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GINA recommendations in adults with symptomatic mild asthma and a smoking history.

Thomson NC, Chaudhuri R.

Eur Respir J. 2020 Feb 6;55(2). pii: 1902043. doi: 10.1183/13993003.02043-2019. Print 2020 Feb. No abstract available.


Recent Developments In Bronchial Thermoplasty For Severe Asthma.

Thomson NC.

J Asthma Allergy. 2019 Nov 19;12:375-387. doi: 10.2147/JAA.S200912. eCollection 2019. Review.


Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Shrine N, Portelli MA, John C, Soler Artigas M, Bennett N, Hall R, Lewis J, Henry AP, Billington CK, Ahmad A, Packer RJ, Shaw D, Pogson ZEK, Fogarty A, McKeever TM, Singapuri A, Heaney LG, Mansur AH, Chaudhuri R, Thomson NC, Holloway JW, Lockett GA, Howarth PH, Djukanovic R, Hankinson J, Niven R, Simpson A, Chung KF, Sterk PJ, Blakey JD, Adcock IM, Hu S, Guo Y, Obeidat M, Sin DD, van den Berge M, Nickle DC, Bossé Y, Tobin MD, Hall IP, Brightling CE, Wain LV, Sayers I.

Lancet Respir Med. 2019 Jan;7(1):20-34. doi: 10.1016/S2213-2600(18)30389-8. Epub 2018 Dec 11.


Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations.

Yang JF, Chaudhuri R, Thomson NC, Ramparsad N, O'Pray H, Barclay S, MacBride-Stewart S, McCallum C, Sharma V, McSharry C, Murray D, Shepherd M, Lee WN.

NPJ Prim Care Respir Med. 2018 Sep 19;28(1):35. doi: 10.1038/s41533-018-0103-9.


Challenges in the management of asthma associated with smoking-induced airway diseases.

Thomson NC.

Expert Opin Pharmacother. 2018 Oct;19(14):1565-1579. doi: 10.1080/14656566.2018.1515912. Epub 2018 Sep 8. Review.


Bronchial thermoplasty as a treatment for severe asthma: controversies, progress and uncertainties.

Thomson NC.

Expert Rev Respir Med. 2018 Apr;12(4):269-282. doi: 10.1080/17476348.2018.1444991. Epub 2018 Feb 27. Review.


Respiratory symptoms and small airway dysfunction in current and former smokers without spirometric COPD.

Thomson NC.

Respirology. 2018 May;23(5):446-447. doi: 10.1111/resp.13246. Epub 2018 Jan 9. No abstract available.


Targeting oxidant-dependent mechanisms for the treatment of respiratory diseases and their comorbidities.

Thomson NC.

Curr Opin Pharmacol. 2018 Jun;40:1-8. doi: 10.1016/j.coph.2017.11.013. Epub 2017 Dec 6. Review.


How effective is bronchial thermoplasty for severe asthma in clinical practice?

Thomson NC, Chanez P.

Eur Respir J. 2017 Aug 31;50(2). pii: 1701140. doi: 10.1183/13993003.01140-2017. Print 2017 Aug. No abstract available.


Asthma and smoking-induced airway disease without spirometric COPD.

Thomson NC.

Eur Respir J. 2017 May 1;49(5). pii: 1602061. doi: 10.1183/13993003.02061-2016. Print 2017 May. Review.


New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma.

Thomson NC.

Expert Opin Pharmacother. 2017 Feb;18(3):283-293. doi: 10.1080/14656566.2017.1284794. Epub 2017 Feb 1. Review.


Azithromycin for Acute Exacerbations of Asthma : The AZALEA Randomized Clinical Trial.

Johnston SL, Szigeti M, Cross M, Brightling C, Chaudhuri R, Harrison T, Mansur A, Robison L, Sattar Z, Jackson D, Mallia P, Wong E, Corrigan C, Higgins B, Ind P, Singh D, Thomson NC, Ashby D, Chauhan A; AZALEA Trial Team.

JAMA Intern Med. 2016 Nov 1;176(11):1630-1637. doi: 10.1001/jamainternmed.2016.5664. Erratum in: JAMA Intern Med. 2018 Jul 1;178(7):1003.


Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease.

Huang JT, Bolton CE, Miller BE, Tal-Singer R, Rabinovich RA, Palmer CN, Thomson NC, MacNee W; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators.

Eur Respir J. 2016 Oct;48(4):1215-1218. doi: 10.1183/13993003.01125-2016. Epub 2016 Sep 1. No abstract available.


Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma.

Chaudhuri R, McSharry C, Heaney LG, Niven R, Brightling CE, Menzies-Gow AN, Bucknall C, Mansur AH, Lee W, Shepherd M, Spears M, Cowan DC, Husi H, Thomson NC; BTS Severe Asthma Network.

Respir Med. 2016 Sep;118:46-52. doi: 10.1016/j.rmed.2016.07.005. Epub 2016 Jul 9.


Does Age of Onset of Asthma Influence the Effect of Cigarette Smoking on Lung Function?

Thomson NC.

Am J Respir Crit Care Med. 2016 Aug 1;194(3):249-50. doi: 10.1164/rccm.201602-0389ED. No abstract available.


Findings from a pilot Randomised trial of an Asthma Internet Self-management Intervention (RAISIN).

Morrison D, Wyke S, Saunderson K, McConnachie A, Agur K, Chaudhuri R, Thomas M, Thomson NC, Yardley L, Mair FS.

BMJ Open. 2016 May 12;6(5):e009254. doi: 10.1136/bmjopen-2015-009254.


Objective Cough Frequency, Airway Inflammation, and Disease Control in Asthma.

Marsden PA, Satia I, Ibrahim B, Woodcock A, Yates L, Donnelly I, Jolly L, Thomson NC, Fowler SJ, Smith JA.

Chest. 2016 Jun;149(6):1460-6. doi: 10.1016/j.chest.2016.02.676. Epub 2016 Mar 10.


Novel approaches to the management of noneosinophilic asthma.

Thomson NC.

Ther Adv Respir Dis. 2016 Jun;10(3):211-34. doi: 10.1177/1753465816632638. Epub 2016 Feb 28. Review.


Clinical Studies of Statins in Asthma and COPD.

Thomson NC.

Curr Mol Pharmacol. 2017;10(1):60-71. doi: 10.2174/1874467209666160112125911. Review.


Addressing corticosteroid insensitivity in adults with asthma.

Thomson NC.

Expert Rev Respir Med. 2016 Feb;10(2):137-56. doi: 10.1586/17476348.2016.1133304. Epub 2016 Jan 28.


Reliever Inhaler Overuse, Asthma Symptoms, and Depression.

Thomson NC.

J Allergy Clin Immunol Pract. 2015 Nov-Dec;3(6):963-4. doi: 10.1016/j.jaip.2015.07.002. No abstract available.


The quest for the grail: multidimensional efforts for understanding and targeting severe asthma.

Gaga M, Brand PL, Thomson NC.

Eur Respir J. 2015 Nov;46(5):1227-31. doi: 10.1183/13993003.01414-2015. No abstract available.


Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.

Wain LV, Shrine N, Miller S, Jackson VE, Ntalla I, Soler Artigas M, Billington CK, Kheirallah AK, Allen R, Cook JP, Probert K, Obeidat M, Bossé Y, Hao K, Postma DS, Paré PD, Ramasamy A; UK Brain Expression Consortium (UKBEC), Mägi R, Mihailov E, Reinmaa E, Melén E, O'Connell J, Frangou E, Delaneau O; OxGSK Consortium, Freeman C, Petkova D, McCarthy M, Sayers I, Deloukas P, Hubbard R, Pavord I, Hansell AL, Thomson NC, Zeggini E, Morris AP, Marchini J, Strachan DP, Tobin MD, Hall IP.

Lancet Respir Med. 2015 Oct;3(10):769-81. doi: 10.1016/S2213-2600(15)00283-0. Epub 2015 Sep 27. Erratum in: Lancet Respir Med. 2016 Jan;4(1):e4. Erratum in: Lancet Respir Med. 2016 Jan;4(1):e4.


Effectiveness of bronchial thermoplasty in severe asthma in 'real life' patients compared with those recruited to clinical trials in the same centre.

Bicknell S, Chaudhuri R, Lee N, Shepherd M, Spears M, Pitman N, Cameron E, Cowan D, Nixon J, Thompson J, McSharry C, Thomson NC.

Ther Adv Respir Dis. 2015 Dec;9(6):267-71. doi: 10.1177/1753465815601332. Epub 2015 Aug 24.


Details of development of the resource for adults with asthma in the RAISIN (randomized trial of an asthma internet self-management intervention) study.

Morrison D, Mair FS, Chaudhuri R, McGee-Lennon M, Thomas M, Thomson NC, Yardley L, Wyke S.

