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Items: 1 to 50 of 221


miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis.

Condrat CE, Thompson DC, Barbu MG, Bugnar OL, Boboc A, Cretoiu D, Suciu N, Cretoiu SM, Voinea SC.

Cells. 2020 Jan 23;9(2). pii: E276. doi: 10.3390/cells9020276. Review.


Genetics and functions of the retinoic acid pathway, with special emphasis on the eye.

Thompson B, Katsanis N, Apostolopoulos N, Thompson DC, Nebert DW, Vasiliou V.

Hum Genomics. 2019 Dec 3;13(1):61. doi: 10.1186/s40246-019-0248-9. Review.


Delineating the Asphondylia prosopidis Complex (Diptera: Cecidomyiidae): Possible Biological Control Agents of Honey Mesquite.

Park I, Thompson DC.

Environ Entomol. 2019 Sep 30;48(5):1042-1048. doi: 10.1093/ee/nvz090.


Glutathione deficiency-elicited reprogramming of hepatic metabolism protects against alcohol-induced steatosis.

Chen Y, Manna SK, Golla S, Krausz KW, Cai Y, Garcia-Milian R, Chakraborty T, Chakraborty J, Chatterjee R, Thompson DC, Gonzalez FJ, Vasiliou V.

Free Radic Biol Med. 2019 Nov 1;143:127-139. doi: 10.1016/j.freeradbiomed.2019.07.025. Epub 2019 Jul 24.


1,4-Dioxane as an emerging water contaminant: State of the science and evaluation of research needs.

Godri Pollitt KJ, Kim JH, Peccia J, Elimelech M, Zhang Y, Charkoftaki G, Hodges B, Zucker I, Huang H, Deziel NC, Murphy K, Ishii M, Johnson CH, Boissevain A, O'Keefe E, Anastas PT, Orlicky D, Thompson DC, Vasiliou V.

Sci Total Environ. 2019 Nov 10;690:853-866. doi: 10.1016/j.scitotenv.2019.06.443. Epub 2019 Jun 28. Review.


Encephalitis on deployment in Kenya: think beyond the infections.

Thompson DC, Bailey MS RAMC, Bowley D, Jacob S.

J R Army Med Corps. 2019 Oct;165(5):374-376. doi: 10.1136/jramc-2018-001115. Epub 2019 Apr 16.


Expression, purification and crystallization of the novel Xenopus tropicalis ALDH16B1, a homologue of human ALDH16A1.

Pantouris G, Dioletis E, Chen Y, Thompson DC, Vasiliou V, Lolis EJ.

Chem Biol Interact. 2019 May 1;304:168-172. doi: 10.1016/j.cbi.2019.03.009. Epub 2019 Mar 17.


Integrated multi-omics approach reveals a role of ALDH1A1 in lipid metabolism in human colon cancer cells.

Charkoftaki G, Thompson DC, Golla JP, Garcia-Milian R, Lam TT, Engel J, Vasiliou V.

Chem Biol Interact. 2019 May 1;304:88-96. doi: 10.1016/j.cbi.2019.02.030. Epub 2019 Mar 6. No abstract available.


Hepatic metabolic adaptation in a murine model of glutathione deficiency.

Chen Y, Golla S, Garcia-Milian R, Thompson DC, Gonzalez FJ, Vasiliou V.

Chem Biol Interact. 2019 Apr 25;303:1-6. doi: 10.1016/j.cbi.2019.02.015. Epub 2019 Feb 20.


Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".

Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW.

Hum Genomics. 2019 Feb 19;13(1):11. doi: 10.1186/s40246-019-0191-9. Review.


The effect of anodal/cathodal biphasic electrical stimulation on insulin release.

Siegel D, Baca SM, Thompson DC, Huntsman MM, Mower MM, Ross D.

J Cell Physiol. 2019 Feb 11. doi: 10.1002/jcp.28307. [Epub ahead of print]


Infection Pattern of Mayaro Virus in Aedes aegypti (Diptera: Culicidae) and Transmission Potential of the Virus in Mixed Infections With Chikungunya Virus.

Kantor AM, Lin J, Wang A, Thompson DC, Franz AWE.

J Med Entomol. 2019 Apr 16;56(3):832-843. doi: 10.1093/jme/tjy241.


Evaluation of potential carcinogenicity of organic chemicals in synthetic turf crumb rubber.

Perkins AN, Inayat-Hussain SH, Deziel NC, Johnson CH, Ferguson SS, Garcia-Milian R, Thompson DC, Vasiliou V.

Environ Res. 2019 Feb;169:163-172. doi: 10.1016/j.envres.2018.10.018. Epub 2018 Oct 24.


Engineered Animal Models Designed for Investigating Ethanol Metabolism, Toxicity and Cancer.

Marshall S, Chen Y, Singh S, Berrios-Carcamo P, Heit C, Apostolopoulos N, Golla JP, Thompson DC, Vasiliou V.

Adv Exp Med Biol. 2018;1032:203-221. doi: 10.1007/978-3-319-98788-0_14. Review.


Glutathione and Transsulfuration in Alcohol-Associated Tissue Injury and Carcinogenesis.

Chen Y, Han M, Matsumoto A, Wang Y, Thompson DC, Vasiliou V.

Adv Exp Med Biol. 2018;1032:37-53. doi: 10.1007/978-3-319-98788-0_3. Review.


Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice.

Mineur YS, Cahuzac EL, Mose TN, Bentham MP, Plantenga ME, Thompson DC, Picciotto MR.

Neuropsychopharmacology. 2018 Sep;43(10):2118-2125. doi: 10.1038/s41386-018-0024-x. Epub 2018 Feb 22.


Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway.

