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Items: 1 to 50 of 151

1.

Development of Activity-Based Proteomic Probes for Protein Citrullination.

Nemmara VV, Thompson PR.

Curr Top Microbiol Immunol. 2018 Sep 11. doi: 10.1007/82_2018_132. [Epub ahead of print]

PMID:
30203394
2.

Kinetic Mechanism of Nicotinamide N-Methyltransferase.

Loring HS, Thompson PR.

Biochemistry. 2018 Sep 25;57(38):5524-5532. doi: 10.1021/acs.biochem.8b00775. Epub 2018 Sep 10.

PMID:
30148963
3.

Citrullination Inactivates Nicotinamide- N-methyltransferase.

Nemmara VV, Tilvawala R, Salinger AJ, Miller L, Nguyen SH, Weerapana E, Thompson PR.

ACS Chem Biol. 2018 Sep 21;13(9):2663-2672. doi: 10.1021/acschembio.8b00578. Epub 2018 Aug 8.

PMID:
30044909
4.

Histone citrullination represses miRNA expression resulting in increased oncogene mRNAs in somatolactotrope cells.

DeVore SB, Young CH, Li G, Sundararajan A, Ramaraj T, Mudge J, Schilkey F, Muth A, Thompson PR, Cherrington BD.

Mol Cell Biol. 2018 Jul 9. pii: MCB.00084-18. doi: 10.1128/MCB.00084-18. [Epub ahead of print]

PMID:
29987187
5.

Donated chemical probes for open science.

Müller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, Böttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, Dötsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A.

Elife. 2018 Apr 20;7. pii: e34311. doi: 10.7554/eLife.34311.

6.

BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway.

Ledet MM, Anderson R, Harman R, Muth A, Thompson PR, Coonrod SA, Van de Walle GR.

BMC Cancer. 2018 Apr 12;18(1):412. doi: 10.1186/s12885-018-4323-8.

7.

The Rheumatoid Arthritis-Associated Citrullinome.

Tilvawala R, Nguyen SH, Maurais AJ, Nemmara VV, Nagar M, Salinger AJ, Nagpal S, Weerapana E, Thompson PR.

Cell Chem Biol. 2018 Jun 21;25(6):691-704.e6. doi: 10.1016/j.chembiol.2018.03.002. Epub 2018 Apr 5.

PMID:
29628436
8.

Response to comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis".

Carmona-Rivera C, Bicker KL, Thompson PR, Buckner JH, Robinson WH, Fox DA, Kaplan MJ.

Sci Immunol. 2018 Mar 30;3(21). pii: eaar3701. doi: 10.1126/sciimmunol.aar3701.

PMID:
29602804
9.

Photochemical Control of Protein Arginine Deiminase (PAD) Activity.

Mondal S, Parelkar SS, Nagar M, Thompson PR.

ACS Chem Biol. 2018 Apr 20;13(4):1057-1065. doi: 10.1021/acschembio.8b00053. Epub 2018 Mar 16.

PMID:
29517899
10.

A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA.

Wong A, Bryzek D, Dobosz E, Scavenius C, Svoboda P, Rapala-Kozik M, Lesner A, Frydrych I, Enghild J, Mydel P, Pohl J, Thompson PR, Potempa J, Koziel J.

J Immunol. 2018 Apr 1;200(7):2327-2340. doi: 10.4049/jimmunol.1701391. Epub 2018 Feb 23.

PMID:
29475987
11.

The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs).

Nemmara VV, Subramanian V, Muth A, Mondal S, Salinger AJ, Maurais AJ, Tilvawala R, Weerapana E, Thompson PR.

ACS Chem Biol. 2018 Mar 16;13(3):712-722. doi: 10.1021/acschembio.7b00957. Epub 2018 Feb 1.

PMID:
29341591
12.

PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling.

Qin H, Liu X, Li F, Miao L, Li T, Xu B, An X, Muth A, Thompson PR, Coonrod SA, Zhang X.

Cancer Lett. 2017 Nov 28;409:30-41. doi: 10.1016/j.canlet.2017.08.019. Epub 2017 Aug 24.

PMID:
28844713
13.

Citrullination of NF-κB p65 promotes its nuclear localization and TLR-induced expression of IL-1β and TNFα.

Sun B, Dwivedi N, Bechtel TJ, Paulsen JL, Muth A, Bawadekar M, Li G, Thompson PR, Shelef MA, Schiffer CA, Weerapana E, Ho IC.

Sci Immunol. 2017 Jun 9;2(12). pii: eaal3062. doi: 10.1126/sciimmunol.aal3062.

14.

Diverse stimuli engage different neutrophil extracellular trap pathways.

Kenny EF, Herzig A, Krüger R, Muth A, Mondal S, Thompson PR, Brinkmann V, Bernuth HV, Zychlinsky A.

Elife. 2017 Jun 2;6. pii: e24437. doi: 10.7554/eLife.24437.

15.

Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration.

Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA.

BMC Cancer. 2017 May 26;17(1):378. doi: 10.1186/s12885-017-3354-x.

16.

Chloramidine/Bisindolylmaleimide-I-Mediated Inhibition of Exosome and Microvesicle Release and Enhanced Efficacy of Cancer Chemotherapy.

Kosgodage US, Trindade RP, Thompson PR, Inal JM, Lange S.

Int J Mol Sci. 2017 May 9;18(5). pii: E1007. doi: 10.3390/ijms18051007.

17.

Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription.

Clancy KW, Russell AM, Subramanian V, Nguyen H, Qian Y, Campbell RM, Thompson PR.

ACS Chem Biol. 2017 Jun 16;12(6):1691-1702. doi: 10.1021/acschembio.7b00241. Epub 2017 May 9.

18.

Development of a Selective Inhibitor of Protein Arginine Deiminase 2.

Muth A, Subramanian V, Beaumont E, Nagar M, Kerry P, McEwan P, Srinath H, Clancy K, Parelkar S, Thompson PR.

J Med Chem. 2017 Apr 13;60(7):3198-3211. doi: 10.1021/acs.jmedchem.7b00274. Epub 2017 Mar 31.

19.

DTNB-Based Quantification of In Vitro Enzymatic N-Terminal Acetyltransferase Activity.

Foyn H, Thompson PR, Arnesen T.

Methods Mol Biol. 2017;1574:9-15. doi: 10.1007/978-1-4939-6850-3_2.

PMID:
28315240
20.

Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown.

Cau L, Pendaries V, Lhuillier E, Thompson PR, Serre G, Takahara H, Méchin MC, Simon M.

J Dermatol Sci. 2017 May;86(2):106-113. doi: 10.1016/j.jdermsci.2017.02.280. Epub 2017 Feb 20.

21.

Citrullination regulates the expression of insulin-like growth factor-binding protein 1 (IGFBP1) in ovine uterine luminal epithelial cells.

Young CH, Rothfuss HM, Gard PF, Muth A, Thompson PR, Ashley RL, Cherrington BD.

Reproduction. 2017 Jan;153(1):1-10. doi: 10.1530/REP-16-0494. Epub 2016 Oct 10.

22.

Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.

Zhang X, Liu X, Zhang M, Li T, Muth A, Thompson PR, Coonrod SA, Zhang X.

Sci Rep. 2016 Dec 8;6:38727. doi: 10.1038/srep38727.

23.

Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation.

Papadaki G, Kambas K, Choulaki C, Vlachou K, Drakos E, Bertsias G, Ritis K, Boumpas DT, Thompson PR, Verginis P, Sidiropoulos P.

Eur J Immunol. 2016 Nov;46(11):2542-2554. doi: 10.1002/eji.201646542. Epub 2016 Oct 5.

24.

Nicotine induces neutrophil extracellular traps.

Hosseinzadeh A, Thompson PR, Segal BH, Urban CF.

J Leukoc Biol. 2016 Nov;100(5):1105-1112. Epub 2016 Jun 16.

25.

A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.

Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC.

JCI Insight. 2016 Oct 20;1(17):e90045.

26.

GnRH Stimulates Peptidylarginine Deiminase Catalyzed Histone Citrullination in Gonadotrope Cells.

Khan SA, Edwards BS, Muth A, Thompson PR, Cherrington BD, Navratil AM.

Mol Endocrinol. 2016 Oct;30(10):1081-1091. Epub 2016 Sep 7.

27.

Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation.

Fuhrmann J, Subramanian V, Kojetin DJ, Thompson PR.

Cell Chem Biol. 2016 Aug 18;23(8):967-977. doi: 10.1016/j.chembiol.2016.07.008. Epub 2016 Aug 11.

28.

Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.

Bawadekar M, Gendron-Fitzpatrick A, Rebernick R, Shim D, Warner TF, Nicholas AP, Lundblad LK, Thompson PR, Shelef MA.

Arthritis Res Ther. 2016 Jul 22;18(1):173. doi: 10.1186/s13075-016-1068-0.

29.

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses.

Kawalkowska J, Quirke AM, Ghari F, Davis S, Subramanian V, Thompson PR, Williams RO, Fischer R, La Thangue NB, Venables PJ.

Sci Rep. 2016 May 23;6:26430. doi: 10.1038/srep26430.

30.

Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response.

Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB.

Sci Adv. 2016 Feb 5;2(2):e1501257. doi: 10.1126/sciadv.1501257. eCollection 2016 Feb.

31.

Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland.

Li G, Hayward IN, Jenkins BR, Rothfuss HM, Young CH, Nevalainen MT, Muth A, Thompson PR, Navratil AM, Cherrington BD.

PLoS One. 2016 Jan 22;11(1):e0147503. doi: 10.1371/journal.pone.0147503. eCollection 2016.

32.

Protein Arginine Methylation and Citrullination in Epigenetic Regulation.

