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Promoter Methylation-Regulated miR-145-5p Inhibits Laryngeal Squamous Cell Carcinoma Progression by Targeting FSCN1.

Gao W, Zhang C, Li W, Li H, Sang J, Zhao Q, Bo Y, Luo H, Zheng X, Lu Y, Shi Y, Yang D, Zhang R, Li Z, Cui J, Zhang Y, Niu M, Li J, Wu Z, Guo H, Xiang C, Wang J, Hou J, Zhang L, Thorne RF, Cui Y, Wu Y, Wen S, Wang B.

Mol Ther. 2018 Sep 27. pii: S1525-0016(18)30459-3. doi: 10.1016/j.ymthe.2018.09.018. [Epub ahead of print]


A p53-responsive microRNA network promotes cancer cell quiescence.

La T, Liu GZ, Farrelly M, Cole N, Feng YC, Zhang YY, Sherwin SK, Yari H, Tabatabaee H, Yan XG, Guo ST, Liu T, Thorne RF, Jin L, Zhang XD.

Cancer Res. 2018 Oct 9. pii: canres.1886.2018. doi: 10.1158/0008-5472.CAN-18-1886. [Epub ahead of print]


Passive Immunotherapies for Central Nervous System Disorders: Current Delivery Challenges and New Approaches.

Kumar NN, Pizzo ME, Nehra G, Wilken-Resman B, Boroumand S, Thorne RG.

Bioconjug Chem. 2018 Oct 24. doi: 10.1021/acs.bioconjchem.8b00548. [Epub ahead of print]


Translating advice to eat more vegetables into practice: observations from a 12-month weight loss trial.

O'Shea J, Tapsell L, Thorne R, Probst Y.

Eur J Clin Nutr. 2018 Aug 13. doi: 10.1038/s41430-018-0277-9. [Epub ahead of print]


Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery.

Kumar NN, Lochhead JJ, Pizzo ME, Nehra G, Boroumand S, Greene G, Thorne RG.

J Control Release. 2018 Sep 28;286:467-484. doi: 10.1016/j.jconrel.2018.08.006. Epub 2018 Aug 4.


Assembly and activation of the Hippo signalome by FAT1 tumor suppressor.

Martin D, Degese MS, Vitale-Cross L, Iglesias-Bartolome R, Valera JLC, Wang Z, Feng X, Yeerna H, Vadmal V, Moroishi T, Thorne RF, Zaida M, Siegele B, Cheong SC, Molinolo AA, Samuels Y, Tamayo P, Guan KL, Lippman SM, Lyons JG, Gutkind JS.

Nat Commun. 2018 Jul 9;9(1):2372. doi: 10.1038/s41467-018-04590-1.


The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung.

Gao F, Griffin N, Faulkner S, Rowe CW, Williams L, Roselli S, Thorne RF, Ferdoushi A, Jobling P, Walker MM, Hondermarck H.

Sci Rep. 2018 May 25;8(1):8135. doi: 10.1038/s41598-018-26408-2.


Density and electron density of aqueous cryoprotectant solutions at cryogenic temperatures for optimized cryoprotection and diffraction contrast.

Tyree TJ, Dan R, Thorne RE.

Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):471-479. doi: 10.1107/S2059798318003078. Epub 2018 Apr 27.


ACTN4 regulates the stability of RIPK1 in melanoma.

Zhang YY, Tabataba H, Liu XY, Wang JY, Yan XG, Farrelly M, Jiang CC, Guo ST, Liu T, Kao HY, Thorne RF, Zhang XD, Jin L.

Oncogene. 2018 Jul;37(29):4033-4045. doi: 10.1038/s41388-018-0260-x. Epub 2018 Apr 30.


Strategies for enumeration of circulating microvesicles on a conventional flow cytometer: Counting beads and scatter parameters.

Alkhatatbeh MJ, Enjeti AK, Baqar S, Ekinci EI, Liu D, Thorne RF, Lincz LF.

J Circ Biomark. 2018 Apr 5;7:1849454418766966. doi: 10.1177/1849454418766966. eCollection 2018 Jan-Dec.


Effects of protein-crystal hydration and temperature on side-chain conformational heterogeneity in monoclinic lysozyme crystals.

Atakisi H, Moreau DW, Thorne RE.

Acta Crystallogr D Struct Biol. 2018 Apr 1;74(Pt 4):264-278. doi: 10.1107/S2059798318000207. Epub 2018 Apr 3.


GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability.

Hu WL, Jin L, Xu A, Wang YF, Thorne RF, Zhang XD, Wu M.

Nat Cell Biol. 2018 Apr;20(4):492-502. doi: 10.1038/s41556-018-0066-7. Epub 2018 Mar 28.


Awareness and compliance with pharmacovigilance requirements amongst UK oncology healthcare professionals.

Thorne RJ, Bruggink RJ, Kelly SJ, Payne SJ, Purcell SJ, Montgomery DA.

Ecancermedicalscience. 2018 Feb 8;12:809. doi: 10.3332/ecancer.2018.809. eCollection 2018.


The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic' system?

Abbott NJ, Pizzo ME, Preston JE, Janigro D, Thorne RG.

Acta Neuropathol. 2018 Mar;135(3):387-407. doi: 10.1007/s00401-018-1812-4. Epub 2018 Feb 10. Review.


LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect.

Xiang S, Gu H, Jin L, Thorne RF, Zhang XD, Wu M.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1465-E1474. doi: 10.1073/pnas.1711257115. Epub 2018 Jan 29.


Molecular characterization of perivascular drainage pathways in the murine brain.

Hannocks MJ, Pizzo ME, Huppert J, Deshpande T, Abbott NJ, Thorne RG, Sorokin L.

J Cereb Blood Flow Metab. 2018 Apr;38(4):669-686. doi: 10.1177/0271678X17749689. Epub 2017 Dec 28.


Lifetimes and spatio-temporal response of protein crystals in intense X-ray microbeams.

Warkentin MA, Atakisi H, Hopkins JB, Walko D, Thorne RE.

IUCrJ. 2017 Oct 13;4(Pt 6):785-794. doi: 10.1107/S2052252517013495. eCollection 2017 Nov 1.


Development of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad β Residue Distribution.

Cheloha RW, Chen B, Kumar NN, Watanabe T, Thorne RG, Li L, Gardella TJ, Gellman SH.

J Med Chem. 2017 Nov 9;60(21):8816-8833. doi: 10.1021/acs.jmedchem.7b00876. Epub 2017 Oct 24.


BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma.

Liu F, Jiang CC, Yan XG, Tseng HY, Wang CY, Zhang YY, Yari H, La T, Farrelly M, Guo ST, Thorne RF, Jin L, Wang Q, Zhang XD.

Oncotarget. 2017 May 9;8(41):69477-69492. doi: 10.18632/oncotarget.17704. eCollection 2017 Sep 19.


Neurotrophin Receptors TrkA, p75NTR, and Sortilin Are Increased and Targetable in Thyroid Cancer.

Faulkner S, Jobling P, Rowe CW, Rodrigues Oliveira SM, Roselli S, Thorne RF, Oldmeadow C, Attia J, Jiang CC, Zhang XD, Walker MM, Hondermarck H.

Am J Pathol. 2018 Jan;188(1):229-241. doi: 10.1016/j.ajpath.2017.09.008. Epub 2017 Oct 14.


Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery.

Pizzo ME, Wolak DJ, Kumar NN, Brunette E, Brunnquell CL, Hannocks MJ, Abbott NJ, Meyerand ME, Sorokin L, Stanimirovic DB, Thorne RG.

J Physiol. 2018 Feb 1;596(3):445-475. doi: 10.1113/JP275105. Epub 2017 Dec 18.


Skp2-Mediated Stabilization of MTH1 Promotes Survival of Melanoma Cells upon Oxidative Stress.

Wang JY, Liu GZ, Wilmott JS, La T, Feng YC, Yari H, Yan XG, Thorne RF, Scolyer RA, Zhang XD, Jin L.

Cancer Res. 2017 Nov 15;77(22):6226-6239. doi: 10.1158/0008-5472.CAN-17-1965. Epub 2017 Sep 25.


Active-site protein dynamics and solvent accessibility in native Achromobacter cycloclastes copper nitrite reductase.

Sen K, Horrell S, Kekilli D, Yong CW, Keal TW, Atakisi H, Moreau DW, Thorne RE, Hough MA, Strange RW.

IUCrJ. 2017 Jun 16;4(Pt 4):495-505. doi: 10.1107/S2052252517007527. eCollection 2017 Jul 1.


Measuring the Densities of Aqueous Glasses at Cryogenic Temperatures.

Shen C, Julius EF, Tyree TJ, Dan R, Moreau DW, Thorne R.

