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Items: 1 to 50 of 117

1.

Non-alcoholic fatty liver disease (NAFLD) is associated with dynamic changes in DNA hydroxymethylation.

Lyall MJ, Thomson JP, Cartier J, Ottaviano R, Kendall TJ, Meehan RR, Drake AJ.

Epigenetics. 2019 Aug 7:1-11. doi: 10.1080/15592294.2019.1649527. [Epub ahead of print]

PMID:
31389294
2.

Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells.

Lyall MJ, Cartier J, Thomson JP, Cameron K, Meseguer-Ripolles J, O'Duibhir E, Szkolnicka D, Villarin BL, Wang Y, Blanco GR, Dunn WB, Meehan RR, Hay DC, Drake AJ.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170362. doi: 10.1098/rstb.2017.0362.

3.

Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD.

Lyall MJ, Cartier J, Richards JA, Cobice D, Thomson JP, Meehan RR, Anderton SM, Drake AJ.

Wellcome Open Res. 2017 Aug 22;2:67. doi: 10.12688/wellcomeopenres.12199.1. eCollection 2017.

4.

Investigation into the role of the germline epigenome in the transmission of glucocorticoid-programmed effects across generations.

Cartier J, Smith T, Thomson JP, Rose CM, Khulan B, Heger A, Meehan RR, Drake AJ.

Genome Biol. 2018 Apr 10;19(1):50. doi: 10.1186/s13059-018-1422-4.

5.

Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2018 Mar 14;555(7696):402. doi: 10.1038/nature25996.

PMID:
29542689
6.

DNA methylation as a genomic marker of exposure to chemical and environmental agents.

Meehan RR, Thomson JP, Lentini A, Nestor CE, Pennings S.

Curr Opin Chem Biol. 2018 Aug;45:48-56. doi: 10.1016/j.cbpa.2018.02.006. Epub 2018 Mar 2. Review.

7.

Affinity-Based Enrichment Techniques for the Genome-Wide Analysis of 5-Hydroxymethylcytosine.

Thomson JP, Meehan RR.

Methods Mol Biol. 2018;1708:679-696. doi: 10.1007/978-1-4939-7481-8_35.

PMID:
29224170
8.

Defining baseline epigenetic landscapes in the rat liver.

Thomson JP, Ottaviano R, Buesen R, Moggs JG, Schwarz M, Meehan RR.

Epigenomics. 2017 Dec;9(12):1503-1527. doi: 10.2217/epi-2017-0029. Epub 2017 Nov 13.

9.

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration.

Raven A, Lu WY, Man TY, Ferreira-Gonzalez S, O'Duibhir E, Dwyer BJ, Thomson JP, Meehan RR, Bogorad R, Koteliansky V, Kotelevtsev Y, Ffrench-Constant C, Boulter L, Forbes SJ.

Nature. 2017 Jul 20;547(7663):350-354. doi: 10.1038/nature23015. Epub 2017 Jul 12. Erratum in: Nature. 2018 Mar 14;555(7696):402.

10.

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.

11.

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions.

Cole JJ, Robertson NA, Rather MI, Thomson JP, McBryan T, Sproul D, Wang T, Brock C, Clark W, Ideker T, Meehan RR, Miller RA, Brown-Borg HM, Adams PD.

Genome Biol. 2017 Mar 28;18(1):58. doi: 10.1186/s13059-017-1185-3.

12.

The application of genome-wide 5-hydroxymethylcytosine studies in cancer research.

Thomson JP, Meehan RR.

Epigenomics. 2017 Jan;9(1):77-91. doi: 10.2217/epi-2016-0122. Epub 2016 Dec 12. Review.

13.

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

Thomson JP, Ottaviano R, Unterberger EB, Lempiäinen H, Muller A, Terranova R, Illingworth RS, Webb S, Kerr AR, Lyall MJ, Drake AJ, Wolf CR, Moggs JG, Schwarz M, Meehan RR.

Cancer Res. 2016 May 15;76(10):3097-108. doi: 10.1158/0008-5472.CAN-15-1910. Epub 2016 Apr 6.

14.

5-Hydroxymethylcytosine Profiling in Human DNA.

Thomson JP, Nestor CE, Meehan RR.

Methods Mol Biol. 2017;1589:89-98. doi: 10.1007/7651_2015_268.

PMID:
26126447
15.

DNA immunoprecipitation semiconductor sequencing (DIP-SC-seq) as a rapid method to generate genome wide epigenetic signatures.

Thomson JP, Fawkes A, Ottaviano R, Hunter JM, Shukla R, Mjoseng HK, Clark R, Coutts A, Murphy L, Meehan RR.

Sci Rep. 2015 May 14;5:9778. doi: 10.1038/srep09778.

