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Application of patient-derived liver cancer cells for phenotypic characterization and therapeutic target identification.

Castven D, Becker D, Czauderna C, Wilhelm D, Andersen JB, Strand S, Hartmann M, Heilmann-Heimbach S, Roth W, Hartmann N, Straub BK, Mahn FL, Franck S, Pereira S, Haupts A, Vogel A, Wörns MA, Weinmann A, Heinrich S, Lang H, Thorgeirsson SS, Galle PR, Marquardt JU.

Int J Cancer. 2018 Nov 28. doi: 10.1002/ijc.32026. [Epub ahead of print]


Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer.

Yim SY, Shim JJ, Shin JH, Jeong YS, Kang SH, Kim SB, Eun YG, Lee DJ, Conner EA, Factor VM, Moore DD, Johnson RL, Thorgeirsson SS, Lee JS.

Mol Cancer Res. 2018 Nov;16(11):1713-1723. doi: 10.1158/1541-7786.MCR-18-0313. Epub 2018 Aug 6.


Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.

Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, Forgues M, Pomyen Y, Bhudhisawasdi V, Lertprasertsuke N, Chotirosniramit A, Pairojkul C, Auewarakul CU, Sricharunrat T, Phornphutkul K, Sangrajrang S, Cam M, He P, Hewitt SM, Ylaya K, Wu X, Andersen JB, Thorgeirsson SS, Waterfall JJ, Zhu YJ, Walling J, Stevenson HS, Edelman D, Meltzer PS, Loffredo CA, Hama N, Shibata T, Wiltrout RH, Harris CC, Mahidol C, Ruchirawat M, Wang XW; TIGER-LC Consortium.

Cancer Cell. 2017 Jul 10;32(1):57-70.e3. doi: 10.1016/j.ccell.2017.05.009. Epub 2017 Jun 22.


Transcriptomic and histopathological analysis of cholangiolocellular differentiation trait in intrahepatic cholangiocarcinoma.

Rhee H, Ko JE, Chung T, Jee BA, Kwon SM, Nahm JH, Seok JY, Yoo JE, Choi JS, Thorgeirsson SS, Andersen JB, Lee HS, Woo HG, Park YN.

Liver Int. 2018 Jan;38(1):113-124. doi: 10.1111/liv.13492. Epub 2017 Jul 10.


Stemness in Liver Cancer.

Thorgeirsson SS.

Dig Dis. 2017;35(4):387-389. doi: 10.1159/000456592. Epub 2017 May 3.


Adverse genomic alterations and stemness features are induced by field cancerization in the microenvironment of hepatocellular carcinomas.

Castven D, Fischer M, Becker D, Heinrich S, Andersen JB, Strand D, Sprinzl MF, Strand S, Czauderna C, Heilmann-Heimbach S, Roessler S, Weinmann A, Wörns MA, Thorgeirsson SS, Galle PR, Matter MS, Lang H, Marquardt JU.

Oncotarget. 2017 Jul 25;8(30):48688-48700. doi: 10.18632/oncotarget.16231.


Transcriptional Induction of Periostin by a Sulfatase 2-TGFβ1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma.

Chen G, Nakamura I, Dhanasekaran R, Iguchi E, Tolosa EJ, Romecin PA, Vera RE, Almada LL, Miamen AG, Chaiteerakij R, Zhou M, Asiedu MK, Moser CD, Han S, Hu C, Banini BA, Oseini AM, Chen Y, Fang Y, Yang D, Shaleh HM, Wang S, Wu D, Song T, Lee JS, Thorgeirsson SS, Chevet E, Shah VH, Fernandez-Zapico ME, Roberts LR.

Cancer Res. 2017 Feb 1;77(3):632-645. doi: 10.1158/0008-5472.CAN-15-2556. Epub 2016 Nov 21.


Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis.

Lee JH, Cho HS, Lee JJ, Jun SY, Ahn JH, Min JS, Yoon JY, Choi MH, Jeon SJ, Lim JH, Jung CR, Kim DS, Kim HT, Factor VM, Lee YH, Thorgeirsson SS, Kim CH, Kim NS.

