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Items: 1 to 50 of 196

1.

Pathogenic CD8+ epidermis-resident memory T cells displace dendritic epidermal T cells in allergic dermatitis.

Ø Gadsbøll AS, Jee MH, Funch AB, Alhede M, Mraz V, Weber JF, Callender LA, Carroll EC, Bjarnsholt T, Woetmann A, Ødum N, Thomsen AR, Johansen JD, Henson SM, Geisler C, Bonefeld CM.

J Invest Dermatol. 2019 Sep 10. pii: S0022-202X(19)33218-X. doi: 10.1016/j.jid.2019.07.722. [Epub ahead of print]

PMID:
31518559
2.

Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles.

Voglstaetter M, Thomsen AR, Nouvel J, Koch A, Jank P, Navarro EG, Gainey-Schleicher T, Khanduri R, Groß A, Rossner F, Blaue C, Franz CM, Veil M, Puetz G, Hippe A, Dindorf J, Kashef J, Thiele W, Homey B, Greco C, Boucheix C, Baur A, Erbes T, Waller CF, Follo M, Hossein G, Sers C, Sleeman J, Nazarenko I.

J Pathol. 2019 Aug;248(4):421-437. doi: 10.1002/path.5281. Epub 2019 Jun 18.

3.

Local Antigen Encounter Is Essential for Establishing Persistent CD8+ T-Cell Memory in the CNS.

Schøller AS, Fonnes M, Nazerai L, Christensen JP, Thomsen AR.

Front Immunol. 2019 Mar 4;10:351. doi: 10.3389/fimmu.2019.00351. eCollection 2019.

4.

3D Cellular Architecture Affects MicroRNA and Protein Cargo of Extracellular Vesicles.

Rocha S, Carvalho J, Oliveira P, Voglstaetter M, Schvartz D, Thomsen AR, Walter N, Khanduri R, Sanchez JC, Keller A, Oliveira C, Nazarenko I.

Adv Sci (Weinh). 2018 Dec 20;6(4):1800948. doi: 10.1002/advs.201800948. eCollection 2019 Feb 20.

5.

Chemokine Expression in Murine RPE/Choroid in Response to Systemic Viral Infection and Elevated Levels of Circulating Interferon-γ.

Faber C, Juel HB, Jensen BAH, Christensen JP, Prause JU, Thomsen AR, Nissen MH.

Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):192-201. doi: 10.1167/iovs.18-25721.

PMID:
30654385
6.

Commentary: Endogenous glucocorticoids control host resistance to viral infection through  tissue-specific regulation of PD-1 expression on NK cells.

Thomsen AR.

Cell Mol Immunol. 2019 Mar;16(3):203-204. doi: 10.1038/s41423-018-0190-0. Epub 2018 Dec 12. No abstract available.

PMID:
30542143
7.

Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis.

Dahl SL, Woodworth JS, Lerche CJ, Cramer EP, Nielsen PR, Moser C, Thomsen AR, Borregaard N, Cowland JB.

Front Immunol. 2018 Nov 26;9:2717. doi: 10.3389/fimmu.2018.02717. eCollection 2018.

8.

Replication deficient human adenovirus vector serotype 19a/64: Immunogenicity in mice and female cynomolgus macaques.

Ragonnaud E, Schroedel S, Mariya S, Iskandriati D, Pamungkas J, Fougeroux C, Daradoumis J, Thomsen AR, Neukirch L, Ruzsics Z, Salomon M, Thirion C, Holst PJ.

Vaccine. 2018 Oct 1;36(41):6212-6222. doi: 10.1016/j.vaccine.2018.07.075. Epub 2018 Sep 3.

PMID:
30190120
9.

Therapeutic Targeting of Endosomal G-Protein-Coupled Receptors.

Thomsen ARB, Jensen DD, Hicks GA, Bunnett NW.

Trends Pharmacol Sci. 2018 Oct;39(10):879-891. doi: 10.1016/j.tips.2018.08.003. Epub 2018 Sep 1. Review.