16.

Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems.

Nestor CE, Ottaviano R, Reinhardt D, Cruickshanks HA, Mjoseng HK, McPherson RC, Lentini A, Thomson JP, Dunican DS, Pennings S, Anderton SM, Benson M, Meehan RR.

Genome Biol. 2015 Feb 4;16:11. doi: 10.1186/s13059-014-0576-y.

17.

Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.

McPherson RC, Konkel JE, Prendergast CT, Thomson JP, Ottaviano R, Leech MD, Kay O, Zandee SE, Sweenie CH, Wraith DC, Meehan RR, Drake AJ, Anderton SM.

Elife. 2014 Dec 29;3. doi: 10.7554/eLife.03416.

18.

Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.

Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG.

Toxicol Sci. 2014 Jun;139(2):501-11. doi: 10.1093/toxsci/kfu038. Epub 2014 Apr 1.

PMID:
24690595
19.

5-hydroxymethylcytosine profiling as an indicator of cellular state.

Laird A, Thomson JP, Harrison DJ, Meehan RR.

Epigenomics. 2013 Dec;5(6):655-69. doi: 10.2217/epi.13.69. Review.

20.

Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques.

Thomson JP, Hunter JM, Nestor CE, Dunican DS, Terranova R, Moggs JG, Meehan RR.

Nucleic Acids Res. 2013 Dec;41(22):e206. doi: 10.1093/nar/gkt1080. Epub 2013 Nov 7. Erratum in: Nucleic Acids Res. . 2014 Apr;42(6):4142.

21.

CpG island chromatin is shaped by recruitment of ZF-CxxC proteins.

Blackledge NP, Thomson JP, Skene PJ.

Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a018648. doi: 10.1101/cshperspect.a018648. Review.

22.

Epigenetic profiles as defined signatures of xenobiotic exposure.

Thomson JP, Moggs JG, Wolf CR, Meehan RR.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Apr;764-765:3-9. doi: 10.1016/j.mrgentox.2013.08.007. Epub 2013 Aug 31. Review.

PMID:
24001620
23.

Deep C diving: mapping the low-abundance modifications of the DNA demethylation pathway.

Thomson JP, Hunter JM, Meehan RR.

Genome Biol. 2013 May 29;14(5):118. doi: 10.1186/gb-2013-14-5-118.

24.

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.

Thomson JP, Hunter JM, Lempiäinen H, Müller A, Terranova R, Moggs JG, Meehan RR.

Nucleic Acids Res. 2013 Jun;41(11):5639-54. doi: 10.1093/nar/gkt232. Epub 2013 Apr 17.

25.

Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion.

Lempiäinen H, Couttet P, Bolognani F, Müller A, Dubost V, Luisier R, Del Rio Espinola A, Vitry V, Unterberger EB, Thomson JP, Treindl F, Metzger U, Wrzodek C, Hahne F, Zollinger T, Brasa S, Kalteis M, Marcellin M, Giudicelli F, Braeuning A, Morawiec L, Zamurovic N, Längle U, Scheer N, Schübeler D, Goodman J, Chibout SD, Marlowe J, Theil D, Heard DJ, Grenet O, Zell A, Templin MF, Meehan RR, Wolf RC, Elcombe CR, Schwarz M, Moulin P, Terranova R, Moggs JG.

Toxicol Sci. 2013 Feb;131(2):375-86. doi: 10.1093/toxsci/kfs303. Epub 2012 Oct 22.

PMID:
23091169
26.

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome.

Thomson JP, Lempiäinen H, Hackett JA, Nestor CE, Müller A, Bolognani F, Oakeley EJ, Schübeler D, Terranova R, Reinhardt D, Moggs JG, Meehan RR.

Genome Biol. 2012 Oct 3;13(10):R93. doi: 10.1186/gb-2012-13-10-r93.

27.

CpG islands influence chromatin structure via the CpG-binding protein Cfp1.

Thomson JP, Skene PJ, Selfridge J, Clouaire T, Guy J, Webb S, Kerr AR, Deaton A, Andrews R, James KD, Turner DJ, Illingworth R, Bird A.

Nature. 2010 Apr 15;464(7291):1082-6. doi: 10.1038/nature08924.

28.

A prospective audit of fistula-in-ano at St. Mark's hospital.

Malouf AJ, Buchanan GN, Carapeti EA, Rao S, Guy RJ, Westcott E, Thomson JP, Cohen CR.

Colorectal Dis. 2002 Jan;4(1):13-19.

PMID:
12780648
29.

[The polyposis register of St. Marks Hospital in London].

Thomson JP, Obrador A.

Gastroenterol Hepatol. 2002 Apr;25(4):267-71. Review. Spanish. No abstract available.