Oncotarget. 2016 Nov 29;7(48):79774-79786. doi: 10.18632/oncotarget.12967.


Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress.

Thompson SM, Callstrom MR, Jondal DE, Butters KA, Knudsen BE, Anderson JL, Lien KR, Sutor SL, Lee JS, Thorgeirsson SS, Grande JP, Roberts LR, Woodrum DA.

PLoS One. 2016 Sep 9;11(9):e0162634. doi: 10.1371/journal.pone.0162634. eCollection 2016.


Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress.

Gomez-Quiroz LE, Seo D, Lee YH, Kitade M, Gaiser T, Gillen M, Lee SB, Gutierrez-Ruiz MC, Conner EA, Factor VM, Thorgeirsson SS, Marquardt JU.

Toxicology. 2016 Jun 15;361-362:39-48. doi: 10.1016/j.tox.2016.07.004. Epub 2016 Jul 6.


Liver Label Retaining Cancer Cells Are Relatively Resistant to the Reported Anti-Cancer Stem Cell Drug Metformin.

Xin HW, Ambe CM, Miller TC, Chen JQ, Wiegand GW, Anderson AJ, Ray S, Mullinax JE, Hari DM, Koizumi T, Godbout JD, Goldsmith PK, Stojadinovic A, Rudloff U, Thorgeirsson SS, Avital I.

J Cancer. 2016 Jun 6;7(9):1142-51. doi: 10.7150/jca.10047. eCollection 2016.


DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration.

Kaji K, Factor VM, Andersen JB, Durkin ME, Tomokuni A, Marquardt JU, Matter MS, Hoang T, Conner EA, Thorgeirsson SS.

Hepatology. 2016 Aug;64(2):582-98. doi: 10.1002/hep.28563. Epub 2016 Apr 28.


Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.

Matter MS, Marquardt JU, Andersen JB, Quintavalle C, Korokhov N, Stauffer JK, Kaji K, Decaens T, Quagliata L, Elloumi F, Hoang T, Molinolo A, Conner EA, Weber A, Heikenwalder M, Factor VM, Thorgeirsson SS.

Hepatology. 2016 Jun;63(6):1888-99. doi: 10.1002/hep.28487. Epub 2016 Mar 15.


A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy.

Gillet JP, Andersen JB, Madigan JP, Varma S, Bagni RK, Powell K, Burgan WE, Wu CP, Calcagno AM, Ambudkar SV, Thorgeirsson SS, Gottesman MM.

Mol Pharmacol. 2016 Feb;89(2):263-72. doi: 10.1124/mol.115.101360. Epub 2015 Dec 14.


Stemness and reprogramming in liver cancer.

Thorgeirsson SS.

Hepatology. 2016 Apr;63(4):1068-70. doi: 10.1002/hep.28362. Epub 2016 Jan 14. No abstract available.


Functional and genetic deconstruction of the cellular origin in liver cancer.

Marquardt JU, Andersen JB, Thorgeirsson SS.

Nat Rev Cancer. 2015 Nov;15(11):653-67. doi: 10.1038/nrc4017. Review.


Lack of mitochondrial topoisomerase I (TOP1mt) impairs liver regeneration.

Khiati S, Baechler SA, Factor VM, Zhang H, Huang SY, Dalla Rosa I, Sourbier C, Neckers L, Thorgeirsson SS, Pommier Y.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11282-7. doi: 10.1073/pnas.1511016112. Epub 2015 Aug 24.


Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression.

Lee YK, Jee BA, Kwon SM, Yoon YS, Xu WG, Wang HJ, Wang XW, Thorgeirsson SS, Lee JS, Woo HG, Yoon G.

Hepatology. 2015 Oct;62(4):1174-89. doi: 10.1002/hep.27976. Epub 2015 Aug 7.


Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma.

