tay KH, Croft A, Rizos H, Becker TM, Yang F, Liu H, Thorne RF, Hersey P, Zhang XD.

Cell Death Dis. 2010 Sep 2;1:e69. doi: 10.1038/cddis.2010.48.

45.

The putative diabetic plasma marker, soluble CD36, is non-cleaved, non-soluble and entirely associated with microparticles.

Alkhatatbeh MJ, Mhaidat NM, Enjeti AK, Lincz LF, Thorne RF.

J Thromb Haemost. 2011 Apr;9(4):844-51. doi: 10.1111/j.1538-7836.2011.04220.x.

46.

Contrasting effects of nutlin-3 on TRAIL- and docetaxel-induced apoptosis due to upregulation of TRAIL-R2 and Mcl-1 in human melanoma cells.

Tseng HY, Jiang CC, Croft A, Tay KH, Thorne RF, Yang F, Liu H, Hersey P, Zhang XD.

Mol Cancer Ther. 2010 Dec;9(12):3363-74. doi: 10.1158/1535-7163.MCT-10-0646.

47.

MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720.

Jiang CC, Lai F, Thorne RF, Yang F, Liu H, Hersey P, Zhang XD.

Clin Cancer Res. 2011 Feb 15;17(4):721-30. doi: 10.1158/1078-0432.CCR-10-2225. Epub 2010 Nov 18.

48.

Palmitoylation of CD36/FAT regulates the rate of its post-transcriptional processing in the endoplasmic reticulum.

Thorne RF, Ralston KJ, de Bock CE, Mhaidat NM, Zhang XD, Boyd AW, Burns GF.

Biochim Biophys Acta. 2010 Nov;1803(11):1298-307. doi: 10.1016/j.bbamcr.2010.07.002. Epub 2010 Jul 13.

49.

TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.

Mao ZG, Jiang CC, Yang F, Thorne RF, Hersey P, Zhang XD.

Apoptosis. 2010 Oct;15(10):1211-22. doi: 10.1007/s10495-010-0513-9.

PMID:
20514521
50.

Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells.

Yang F, Tay KH, Dong L, Thorne RF, Jiang CC, Yang E, Tseng HY, Liu H, Christopherson R, Hersey P, Zhang XD.

Cell Death Differ. 2010 Aug;17(8):1354-67. doi: 10.1038/cdd.2010.29. Epub 2010 Mar 19.

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