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Cycles of myofiber degeneration and regeneration lead to remodeling of the neuromuscular junction in two mammalian models of Duchenne muscular dystrophy.

Haddix SG, Lee YI, Kornegay JN, Thompson WJ.

PLoS One. 2018 Oct 31;13(10):e0205926. doi: 10.1371/journal.pone.0205926. eCollection 2018.


The epidemiologic evidence for elongate mineral particle (EMP)-related human cancer risk.

Boffetta P, Mundt KA, Thompson WJ.

Toxicol Appl Pharmacol. 2018 Dec 15;361:100-106. doi: 10.1016/j.taap.2018.09.021. Epub 2018 Sep 19.


Using Stepwise Pharmacogenomics and Proteomics to Predict Hepatitis C Treatment Response in Difficult to Treat Patient Populations.

Naggie S, Clement M, Lusk S, Osinusi A, Himmel T, Lucas JE, Thompson WJ, Dubois L, Moseley MA, Clark PJ, Kottilil S, Patel K.

Proteomics Clin Appl. 2018 Jul 30:e1800006. doi: 10.1002/prca.201800006. [Epub ahead of print]


Schwann cells participate in synapse elimination at the developing neuromuscular junction.

Lee YI, Thompson WJ, Harlow ML.

Curr Opin Neurobiol. 2017 Dec;47:176-181. doi: 10.1016/j.conb.2017.10.010. Epub 2017 Nov 6. Review.


Neuregulin1 displayed on motor axons regulates terminal Schwann cell-mediated synapse elimination at developing neuromuscular junctions.

Lee YI, Li Y, Mikesh M, Smith I, Nave KA, Schwab MH, Thompson WJ.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E479-87. doi: 10.1073/pnas.1519156113. Epub 2016 Jan 11.



Chrysikou EG, Thompson WJ.

Assessment. 2016 Dec;23(6):778. Epub 2015 Nov 23.


Transcription errors induce proteotoxic stress and shorten cellular lifespan.

Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Thompson JW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA.

Nat Commun. 2015 Aug 25;6:8065. doi: 10.1038/ncomms9065. Erratum in: Nat Commun. 2015;6:8738. Thompson, William J and Mosely, Arthur M [Corrected to Thompson, J Will and Moseley, M Arthur].


Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum.

Jagannathan S, Hsu JC, Reid DW, Chen Q, Thompson WJ, Moseley AM, Nicchitta CV.

J Biol Chem. 2014 Sep 12;289(37):25907-24. doi: 10.1074/jbc.M114.580688. Epub 2014 Jul 25.


Terminal Schwann cells participate in neuromuscular synapse remodeling during reinnervation following nerve injury.

Kang H, Tian L, Mikesh M, Lichtman JW, Thompson WJ.

J Neurosci. 2014 Apr 30;34(18):6323-33. doi: 10.1523/JNEUROSCI.4673-13.2014.


Terminal Schwann cells participate in the competition underlying neuromuscular synapse elimination.

Smith IW, Mikesh M, Lee Yi, Thompson WJ.

J Neurosci. 2013 Nov 6;33(45):17724-36. doi: 10.1523/JNEUROSCI.3339-13.2013.


Real-time understanding of lignocellulosic bioethanol fermentation by Raman spectroscopy.

Ewanick SM, Thompson WJ, Marquardt BJ, Bura R.

Biotechnol Biofuels. 2013 Feb 20;6(1):28. doi: 10.1186/1754-6834-6-28.


Changes in aging mouse neuromuscular junctions are explained by degeneration and regeneration of muscle fiber segments at the synapse.

Li Y, Lee Yi, Thompson WJ.

J Neurosci. 2011 Oct 19;31(42):14910-9. doi: 10.1523/JNEUROSCI.3590-11.2011.


Nerve terminal growth remodels neuromuscular synapses in mice following regeneration of the postsynaptic muscle fiber.

Li Y, Thompson WJ.

J Neurosci. 2011 Sep 14;31(37):13191-203. doi: 10.1523/JNEUROSCI.2953-11.2011.


