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Items: 1 to 50 of 59

1.

Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics.

Timmermand OV, Elgqvist J, Beattie KA, Örbom A, Larsson E, Eriksson SE, Thorek DLJ, Beattie BJ, Tran TA, Ulmert D, Strand SE.

Theranostics. 2019 Apr 6;9(8):2129-2142. doi: 10.7150/thno.31179. eCollection 2019.

2.

Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression.

Hughes RM, Simons BW, Khan H, Miller R, Kugler V, Torquato S, Theodros D, Haffner MC, Lotan TL, Huang J, Davicioni E, An SS, Riddle RC, Thorek DL, Garraway IP, Fertig EJ, Isaacs JT, Brennen WN, Park BH, Hurley PJ.

Cancer Res. 2019 May 23. pii: canres.2931.2018. doi: 10.1158/0008-5472.CAN-18-2931. [Epub ahead of print]

PMID:
31123087
3.

PSMA expression in the Hi-Myc model; extended utility of a representative model of prostate adenocarcinoma for biological insight and as a drug discovery tool.

Simons BW, Turtle NF, Ulmert DH, Abou DS, Thorek DLJ.

Prostate. 2019 May;79(6):678-685. doi: 10.1002/pros.23770. Epub 2019 Jan 17.

4.

Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer?

Krueger TE, Thorek DLJ, Meeker AK, Isaacs JT, Brennen WN.

Prostate. 2019 Feb;79(3):320-330. doi: 10.1002/pros.23738. Epub 2018 Nov 28.

5.

Role of noninvasive molecular imaging in determining response.

Marciscano AE, Thorek DLJ.

Adv Radiat Oncol. 2018 Oct 23;3(4):534-547. doi: 10.1016/j.adro.2018.07.006. eCollection 2018 Oct-Dec. Review.

6.

Voltage-sensitive dye delivery through the blood brain barrier using adenosine receptor agonist regadenoson.

Pak RW, Kang J, Valentine H, Loew LM, Thorek DLJ, Boctor EM, Wong DF, Kang JU.

Biomed Opt Express. 2018 Jul 30;9(8):3915-3922. doi: 10.1364/BOE.9.003915. eCollection 2018 Aug 1.

7.

Efficacy of Radium-223 in Bone-metastatic Castration-resistant Prostate Cancer with and Without Homologous Repair Gene Defects.

Isaacsson Velho P, Qazi F, Hassan S, Carducci MA, Denmeade SR, Markowski MC, Thorek DL, DeWeese TL, Song DY, Tran PT, Eisenberger MA, Antonarakis ES.

Eur Urol. 2018 Oct 4. pii: S0302-2838(18)30729-2. doi: 10.1016/j.eururo.2018.09.040. [Epub ahead of print]

PMID:
30293905
8.

Harnessing Androgen Receptor Pathway Activation for Targeted Alpha Particle Radioimmunotherapy of Breast Cancer.

Thorek DLJ, Ku AT, Mitsiades N, Veach D, Watson PA, Metha D, Strand SE, Sharma SK, Lewis JS, Abou DS, Lilja HG, Larson SM, McDevitt MR, Ulmert D.

Clin Cancer Res. 2019 Jan 15;25(2):881-891. doi: 10.1158/1078-0432.CCR-18-1521. Epub 2018 Sep 25.

9.

Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.

Thompson JM, Miller RJ, Ashbaugh AG, Dillen CA, Pickett JE, Wang Y, Ortines RV, Sterling RS, Francis KP, Bernthal NM, Cohen TS, Tkaczyk C, Yu L, Stover CK, DiGiandomenico A, Sellman BR, Thorek DL, Miller LS.

JCI Insight. 2018 Sep 6;3(17). pii: 121737. doi: 10.1172/jci.insight.121737. eCollection 2018 Sep 6.

10.

Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise.

Krueger TEG, Thorek DLJ, Denmeade SR, Isaacs JT, Brennen WN.

Stem Cells Transl Med. 2018 Sep;7(9):651-663. doi: 10.1002/sctm.18-0024. Epub 2018 Aug 1. Review.

11.

Elective Nodal Irradiation Attenuates the Combinatorial Efficacy of Stereotactic Radiation Therapy and Immunotherapy.

Marciscano AE, Ghasemzadeh A, Nirschl TR, Theodros D, Kochel CM, Francica BJ, Muroyama Y, Anders RA, Sharabi AB, Velarde E, Mao W, Chaudhary KR, Chaimowitz MG, Wong J, Selby MJ, Thudium KB, Korman AJ, Ulmert D, Thorek DLJ, DeWeese TL, Drake CG.

Clin Cancer Res. 2018 Oct 15;24(20):5058-5071. doi: 10.1158/1078-0432.CCR-17-3427. Epub 2018 Jun 13.

PMID:
29898992
12.

