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Items: 1 to 50 of 268

1.

Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal.

Irshad Z, Xue M, Ashour A, Larkin JR, Thornalley PJ, Rabbani N.

Sci Rep. 2019 May 27;9(1):7889. doi: 10.1038/s41598-019-44358-1.

2.

Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage.

Hariton F, Xue M, Rabbani N, Fowler M, Thornalley PJ.

Oxid Med Cell Longev. 2018 Nov 22;2018:5642148. doi: 10.1155/2018/5642148. eCollection 2018.

3.

Correction to: Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.

Spanos C, Maldonado EM, Fisher CP, Leenutaphong P, Oviedo-Orta E, Windridge D, Salguero FJ, Bermúdez-Fajardo A, Weeks ME, Evans C, Corfe BM, Rabbani N, Thornalley PJ, Miller MH, Wang H, Dillon JF, Quaglia A, Dhawan A, Fitzpatrick E, Moore JB.

Proteome Sci. 2018 Jun 25;16:13. doi: 10.1186/s12953-018-0142-8. eCollection 2018.

4.

Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo.

Legrand C, Ahmed U, Anwar A, Rajpoot K, Pasha S, Lambert C, Davidson RK, Clark IM, Thornalley PJ, Henrotin Y, Rabbani N.

Arthritis Res Ther. 2018 Jun 22;20(1):131. doi: 10.1186/s13075-018-1636-6.

5.

Studies of advanced glycation end products and oxidation biomarkers for type 2 diabetes.

Chiu CJ, Rabbani N, Rowan S, Chang ML, Sawyer S, Hu FB, Willett W, Thornalley PJ, Anwar A, Bar L, Kang JH, Taylor A.

Biofactors. 2018 May;44(3):281-288. doi: 10.1002/biof.1423. Epub 2018 May 2.

PMID:
29718545
6.

Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis.

Anwar A, Abruzzo PM, Pasha S, Rajpoot K, Bolotta A, Ghezzo A, Marini M, Posar A, Visconti P, Thornalley PJ, Rabbani N.

Mol Autism. 2018 Feb 19;9:3. doi: 10.1186/s13229-017-0183-3. eCollection 2018.

7.

Advanced glycation end products in the pathogenesis of chronic kidney disease.

Rabbani N, Thornalley PJ.

Kidney Int. 2018 Apr;93(4):803-813. doi: 10.1016/j.kint.2017.11.034. Epub 2018 Feb 22. Review.

PMID:
29477239
8.

Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.

Spanos C, Maldonado EM, Fisher CP, Leenutaphong P, Oviedo-Orta E, Windridge D, Salguero FJ, Bermúdez-Fajardo A, Weeks ME, Evans C, Corfe BM, Rabbani N, Thornalley PJ, Miller MH, Wang H, Dillon JF, Quaglia A, Dhawan A, Fitzpatrick E, Bernadette Moore J.

Proteome Sci. 2018 Feb 14;16:4. doi: 10.1186/s12953-018-0131-y. eCollection 2018. Erratum in: Proteome Sci. 2018 Jun 25;16:13.

9.

Glyoxalase 1 Modulation in Obesity and Diabetes.

Rabbani N, Thornalley PJ.

Antioxid Redox Signal. 2018 Jan 2. doi: 10.1089/ars.2017.7424. [Epub ahead of print]

PMID:
29160087
10.

Glyoxalase 1 copy number variation in patients with well differentiated gastro-entero-pancreatic neuroendocrine tumours (GEP-NET).

Xue M, Shafie A, Qaiser T, Rajpoot NM, Kaltsas G, James S, Gopalakrishnan K, Fisk A, Dimitriadis GK, Grammatopoulos DK, Rabbani N, Thornalley PJ, Weickert MO.

Oncotarget. 2017 Aug 16;8(44):76961-76973. doi: 10.18632/oncotarget.20290. eCollection 2017 Sep 29.

11.

Relation of the protein glycation, oxidation and nitration to the osteocalcin level in obese subjects.

Razny U, Goralska J, Zdzienicka A, Fedak D, Masania J, Rabbani N, Thornalley P, Pawlica-Gosiewska D, Gawlik K, Dembinska-Kiec A, Solnica B, Malczewska-Malec M.