Won C, Kim BH, Yi EH, Choi KJ, Kim EK, Jeong JM, Lee JH, Jang JJ, Yoon JH, Jeong WI, Park IC, Kim TW, Bae SS, Factor VM, Ma S, Thorgeirsson SS, Lee YH, Ye SK.

Hepatology. 2015 Oct;62(4):1160-73. doi: 10.1002/hep.27968. Epub 2015 Aug 28.


Identification of microRNAs specific for epithelial cell adhesion molecule-positive tumor cells in hepatocellular carcinoma.

Ji J, Zheng X, Forgues M, Yamashita T, Wauthier EL, Reid LM, Wen X, Song Y, Wei JS, Khan J, Thorgeirsson SS, Wang XW.

Hepatology. 2015 Sep;62(3):829-40. doi: 10.1002/hep.27886. Epub 2015 Jun 30.


Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer.

Marquardt JU, Gomez-Quiroz L, Arreguin Camacho LO, Pinna F, Lee YH, Kitade M, Domínguez MP, Castven D, Breuhahn K, Conner EA, Galle PR, Andersen JB, Factor VM, Thorgeirsson SS.

J Hepatol. 2015 Sep;63(3):661-9. doi: 10.1016/j.jhep.2015.04.018. Epub 2015 May 1.


Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells.

Hayase S, Sasaki Y, Matsubara T, Seo D, Miyakoshi M, Murata T, Ozaki T, Kakudo K, Kumamoto K, Ylaya K, Cheng SY, Thorgeirsson SS, Hewitt SM, Ward JM, Kimura S.

Thyroid. 2015 Apr;25(4):425-36. doi: 10.1089/thy.2014.0464. Epub 2015 Mar 23.


Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM(+) AFP(+) hepatocellular carcinoma.

Zhao X, Parpart S, Takai A, Roessler S, Budhu A, Yu Z, Blank M, Zhang YE, Jia HL, Ye QH, Qin LX, Tang ZY, Thorgeirsson SS, Wang XW.

Oncogene. 2015 Sep 24;34(39):5095-104. doi: 10.1038/onc.2014.438. Epub 2015 Jan 19.


Genomic predictors for recurrence patterns of hepatocellular carcinoma: model derivation and validation.

Kim JH, Sohn BH, Lee HS, Kim SB, Yoo JE, Park YY, Jeong W, Lee SS, Park ES, Kaseb A, Kim BH, Kim WB, Yeon JE, Byun KS, Chu IS, Kim SS, Wang XW, Thorgeirsson SS, Luk JM, Kang KJ, Heo J, Park YN, Lee JS.

PLoS Med. 2014 Dec 23;11(12):e1001770. doi: 10.1371/journal.pmed.1001770. eCollection 2014 Dec.


The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina.

Masuda T, Zhang X, Berlinicke C, Wan J, Yerrabelli A, Conner EA, Kjellstrom S, Bush R, Thorgeirsson SS, Swaroop A, Chen S, Zack DJ.

J Neurosci. 2014 Nov 12;34(46):15356-68. doi: 10.1523/JNEUROSCI.2089-14.2014.


Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model.

Carpentier A, Tesfaye A, Chu V, Nimgaonkar I, Zhang F, Lee SB, Thorgeirsson SS, Feinstone SM, Liang TJ.

J Clin Invest. 2014 Nov;124(11):4953-64. doi: 10.1172/JCI75456. Epub 2014 Oct 8.


The biological and clinical challenge of liver cancer heterogeneity.

Wang XW, Thorgeirsson SS.

Hepat Oncol. 2014 Oct;1(4):349-353. doi: 10.2217/hep.14.18. Epub 2014 Dec 11. No abstract available.


MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism.

Akita H, Marquardt JU, Durkin ME, Kitade M, Seo D, Conner EA, Andersen JB, Factor VM, Thorgeirsson SS.

Cancer Res. 2014 Oct 15;74(20):5903-13. doi: 10.1158/0008-5472.CAN-14-0527. Epub 2014 Sep 4.


Antitumor effects in hepatocarcinoma of isoform-selective inhibition of HDAC2.