J Vis Exp. 2017 Jun 28;(124). doi: 10.3791/55761.


Effect of interdisciplinary care on weight loss: a randomised controlled trial.

Tapsell LC, Lonergan M, Batterham MJ, Neale EP, Martin A, Thorne R, Deane F, Peoples G.

BMJ Open. 2017 Jul 13;7(7):e014533. doi: 10.1136/bmjopen-2016-014533.


Jupiter's magnetosphere and aurorae observed by the Juno spacecraft during its first polar orbits.

Connerney JEP, Adriani A, Allegrini F, Bagenal F, Bolton SJ, Bonfond B, Cowley SWH, Gerard JC, Gladstone GR, Grodent D, Hospodarsky G, Jorgensen JL, Kurth WS, Levin SM, Mauk B, McComas DJ, Mura A, Paranicas C, Smith EJ, Thorne RM, Valek P, Waite J.

Science. 2017 May 26;356(6340):826-832. doi: 10.1126/science.aam5928.


Jupiter's interior and deep atmosphere: The initial pole-to-pole passes with the Juno spacecraft.

Bolton SJ, Adriani A, Adumitroaie V, Allison M, Anderson J, Atreya S, Bloxham J, Brown S, Connerney JEP, DeJong E, Folkner W, Gautier D, Grassi D, Gulkis S, Guillot T, Hansen C, Hubbard WB, Iess L, Ingersoll A, Janssen M, Jorgensen J, Kaspi Y, Levin SM, Li C, Lunine J, Miguel Y, Mura A, Orton G, Owen T, Ravine M, Smith E, Steffes P, Stone E, Stevenson D, Thorne R, Waite J, Durante D, Ebert RW, Greathouse TK, Hue V, Parisi M, Szalay JR, Wilson R.

Science. 2017 May 26;356(6340):821-825. doi: 10.1126/science.aal2108.


MicroRNA-645 is an oncogenic regulator in colon cancer.

Guo ST, Guo XY, Wang J, Wang CY, Yang RH, Wang FH, Li XY, Hondermarck H, Thorne RF, Wang YF, Jin L, Zhang XD, Jiang CC.

Oncogenesis. 2017 May 15;6(5):e335. doi: 10.1038/oncsis.2017.37.


Using data mining to predict success in a weight loss trial.

Batterham M, Tapsell L, Charlton K, O'Shea J, Thorne R.

J Hum Nutr Diet. 2017 Aug;30(4):471-478. doi: 10.1111/jhn.12448. Epub 2017 Feb 7.


Protein interaction screening identifies SH3RF1 as a new regulator of FAT1 protein levels.

de Bock CE, Hughes MR, Snyder K, Alley S, Sadeqzadeh E, Dun MD, McNagny KM, Molloy TJ, Hondermarck H, Thorne RF.

FEBS Lett. 2017 Feb;591(4):667-678. doi: 10.1002/1873-3468.12569. Epub 2017 Feb 16.


Bio-maleimide-stained plasma microparticles can be purified in a native state and target human proximal tubular HK2 cells.

Alkhatatbeh MJ, Lincz LF, Thorne RF.

Biomed Rep. 2017 Jan;6(1):63-68. doi: 10.3892/br.2016.806. Epub 2016 Nov 9.


Global Sources and Pathways of Mercury in the Context of Human Health.

Sundseth K, Pacyna JM, Pacyna EG, Pirrone N, Thorne RJ.

Int J Environ Res Public Health. 2017 Jan 22;14(1). pii: E105. doi: 10.3390/ijerph14010105. Review.


MLL-AF4 binds directly to a BCL-2 specific enhancer and modulates H3K27 acetylation.

Godfrey L, Kerry J, Thorne R, Repapi E, Davies JO, Tapia M, Ballabio E, Hughes JR, Geng H, Konopleva M, Milne TA.

Exp Hematol. 2017 Mar;47:64-75. doi: 10.1016/j.exphem.2016.11.003. Epub 2016 Nov 14.


Cell biology: A mitochondrial brake on vascular repair.

de Bock CE, Thorne RF.

Nature. 2016 Nov 24;539(7630):503-505. doi: 10.1038/nature20476. Epub 2016 Nov 9. No abstract available.


Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery.

Kumar NN, Gautam M, Lochhead JJ, Wolak DJ, Ithapu V, Singh V, Thorne RG.

Sci Rep. 2016 Aug 25;6:31732. doi: 10.1038/srep31732.