Acta Biochim Pol. 2017;64(3):415-422. doi: 10.18388/abp.2017_1627. Epub 2017 Jul 28.

12.

Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration.

Rowan S, Jiang S, Korem T, Szymanski J, Chang ML, Szelog J, Cassalman C, Dasuri K, McGuire C, Nagai R, Du XL, Brownlee M, Rabbani N, Thornalley PJ, Baleja JD, Deik AA, Pierce KA, Scott JM, Clish CB, Smith DE, Weinberger A, Avnit-Sagi T, Lotan-Pompan M, Segal E, Taylor A.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4472-E4481. doi: 10.1073/pnas.1702302114. Epub 2017 May 15.

13.

Multiple roles of glyoxalase 1-mediated suppression of methylglyoxal glycation in cancer biology-Involvement in tumour suppression, tumour growth, multidrug resistance and target for chemotherapy.

Rabbani N, Xue M, Weickert MO, Thornalley PJ.

Semin Cancer Biol. 2018 Apr;49:83-93. doi: 10.1016/j.semcancer.2017.05.006. Epub 2017 May 12. Review.

PMID:
28506645
14.

Intracellular Accumulation of Methylglyoxal by Glyoxalase 1 Knock Down Alters Collagen Homoeostasis in L6 Myoblasts.

Stratmann B, Goldstein B, Thornalley PJ, Rabbani N, Tschoepe D.

Int J Mol Sci. 2017 Feb 23;18(3). pii: E480. doi: 10.3390/ijms18030480.

15.

Glyoxalase 1-knockdown in human aortic endothelial cells - effect on the proteome and endothelial function estimates.

Stratmann B, Engelbrecht B, Espelage BC, Klusmeier N, Tiemann J, Gawlowski T, Mattern Y, Eisenacher M, Meyer HE, Rabbani N, Thornalley PJ, Tschoepe D, Poschmann G, Stühler K.

Sci Rep. 2016 Nov 29;6:37737. doi: 10.1038/srep37737.

16.

Quantitation of plasma thiamine, related metabolites and plasma protein oxidative damage markers in children with autism spectrum disorder and healthy controls.

Anwar A, Marini M, Abruzzo PM, Bolotta A, Ghezzo A, Visconti P, Thornalley PJ, Rabbani N.

Free Radic Res. 2016 Nov;50(sup1):S85-S90. Epub 2016 Nov 2.

PMID:
27667096
17.
18.

Reappraisal of putative glyoxalase 1-deficient mouse and dicarbonyl stress on embryonic stem cells in vitro.

Shafie A, Xue M, Barker G, Zehnder D, Thornalley PJ, Rabbani N.

Biochem J. 2016 Nov 15;473(22):4255-4270. Epub 2016 Sep 26.

PMID:
27671893
19.

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments.

Rabbani N, Xue M, Thornalley PJ.

Clin Sci (Lond). 2016 Oct 1;130(19):1677-96. doi: 10.1042/CS20160025. Review.

PMID:
27555612
20.

Mass spectrometric determination of early and advanced glycation in biology.

Rabbani N, Ashour A, Thornalley PJ.

Glycoconj J. 2016 Aug;33(4):553-68. doi: 10.1007/s10719-016-9709-8. Epub 2016 Jul 20. Review.

21.

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics.

Rabbani N, Xue M, Thornalley PJ.

Glycoconj J. 2016 Aug;33(4):513-25. doi: 10.1007/s10719-016-9705-z. Epub 2016 Jul 12. Review.

22.

Dicarbonyl stress in clinical obesity.

Masania J, Malczewska-Malec M, Razny U, Goralska J, Zdzienicka A, Kiec-Wilk B, Gruca A, Stancel-Mozwillo J, Dembinska-Kiec A, Rabbani N, Thornalley PJ.

Glycoconj J. 2016 Aug;33(4):581-9. doi: 10.1007/s10719-016-9692-0. Epub 2016 Jun 24. Review.

23.

Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation.

Xue M, Weickert MO, Qureshi S, Kandala NB, Anwar A, Waldron M, Shafie A, Messenger D, Fowler M, Jenkins G, Rabbani N, Thornalley PJ.

