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Items: 1 to 50 of 245

1.

Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion - A step towards precision medicine.

Thorens B, Rodriguez A, Cruciani-Guglielmacci C, Wigger L, Ibberson M, Magnan C.

Mol Metab. 2019 Sep;27S:S147-S154. doi: 10.1016/j.molmet.2019.06.008. Review.

2.

Fostering improved human islet research: a European perspective.

Marchetti P, Schulte AM, Marselli L, Schoniger E, Bugliani M, Kramer W, Overbergh L, Ullrich S, Gloyn AL, Ibberson M, Rutter G, Froguel P, Groop L, McCarthy MI, Dotta F, Scharfmann R, Magnan C, Eizirik DL, Mathieu C, Cnop M, Thorens B, Solimena M.

Diabetologia. 2019 Aug;62(8):1514-1516. doi: 10.1007/s00125-019-4911-4. Epub 2019 Jun 13. No abstract available.

3.

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.

Khamis A, Canouil M, Siddiq A, Crouch H, Falchi M, Bulow MV, Ehehalt F, Marselli L, Distler M, Richter D, Weitz J, Bokvist K, Xenarios I, Thorens B, Schulte AM, Ibberson M, Bonnefond A, Marchetti P, Solimena M, Froguel P.

Mol Metab. 2019 Jun;24:98-107. doi: 10.1016/j.molmet.2019.03.004. Epub 2019 Mar 18.

4.

Targeting the Brain to Cure Type 2 Diabetes.

Thorens B.

Diabetes. 2019 Mar;68(3):476-478. doi: 10.2337/dbi18-0051. No abstract available.

5.

Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk.

Cirulli ET, Guo L, Leon Swisher C, Shah N, Huang L, Napier LA, Kirkness EF, Spector TD, Caskey CT, Thorens B, Venter JC, Telenti A.

Cell Metab. 2019 Feb 5;29(2):488-500.e2. doi: 10.1016/j.cmet.2018.09.022. Epub 2018 Oct 11.

6.

SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney.

Auberson M, Stadelmann S, Stoudmann C, Seuwen K, Koesters R, Thorens B, Bonny O.

Pflugers Arch. 2018 Dec;470(12):1739-1751. doi: 10.1007/s00424-018-2190-4. Epub 2018 Aug 13.

7.

Protective role of the ELOVL2/docosahexaenoic acid axis in glucolipotoxicity-induced apoptosis in rodent beta cells and human islets.

Bellini L, Campana M, Rouch C, Chacinska M, Bugliani M, Meneyrol K, Hainault I, Lenoir V, Denom J, Véret J, Kassis N, Thorens B, Ibberson M, Marchetti P, Blachnio-Zabielska A, Cruciani-Guglielmacci C, Prip-Buus C, Magnan C, Le Stunff H.

Diabetologia. 2018 Aug;61(8):1780-1793. doi: 10.1007/s00125-018-4629-8. Epub 2018 May 12.

PMID:
29754287
8.

Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow.

Lei H, Preitner F, Labouèbe G, Gruetter R, Thorens B.

J Cereb Blood Flow Metab. 2019 Sep;39(9):1725-1736. doi: 10.1177/0271678X18766743. Epub 2018 Mar 21.

PMID:
29561214
9.

α-cell glucokinase suppresses glucose-regulated glucagon secretion.

Basco D, Zhang Q, Salehi A, Tarasov A, Dolci W, Herrera P, Spiliotis I, Berney X, Tarussio D, Rorsman P, Thorens B.

Nat Commun. 2018 Feb 7;9(1):546. doi: 10.1038/s41467-018-03034-0.

10.

GLUT2-Expressing Neurons as Glucose Sensors in the Brain: Electrophysiological Analysis.

Labouèbe G, Thorens B, Lamy C.

Methods Mol Biol. 2018;1713:255-267. doi: 10.1007/978-1-4939-7507-5_19.

PMID:
29218531
11.

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

Solimena M, Schulte AM, Marselli L, Ehehalt F, Richter D, Kleeberg M, Mziaut H, Knoch KP, Parnis J, Bugliani M, Siddiq A, Jörns A, Burdet F, Liechti R, Suleiman M, Margerie D, Syed F, Distler M, Grützmann R, Petretto E, Moreno-Moral A, Wegbrod C, Sönmez A, Pfriem K, Friedrich A, Meinel J, Wollheim CB, Baretton GB, Scharfmann R, Nogoceke E, Bonifacio E, Sturm D, Meyer-Puttlitz B, Boggi U, Saeger HD, Filipponi F, Lesche M, Meda P, Dahl A, Wigger L, Xenarios I, Falchi M, Thorens B, Weitz J, Bokvist K, Lenzen S, Rutter GA, Froguel P, von Bülow M, Ibberson M, Marchetti P.

