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Items: 1 to 50 of 631

1.

Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors.

Zhang J, Tao R, Campbell KF, Carvalho JL, Ruiz EC, Kim GC, Schmuck EG, Raval AN, da Rocha AM, Herron TJ, Jalife J, Thomson JA, Kamp TJ.

Nat Commun. 2019 May 20;10(1):2238. doi: 10.1038/s41467-019-09831-5.

2.

Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat.

Toh H, Smolentsev A, Bozadjian RV, Keeley PW, Lockwood MD, Sadjadi R, Clegg DO, Blodi BA, Coffey PJ, Reese BE, Thomson JA.

Lab Invest. 2019 May 17. doi: 10.1038/s41374-019-0264-3. [Epub ahead of print]

PMID:
31101854
3.

A Human Pluripotent Stem Cell-Based Screen for Smooth Muscle Cell Differentiation and Maturation Identifies Inhibitors of Intimal Hyperplasia.

Zhang J, McIntosh BE, Wang B, Brown ME, Probasco MD, Webster S, Duffin B, Zhou Y, Guo LW, Burlingham WJ, Kent C, Ferris M, Thomson JA.

Stem Cell Reports. 2019 Jun 11;12(6):1269-1281. doi: 10.1016/j.stemcr.2019.04.013. Epub 2019 May 9.

4.

Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm.

Magli A, Baik J, Mills LJ, Kwak IY, Dillon BS, Mondragon Gonzalez R, Stafford DA, Swanson SA, Stewart R, Thomson JA, Garry DJ, Dynlacht BD, Perlingeiro RCR.

PLoS Biol. 2019 Feb 26;17(2):e3000153. doi: 10.1371/journal.pbio.3000153. eCollection 2019 Feb.

5.

A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma.

Hall PE, Lewis R, Syed N, Shaffer R, Evanson J, Ellis S, Williams M, Feng X, Johnston A, Thomson JA, Harris FP, Jena R, Matys T, Jefferies S, Smith K, Wu BW, Bomalaski JS, Crook T, O'Neill K, Paraskevopoulos D, Khadeir RS, Sheaff M, Pacey S, Plowman PN, Szlosarek PW.

Clin Cancer Res. 2019 May 1;25(9):2708-2716. doi: 10.1158/1078-0432.CCR-18-3729. Epub 2019 Feb 22.

PMID:
30796035
6.

Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment.

Incitti T, Magli A, Darabi R, Yuan C, Lin K, Arpke RW, Azzag K, Yamamoto A, Stewart R, Thomson JA, Kyba M, Perlingeiro RCR.

Proc Natl Acad Sci U S A. 2019 Feb 13. pii: 201808303. doi: 10.1073/pnas.1808303116. [Epub ahead of print]

PMID:
30760602
7.

Fabrication and modification of wavy multicomponent vascular grafts with biomimetic mechanical properties, antithrombogenicity, and enhanced endothelial cell affinity.

Mi HY, Jing X, Li ZT, Lin YJ, Thomson JA, Turng LS.

J Biomed Mater Res B Appl Biomater. 2019 Jan 28. doi: 10.1002/jbm.b.34333. [Epub ahead of print]

PMID:
30689292
8.

Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds.

Joseph DB, Chandrashekar AS, Abler LL, Chu LF, Thomson JA, Vezina CM.

Dev Biol. 2019 Mar 15;447(2):157-169. doi: 10.1016/j.ydbio.2019.01.011. Epub 2019 Jan 16.

PMID:
30659795
9.

Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9.

Foltz LP, Howden SE, Thomson JA, Clegg DO.

Int J Mol Sci. 2018 Dec 19;19(12). pii: E4127. doi: 10.3390/ijms19124127.

10.

Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels.

Kaushik G, Gil DA, Torr E, Berge ES, Soref C, Uhl P, Fontana G, Antosiewicz-Bourget J, Edington C, Schwartz MP, Griffith LG, Thomson JA, Skala MC, Daly WT, Murphy WL.