The impact of age on radium-223 distribution and an evaluation of molecular imaging surrogates.

Jiang W, Ulmert D, Simons BW, Abou DS, Thorek DLJ.

Nucl Med Biol. 2018 Jul - Aug;62-63:1-8. doi: 10.1016/j.nucmedbio.2018.05.003. Epub 2018 May 8.

13.

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.

Pickett JE, Thompson JM, Sadowska A, Tkaczyk C, Sellman BR, Minola A, Corti D, Lanzavecchia A, Miller LS, Thorek DL.

Bone Res. 2018 Apr 25;6:13. doi: 10.1038/s41413-018-0014-y. eCollection 2018.

14.

Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer.

McDevitt MR, Thorek DLJ, Hashimoto T, Gondo T, Veach DR, Sharma SK, Kalidindi TM, Abou DS, Watson PA, Beattie BJ, Timmermand OV, Strand SE, Lewis JS, Scardino PT, Scher HI, Lilja H, Larson SM, Ulmert D.

Nat Commun. 2018 Apr 24;9(1):1629. doi: 10.1038/s41467-018-04107-w.

15.

Long-term prediction of prostate cancer diagnosis and death using PSA and obesity related anthropometrics at early middle age: data from the malmö preventive project.

Assel MJ, Gerdtsson A, Thorek DLJ, Carlsson SV, Malm J, Scardino PT, Vickers A, Lilja H, Ulmert D.

Oncotarget. 2017 Dec 5;9(5):5778-5785. doi: 10.18632/oncotarget.22981. eCollection 2018 Jan 19.

16.

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes.

Kim SP, Frey JL, Li Z, Kushwaha P, Zoch ML, Tomlinson RE, Da H, Aja S, Noh HL, Kim JK, Hussain MA, Thorek DLJ, Wolfgang MJ, Riddle RC.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11238-E11247. doi: 10.1073/pnas.1707876115. Epub 2017 Dec 11.

17.

Noninvasive optical and nuclear imaging of Staphylococcus-specific infection with a human monoclonal antibody-based probe.

Romero Pastrana F, Thompson JM, Heuker M, Hoekstra H, Dillen CA, Ortines RV, Ashbaugh AG, Pickett JE, Linssen MD, Bernthal NM, Francis KP, Buist G, van Oosten M, van Dam GM, Thorek DLJ, Miller LS, van Dijl JM.

Virulence. 2018 Jan 1;9(1):262-272. doi: 10.1080/21505594.2017.1403004. Epub 2017 Dec 26.

18.

In vivo immuno-targeting of an extracellular epitope of membrane bound preferentially expressed antigen in melanoma (PRAME).

Pankov D, Sjöström L, Kalidindi T, Lee SG, Sjöström K, Gardner R, McDevitt MR, O'Reilly R, Thorek DLJ, Larson SM, Veach D, Ulmert D.

Oncotarget. 2017 Jul 26;8(39):65917-65931. doi: 10.18632/oncotarget.19579. eCollection 2017 Sep 12.

19.

Carbon nanotubes exhibit fibrillar pharmacology in primates.

Alidori S, Thorek DLJ, Beattie BJ, Ulmert D, Almeida BA, Monette S, Scheinberg DA, McDevitt MR.

PLoS One. 2017 Aug 28;12(8):e0183902. doi: 10.1371/journal.pone.0183902. eCollection 2017.

20.

Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner.

Kim SP, Li Z, Zoch ML, Frey JL, Bowman CE, Kushwaha P, Ryan KA, Goh BC, Scafidi S, Pickett JE, Faugere MC, Kershaw EE, Thorek DLJ, Clemens TL, Wolfgang MJ, Riddle RC.

JCI Insight. 2017 Aug 17;2(16). pii: 92704. doi: 10.1172/jci.insight.92704. eCollection 2017 Aug 17.

21.

Listening to membrane potential: photoacoustic voltage-sensitive dye recording.

Zhang HK, Yan P, Kang J, Abou DS, Le HN, Jha AK, Thorek DL, Kang JU, Rahmim A, Wong DF, Boctor EM, Loew LM.

J Biomed Opt. 2017 Apr 1;22(4):45006. doi: 10.1117/1.JBO.22.4.045006.

22.

Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis.

Thorek DL, Watson PA, Lee SG, Ku AT, Bournazos S, Braun K, Kim K, Sjöström K, Doran MG, Lamminmäki U, Santos E, Veach D, Turkekul M, Casey E, Lewis JS, Abou DS, van Voss MR, Scardino PT, Strand SE, Alpaugh ML, Scher HI, Lilja H, Larson SM, Ulmert D.

Sci Transl Med. 2016 Nov 30;8(367):367ra167.

23.

A Radium-223 microgenerator from cyclotron-produced trace Actinium-227.

Abou DS, Pickett J, Mattson JE, Thorek DLJ.