Biology and pathology of nonmyelinating Schwann cells.

Griffin JW, Thompson WJ.

Glia. 2008 Nov 1;56(14):1518-31. doi: 10.1002/glia.20778. Review.


Induction of zinc-finger proliferation 1 expression in non-myelinating Schwann cells after denervation.

Ellerton EL, Thompson WJ, Rimer M.

Neuroscience. 2008 Jun 2;153(4):975-85. doi: 10.1016/j.neuroscience.2008.02.078. Epub 2008 Mar 19.


A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.

Cahoy JD, Emery B, Kaushal A, Foo LC, Zamanian JL, Christopherson KS, Xing Y, Lubischer JL, Krieg PA, Krupenko SA, Thompson WJ, Barres BA.

J Neurosci. 2008 Jan 2;28(1):264-78. doi: 10.1523/JNEUROSCI.4178-07.2008.


Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.

Soh JW, Kazi JU, Li H, Thompson WJ, Weinstein IB.

Mol Carcinog. 2008 Jul;47(7):519-25. doi: 10.1002/mc.20409.


Induction of neuregulin signaling in mouse schwann cells in vivo mimics responses to denervation.

Hayworth CR, Moody SE, Chodosh LA, Krieg P, Rimer M, Thompson WJ.

J Neurosci. 2006 Jun 21;26(25):6873-84.


Adenylyl and guanylyl cyclase assays.

Kelly JJ, Stevens T, Thompson WJ, Seifert R.

Curr Protoc Pharmacol. 2005 Oct;Chapter 2:Unit2.2. doi: 10.1002/0471141755.ph0202s30.


Fluorescent proteins expressed in mouse transgenic lines mark subsets of glia, neurons, macrophages, and dendritic cells for vital examination.

Zuo Y, Lubischer JL, Kang H, Tian L, Mikesh M, Marks A, Scofield VL, Maika S, Newman C, Krieg P, Thompson WJ.

J Neurosci. 2004 Dec 8;24(49):10999-1009.


Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells.

Zhu B, Vemavarapu L, Thompson WJ, Strada SJ.

J Cell Biochem. 2005 Feb 1;94(2):336-50.


Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells.

Zhu B, Kelly J, Vemavarapu L, Thompson WJ, Strada SJ.

Biochem Pharmacol. 2004 Aug 1;68(3):479-91.


Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells.

Lim JT, Piazza GA, Pamukcu R, Thompson WJ, Weinstein IB.

Clin Cancer Res. 2003 Oct 15;9(13):4972-82.


Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancer.

Pusztai L, Zhen JH, Arun B, Rivera E, Whitehead C, Thompson WJ, Nealy KM, Gibbs A, Symmans WF, Esteva FJ, Booser D, Murray JL, Valero V, Smith TL, Hortobagyi GN.

J Clin Oncol. 2003 Sep 15;21(18):3454-61.


Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells.

Joe AK, Liu H, Xiao D, Soh JW, Pinto JT, Beer DG, Piazza GA, Thompson WJ, Weinstein IB.

J Exp Ther Oncol. 2003 Mar-Apr;3(2):83-94.


Exisulind-induced apoptosis in a non-small cell lung cancer orthotopic lung tumor model augments docetaxel treatment and contributes to increased survival.

Whitehead CM, Earle KA, Fetter J, Xu S, Hartman T, Chan DC, Zhao TL, Piazza G, Klein-Szanto AJ, Pamukcu R, Alila H, Bunn PA Jr, Thompson WJ.

Mol Cancer Ther. 2003 May;2(5):479-88.


Phosphodiesterase 3 activity is reduced in dog lung following pacing-induced heart failure.

Tarpey SB, Sawmiller DR, Kelly C, Thompson WJ, Townsley MI.

Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L766-73. Epub 2003 Jan 10.


beta-Catenin signaling: therapeutic strategies in oncology.

Li H, Pamukcu R, Thompson WJ.

Cancer Biol Ther. 2002 Nov-Dec;1(6):621-5. Review.


Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling.