BMC Med Inform Decis Mak. 2015 Jul 28;15:57. doi: 10.1186/s12911-015-0177-z.



Thomson NC, McSharry C, Chaudhuri R.

Chest. 2015 Jul;148(1):e33-e34. doi: 10.1378/chest.15-0890. No abstract available.


Serum periostin in smokers and never smokers with asthma.

Thomson NC, Chaudhuri R, Spears M, Haughney J, McSharry C.

Respir Med. 2015 Jun;109(6):708-15. doi: 10.1016/j.rmed.2015.03.009. Epub 2015 Apr 3.


Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma.

Thomson NC, Charron CE, Chaudhuri R, Spears M, Ito K, McSharry C.

Pulm Pharmacol Ther. 2015 Apr;31:1-8. doi: 10.1016/j.pupt.2015.01.001. Epub 2015 Jan 14.


Decreased FEV1 % in asthmatic adults in Scottish homes with high Environmental Relative Moldiness Index values.

McSharry C, Vesper S, Wymer L, Howieson S, Chaudhuri R, Wright GR, Thomson NC.

Clin Exp Allergy. 2015 May;45(5):902-907. doi: 10.1111/cea.12482.


Poor symptom control is associated with reduced CT scan segmental airway lumen area in smokers with asthma.

Thomson NC, Chaudhuri R, Spears M, Messow CM, MacNee W, Connell M, Murchison JT, Sproule M, McSharry C.

Chest. 2015 Mar;147(3):735-744. doi: 10.1378/chest.14-1119. Erratum in: Chest. 2015 Aug;148(2):572.


Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients.

McSharry C, Spears M, Chaudhuri R, Cameron EJ, Husi H, Thomson NC.

J Allergy Clin Immunol. 2014 Nov;134(5):1068-75. doi: 10.1016/j.jaci.2014.08.022. Epub 2014 Sep 26.


Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma.

Chaudhuri R, McSharry C, Brady J, Grierson C, Messow CM, Spears M, Miele G, Nocka K, MacNee W, Connell M, Murchison JT, Sproule M, Hilmi OJ, Miller DK, Thomson NC.

Eur Respir J. 2014 Oct;44(4):895-904. doi: 10.1183/09031936.00047014. Epub 2014 Jul 3.


The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Djukanović R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, Niven R, Singh D, Reddel HK, Davies DE, Marsden R, Boxall C, Dudley S, Plagnol V, Holgate ST, Monk P; INTERCIA Study Group.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):145-54. doi: 10.1164/rccm.201312-2235OC.


The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry.

O'Neill S, Sweeney J, Patterson CC, Menzies-Gow A, Niven R, Mansur AH, Bucknall C, Chaudhuri R, Thomson NC, Brightling CE, O'Neill C, Heaney LG; British Thoracic Society Difficult Asthma Network.

Thorax. 2015 Apr;70(4):376-8. doi: 10.1136/thoraxjnl-2013-204114. Epub 2014 Jun 10.


A Randomized trial of an Asthma Internet Self-management Intervention (RAISIN): study protocol for a randomized controlled trial.

Morrison D, Wyke S, Thomson NC, McConnachie A, Agur K, Saunderson K, Chaudhuri R, Mair FS.

Trials. 2014 May 24;15:185. doi: 10.1186/1745-6215-15-185.


Novel therapies targeting eosinophilic inflammation in asthma.

Thomson NC.

Clin Exp Allergy. 2014 Apr;44(4):462-8. doi: 10.1111/cea.12268. No abstract available.


Omalizumab decreases exacerbations and allows a step down in daily inhaled corticosteroid dose in adults and children with moderate-to-severe asthma.

Thomson NC.

Evid Based Med. 2014 Aug;19(4):135. doi: 10.1136/eb-2014-101759. Epub 2014 Mar 13. No abstract available.


Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking.

Thomson NC, Chaudhuri R, Spears M, Messow CM, Jelinsky S, Miele G, Nocka K, Takahashi E, Hilmi OJ, Shepherd MC, Miller DK, McSharry C.

Allergy. 2014 Apr;69(4):527-36. doi: 10.1111/all.12376. Epub 2014 Feb 26.


Digital asthma self-management interventions: a systematic review.

Morrison D, Wyke S, Agur K, Cameron EJ, Docking RI, Mackenzie AM, McConnachie A, Raghuvir V, Thomson NC, Mair FS.

J Med Internet Res. 2014 Feb 18;16(2):e51. doi: 10.2196/jmir.2814. Review.


Effects of a FLAP inhibitor, GSK2190915, in asthmatics with high sputum neutrophils.