Diabetologia. 2018 Mar;61(3):641-657. doi: 10.1007/s00125-017-4500-3. Epub 2017 Nov 28.

12.

Alain Ktorza, PhD.

Thorens B, Accili D, Ahrén B, Boitard C, Seino S, Cerasi E.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:3. doi: 10.1111/dom.13036. No abstract available.

PMID:
28880483
13.

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion.

Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lefèvre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M.

Mol Metab. 2017 Jan 26;6(4):340-351. doi: 10.1016/j.molmet.2017.01.009. eCollection 2017 Apr.

14.

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans.

Wigger L, Cruciani-Guglielmacci C, Nicolas A, Denom J, Fernandez N, Fumeron F, Marques-Vidal P, Ktorza A, Kramer W, Schulte A, Le Stunff H, Liechti R, Xenarios I, Vollenweider P, Waeber G, Uphues I, Roussel R, Magnan C, Ibberson M, Thorens B.

Cell Rep. 2017 Feb 28;18(9):2269-2279. doi: 10.1016/j.celrep.2017.02.019.

15.

Postprandial macrophage-derived IL-1β stimulates insulin, and both synergistically promote glucose disposal and inflammation.

Dror E, Dalmas E, Meier DT, Wueest S, Thévenet J, Thienel C, Timper K, Nordmann TM, Traub S, Schulze F, Item F, Vallois D, Pattou F, Kerr-Conte J, Lavallard V, Berney T, Thorens B, Konrad D, Böni-Schnetzler M, Donath MY.

Nat Immunol. 2017 Mar;18(3):283-292. doi: 10.1038/ni.3659. Epub 2017 Jan 16.

16.

Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction.

Duszka K, Picard A, Ellero-Simatos S, Chen J, Defernez M, Paramalingam E, Pigram A, Vanoaica L, Canlet C, Parini P, Narbad A, Guillou H, Thorens B, Wahli W.

Sci Rep. 2016 Nov 17;6:36937. doi: 10.1038/srep36937.

17.

A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion.

Picard A, Soyer J, Berney X, Tarussio D, Quenneville S, Jan M, Grouzmann E, Burdet F, Ibberson M, Thorens B.

Cell Rep. 2016 Nov 8;17(7):1795-1806. doi: 10.1016/j.celrep.2016.10.041.

18.

Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group.

Barazzoni R, Deutz NEP, Biolo G, Bischoff S, Boirie Y, Cederholm T, Cuerda C, Delzenne N, Leon Sanz M, Ljungqvist O, Muscaritoli M, Pichard C, Preiser JC, Sbraccia P, Singer P, Tappy L, Thorens B, Van Gossum A, Vettor R, Calder PC.

Clin Nutr. 2017 Apr;36(2):355-363. doi: 10.1016/j.clnu.2016.09.010. Epub 2016 Sep 19. Review.

PMID:
27686693
19.

Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase.

Steinbusch LK, Picard A, Bonnet MS, Basco D, Labouèbe G, Thorens B.

Diabetes. 2016 Oct;65(10):2920-31. doi: 10.2337/db15-1514. Epub 2016 Jul 15.

20.

Glucose-responsive neurons of the paraventricular thalamus control sucrose-seeking behavior.

Labouèbe G, Boutrel B, Tarussio D, Thorens B.

Nat Neurosci. 2016 Aug;19(8):999-1002. doi: 10.1038/nn.4331. Epub 2016 Jun 20.

21.

The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response.

Agrawal N, Delanoue R, Mauri A, Basco D, Pasco M, Thorens B, Léopold P.

Cell Metab. 2016 Apr 12;23(4):675-84. doi: 10.1016/j.cmet.2016.03.003.

22.

Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice.

Sala-Rabanal M, Hirayama BA, Ghezzi C, Liu J, Huang SC, Kepe V, Koepsell H, Yu A, Powell DR, Thorens B, Wright EM, Barrio JR.

J Physiol. 2016 Aug 1;594(15):4425-38. doi: 10.1113/JP271904. Epub 2016 May 10.

23.

Sorcin Links Pancreatic β-Cell Lipotoxicity to ER Ca2+ Stores.