10.

Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance.

Oria VO, Bronsert P, Thomsen AR, Föll MC, Zamboglou C, Hannibal L, Behringer S, Biniossek ML, Schreiber C, Grosu AL, Bolm L, Rades D, Keck T, Werner M, Wellner UF, Schilling O.

Transl Oncol. 2018 Dec;11(6):1307-1322. doi: 10.1016/j.tranon.2018.08.001. Epub 2018 Aug 30.

11.

Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection.

Geary CD, Krishna C, Lau CM, Adams NM, Gearty SV, Pritykin Y, Thomsen AR, Leslie CS, Sun JC.

Cell Rep. 2018 Aug 21;24(8):1949-1957.e6. doi: 10.1016/j.celrep.2018.07.060.

12.

Analysis of adenovirus-induced immunity to infection with Listeria monocytogenes: Fading protection coincides with declining CD8 T cell numbers and phenotypic changes.

Jahn ML, Steffensen MA, Christensen JP, Thomsen AR.

Vaccine. 2018 May 11;36(20):2825-2832. doi: 10.1016/j.vaccine.2018.03.080. Epub 2018 Apr 5.

PMID:
29627230
13.

A New In Vivo Model to Study Protective Immunity to Zika Virus Infection in Mice With Intact Type I Interferon Signaling.

Nazerai L, Schøller AS, Rasmussen POS, Buus S, Stryhn A, Christensen JP, Thomsen AR.

Front Immunol. 2018 Mar 22;9:593. doi: 10.3389/fimmu.2018.00593. eCollection 2018.

14.

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility.

Zhang DL, Sun YJ, Ma ML, Wang YJ, Lin H, Li RR, Liang ZL, Gao Y, Yang Z, He DF, Lin A, Mo H, Lu YJ, Li MJ, Kong W, Chung KY, Yi F, Li JY, Qin YY, Li J, Thomsen ARB, Kahsai AW, Chen ZJ, Xu ZG, Liu M, Li D, Yu X, Sun JP.

Elife. 2018 Feb 2;7. pii: e33432. doi: 10.7554/eLife.33432.

15.

Seasonal Influenza Split Vaccines Confer Partial Cross-Protection against Heterologous Influenza Virus in Ferrets When Combined with the CAF01 Adjuvant.

Christensen D, Christensen JP, Korsholm KS, Isling LK, Erneholm K, Thomsen AR, Andersen P.

Front Immunol. 2018 Jan 8;8:1928. doi: 10.3389/fimmu.2017.01928. eCollection 2017.

16.

A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement.

Thomsen AR, Aldrian C, Bronsert P, Thomann Y, Nanko N, Melin N, Rücker G, Follo M, Grosu AL, Niedermann G, Layer PG, Heselich A, Lund PG.

Lab Chip. 2017 Dec 19;18(1):179-189. doi: 10.1039/c7lc00832e.

17.

Diagnostic and Prognostic MicroRNA Biomarkers for Prostate Cancer in Cell-free Urine.

Fredsøe J, Rasmussen AKI, Thomsen AR, Mouritzen P, Høyer S, Borre M, Ørntoft TF, Sørensen KD.

Eur Urol Focus. 2018 Dec;4(6):825-833. doi: 10.1016/j.euf.2017.02.018. Epub 2017 Mar 9.

18.

Pancreatic stellate cells in pancreatic cancer: In focus.

Allam A, Thomsen AR, Gothwal M, Saha D, Maurer J, Brunner TB.

Pancreatology. 2017 Jul - Aug;17(4):514-522. doi: 10.1016/j.pan.2017.05.390. Epub 2017 May 27. Review.

PMID:
28601475
19.

A new vaccination strategy to trigger specific CD4 T-cell response in chronic viral infection.

Thomsen AR.

Cell Mol Immunol. 2018 Sep;15(9):868-869. doi: 10.1038/cmi.2017.19. Epub 2017 May 8. No abstract available.