Adv Healthc Mater. 2019 Jan;8(2):e1801186. doi: 10.1002/adhm.201801186. Epub 2018 Dec 19.

PMID:
30565891
11.

Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells.

Meng Y, Ren Z, Xu F, Zhou X, Song C, Wang VY, Liu W, Lu L, Thomson JA, Chen G.

Stem Cell Reports. 2018 Dec 11;11(6):1347-1356. doi: 10.1016/j.stemcr.2018.10.023. Epub 2018 Nov 29.

12.

Trendy: segmented regression analysis of expression dynamics in high-throughput ordered profiling experiments.

Bacher R, Leng N, Chu LF, Ni Z, Thomson JA, Kendziorski C, Stewart R.

BMC Bioinformatics. 2018 Oct 16;19(1):380. doi: 10.1186/s12859-018-2405-x.

13.

A folic acid-enriched diet attenuates prostate involution in response to androgen deprivation.

Joseph DB, Chandrashekar AS, Chu LF, Thomson JA, Vezina CM.

Prostate. 2019 Feb;79(2):183-194. doi: 10.1002/pros.23723. Epub 2018 Oct 8.

PMID:
30298636
14.

In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells.

Joseph DB, Chandrashekar AS, Abler LL, Chu LF, Thomson JA, Mendelsohn C, Vezina CM.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8394-8399. doi: 10.1073/pnas.1802966115. Epub 2018 Jul 30.

15.

Individual specialization in a migratory grazer reflects long-term diet selectivity on a foraging ground: implications for isotope-based tracking.

Thomson JA, Whitman ER, Garcia-Rojas MI, Bellgrove A, Ekins M, Hays GC, Heithaus MR.

Oecologia. 2018 Oct;188(2):429-439. doi: 10.1007/s00442-018-4218-z. Epub 2018 Jul 10.

PMID:
29992416
16.

GATA2 Is Dispensable for Specification of Hemogenic Endothelium but Promotes Endothelial-to-Hematopoietic Transition.

Kang H, Mesquitta WT, Jung HS, Moskvin OV, Thomson JA, Slukvin II.

Stem Cell Reports. 2018 Jul 10;11(1):197-211. doi: 10.1016/j.stemcr.2018.05.002. Epub 2018 May 31.

17.

Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential.

Park MA, Kumar A, Jung HS, Uenishi G, Moskvin OV, Thomson JA, Slukvin II.

Cell Rep. 2018 May 22;23(8):2467-2481. doi: 10.1016/j.celrep.2018.04.092.

18.

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.

Uenishi GI, Jung HS, Kumar A, Park MA, Hadland BK, McLeod E, Raymond M, Moskvin O, Zimmerman CE, Theisen DJ, Swanson S, J Tamplin O, Zon LI, Thomson JA, Bernstein ID, Slukvin II.

Nat Commun. 2018 May 8;9(1):1828. doi: 10.1038/s41467-018-04134-7.

19.

Spatial patterns of gene expression are unveiled in the chick primitive streak by ordering single-cell transcriptomes.

Vermillion KL, Bacher R, Tannenbaum AP, Swanson S, Jiang P, Chu LF, Stewart R, Thomson JA, Vereide DT.

Dev Biol. 2018 Jul 1;439(1):30-41. doi: 10.1016/j.ydbio.2018.04.007. Epub 2018 Apr 17.

20.

Simultaneous reprogramming and gene editing of human fibroblasts.

Howden SE, Thomson JA, Little MH.

Nat Protoc. 2018 May;13(5):875-898. doi: 10.1038/nprot.2018.007. Epub 2018 Apr 5.

21.

A Humanized Mouse Model Generated Using Surplus Neonatal Tissue.

Brown ME, Zhou Y, McIntosh BE, Norman IG, Lou HE, Biermann M, Sullivan JA, Kamp TJ, Thomson JA, Anagnostopoulos PV, Burlingham WJ.

