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Items: 27

1.

Loss of protein synthesis quality control in host-restricted organisms.

Melnikov SV, van den Elzen A, Stevens DL, Thoreen CC, Söll D.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):E11505-E11512. doi: 10.1073/pnas.1815992115. Epub 2018 Nov 19.

2.

La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region.

Philippe L, Vasseur JJ, Debart F, Thoreen CC.

Nucleic Acids Res. 2018 Feb 16;46(3):1457-1469. doi: 10.1093/nar/gkx1237.

3.

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4.

Park Y, Reyna-Neyra A, Philippe L, Thoreen CC.

Cell Rep. 2017 May 9;19(6):1083-1090. doi: 10.1016/j.celrep.2017.04.042.

4.

The molecular basis of mTORC1-regulated translation.

Thoreen CC.

Biochem Soc Trans. 2017 Feb 8;45(1):213-221. doi: 10.1042/BST20160072. Review.

PMID:
28202675
5.

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS.

Cancer Res. 2016 Dec 15;76(24):7168-7180. Epub 2016 Oct 20.

6.

Many roads from mTOR to eIF4F.

Thoreen CC.

Biochem Soc Trans. 2013 Aug;41(4):913-6. doi: 10.1042/BST20130082. Review.

PMID:
23863155
7.

Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.

Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, Wang Y, Tupper T, Altabef A, Kawamura H, Held KD, Chou DM, Elledge SJ, Janne PA, Wong KK, Sabatini DM, Gray NS.

Cancer Res. 2013 Apr 15;73(8):2574-86. doi: 10.1158/0008-5472.CAN-12-1702. Epub 2013 Feb 22.

8.

A unifying model for mTORC1-mediated regulation of mRNA translation.

Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM.

Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083.

9.

Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.

Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS.

J Biol Chem. 2012 Mar 23;287(13):9742-52. doi: 10.1074/jbc.M111.304485. Epub 2012 Jan 5.

10.

Development of ATP-competitive mTOR inhibitors.

Liu Q, Kang SA, Thoreen CC, Hur W, Wang J, Chang JW, Markhard A, Zhang J, Sim T, Sabatini DM, Gray NS.

Methods Mol Biol. 2012;821:447-60. doi: 10.1007/978-1-61779-430-8_29.

11.

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability.

Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Choi HG, Waller DL, Sim T, Sabatini DM, Gray NS.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4036-40. doi: 10.1016/j.bmcl.2011.04.129. Epub 2011 May 7.

12.
13.

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling.

Lindquist RA, Ottina KA, Wheeler DB, Hsu PP, Thoreen CC, Guertin DA, Ali SM, Sengupta S, Shaul YD, Lamprecht MR, Madden KL, Papallo AR, Jones TR, Sabatini DM, Carpenter AE.

Genome Res. 2011 Mar;21(3):433-46. doi: 10.1101/gr.111492.110. Epub 2011 Jan 14.

14.

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer.

Liu Q, Chang JW, Wang J, Kang SA, Thoreen CC, Markhard A, Hur W, Zhang J, Sim T, Sabatini DM, Gray NS.

J Med Chem. 2010 Oct 14;53(19):7146-55. doi: 10.1021/jm101144f.

15.

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.

Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS, Sabatini DM.

Cell. 2009 May 29;137(5):873-86. doi: 10.1016/j.cell.2009.03.046. Epub 2009 May 14.

16.

Rapamycin inhibits mTORC1, but not completely.

Thoreen CC, Sabatini DM.

Autophagy. 2009 Jul;5(5):725-6. Epub 2009 Jul 22.

PMID:
19395872
17.

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.

Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS.

J Biol Chem. 2009 Mar 20;284(12):8023-32. doi: 10.1074/jbc.M900301200. Epub 2009 Jan 15.

18.

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.

Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM.

Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22.

19.

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.

Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM.

Mol Cell. 2007 Mar 23;25(6):903-15.

20.

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.

21.

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.

Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM.

Curr Biol. 2006 Sep 19;16(18):1865-70. Epub 2006 Aug 17.

22.

Functional genomics identifies TOR-regulated genes that control growth and division.

Guertin DA, Guntur KV, Bell GW, Thoreen CC, Sabatini DM.

Curr Biol. 2006 May 23;16(10):958-70.

23.

AMPK and p53 help cells through lean times.

Thoreen CC, Sabatini DM.

Cell Metab. 2005 May;1(5):287-8. Review.

24.

Huntingtin aggregates ask to be eaten.

Thoreen CC, Sabatini DM.

Nat Genet. 2004 Jun;36(6):553-4. No abstract available.

PMID:
15167929
25.

A proteomics approach to understanding protein ubiquitination.

Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.

Nat Biotechnol. 2003 Aug;21(8):921-6. Epub 2003 Jul 20.

PMID:
12872131
26.
27.

Automation of nanoscale microcapillary liquid chromatography-tandem mass spectrometry with a vented column.

Licklider LJ, Thoreen CC, Peng J, Gygi SP.

Anal Chem. 2002 Jul 1;74(13):3076-83.

PMID:
12141667

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