20.

Broadening CD4+ and CD8+ T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes.

Filskov J, Mikkelsen M, Hansen PR, Christensen JP, Thomsen AR, Andersen P, Bukh J, Agger EM.

J Virol. 2017 Jun 26;91(14). pii: e00130-17. doi: 10.1128/JVI.00130-17. Print 2017 Jul 15.

21.

Adaptive immune responses to booster vaccination against yellow fever virus are much reduced compared to those after primary vaccination.

Kongsgaard M, Bassi MR, Rasmussen M, Skjødt K, Thybo S, Gabriel M, Hansen MB, Christensen JP, Thomsen AR, Buus S, Stryhn A.

Sci Rep. 2017 Apr 6;7(1):662. doi: 10.1038/s41598-017-00798-1.

22.

Mucosal Vaccination with Heterologous Viral Vectored Vaccine Targeting Subdominant SIV Accessory Antigens Strongly Inhibits Early Viral Replication.

Xu H, Andersson AM, Ragonnaud E, Boilesen D, Tolver A, Jensen BAH, Blanchard JL, Nicosia A, Folgori A, Colloca S, Cortese R, Thomsen AR, Christensen JP, Veazey RS, Holst PJ.

EBioMedicine. 2017 Apr;18:204-215. doi: 10.1016/j.ebiom.2017.03.003. Epub 2017 Mar 8.

23.

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567. doi: 10.1073/pnas.1701529114. Epub 2017 Feb 21.

24.

The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung.

Grujic M, Paivandy A, Gustafson AM, Thomsen AR, Öhrvik H, Pejler G.

Oncotarget. 2017 Apr 11;8(15):25066-25079. doi: 10.18632/oncotarget.15339.

25.

Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.

Liu CH, Gong Z, Liang ZL, Liu ZX, Yang F, Sun YJ, Ma ML, Wang YJ, Ji CR, Wang YH, Wang MJ, Cui FA, Lin A, Zheng WS, He DF, Qu CX, Xiao P, Liu CY, Thomsen AR, Joseph Cahill T 3rd, Kahsai AW, Yi F, Xiao KH, Xue T, Zhou Z, Yu X, Sun JP.

Nat Commun. 2017 Feb 9;8:14335. doi: 10.1038/ncomms14335.

26.

EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia-like B-cell malignancies.

Niss Arfelt K, Barington L, Benned-Jensen T, Kubale V, Kovalchuk AL, Daugvilaite V, Christensen JP, Thomsen AR, Egerod KL, Bassi MR, Spiess K, Schwartz TW, Wang H, Morse HC 3rd, Holst PJ, Rosenkilde MM.

Blood. 2017 Feb 16;129(7):866-878. doi: 10.1182/blood-2016-02-697185. Epub 2016 Dec 21.

27.

Early life vaccination: Generation of adult-quality memory CD8+ T cells in infant mice using non-replicating adenoviral vectors.

Nazerai L, Bassi MR, Uddback IE, Holst PJ, Christensen JP, Thomsen AR.

Sci Rep. 2016 Dec 8;6:38666. doi: 10.1038/srep38666.

28.

Rapid allergen-induced interleukin-17 and interferon-γ secretion by skin-resident memory CD8+ T cells.

Schmidt JD, Ahlström MG, Johansen JD, Dyring-Andersen B, Agerbeck C, Nielsen MM, Poulsen SS, Woetmann A, Ødum N, Thomsen AR, Geisler C, Bonefeld CM.

Contact Dermatitis. 2017 Apr;76(4):218-227. doi: 10.1111/cod.12715. Epub 2016 Nov 22.

PMID:
27873334
29.

PB1 as a potential target for increasing the breadth of T-cell mediated immunity to Influenza A.

Uddbäck IE, Steffensen MA, Pedersen SR, Nazerai L, Thomsen AR, Christensen JP.

Sci Rep. 2016 Oct 7;6:35033. doi: 10.1038/srep35033.