Chaudhuri R, Norris V, Kelly K, Zhu CQ, Ambery C, Lafferty J, Cameron E, Thomson NC.

Pulm Pharmacol Ther. 2014 Feb;27(1):62-9. doi: 10.1016/j.pupt.2013.11.007. Epub 2013 Dec 10.


Sputum matrix metalloproteinase-9 is associated with the degree of emphysema on computed tomography in COPD.

Chaudhuri R, McSharry C, Spears M, Brady J, Grierson C, Messow CM, Miele G, Nocka K, MacNee W, Connell M, Murchison JT, Sproule M, Hilmi O, Miller DK, Thomson NC.

Transl Respir Med. 2013 Dec;1(1):11. doi: 10.1186/2213-0802-1-11. Epub 2013 Jun 6.


Disconnect between sputum neutrophils and other measures of airway inflammation in asthma.

Arron JR, Choy DF, Laviolette M, Kelsen SG, Hatab A, Leigh R, Thomson NC, Bleecker ER, Olivenstein R, Avila PC, Jarjour NN, Castro M, Gauvreau GM, Good JT, Kline JN, Mansur A, Mayers I, Heaney LG, Hamid Q, Harris JM.

Eur Respir J. 2014 Feb;43(2):627-9. doi: 10.1183/09031936.00117013. Epub 2013 Oct 31. No abstract available.


Inhaled corticosteroids for asthma: on-demand or continuous use.

Thomson NC, Spears M.

Expert Rev Respir Med. 2013 Dec;7(6):687-99. doi: 10.1586/17476348.2013.836062. Epub 2013 Oct 22. Review.


Safety of bronchial thermoplasty in patients with severe refractory asthma.

Pavord ID, Thomson NC, Niven RM, Corris PA, Chung KF, Cox G, Armstrong B, Shargill NS, Laviolette M; Research in Severe Asthma Trial Study Group.

Ann Allergy Asthma Immunol. 2013 Nov;111(5):402-7. doi: 10.1016/j.anai.2013.05.002. Epub 2013 Jun 13.


Randomised controlled trial of azithromycin in smokers with asthma.

Cameron EJ, Chaudhuri R, Mair F, McSharry C, Greenlaw N, Weir CJ, Jolly L, Donnelly I, Gallacher K, Morrison D, Spears M, Evans TJ, Anderson K, Thomson NC.

Eur Respir J. 2013 Nov;42(5):1412-5. doi: 10.1183/09031936.00093913. Epub 2013 Sep 13. No abstract available.


Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma.

Wechsler ME, Laviolette M, Rubin AS, Fiterman J, Lapa e Silva JR, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Hales JB, McEvoy C, Slebos DJ, Holmes M, Phillips MJ, Erzurum SC, Hanania NA, Sumino K, Kraft M, Cox G, Sterman DH, Hogarth K, Kline JN, Mansur AH, Louie BE, Leeds WM, Barbers RG, Austin JH, Shargill NS, Quiring J, Armstrong B, Castro M; Asthma Intervention Research 2 Trial Study Group.

J Allergy Clin Immunol. 2013 Dec;132(6):1295-302. doi: 10.1016/j.jaci.2013.08.009. Epub 2013 Aug 30.


Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines-an exploratory study.

Spears M, McSharry C, Chaudhuri R, Weir CJ, de Wet C, Thomson NC.

PLoS One. 2013 Aug 9;8(8):e71460. doi: 10.1371/journal.pone.0071460. eCollection 2013.


Characterization and validation of an isotope-dilution LC-MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum.

Albarbarawi O, Barton A, Miller D, McSharry C, Chaudhuri R, Thomson NC, Palmer CN, Devereux G, Huang JT.

Bioanalysis. 2013 Aug;5(16):1991-2001. doi: 10.4155/bio.13.164.


Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma.

Thomson NC, Chaudhuri R, Messow CM, Spears M, MacNee W, Connell M, Murchison JT, Sproule M, McSharry C.

Respir Med. 2013 Oct;107(10):1501-8. doi: 10.1016/j.rmed.2013.07.017. Epub 2013 Aug 6.


Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma.

Thomson NC, Chaudhuri R, Heaney LG, Bucknall C, Niven RM, Brightling CE, Menzies-Gow AN, Mansur AH, McSharry C.

J Allergy Clin Immunol. 2013 Apr;131(4):1008-16. doi: 10.1016/j.jaci.2012.12.1574. Epub 2013 Feb 16.


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