Erratum: Excitation of Chirping Whistler Waves in a Laboratory Plasma [Phys. Rev. Lett. 114, 245002 (2015)].

Van Compernolle B, An X, Bortnik J, Thorne RM, Pribyl P, Gekelman W.

Phys Rev Lett. 2016 Jul 29;117(5):059901. Epub 2016 Jul 26.


Thermal contraction of aqueous glycerol and ethylene glycol solutions for optimized protein-crystal cryoprotection.

Shen C, Julius EF, Tyree TJ, Moreau DW, Atakisi H, Thorne RE.

Acta Crystallogr D Struct Biol. 2016 Jun;72(Pt 6):742-52. doi: 10.1107/S2059798316005490. Epub 2016 May 25.


Quantifying radiation damage in biomolecular small-angle X-ray scattering.

Hopkins JB, Thorne RE.

J Appl Crystallogr. 2016 May 4;49(Pt 3):880-890. eCollection 2016 Jun 1.


Charm and beauty quark masses in the MMHT2014 global PDF analysis.

Harland-Lang LA, Martin AD, Motylinski P, Thorne RS.

Eur Phys J C Part Fields. 2016;76:10. Epub 2016 Jan 6.


Circulating CD36+ microparticles are not altered by docosahexaenoic or eicosapentaenoic acid supplementation.

Phang M, Thorne RF, Alkhatatbeh MJ, Garg ML, Lincz LF.

Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):254-60. doi: 10.1016/j.numecd.2015.12.003. Epub 2015 Dec 18.


An investigation of anode and cathode materials in photomicrobial fuel cells.

Schneider K, Thorne RJ, Cameron PJ.

Philos Trans A Math Phys Eng Sci. 2016 Feb 28;374(2061). pii: 20150080. doi: 10.1098/rsta.2015.0080. Review.


The impact of the final HERA combined data on PDFs obtained from a global fit.

Harland-Lang LA, Martin AD, Motylinski P, Thorne RS.

Eur Phys J C Part Fields. 2016;76(4):186. doi: 10.1140/epjc/s10052-016-4020-1. Epub 2016 Apr 6.


Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

Keedy DA, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM, Lemke H, Gonzalez A, Sauter NK, Cohen AE, van den Bedem H, Thorne RE, Fraser JS.

Elife. 2015 Sep 30;4. pii: e07574. doi: 10.7554/eLife.07574.


Uncertainties on [Formula: see text] in the MMHT2014 global PDF analysis and implications for SM predictions.

Harland-Lang LA, Martin AD, Motylinski P, Thorne RS.

Eur Phys J C Part Fields. 2015;75(9):435. Epub 2015 Sep 21.


INPP4B is an oncogenic regulator in human colon cancer.

Guo ST, Chi MN, Yang RH, Guo XY, Zan LK, Wang CY, Xi YF, Jin L, Croft A, Tseng HY, Yan XG, Farrelly M, Wang FH, Lai F, Wang JF, Li YP, Ackland S, Scott R, Agoulnik IU, Hondermarck H, Thorne RF, Liu T, Zhang XD, Jiang CC.

Oncogene. 2016 Jun 9;35(23):3049-61. doi: 10.1038/onc.2015.361. Epub 2015 Sep 28.


Excitation of Chirping Whistler Waves in a Laboratory Plasma.

Van Compernolle B, An X, Bortnik J, Thorne RM, Pribyl P, Gekelman W.

Phys Rev Lett. 2015 Jun 19;114(24):245002. Epub 2015 Jun 17. Erratum in: Phys Rev Lett. 2016 Jul 29;117(5):059901.


Dangerous liaisons: cooperation between Pbx3, Meis1 and Hoxa9 in leukemia.

Thorne RM, Milne TA.

Haematologica. 2015 Jul;100(7):850-3. doi: 10.3324/haematol.2015.129932. No abstract available.


Parton distributions in the LHC era: MMHT 2014 PDFs.

Harland-Lang LA, Martin AD, Motylinski P, Thorne RS.

Eur Phys J C Part Fields. 2015;75(5):204. Epub 2015 May 9.


FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation.

Ahmed AF, de Bock CE, Lincz LF, Pundavela J, Zouikr I, Sontag E, Hondermarck H, Thorne RF.

Cell Mol Life Sci. 2015 Dec;72(23):4653-69. doi: 10.1007/s00018-015-1955-6. Epub 2015 Jun 24.


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