Appl Radiat Isot. 2017 Jan;119:36-42. doi: 10.1016/j.apradiso.2016.10.015. Epub 2016 Nov 4.

24.

NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone.

Tomlinson RE, Li Z, Zhang Q, Goh BC, Li Z, Thorek DLJ, Rajbhandari L, Brushart TM, Minichiello L, Zhou F, Venkatesan A, Clemens TL.

Cell Rep. 2016 Sep 6;16(10):2723-2735. doi: 10.1016/j.celrep.2016.08.002. Epub 2016 Aug 25.

25.

Deconvoluting hepatic processing of carbon nanotubes.

Alidori S, Bowman RL, Yarilin D, Romin Y, Barlas A, Mulvey JJ, Fujisawa S, Xu K, Ruggiero A, Riabov V, Thorek DL, Ulmert HD, Brea EJ, Behling K, Kzhyshkowska J, Manova-Todorova K, Scheinberg DA, McDevitt MR.

Nat Commun. 2016 Jul 29;7:12343. doi: 10.1038/ncomms12343.

26.

In vivo radiometric analysis of glucose uptake and distribution in mouse bone.

Zoch ML, Abou DS, Clemens TL, Thorek DL, Riddle RC.

Bone Res. 2016 Apr 5;4:16004. doi: 10.1038/boneres.2016.4. eCollection 2016.

27.

Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury.

Alidori S, Akhavein N, Thorek DL, Behling K, Romin Y, Queen D, Beattie BJ, Manova-Todorova K, Bergkvist M, Scheinberg DA, McDevitt MR.

Sci Transl Med. 2016 Mar 23;8(331):331ra39. doi: 10.1126/scitranslmed.aac9647.

28.

Whole-Body and Microenvironmental Localization of Radium-223 in Naïve and Mouse Models of Prostate Cancer Metastasis.

Abou DS, Ulmert D, Doucet M, Hobbs RF, Riddle RC, Thorek DL.

J Natl Cancer Inst. 2015 Dec 18;108(5). pii: djv380. doi: 10.1093/jnci/djv380. Print 2016 May.

29.

Contemporary approaches for imaging skeletal metastasis.

Ulmert D, Solnes L, Thorek DLj.

Bone Res. 2015 Jul 14;3:15024. doi: 10.1038/boneres.2015.24. eCollection 2015. Review.

30.

Reverse-Contrast Imaging and Targeted Radiation Therapy of Advanced Pancreatic Cancer Models.

Thorek DL, Kramer RM, Chen Q, Jeong J, Lupu ME, Lee AM, Moynahan ME, Lowery M, Ulmert D, Zanzonico P, Deasy JO, Humm JL, Russell J.

Int J Radiat Oncol Biol Phys. 2015 Oct 1;93(2):444-53. doi: 10.1016/j.ijrobp.2015.06.001. Epub 2015 Jun 9.

31.

Nuclear molecular imaging with nanoparticles: radiochemistry, applications and translation.

Abou DS, Pickett JE, Thorek DL.

Br J Radiol. 2015 Oct;88(1054):20150185. doi: 10.1259/bjr.20150185. Epub 2015 Jul 2. Review.

32.

Cerenkov Luminescence Imaging for Radiation Dose Calculation of a ⁹⁰Y-Labeled Gastrin-Releasing Peptide Receptor Antagonist.

Lohrmann C, Zhang H, Thorek DL, Desai P, Zanzonico PB, O'Donoghue J, Irwin CP, Reiner T, Grimm J, Weber WA.

J Nucl Med. 2015 May;56(5):805-11. doi: 10.2967/jnumed.114.149054. Epub 2015 Apr 3.

33.

Anthropometric Measures at Multiple Times Throughout Life and Prostate Cancer Diagnosis, Metastasis, and Death.

Gerdtsson A, Poon JB, Thorek DL, Mucci LA, Evans MJ, Scardino P, Abrahamsson PA, Nilsson P, Manjer J, Bjartell A, Malm J, Vickers A, Freedland SJ, Lilja H, Ulmert D.

Eur Urol. 2015 Dec;68(6):1076-82. doi: 10.1016/j.eururo.2015.03.017. Epub 2015 Mar 18.

34.

Gene therapy using therapeutic and diagnostic recombinant oncolytic vaccinia virus GLV-1h153 for management of colorectal peritoneal carcinomatosis.

Eveno C, Mojica K, Ady JW, Thorek DL, Longo V, Belin LJ, Gholami S, Johnsen C, Zanzonico P, Chen N, Yu T, Szalay AA, Fong Y.

Surgery. 2015 Feb;157(2):331-7. doi: 10.1016/j.surg.2014.09.008.

35.

Radiolabeled antibodies in prostate cancer: a case study showing the effect of host immunity on antibody bio-distribution.