Diabetes. 2016 Aug;65(8):2282-94. doi: 10.2337/db16-0153. Epub 2016 May 11.

24.

The uremic toxin oxythiamine causes functional thiamine deficiency in end-stage renal disease by inhibiting transketolase activity.

Zhang F, Masania J, Anwar A, Xue M, Zehnder D, Kanji H, Rabbani N, Thornalley PJ.

Kidney Int. 2016 Aug;90(2):396-403. doi: 10.1016/j.kint.2016.03.010. Epub 2016 May 16.

PMID:
27198804
25.

Frequency modulated translocational oscillations of Nrf2, a transcription factor functioning like a wireless sensor.

Xue M, Momiji H, Rabbani N, Bretschneider T, Rand DA, Thornalley PJ.

Biochem Soc Trans. 2015 Aug;43(4):669-73. doi: 10.1042/BST20150060. Epub 2015 Aug 3.

PMID:
26551710
26.

New development in a blood-based diagnostic test for early-stage arthritis.

Ahmed U, Thornalley PJ, Rabbani N.

Biomark Med. 2015;9(10):943-5. doi: 10.2217/bmm.15.77. Epub 2015 Oct 6. No abstract available.

PMID:
26439368
27.

Increased DNA dicarbonyl glycation and oxidation markers in patients with type 2 diabetes and link to diabetic nephropathy.

Waris S, Winklhofer-Roob BM, Roob JM, Fuchs S, Sourij H, Rabbani N, Thornalley PJ.

J Diabetes Res. 2015;2015:915486. doi: 10.1155/2015/915486. Epub 2015 Apr 9.

28.

Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.

Ahmed U, Anwar A, Savage RS, Costa ML, Mackay N, Filer A, Raza K, Watts RA, Winyard PG, Tarr J, Haigh RC, Thornalley PJ, Rabbani N.

Sci Rep. 2015 Mar 19;5:9259. doi: 10.1038/srep09259.

29.

Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.

Rabbani N, Thornalley PJ.

Biochem Biophys Res Commun. 2015 Mar 6;458(2):221-6. doi: 10.1016/j.bbrc.2015.01.140. Epub 2015 Feb 7. Review.

30.
31.

Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response.

Xue M, Momiji H, Rabbani N, Barker G, Bretschneider T, Shmygol A, Rand DA, Thornalley PJ.

Antioxid Redox Signal. 2015 Sep 1;23(7):613-29. doi: 10.1089/ars.2014.5962. Epub 2014 Oct 3.

32.

Arginine-directed glycation and decreased HDL plasma concentration and functionality.

Godfrey L, Yamada-Fowler N, Smith J, Thornalley PJ, Rabbani N.

Nutr Diabetes. 2014 Sep 1;4:e134. doi: 10.1038/nutd.2014.31.

33.

Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samples.

Rabbani N, Thornalley PJ.

Nat Protoc. 2014 Aug;9(8):1969-79. doi: 10.1038/nprot.2014.129. Epub 2014 Jul 24.

PMID:
25058644
34.

Oxygen restriction as challenge test reveals early high-fat-diet-induced changes in glucose and lipid metabolism.

Duivenvoorde LP, van Schothorst EM, Derous D, van der Stelt I, Masania J, Rabbani N, Thornalley PJ, Keijer J.

Pflugers Arch. 2015 Jun;467(6):1179-93. doi: 10.1007/s00424-014-1553-8. Epub 2014 Jul 1.

PMID:
24974902
35.

Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice.

Geoffrion M, Du X, Irshad Z, Vanderhyden BC, Courville K, Sui G, D'Agati VD, Ott-Braschi S, Rabbani N, Thornalley PJ, Brownlee M, Milne RW.

Physiol Rep. 2014 Jun 11;2(6). pii: e12043. doi: 10.14814/phy2.12043. Print 2014 Jun 1.

36.

A fluorogenic assay for methylglyoxal.

Shaheen F, Shmygol A, Rabbani N, Thornalley PJ.

Biochem Soc Trans. 2014 Apr;42(2):548-55. doi: 10.1042/BST20140028. Review.

PMID:
24646277
37.

Possible role of methylglyoxal and glyoxalase in arthritis.