Stem Cell Reports. 2018 Apr 10;10(4):1175-1183. doi: 10.1016/j.stemcr.2018.02.011. Epub 2018 Mar 22.

22.

Expandable Arterial Endothelial Precursors from Human CD34+ Cells Differ in Their Proclivity to Undergo an Endothelial-to-Mesenchymal Transition.

Miller AZ, Satchie A, Tannenbaum AP, Nihal A, Thomson JA, Vereide DT.

Stem Cell Reports. 2018 Jan 9;10(1):73-86. doi: 10.1016/j.stemcr.2017.12.011.

23.

Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.

Wang T, Bemis G, Hanzelka B, Zuccola H, Wynn M, Moody CS, Green J, Locher C, Liu A, Gao H, Xu Y, Wang S, Wang J, Bennani YL, Thomson JA, Müh U.

ACS Med Chem Lett. 2017 Nov 28;8(12):1224-1229. doi: 10.1021/acsmedchemlett.7b00239. eCollection 2017 Dec 14.

24.

A Novel Approach to Single Cell RNA-Sequence Analysis Facilitates In Silico Gene Reporting of Human Pluripotent Stem Cell-Derived Retinal Cell Types.

Phillips MJ, Jiang P, Howden S, Barney P, Min J, York NW, Chu LF, Capowski EE, Cash A, Jain S, Barlow K, Tabassum T, Stewart R, Pattnaik BR, Thomson JA, Gamm DM.

Stem Cells. 2018 Mar;36(3):313-324. doi: 10.1002/stem.2755. Epub 2017 Dec 25. Erratum in: Stem Cells. 2018 Jul;36(7):1133.

25.

Development of biomimetic thermoplastic polyurethane/fibroin small-diameter vascular grafts via a novel electrospinning approach.

Yu E, Mi HY, Zhang J, Thomson JA, Turng LS.

J Biomed Mater Res A. 2018 Apr;106(4):985-996. doi: 10.1002/jbm.a.36297. Epub 2017 Dec 5.

26.
27.

Feeding the world's largest fish: highly variable whale shark residency patterns at a provisioning site in the Philippines.

Thomson JA, Araujo G, Labaja J, McCoy E, Murray R, Ponzo A.

R Soc Open Sci. 2017 Sep 27;4(9):170394. doi: 10.1098/rsos.170394. eCollection 2017 Sep.

28.

RNA-Seq of Human Neural Progenitor Cells Exposed to Lead (Pb) Reveals Transcriptome Dynamics, Splicing Alterations and Disease Risk Associations.

Jiang P, Hou Z, Bolin JM, Thomson JA, Stewart R.

Toxicol Sci. 2017 Sep 1;159(1):251-265. doi: 10.1093/toxsci/kfx129.

29.

The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis.

Maslej MM, Bolker BM, Russell MJ, Eaton K, Durisko Z, Hollon SD, Swanson GM, Thomson JA Jr, Mulsant BH, Andrews PW.

Psychother Psychosom. 2017;86(5):268-282. doi: 10.1159/000477940. Epub 2017 Sep 14. Review.

PMID:
28903117
30.

2-N-Arylthiazole inhibitors of Mycobacterium tuberculosis.

Clark MP, Wang T, Perola E, Deininger DD, Zuccola HJ, Jones SM, Gao H, VanderVen BC, Russell DG, Shoen CM, Cynamon MH, Thomson JA, Locher CP.

Bioorg Med Chem Lett. 2017 Sep 1;27(17):3987-3991. doi: 10.1016/j.bmcl.2017.07.067. Epub 2017 Jul 27.

PMID:
28778468
31.

Functional characterization of human pluripotent stem cell-derived arterial endothelial cells.

Zhang J, Chu LF, Hou Z, Schwartz MP, Hacker T, Vickerman V, Swanson S, Leng N, Nguyen BK, Elwell A, Bolin J, Brown ME, Stewart R, Burlingham WJ, Murphy WL, Thomson JA.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6072-E6078. doi: 10.1073/pnas.1702295114. Epub 2017 Jul 10.