Fuhrmann J, Thompson PR.

ACS Chem Biol. 2016 Mar 18;11(3):654-68. doi: 10.1021/acschembio.5b00942. Epub 2015 Dec 31.

33.

Detection and identification of protein citrullination in complex biological systems.

Clancy KW, Weerapana E, Thompson PR.

Curr Opin Chem Biol. 2016 Feb;30:1-6. doi: 10.1016/j.cbpa.2015.10.014. Epub 2015 Oct 27. Review.

34.

Synthesis and Use of a Phosphonate Amidine to Generate an Anti-Phosphoarginine-Specific Antibody.

Fuhrmann J, Subramanian V, Thompson PR.

Angew Chem Int Ed Engl. 2015 Dec 1;54(49):14715-8. doi: 10.1002/anie.201506737. Epub 2015 Oct 12.

35.

Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer.

Witalison EE, Cui X, Causey CP, Thompson PR, Hofseth LJ.

Oncotarget. 2015 Nov 3;6(34):36053-62. doi: 10.18632/oncotarget.5937.

36.

Chemical Proteomic Platform To Identify Citrullinated Proteins.

Lewallen DM, Bicker KL, Subramanian V, Clancy KW, Slade DJ, Martell J, Dreyton CJ, Sokolove J, Weerapana E, Thompson PR.

ACS Chem Biol. 2015 Nov 20;10(11):2520-8. doi: 10.1021/acschembio.5b00438. Epub 2015 Sep 23.

37.

A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy.

Kholia S, Jorfi S, Thompson PR, Causey CP, Nicholas AP, Inal JM, Lange S.

J Extracell Vesicles. 2015 Jun 19;4:26192. doi: 10.3402/jev.v4.26192. eCollection 2015.

38.

Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells.

Horibata S, Vo TV, Subramanian V, Thompson PR, Coonrod SA.

J Vis Exp. 2015 May 20;(99):e52727. doi: 10.3791/52727.

39.

Chemical biology of protein arginine modifications in epigenetic regulation.

Fuhrmann J, Clancy KW, Thompson PR.

Chem Rev. 2015 Jun 10;115(11):5413-61. doi: 10.1021/acs.chemrev.5b00003. Epub 2015 May 13. Review. No abstract available.

40.
41.

Inhibiting protein arginine deiminases has antioxidant consequences.

Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ.

J Pharmacol Exp Ther. 2015 Apr;353(1):64-70. doi: 10.1124/jpet.115.222745. Epub 2015 Jan 29.

42.

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM.

Nat Chem Biol. 2015 Mar;11(3):189-91. doi: 10.1038/nchembio.1735. Epub 2015 Jan 26.

43.

Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.

Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, Bax BD, Coonrod SA, Lewis HD, Guo M, Gross ML, Thompson PR.

ACS Chem Biol. 2015 Apr 17;10(4):1043-53. doi: 10.1021/cb500933j. Epub 2015 Jan 26.

44.

Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors.

Subramanian V, Knight JS, Parelkar S, Anguish L, Coonrod SA, Kaplan MJ, Thompson PR.

J Med Chem. 2015 Feb 12;58(3):1337-44. doi: 10.1021/jm501636x. Epub 2015 Jan 16.

45.

Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion.

Wang M, Fuhrmann J, Thompson PR.

Biochemistry. 2014 Dec 23;53(50):7884-92. doi: 10.1021/bi501279g. Epub 2014 Dec 8.

PMID:
25485739
46.

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice.

Knight JS, Subramanian V, O'Dell AA, Yalavarthi S, Zhao W, Smith CK, Hodgin JB, Thompson PR, Kaplan MJ.

Ann Rheum Dis. 2015 Dec;74(12):2199-206. doi: 10.1136/annrheumdis-2014-205365. Epub 2014 Aug 7.

47.

Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism.

Dreyton CJ, Knuckley B, Jones JE, Lewallen DM, Thompson PR.

Biochemistry. 2014 Jul 15;53(27):4426-33. doi: 10.1021/bi500554b. Epub 2014 Jul 3.

48.

A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming.

Slade DJ, Horibata S, Coonrod SA, Thompson PR.

Bioessays. 2014 Aug;36(8):736-40. doi: 10.1002/bies.201400057. Epub 2014 May 30.

49.

Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus.

Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, Gillespie BW, Carmona-Rivera C, Liu X, Subramanian V, Hasni S, Thompson PR, Heinecke JW, Saran R, Pennathur S, Kaplan MJ.

Arthritis Rheumatol. 2014 Sep;66(9):2532-2544. doi: 10.1002/art.38703.

50.

Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates.

Lange S, Rocha-Ferreira E, Thei L, Mawjee P, Bennett K, Thompson PR, Subramanian V, Nicholas AP, Peebles D, Hristova M, Raivich G.

J Neurochem. 2014 Aug;130(4):555-62. doi: 10.1111/jnc.12744. Epub 2014 May 24.

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