Ahmed U, Thornalley PJ, Rabbani N.

Biochem Soc Trans. 2014 Apr;42(2):538-42. doi: 10.1042/BST20140024. Review.

PMID:
24646275
38.

Assay of methylglyoxal-derived protein and nucleotide AGEs.

Rabbani N, Shaheen F, Anwar A, Masania J, Thornalley PJ.

Biochem Soc Trans. 2014 Apr;42(2):511-7. doi: 10.1042/BST20140019.

PMID:
24646270
39.

Assay of methylglyoxal and glyoxal and control of peroxidase interference.

Thornalley PJ, Rabbani N.

Biochem Soc Trans. 2014 Apr;42(2):504-10. doi: 10.1042/BST20140009. Review.

PMID:
24646269
40.

Copy number variation of glyoxalase I.

Shafie A, Xue M, Thornalley PJ, Rabbani N.

Biochem Soc Trans. 2014 Apr;42(2):500-3. doi: 10.1042/BST20140011. Review.

PMID:
24646268
41.

Measurement of glyoxalase gene expression.

Xue M, Rabbani N, Thornalley PJ.

Biochem Soc Trans. 2014 Apr;42(2):495-9. doi: 10.1042/BST20140026.

PMID:
24646267
42.

Measurement of glyoxalase activities.

Arai M, Nihonmatsu-Kikuchi N, Itokawa M, Rabbani N, Thornalley PJ.

Biochem Soc Trans. 2014 Apr;42(2):491-4. doi: 10.1042/BST20140010.

PMID:
24646266
43.

Dicarbonyl proteome and genome damage in metabolic and vascular disease.

Rabbani N, Thornalley PJ.

Biochem Soc Trans. 2014 Apr;42(2):425-32. doi: 10.1042/BST20140018. Review.

PMID:
24646255
44.

Activity, regulation, copy number and function in the glyoxalase system.

Rabbani N, Xue M, Thornalley PJ.

Biochem Soc Trans. 2014 Apr;42(2):419-24. doi: 10.1042/BST20140008. Review.

PMID:
24646254
45.

Glyoxalase Centennial conference: introduction, history of research on the glyoxalase system and future prospects.

Rabbani N, Thornalley PJ.

Biochem Soc Trans. 2014 Apr;42(2):413-8. doi: 10.1042/BST20140014.

PMID:
24646253
46.

Study of an unusual advanced glycation end-product (AGE) derived from glyoxal using mass spectrometry.

Lopez-Clavijo AF, Duque-Daza CA, Romero Canelon I, Barrow MP, Kilgour D, Rabbani N, Thornalley PJ, O'Connor PB.

J Am Soc Mass Spectrom. 2014 Apr;25(4):673-83. doi: 10.1007/s13361-013-0799-2. Epub 2014 Jan 28.

PMID:
24470193
47.

The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy.

Rabbani N, Thornalley PJ.

Diabetes. 2014 Jan;63(1):50-2. doi: 10.2337/db13-1606. No abstract available.

48.

Special edition of Amino Acids of selected papers from the eleventh international symposium on the Maillard reaction, September 16-20, 2012.

Rabbani N, Thornalley PJ.

Amino Acids. 2014 Feb;46(2):259. doi: 10.1007/s00726-013-1635-5. No abstract available.

PMID:
24352517
49.

Aging-dependent reduction in glyoxalase 1 delays wound healing.

Fleming TH, Theilen TM, Masania J, Wunderle M, Karimi J, Vittas S, Bernauer R, Bierhaus A, Rabbani N, Thornalley PJ, Kroll J, Tyedmers J, Nawrotzki R, Herzig S, Brownlee M, Nawroth PP.

Gerontology. 2013;59(5):427-37. doi: 10.1159/000351628. Epub 2013 Jun 22.

PMID:
23797271
50.

Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity.

Ajjan RA, Gamlen T, Standeven KF, Mughal S, Hess K, Smith KA, Dunn EJ, Anwar MM, Rabbani N, Thornalley PJ, Philippou H, Grant PJ.

Blood. 2013 Jul 4;122(1):134-42. doi: 10.1182/blood-2013-04-494641. Epub 2013 May 22.

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