Lee YH, Seo D, Choi KJ, Andersen JB, Won MA, Kitade M, Gómez-Quiroz LE, Judge AD, Marquardt JU, Raggi C, Conner EA, MacLachlan I, Factor VM, Thorgeirsson SS.

Cancer Res. 2014 Sep 1;74(17):4752-61. doi: 10.1158/0008-5472.CAN-13-3531. Epub 2014 Jun 23.


SnapShot: Hepatocellular carcinoma.

Marquardt JU, Thorgeirsson SS.

Cancer Cell. 2014 Apr 14;25(4):550.e1. doi: 10.1016/j.ccr.2014.04.002.


Next-generation genomic profiling of hepatocellular adenomas: a new era of individualized patient care.

Marquardt JU, Thorgeirsson SS.

Cancer Cell. 2014 Apr 14;25(4):409-11. doi: 10.1016/j.ccr.2014.03.032.


Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits.

Marquardt JU, Seo D, Andersen JB, Gillen MC, Kim MS, Conner EA, Galle PR, Factor VM, Park YN, Thorgeirsson SS.

J Hepatol. 2014 Feb;60(2):346-353. doi: 10.1016/j.jhep.2013.10.014. Epub 2013 Oct 26.


Epigenetic reprogramming modulates malignant properties of human liver cancer.

Raggi C, Factor VM, Seo D, Holczbauer A, Gillen MC, Marquardt JU, Andersen JB, Durkin M, Thorgeirsson SS.

Hepatology. 2014 Jun;59(6):2251-62. doi: 10.1002/hep.27026. Epub 2014 May 1.


Molecular constituents of the extracellular matrix in rat liver mounting a hepatic progenitor cell response for tissue repair.

Vestentoft PS, Jelnes P, Andersen JB, Tran TA, Jørgensen T, Rasmussen M, Bornholdt J, Grøvdal LM, Jensen CH, Vogel LK, Thorgeirsson SS, Bisgaard HC.

Fibrogenesis Tissue Repair. 2013 Dec 20;6(1):21. doi: 10.1186/1755-1536-6-21.


Targeting the mTOR pathway in hepatocellular carcinoma: current state and future trends.

Matter MS, Decaens T, Andersen JB, Thorgeirsson SS.

J Hepatol. 2014 Apr;60(4):855-65. doi: 10.1016/j.jhep.2013.11.031. Epub 2013 Dec 3. Review.


An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer.

Jia J, Parikh H, Xiao W, Hoskins JW, Pflicke H, Liu X, Collins I, Zhou W, Wang Z, Powell J, Thorgeirsson SS, Rudloff U, Petersen GM, Amundadottir LT.

BMC Med Genomics. 2013 Sep 22;6:33. doi: 10.1186/1755-8794-6-33.


CellMinerHCC: a microarray-based expression database for hepatocellular carcinoma cell lines.

Staib F, Krupp M, Maass T, Itzel T, Weinmann A, Lee JS, Schmidt B, Müller M, Thorgeirsson SS, Galle PR, Teufel A.

Liver Int. 2014 Apr;34(4):621-31. doi: 10.1111/liv.12292. Epub 2013 Sep 9.


Linking MLL and the HGF-MET signaling pathway in liver cancer.

Marquardt JU, Thorgeirsson SS.

J Clin Invest. 2013 Jul;123(7):2780-3. doi: 10.1172/JCI70235. Epub 2013 Jun 24.


Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling.

Kitade M, Factor VM, Andersen JB, Tomokuni A, Kaji K, Akita H, Holczbauer A, Seo D, Marquardt JU, Conner EA, Lee SB, Lee YH, Thorgeirsson SS.

Genes Dev. 2013 Aug 1;27(15):1706-17. doi: 10.1101/gad.214601.113.


Wnt and the cancer niche: paracrine interactions with gastrointestinal cancer cells undergoing asymmetric cell division.

Xin HW, Ambe CM, Ray S, Kim BK, Koizumi T, Wiegand GW, Hari D, Mullinax JE, Jaiswal KR, Garfield SH, Stojadinovic A, Rudloff U, Thorgeirsson SS, Avital I.