32.

PAX7 Targets, CD54, Integrin α9β1, and SDC2, Allow Isolation of Human ESC/iPSC-Derived Myogenic Progenitors.

Magli A, Incitti T, Kiley J, Swanson SA, Darabi R, Rinaldi F, Selvaraj S, Yamamoto A, Tolar J, Yuan C, Stewart R, Thomson JA, Perlingeiro RCR.

Cell Rep. 2017 Jun 27;19(13):2867-2877. doi: 10.1016/j.celrep.2017.06.005.

33.

Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts.

Vermilyea SC, Guthrie S, Meyer M, Smuga-Otto K, Braun K, Howden S, Thomson JA, Zhang SC, Emborg ME, Golos TG.

Stem Cells Dev. 2017 Sep 1;26(17):1225-1235. doi: 10.1089/scd.2017.0069. Epub 2017 Jul 24.

34.

Uniform neural tissue models produced on synthetic hydrogels using standard culture techniques.

Barry C, Schmitz MT, Propson NE, Hou Z, Zhang J, Nguyen BK, Bolin JM, Jiang P, McIntosh BE, Probasco MD, Swanson S, Stewart R, Thomson JA, Schwartz MP, Murphy WL.

Exp Biol Med (Maywood). 2017 Nov;242(17):1679-1689. doi: 10.1177/1535370217715028. Epub 2017 Jun 9.

35.

Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts.

Kumar A, D'Souza SS, Moskvin OV, Toh H, Wang B, Zhang J, Swanson S, Guo LW, Thomson JA, Slukvin II.

Cell Rep. 2017 May 30;19(9):1902-1916. doi: 10.1016/j.celrep.2017.05.019.

36.

SCnorm: robust normalization of single-cell RNA-seq data.

Bacher R, Chu LF, Leng N, Gasch AP, Thomson JA, Stewart RM, Newton M, Kendziorski C.

Nat Methods. 2017 Jun;14(6):584-586. doi: 10.1038/nmeth.4263. Epub 2017 Apr 17.

37.

A Genome-wide Analysis of Human Pluripotent Stem Cell-Derived Endothelial Cells in 2D or 3D Culture.

Zhang J, Schwartz MP, Hou Z, Bai Y, Ardalani H, Swanson S, Steill J, Ruotti V, Elwell A, Nguyen BK, Bolin J, Stewart R, Thomson JA, Murphy WL.

Stem Cell Reports. 2017 Apr 11;8(4):907-918. doi: 10.1016/j.stemcr.2017.02.014. Epub 2017 Mar 23.

38.

Species-specific developmental timing is maintained by pluripotent stem cells ex utero.

Barry C, Schmitz MT, Jiang P, Schwartz MP, Duffin BM, Swanson S, Bacher R, Bolin JM, Elwell AL, McIntosh BE, Stewart R, Thomson JA.

Dev Biol. 2017 Mar 15;423(2):101-110. doi: 10.1016/j.ydbio.2017.02.002. Epub 2017 Feb 6.

39.

Reprogramming cell fate with a genome-scale library of artificial transcription factors.

Eguchi A, Wleklinski MJ, Spurgat MC, Heiderscheit EA, Kropornicka AS, Vu CK, Bhimsaria D, Swanson SA, Stewart R, Ramanathan P, Kamp TJ, Slukvin I, Thomson JA, Dutton JR, Ansari AZ.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8257-E8266. doi: 10.1073/pnas.1611142114. Epub 2016 Dec 5.

40.

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.

Lee WH, Higuchi H, Ikeda S, Macke EL, Takimoto T, Pattnaik BR, Liu C, Chu LF, Siepka SM, Krentz KJ, Rubinstein CD, Kalejta RF, Thomson JA, Mullins RF, Takahashi JS, Pinto LH, Ikeda A.