Mullershausen F, Friebe A, Feil R, Thompson WJ, Hofmann F, Koesling D.

J Cell Biol. 2003 Mar 3;160(5):719-27. Epub 2003 Feb 25.


Closing anterior open bites by intruding molars with titanium miniplate anchorage.

Sherwood KH, Burch JG, Thompson WJ.

Am J Orthod Dentofacial Orthop. 2002 Dec;122(6):593-600.


CP248, a derivative of exisulind, causes growth inhibition, mitotic arrest, and abnormalities in microtubule polymerization in glioma cells.

Yoon JT, Palazzo AF, Xiao D, Delohery TM, Warburton PE, Bruce JN, Thompson WJ, Sperl G, Whitehead C, Fetter J, Pamukcu R, Gundersen GG, Weinstein IB.

Mol Cancer Ther. 2002 Apr;1(6):393-404.


Pro-apoptotic actions of exisulind and CP461 in SW480 colon tumor cells involve beta-catenin and cyclin D1 down-regulation.

Li H, Liu L, David ML, Whitehead CM, Chen M, Fetter JR, Sperl GJ, Pamukcu R, Thompson WJ.

Biochem Pharmacol. 2002 Nov 1;64(9):1325-36.


Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity.

Francis SH, Bessay EP, Kotera J, Grimes KA, Liu L, Thompson WJ, Corbin JD.

J Biol Chem. 2002 Dec 6;277(49):47581-7. Epub 2002 Sep 30.


Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4).

Thompson WJ, Ashikaga T, Kelly JJ, Liu L, Zhu B, Vemavarapu L, Strada SJ.

Biochem Pharmacol. 2002 Feb 15;63(4):797-807.


Exisulind in combination with docetaxel inhibits growth and metastasis of human lung cancer and prolongs survival in athymic nude rats with orthotopic lung tumors.

Chan DC, Earle KA, Zhao TL, Helfrich B, Zeng C, Baron A, Whitehead CM, Piazza G, Pamukcu R, Thompson WJ, Alila H, Nelson P, Bunn PA Jr.

Clin Cancer Res. 2002 Mar;8(3):904-12.


Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase.

Liu L, Underwood T, Li H, Pamukcu R, Thompson WJ.

Cell Signal. 2002 Jan;14(1):45-51.


Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme.

Mullershausen F, Russwurm M, Thompson WJ, Liu L, Koesling D, Friebe A.

J Cell Biol. 2001 Oct 15;155(2):271-8. Epub 2001 Oct 15.


Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells.

Liu L, Li H, Underwood T, Lloyd M, David M, Sperl G, Pamukcu R, Thompson WJ.

J Pharmacol Exp Ther. 2001 Nov;299(2):583-92.


Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis.

Piazza GA, Thompson WJ, Pamukcu R, Alila HW, Whitehead CM, Liu L, Fetter JR, Gresh WE Jr, Klein-Szanto AJ, Farnell DR, Eto I, Grubbs CJ.

Cancer Res. 2001 May 15;61(10):3961-8.


Protein kinase G activates the JNK1 pathway via phosphorylation of MEKK1.

Soh JW, Mao Y, Liu L, Thompson WJ, Pamukcu R, Weinstein IB.

J Biol Chem. 2001 May 11;276(19):16406-10. Epub 2001 Mar 14.


Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.

Soh JW, Mao Y, Kim MG, Pamukcu R, Li H, Piazza GA, Thompson WJ, Weinstein IB.

Clin Cancer Res. 2000 Oct;6(10):4136-41. Erratum in: Clin Cancer Res 2000 Dec;6(12):4967.


Functional identification of phosphodiesterase activity in human trabecular meshwork cells.

Zhou L, Thompson WJ, Potter DE.

J Ocul Pharmacol Ther. 2000 Aug;16(4):317-22.


Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.

Thompson WJ, Piazza GA, Li H, Liu L, Fetter J, Zhu B, Sperl G, Ahnen D, Pamukcu R.

Cancer Res. 2000 Jul 1;60(13):3338-42.

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