Vilhelmsson-Timmermand O, Santos E, Thorek DL, Evans-Axelsson S, Bjartell A, Lilja H, Larson SM, Strand SE, Tran TA, Ulmert D.

Nucl Med Biol. 2015 Apr;42(4):375-80. doi: 10.1016/j.nucmedbio.2014.12.012. Epub 2014 Dec 23.

36.

Cerenkov imaging.

Das S, Thorek DL, Grimm J.

Adv Cancer Res. 2014;124:213-34. doi: 10.1016/B978-0-12-411638-2.00006-9. Review.

37.

Dawn of advanced molecular medicine: nanotechnological advancements in cancer imaging and therapy.

Kaittanis C, Shaffer TM, Thorek DL, Grimm J.

Crit Rev Oncog. 2014;19(3-4):143-76. Review.

38.

Molecular imaging using nanoparticle quenchers of Cerenkov luminescence.

Thorek DL, Das S, Grimm J.

Small. 2014 Sep 24;10(18):3729-34. doi: 10.1002/smll.201400733. Epub 2014 May 26.

39.

Reply: Human Cerenkov imaging using 18F-FDG.

Thorek DL, Riedl CC, Grimm J.

J Nucl Med. 2014 Mar;55(3):523-4. doi: 10.2967/jnumed.113.135533. Epub 2014 Jan 21. No abstract available.

40.

Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.

Thorek DL, Ulmert D, Diop NF, Lupu ME, Doran MG, Huang R, Abou DS, Larson SM, Grimm J.

Nat Commun. 2014;5:3097. doi: 10.1038/ncomms4097.

41.

Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter.

Zhang H, Huang R, Pillarsetty N, Thorek DL, Vaidyanathan G, Serganova I, Blasberg RG, Lewis JS.

Eur J Nucl Med Mol Imaging. 2014 Feb;41(2):322-32. doi: 10.1007/s00259-013-2558-9. Epub 2013 Oct 31.

42.

Clinical Cerenkov luminescence imaging of (18)F-FDG.

Thorek DL, Riedl CC, Grimm J.

J Nucl Med. 2014 Jan;55(1):95-8. doi: 10.2967/jnumed.113.127266. Epub 2013 Sep 27.

43.

Quantitative imaging of disease signatures through radioactive decay signal conversion.

Thorek DL, Ogirala A, Beattie BJ, Grimm J.

Nat Med. 2013 Oct;19(10):1345-50. doi: 10.1038/nm.3323. Epub 2013 Sep 8.

44.

Prostate-specific kallikrein-related peptidases and their relation to prostate cancer biology and detection. Established relevance and emerging roles.

Thorek DL, Evans MJ, Carlsson SV, Ulmert D, Lilja H.

Thromb Haemost. 2013 Sep;110(3):484-92. doi: 10.1160/TH13-04-0275. Epub 2013 Aug 1. Review.

45.

(89)Zr-labeled paramagnetic octreotide-liposomes for PET-MR imaging of cancer.

Abou DS, Thorek DL, Ramos NN, Pinkse MW, Wolterbeek HT, Carlin SD, Beattie BJ, Lewis JS.

Pharm Res. 2013 Mar;30(3):878-88. doi: 10.1007/s11095-012-0929-8. Epub 2012 Dec 7.

46.

Cerenkov imaging - a new modality for molecular imaging.

Thorek DLj, Robertson R, Bacchus WA, Hahn J, Rothberg J, Beattie BJ, Grimm J.

Am J Nucl Med Mol Imaging. 2012;2(2):163-73. Epub 2012 Mar 28.

47.

Evolution of bombesin conjugates for targeted PET imaging of tumors.

Zhang H, Abiraj K, Thorek DL, Waser B, Smith-Jones PM, Honer M, Reubi JC, Maecke HR.

PLoS One. 2012;7(9):e44046. Epub 2012 Sep 14.

48.

Positron lymphography: multimodal, high-resolution, dynamic mapping and resection of lymph nodes after intradermal injection of 18F-FDG.

Thorek DL, Abou DS, Beattie BJ, Bartlett RM, Huang R, Zanzonico PB, Grimm J.

J Nucl Med. 2012 Sep;53(9):1438-45. doi: 10.2967/jnumed.112.104349. Epub 2012 Aug 7.

49.

Quantitative modeling of Cerenkov light production efficiency from medical radionuclides.

Beattie BJ, Thorek DL, Schmidtlein CR, Pentlow KS, Humm JL, Hielscher AH.

PLoS One. 2012;7(2):e31402. doi: 10.1371/journal.pone.0031402. Epub 2012 Feb 20.

50.

Enzymatically activatable diagnostic probes.

Thorek DL, Grimm J.

Curr Pharm Biotechnol. 2012 Mar;13(4):523-36. Review.

PMID:
22214507

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