PMID:
11975876
30.

The college links with St Paul's Cathedral.

Craig T, Knight T, Thomson JP, Wisdom JJ.

Ann R Coll Surg Engl. 2000 Sep;82(8 Suppl):250-6. No abstract available.

PMID:
11045078
31.

The fellowship and the definition of surgery.

Thomson JP.

Ann R Coll Surg Engl. 1997 May;79(3 Suppl):126. No abstract available.

PMID:
9227180
32.

Overlap repair of damaged anal sphincter. A single surgeon's series.

Sitzler PJ, Thomson JP.

Dis Colon Rectum. 1996 Dec;39(12):1356-60.

PMID:
8969660
33.

Trephine colostomy: a warning.

Loder PB, Thomson JP.

Ann R Coll Surg Engl. 1995 Nov;77(6):462.

34.

Persistence of idiopathic anal fistula may be related to epithelialization.

Lunniss PJ, Sheffield JP, Talbot IC, Thomson JP, Phillips RK.

Br J Surg. 1995 Jan;82(1):32-3.

PMID:
7881949
35.

CT appearances of desmoid tumours in familial adenomatous polyposis: further observations.

Brooks AP, Reznek RH, Nugent K, Farmer KC, Thomson JP, Phillips RK.

Clin Radiol. 1994 Sep;49(9):601-7.

PMID:
7955885
36.

Results of Delorme's procedure for rectal prolapse.

Senapati A, Nicholls RJ, Thomson JP, Phillips RK.

Dis Colon Rectum. 1994 May;37(5):456-60. Review.

PMID:
8181407
37.

Overlapping anal sphincter repair for faecal incontinence due to sphincter trauma: five year follow-up functional results.

Londono-Schimmer EE, Garcia-Duperly R, Nicholls RJ, Ritchie JK, Hawley PR, Thomson JP.

Int J Colorectal Dis. 1994 May;9(2):110-3.

PMID:
8064190
38.

Eye movement during cataract surgery.

Thomson JP.

Anaesth Intensive Care. 1993 Jun;21(3):376. No abstract available.

PMID:
8342780
39.

Oral calcium inhibits rectal epithelial proliferation in familial adenomatous polyposis.

Thomas MG, Thomson JP, Williamson RC.

Br J Surg. 1993 Apr;80(4):499-501.

PMID:
8388307
40.

An evaluation of the penetration of cefuroxime axetil into human paranasal sinus tissue.

Sudderick RM, Lund VJ, Thomson JP, McCombe A, Mackay IS.

Rhinology. 1992 Mar;30(1):11-6.

PMID:
1579807
41.

Management of familial adenomatous polyposis.

Spigelman AD, Hodgson SV, Thomson JP.

Baillieres Clin Gastroenterol. 1992 Mar;6(1):75-94. Review.

PMID:
1316794
42.

Clinical and functional results of abdominal rectopexy for complete rectal prolapse.

McCue JL, Thomson JP.

Br J Surg. 1991 Aug;78(8):921-3.

PMID:
1913105
43.

Comparison of morbidity and function after colectomy with ileorectal anastomosis or restorative proctocolectomy for familial adenomatous polyposis.

Madden MV, Neale KF, Nicholls RJ, Landgrebe JC, Chapman PD, Bussey HJ, Thomson JP.

Br J Surg. 1991 Jul;78(7):789-92.

PMID:
1651799
44.

A review of physical abnormalities in familial adenomatous polyposis.

Seow C, Neale K, Landgrebe JC, Bussey HJ, Thomson JP.

Singapore Med J. 1991 Jun;32(3):139-42. Review.

PMID:
1652160
45.

Rectopexy for internal rectal intussusception.

McCue JL, Thomson JP.

Br J Surg. 1990 Jun;77(6):632-4.

PMID:
2383728
46.

Familial adenomatous polyposis: the large bowel.

Thomson JP.

Ann R Coll Surg Engl. 1990 May;72(3):177-80. No abstract available.

47.

Postanal repair: which patients derive most benefit?

Rainey JB, Donaldson DR, Thomson JP.

J R Coll Surg Edinb. 1990 Apr;35(2):101-5.

PMID:
2355371
48.

Clinical compliance of two resilient denture liners.

Graham BS, Jones DW, Thomson JP, Johnson JA.

J Oral Rehabil. 1990 Mar;17(2):157-63.

PMID:
2341956
49.
50.

Pigmented lesions of the retinal pigment epithelium and familial adenomatous polyposis.

Polkinghorne PJ, Ritchie S, Neale K, Schoeppner G, Thomson JP, Jay BS.

Eye (Lond). 1990;4 ( Pt 1):216-21.

PMID:
2157613

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