Elife. 2016 Nov 15;5. pii: e19264. doi: 10.7554/eLife.19264.

41.

Synthetic genome readers target clustered binding sites across diverse chromatin states.

Erwin GS, Grieshop MP, Bhimsaria D, Do TJ, Rodríguez-Martínez JA, Mehta C, Khanna K, Swanson SA, Stewart R, Thomson JA, Ramanathan P, Ansari AZ.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7418-E7427. Epub 2016 Nov 8.

42.

Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2.

Baik J, Magli A, Tahara N, Swanson SA, Koyano-Nakagawa N, Borges L, Stewart R, Garry DJ, Kawakami Y, Thomson JA, Perlingeiro RC.

Nat Commun. 2016 Oct 7;7:13101. doi: 10.1038/ncomms13101.

43.

Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm.

Chu LF, Leng N, Zhang J, Hou Z, Mamott D, Vereide DT, Choi J, Kendziorski C, Stewart R, Thomson JA.

Genome Biol. 2016 Aug 17;17(1):173. doi: 10.1186/s13059-016-1033-x.

44.

Analysis of embryonic development in the unsequenced axolotl: Waves of transcriptomic upheaval and stability.

Jiang P, Nelson JD, Leng N, Collins M, Swanson S, Dewey CN, Thomson JA, Stewart R.

Dev Biol. 2017 Jun 15;426(2):143-154. doi: 10.1016/j.ydbio.2016.05.024. Epub 2016 Jul 28.

45.

Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells.

Capowski EE, Wright LS, Liang K, Phillips MJ, Wallace K, Petelinsek A, Hagstrom A, Pinilla I, Borys K, Lien J, Min JH, Keles S, Thomson JA, Gamm DM.

Stem Cells. 2016 Nov;34(11):2625-2634. doi: 10.1002/stem.2414. Epub 2016 Jul 5.

46.

Quality control of single-cell RNA-seq by SinQC.

Jiang P, Thomson JA, Stewart R.

Bioinformatics. 2016 Aug 15;32(16):2514-6. doi: 10.1093/bioinformatics/btw176. Epub 2016 Apr 10.

47.

Stable engineered vascular networks from human induced pluripotent stem cell-derived endothelial cells cultured in synthetic hydrogels.

Zanotelli MR, Ardalani H, Zhang J, Hou Z, Nguyen EH, Swanson S, Nguyen BK, Bolin J, Elwell A, Bischel LL, Xie AW, Stewart R, Beebe DJ, Thomson JA, Schwartz MP, Murphy WL.

Acta Biomater. 2016 Apr 15;35:32-41. doi: 10.1016/j.actbio.2016.03.001. Epub 2016 Mar 2.

48.

Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors.

Lalit PA, Salick MR, Nelson DO, Squirrell JM, Shafer CM, Patel NG, Saeed I, Schmuck EG, Markandeya YS, Wong R, Lea MR, Eliceiri KW, Hacker TA, Crone WC, Kyba M, Garry DJ, Stewart R, Thomson JA, Downs KM, Lyons GE, Kamp TJ.

Cell Stem Cell. 2016 Mar 3;18(3):354-67. doi: 10.1016/j.stem.2015.12.001. Epub 2016 Feb 11.

49.

GSK3β Inhibition Promotes Efficient Myeloid and Lymphoid Hematopoiesis from Non-human Primate-Induced Pluripotent Stem Cells.

D'Souza SS, Maufort J, Kumar A, Zhang J, Smuga-Otto K, Thomson JA, Slukvin II.

Stem Cell Reports. 2016 Feb 9;6(2):243-56. doi: 10.1016/j.stemcr.2015.12.010. Epub 2016 Jan 21.

50.

Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm.

Chan SS, Hagen HR, Swanson SA, Stewart R, Boll KA, Aho J, Thomson JA, Kyba M.

Stem Cell Reports. 2016 Jan 12;6(1):26-34. doi: 10.1016/j.stemcr.2015.12.003.

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