Marmugi A, Parnis J, Chen X, Carmichael L, Hardy J, Mannan N, Marchetti P, Piemonti L, Bosco D, Johnson P, Shapiro JA, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Thorens B, Valdivia HH, Rutter GA, Leclerc I.

Diabetes. 2016 Apr;65(4):1009-21. doi: 10.2337/db15-1334. Epub 2016 Jan 28.

24.

Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function.

Modi H, Jacovetti C, Tarussio D, Metref S, Madsen OD, Zhang FP, Rantakari P, Poutanen M, Nef S, Gorman T, Regazzi R, Thorens B.

Diabetes. 2015 Dec;64(12):4148-57. doi: 10.2337/db14-1735. Epub 2015 Sep 17.

25.

The Islet and Metabolism Keep Time.

Thorens B, Accili D, Ahrén B, Cerasi E, Seino S, Boitard C.

Diabetes Obes Metab. 2015 Sep;17 Suppl 1:3-5. doi: 10.1111/dom.12547. No abstract available.

PMID:
26332961
26.

Type 2 Diabetes, SGLT2 Inhibitors, and Glucose Secretion.

Hattersley AT, Thorens B.

N Engl J Med. 2015 Sep 3;373(10):974-6. doi: 10.1056/NEJMcibr1506573. No abstract available.

27.

Brain glucose sensing in homeostatic and hedonic regulation.

Steinbusch L, Labouèbe G, Thorens B.

Trends Endocrinol Metab. 2015 Sep;26(9):455-66. doi: 10.1016/j.tem.2015.06.005. Epub 2015 Jul 8. Review.

PMID:
26163755
28.

Clic4, a novel protein that sensitizes β-cells to apoptosis.

Patel D, Ythier D, Brozzi F, Eizirik DL, Thorens B.

Mol Metab. 2015 Jan 20;4(4):253-64. doi: 10.1016/j.molmet.2015.01.003. eCollection 2015 Apr.

29.

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.

Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen MS, Stožer A, Wnendt S, Piemonti L, Köhler M, Ferrer J, Thorens B, Schliess F, Rupnik MS, Heise T, Berggren PO, Klöcker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E.

Nat Med. 2015 Apr;21(4):363-72. doi: 10.1038/nm.3822. Epub 2015 Mar 16.

PMID:
25774850
30.

No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.

Preitner F, Pimentel A, Metref S, Berthonneche C, Sarre A, Moret C, Rotman S, Centeno G, Firsov D, Thorens B.

Kidney Int. 2015 May;87(5):940-7. doi: 10.1038/ki.2014.385. Epub 2015 Jan 7.

31.

Ins1(Cre) knock-in mice for beta cell-specific gene recombination.

Thorens B, Tarussio D, Maestro MA, Rovira M, Heikkilä E, Ferrer J.

Diabetologia. 2015 Mar;58(3):558-65. doi: 10.1007/s00125-014-3468-5. Epub 2014 Dec 11.

32.

GLUT2, glucose sensing and glucose homeostasis.

Thorens B.

Diabetologia. 2015 Feb;58(2):221-32. doi: 10.1007/s00125-014-3451-1. Epub 2014 Nov 25. Review.

PMID:
25421524
33.

Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.

Mitchell RK, Mondragon A, Chen L, Mcginty JA, French PM, Ferrer J, Thorens B, Hodson DJ, Rutter GA, Da Silva Xavier G.

Hum Mol Genet. 2015 Mar 1;24(5):1390-9. doi: 10.1093/hmg/ddu553. Epub 2014 Oct 29.

34.

Glutamine stimulates biosynthesis and secretion of insulin-like growth factor 2 (IGF2), an autocrine regulator of beta cell mass and function.

Modi H, Cornu M, Thorens B.

J Biol Chem. 2014 Nov 14;289(46):31972-82. doi: 10.1074/jbc.M114.587733. Epub 2014 Sep 30.

35.

Neural regulation of pancreatic islet cell mass and function.

Thorens B.

Diabetes Obes Metab. 2014 Sep;16 Suppl 1:87-95. doi: 10.1111/dom.12346. Review.

PMID:
25200301
36.

The mind and the belly: a glance at how the nervous system directs metabolism.

Accili D, Ahrén B, Boitard C, Seino S, Thorens B, Cerasi E.

Diabetes Obes Metab. 2014 Sep;16 Suppl 1:1-3. doi: 10.1111/dom.12353. No abstract available.

PMID:
25200289
37.

Double incretin receptor knock-out (DIRKO) mice present with alterations of trabecular and cortical micromorphology and bone strength.