30.

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ.

Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4.

31.

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.

Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, Alam SM, Sullenger BA, Lefkowitz RJ.

Nat Chem Biol. 2016 Sep;12(9):709-16. doi: 10.1038/nchembio.2126. Epub 2016 Jul 11.

32.

Novel diagnostic and prognostic classifiers for prostate cancer identified by genome-wide microRNA profiling.

Kristensen H, Thomsen AR, Haldrup C, Dyrskjøt L, Høyer S, Borre M, Mouritzen P, Ørntoft TF, Sørensen KD.

Oncotarget. 2016 May 24;7(21):30760-71. doi: 10.18632/oncotarget.8953.

33.

Vaccination with Replication Deficient Adenovectors Encoding YF-17D Antigens Induces Long-Lasting Protection from Severe Yellow Fever Virus Infection in Mice.

Bassi MR, Larsen MA, Kongsgaard M, Rasmussen M, Buus S, Stryhn A, Thomsen AR, Christensen JP.

PLoS Negl Trop Dis. 2016 Feb 17;10(2):e0004464. doi: 10.1371/journal.pntd.0004464. eCollection 2016 Feb.

34.

Vaccine Targeting of Subdominant CD8+ T Cell Epitopes Increases the Breadth of the T Cell Response upon Viral Challenge, but May Impair Immediate Virus Control.

Steffensen MA, Pedersen LH, Jahn ML, Nielsen KN, Christensen JP, Thomsen AR.

J Immunol. 2016 Mar 15;196(6):2666-76. doi: 10.4049/jimmunol.1502018. Epub 2016 Feb 12.

35.

Combined local and systemic immunization is essential for durable T-cell mediated heterosubtypic immunity against influenza A virus.

Uddback IE, Pedersen LM, Pedersen SR, Steffensen MA, Holst PJ, Thomsen AR, Christensen JP.

Sci Rep. 2016 Feb 1;6:20137. doi: 10.1038/srep20137.

36.

An innate antiviral pathway acting before interferons at epithelial surfaces.

Iversen MB, Reinert LS, Thomsen MK, Bagdonaite I, Nandakumar R, Cheshenko N, Prabakaran T, Vakhrushev SY, Krzyzowska M, Kratholm SK, Ruiz-Perez F, Petersen SV, Goriely S, Bibby BM, Eriksson K, Ruland J, Thomsen AR, Herold BC, Wandall HH, Frische S, Holm CK, Paludan SR.

Nat Immunol. 2016 Feb;17(2):150-8. doi: 10.1038/ni.3319. Epub 2015 Nov 30.

PMID:
26595890
37.

[HPV vaccination – should/should not?].

Thomsen AR, Christensen JP.

Ugeskr Laeger. 2015 Aug 31;177(18). pii: V67374. Danish. No abstract available.

PMID:
26324287
38.

Targeting of non-dominant antigens as a vaccine strategy to broaden T-cell responses during chronic viral infection.

Holst PJ, Jensen BA, Ragonnaud E, Thomsen AR, Christensen JP.

PLoS One. 2015 Feb 13;10(2):e0117242. doi: 10.1371/journal.pone.0117242. eCollection 2015.

39.

CD8+ T cells complement antibodies in protecting against yellow fever virus.

Bassi MR, Kongsgaard M, Steffensen MA, Fenger C, Rasmussen M, Skjødt K, Finsen B, Stryhn A, Buus S, Christensen JP, Thomsen AR.

J Immunol. 2015 Feb 1;194(3):1141-53. doi: 10.4049/jimmunol.1402605. Epub 2014 Dec 24.

40.

Suppressors of cytokine signaling 1 and 3 are upregulated in brain resident cells in response to virus-induced inflammation of the central nervous system via at least two distinctive pathways.

Steffensen MA, Fenger C, Christensen JE, Jørgensen CK, Bassi MR, Christensen JP, Finsen B, Thomsen AR.