J Cancer. 2013 Jul 2;4(6):447-57. doi: 10.7150/jca.6896. Print 2013.


Sall4 in "stemness"-driven hepatocarcinogenesis.

Marquardt JU, Thorgeirsson SS.

N Engl J Med. 2013 Jun 13;368(24):2316-8. doi: 10.1056/NEJMe1303026. No abstract available.


Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients.

Marquardt JU, Fischer K, Baus K, Kashyap A, Ma S, Krupp M, Linke M, Teufel A, Zechner U, Strand D, Thorgeirsson SS, Galle PR, Strand S.

Hepatology. 2013 Sep;58(3):1054-64. doi: 10.1002/hep.26413. Epub 2013 Jul 30.


Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types.

Holczbauer Á, Factor VM, Andersen JB, Marquardt JU, Kleiner DE, Raggi C, Kitade M, Seo D, Akita H, Durkin ME, Thorgeirsson SS.

Gastroenterology. 2013 Jul;145(1):221-231. doi: 10.1053/j.gastro.2013.03.013. Epub 2013 Mar 19.


Genomic copy number alterations with transcriptional deregulation at 6p identify an aggressive HCC phenotype.

Kwon SM, Kim DS, Won NH, Park SJ, Chwae YJ, Kang HC, Lee SH, Baik EJ, Thorgeirsson SS, Woo HG.

Carcinogenesis. 2013 Jul;34(7):1543-50. doi: 10.1093/carcin/bgt095. Epub 2013 Mar 18. Erratum in: Carcinogenesis. 2013 Nov;34(11):2682.


Genomic decoding of intrahepatic cholangiocarcinoma reveals therapeutic opportunities.

Andersen JB, Thorgeirsson SS.

Gastroenterology. 2013 Apr;144(4):687-90. doi: 10.1053/j.gastro.2013.02.018. Epub 2013 Feb 24. No abstract available.


Label-retaining liver cancer cells are relatively resistant to sorafenib.

Xin HW, Ambe CM, Hari DM, Wiegand GW, Miller TC, Chen JQ, Anderson AJ, Ray S, Mullinax JE, Koizumi T, Langan RC, Burka D, Herrmann MA, Goldsmith PK, Stojadinovic A, Rudloff U, Thorgeirsson SS, Avital I.

Gut. 2013 Dec;62(12):1777-86. doi: 10.1136/gutjnl-2012-303261. Epub 2013 Feb 14.


Biphasic regulation of the NADPH oxidase by HGF/c-Met signaling pathway in primary mouse hepatocytes.

Clavijo-Cornejo D, Enriquez-Cortina C, López-Reyes A, Domínguez-Pérez M, Nuño N, Domínguez-Meraz M, Bucio L, Souza V, Factor VM, Thorgeirsson SS, Gutiérrez-Ruiz MC, Gómez-Quiroz LE.

Biochimie. 2013 Jun;95(6):1177-84. doi: 10.1016/j.biochi.2013.01.005. Epub 2013 Jan 16.


Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China.

Sun Z, Chen T, Thorgeirsson SS, Zhan Q, Chen J, Park JH, Lu P, Hsia CC, Wang N, Xu L, Lu L, Huang F, Zhu Y, Lu J, Ni Z, Zhang Q, Wu Y, Liu G, Wu Z, Qu C, Gail MH.

Carcinogenesis. 2013 Aug;34(8):1800-5. doi: 10.1093/carcin/bgt007. Epub 2013 Jan 14.


The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism.

Zheng X, Vittar NB, Gai X, Fernandez-Barrena MG, Moser CD, Hu C, Almada LL, McCleary-Wheeler AL, Elsawa SF, Vrabel AM, Shire AM, Comba A, Thorgeirsson SS, Kim Y, Liu Q, Fernandez-Zapico ME, Roberts LR.

PLoS One. 2012;7(11):e49581. doi: 10.1371/journal.pone.0049581. Epub 2012 Nov 19.

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