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Items: 14

1.

Parathyroid hormone (PTH) and PTH-related peptide domains contributing to activation of different PTH receptor-mediated signaling pathways.

Cupp ME, Nayak SK, Adem AS, Thomsen WJ.

J Pharmacol Exp Ther. 2013 Jun;345(3):404-18. doi: 10.1124/jpet.112.199752. Epub 2013 Mar 20.

PMID:
23516330
2.

Nelotanserin, a novel selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia.

Al-Shamma HA, Anderson C, Chuang E, Luthringer R, Grottick AJ, Hauser E, Morgan M, Shanahan W, Teegarden BR, Thomsen WJ, Behan D.

J Pharmacol Exp Ther. 2010 Jan;332(1):281-90. doi: 10.1124/jpet.109.160994. Epub 2009 Oct 19.

PMID:
19841476
3.

Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.

Thomsen WJ, Grottick AJ, Menzaghi F, Reyes-Saldana H, Espitia S, Yuskin D, Whelan K, Martin M, Morgan M, Chen W, Al-Shamma H, Smith B, Chalmers D, Behan D.

J Pharmacol Exp Ther. 2008 May;325(2):577-87. doi: 10.1124/jpet.107.133348. Epub 2008 Feb 5.

PMID:
18252809
4.

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Dosa PI, Covel JA, Ren A, Webb RR, Beeley NR, Martin M, Morgan M, Espitia S, Saldana HR, Bjenning C, Whelan KT, Grottick AJ, Menzaghi F, Thomsen WJ.

J Med Chem. 2008 Jan 24;51(2):305-13. Epub 2007 Dec 21.

PMID:
18095642
5.

The potential use of selective 5-HT2C agonists in treating obesity.

Smith BM, Thomsen WJ, Grottick AJ.

Expert Opin Investig Drugs. 2006 Mar;15(3):257-66. Review.

PMID:
16503763
6.

Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.

Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Thomsen WJ, Saldana HR, Whelan KT, Menzaghi F, Webb RR, Beeley NR.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1467-70.

PMID:
15713408
7.

Molecular approaches to receptors as targets for drug discovery.

Herz JM, Thomsen WJ, Yarbrough GG.

J Recept Signal Transduct Res. 1997 Sep;17(5):671-776. Review.

PMID:
9292776
8.

Photoaffinity labeling of the brevetoxin receptor on sodium channels in rat brain synaptosomes.

Trainer VL, Thomsen WJ, Catterall WA, Baden DG.

Mol Pharmacol. 1991 Dec;40(6):988-94.

PMID:
1661842
9.
10.

How does a key fit a flexible lock? Structure and dynamics in receptor function.

Neubig RR, Thomsen WJ.

Bioessays. 1989 Nov;11(5):136-41. Review.

11.
12.

Inhibition of adenylate cyclase is mediated by the high affinity conformation of the alpha 2-adrenergic receptor.

Thomsen WJ, Jacquez JA, Neubig RR.

Mol Pharmacol. 1988 Dec;34(6):814-22.

PMID:
2904647
13.
14.

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