J Virol. 2014 Dec;88(24):14090-104. doi: 10.1128/JVI.01346-14. Epub 2014 Sep 24.

41.

Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells.

Boding L, Hansen AK, Meroni G, Johansen BB, Braunstein TH, Bonefeld CM, Kongsbak M, Jensen BA, Woetmann A, Thomsen AR, Odum N, von Essen MR, Geisler C.

Eur J Immunol. 2014 Oct;44(10):3109-18. doi: 10.1002/eji.201344388. Epub 2014 Aug 25.

42.

Epicutaneous exposure to nickel induces nickel allergy in mice via a MyD88-dependent and interleukin-1-dependent pathway.

Vennegaard MT, Dyring-Andersen B, Skov L, Nielsen MM, Schmidt JD, Bzorek M, Poulsen SS, Thomsen AR, Woetmann A, Thyssen JP, Johansen JD, Odum N, Menné T, Geisler C, Bonefeld CM.

Contact Dermatitis. 2014 Oct;71(4):224-32. doi: 10.1111/cod.12270. Epub 2014 Jul 18.

PMID:
25040758
43.

Co-expression of tumor antigen and interleukin-2 from an adenoviral vector augments the efficiency of therapeutic tumor vaccination.

Jensen BA, Steffensen MA, Nielsen KN, Christensen JP, Thomsen AR, Holst PJ.

Mol Ther. 2014 Dec;22(12):2107-17. doi: 10.1038/mt.2014.130. Epub 2014 Jul 15.

44.

Priming of CD8 T cells by adenoviral vectors is critically dependent on B7 and dendritic cells but only partially dependent on CD28 ligation on CD8 T cells.

Nielsen KN, Steffensen MA, Christensen JP, Thomsen AR.

J Immunol. 2014 Aug 1;193(3):1223-32. doi: 10.4049/jimmunol.1400197. Epub 2014 Jun 20.

45.

IFNγ and perforin cooperate to control infection and prevent fatal pathology during persistent gammaherpesvirus infection in mice.

Bartholdy C, Høgh-Petersen M, Storm P, Holst PJ, Orskov C, Christensen JP, Thomsen AR.

Scand J Immunol. 2014 Jun;79(6):395-403. doi: 10.1111/sji.12176.

46.

Recent developments in biased agonism.

Wisler JW, Xiao K, Thomsen AR, Lefkowitz RJ.

Curr Opin Cell Biol. 2014 Apr;27:18-24. doi: 10.1016/j.ceb.2013.10.008. Epub 2013 Nov 20. Review.

47.

G protein-coupled receptor signaling analysis using homogenous time-resolved Förster resonance energy transfer (HTRF®) technology.

Nørskov-Lauritsen L, Thomsen AR, Bräuner-Osborne H.

Int J Mol Sci. 2014 Feb 13;15(2):2554-72. doi: 10.3390/ijms15022554.

48.

Quantification of B16 melanoma cells in lungs using triplex Q-PCR--a new approach to evaluate melanoma cell metastasis and tumor control.

Sorensen MR, Pedersen SR, Lindkvist A, Christensen JP, Thomsen AR.

PLoS One. 2014 Jan 31;9(1):e87831. doi: 10.1371/journal.pone.0087831. eCollection 2014.

49.

Adenovirus-based vaccine against Listeria monocytogenes: extending the concept of invariant chain linkage.

Jensen S, Steffensen MA, Jensen BA, Schlüter D, Christensen JP, Thomsen AR.

J Immunol. 2013 Oct 15;191(8):4152-64. doi: 10.4049/jimmunol.1301290. Epub 2013 Sep 16.

50.

Comparison of vaccine-induced effector CD8 T cell responses directed against self- and non-self-tumor antigens: implications for cancer immunotherapy.

Pedersen SR, Sørensen MR, Buus S, Christensen JP, Thomsen AR.

J Immunol. 2013 Oct 1;191(7):3955-67. doi: 10.4049/jimmunol.1300555. Epub 2013 Sep 9.

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