Mieczkowska A, Mansur S, Bouvard B, Flatt PR, Thorens B, Irwin N, Chappard D, Mabilleau G.

Osteoporos Int. 2015 Jan;26(1):209-18. doi: 10.1007/s00198-014-2845-8. Epub 2014 Aug 16.

PMID:
25127672
38.

LKB1 and AMPK differentially regulate pancreatic β-cell identity.

Kone M, Pullen TJ, Sun G, Ibberson M, Martinez-Sanchez A, Sayers S, Nguyen-Tu MS, Kantor C, Swisa A, Dor Y, Gorman T, Ferrer J, Thorens B, Reimann F, Gribble F, McGinty JA, Chen L, French PM, Birzele F, Hildebrandt T, Uphues I, Rutter GA.

FASEB J. 2014 Nov;28(11):4972-85. doi: 10.1096/fj.14-257667. Epub 2014 Jul 28.

39.

Gluco-incretins regulate beta-cell glucose competence by epigenetic silencing of Fxyd3 expression.

Vallois D, Niederhäuser G, Ibberson M, Nagaraj V, Marselli L, Marchetti P, Chatton JY, Thorens B.

PLoS One. 2014 Jul 24;9(7):e103277. doi: 10.1371/journal.pone.0103277. eCollection 2014. Erratum in: PLoS One. 2014;9(12):e116451. Nagaray, Vini [corrected to Nagaraj, Vini].

40.

Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress.

Vasu S, Moffett RC, Thorens B, Flatt PR.

PLoS One. 2014 Jun 26;9(6):e101005. doi: 10.1371/journal.pone.0101005. eCollection 2014.

41.

Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy.

Moffett RC, Vasu S, Thorens B, Drucker DJ, Flatt PR.

PLoS One. 2014 Jun 13;9(6):e96863. doi: 10.1371/journal.pone.0096863. eCollection 2014.

42.

Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion.

Lamy CM, Sanno H, Labouèbe G, Picard A, Magnan C, Chatton JY, Thorens B.

Cell Metab. 2014 Mar 4;19(3):527-38. doi: 10.1016/j.cmet.2014.02.003.

43.

The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing.

Röder PV, Geillinger KE, Zietek TS, Thorens B, Koepsell H, Daniel H.

PLoS One. 2014 Feb 26;9(2):e89977. doi: 10.1371/journal.pone.0089977. eCollection 2014.

44.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

45.

Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development.

Winnik S, Gaul DS, Preitner F, Lohmann C, Weber J, Miranda MX, Liu Y, van Tits LJ, Mateos JM, Brokopp CE, Auwerx J, Thorens B, Lüscher TF, Matter CM.

Basic Res Cardiol. 2014 Jan;109(1):399. doi: 10.1007/s00395-013-0399-0. Epub 2013 Dec 27.

46.

Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 mice.

Lengacher S, Nehiri-Sitayeb T, Steiner N, Carneiro L, Favrod C, Preitner F, Thorens B, Stehle JC, Dix L, Pralong F, Magistretti PJ, Pellerin L.

PLoS One. 2013 Dec 18;8(12):e82505. doi: 10.1371/journal.pone.0082505. eCollection 2013.

47.

Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis.

Tarussio D, Metref S, Seyer P, Mounien L, Vallois D, Magnan C, Foretz M, Thorens B.

J Clin Invest. 2014 Jan;124(1):413-24. doi: 10.1172/JCI69154. Epub 2013 Dec 16.

48.

The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids.

Ding J, Loizides-Mangold U, Rando G, Zoete V, Michielin O, Reddy JK, Wahli W, Riezman H, Thorens B.

Cell Rep. 2013 Oct 17;5(1):248-58. doi: 10.1016/j.celrep.2013.08.032. Epub 2013 Sep 26.

49.

Shifting the paradigm of islet inflammation--good guy or bad guy?

Ahrén B, Accili D, Boitard C, Cerasi E, Thorens B, Seino S.

Diabetes Obes Metab. 2013 Sep;15 Suppl 3:4-9. doi: 10.1111/dom.12184. No abstract available.

50.

Urate-induced acute renal failure and chronic inflammation in liver-specific Glut9 knockout mice.

Preitner F, Laverriere-Loss A, Metref S, Da Costa A, Moret C, Rotman S, Bazin D, Daudon M, Sandt C, Dessombz A, Thorens B.

Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F786-95. doi: 10.1152/ajprenal.00083.2013. Epub 2013 Jun 26.

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