Charkoftaki G, Jester JV, Thompson DC, Vasiliou V.

Ocul Surf. 2018 Jan;16(1):154-162. doi: 10.1016/j.jtos.2017.11.004. Epub 2017 Nov 10.


The pattern of paediatric blast injury in Afghanistan.

Thompson DC, Crooks RJ, Clasper JC, Lupu A, Stapley SA, Cloke DJ.

J R Army Med Corps. 2017 Oct 21. pii: jramc-2017-000795. doi: 10.1136/jramc-2017-000795. [Epub ahead of print]


Aldehyde dehydrogenase 1B1: a novel immunohistological marker for colorectal cancer.

Matsumoto A, Arcaroli J, Chen Y, Gasparetto M, Neumeister V, Thompson DC, Singh S, Smith C, Messersmith W, Vasiliou V.

Br J Cancer. 2017 Nov 7;117(10):1537-1543. doi: 10.1038/bjc.2017.304. Epub 2017 Sep 7.


Menthol disrupts nicotine's psychostimulant properties in an age and sex-dependent manner in C57BL/6J mice.

Fait BW, Thompson DC, Mose TN, Jatlow P, Jordt SE, Picciotto MR, Mineur YS.

Behav Brain Res. 2017 Sep 15;334:72-77. doi: 10.1016/j.bbr.2017.07.027. Epub 2017 Jul 22.


Development and Application of Human Renal Proximal Tubule Epithelial Cells for Assessment of Compound Toxicity.

Li S, Zhao J, Huang R, Steiner T, Bourner M, Mitchell M, Thompson DC, Zhao B, Xia M.

Curr Chem Genom Transl Med. 2017 Feb 14;11:19-30. doi: 10.2174/2213988501711010019. eCollection 2017.


Transcriptomic analysis and plasma metabolomics in Aldh16a1-null mice reveals a potential role of ALDH16A1 in renal function.

Charkoftaki G, Chen Y, Han M, Sandoval M, Yu X, Zhao H, Orlicky DJ, Thompson DC, Vasiliou V.

Chem Biol Interact. 2017 Oct 1;276:15-22. doi: 10.1016/j.cbi.2017.02.013. Epub 2017 Feb 28.


Corneal haze phenotype in Aldh3a1-null mice: In vivo confocal microscopy and tissue imaging mass spectrometry.

Chen Y, Jester JV, Anderson DM, Marchitti SA, Schey KL, Thompson DC, Vasiliou V.

Chem Biol Interact. 2017 Oct 1;276:9-14. doi: 10.1016/j.cbi.2016.12.017. Epub 2016 Dec 27.


Catalase deletion promotes prediabetic phenotype in mice.

Heit C, Marshall S, Singh S, Yu X, Charkoftaki G, Zhao H, Orlicky DJ, Fritz KS, Thompson DC, Vasiliou V.

Free Radic Biol Med. 2017 Feb;103:48-56. doi: 10.1016/j.freeradbiomed.2016.12.011. Epub 2016 Dec 8.


Roles of defective ALDH2 polymorphism on liver protection and cancer development.

Matsumoto A, Thompson DC, Chen Y, Kitagawa K, Vasiliou V.

Environ Health Prev Med. 2016 Nov;21(6):395-402. Epub 2016 Oct 6. Review.


Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC-MS.

Heit C, Eriksson P, Thompson DC, Charkoftaki G, Fritz KS, Vasiliou V.

Alcohol Clin Exp Res. 2016 Sep;40(9):1825-31. doi: 10.1111/acer.13156. Epub 2016 Aug 8.


Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway.

Chen Y, Singh S, Matsumoto A, Manna SK, Abdelmegeed MA, Golla S, Murphy RC, Dong H, Song BJ, Gonzalez FJ, Thompson DC, Vasiliou V.

Sci Rep. 2016 Jul 12;6:29743. doi: 10.1038/srep29743.


Letter to the editor for "Update of the human and mouse Fanconi anemia genes".

Nebert DW, Dong H, Bruford EA, Thompson DC, Joenje H, Vasiliou V.

Hum Genomics. 2016 Jul 4;10(1):25. doi: 10.1186/s40246-016-0081-3. No abstract available.


Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury.

Qiu X, Zhang Y, Liu T, Shen H, Xiao Y, Bourner MJ, Pratt JR, Thompson DC, Marathe P, Humphreys WG, Lai Y.

Mol Pharm. 2016 Apr 4;13(4):1206-16. doi: 10.1021/acs.molpharmaceut.5b00659. Epub 2016 Mar 8.


ALDH3A1 Plays a Functional Role in Maintenance of Corneal Epithelial Homeostasis.

Koppaka V, Chen Y, Mehta G, Orlicky DJ, Thompson DC, Jester JV, Vasiliou V.

PLoS One. 2016 Jan 11;11(1):e0146433. doi: 10.1371/journal.pone.0146433. eCollection 2016.


Update of the human and mouse Fanconi anemia genes.

Dong H, Nebert DW, Bruford EA, Thompson DC, Joenje H, Vasiliou V.

Hum Genomics. 2015 Nov 24;9:32. doi: 10.1186/s40246-015-0054-y. Review.


Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma.

Singh S, Arcaroli JJ, Orlicky DJ, Chen Y, Messersmith WA, Bagby S, Purkey A, Quackenbush KS, Thompson DC, Vasiliou V.

Pancreas. 2016 Jan;45(1):117-22. doi: 10.1097/MPA.0000000000000542.


Dead enzymes in the aldehyde dehydrogenase gene family: role in drug metabolism and toxicology.

Jackson BC, Thompson DC, Charkoftaki G, Vasiliou V.

Expert Opin Drug Metab Toxicol. 2015;11(12):1839-47. doi: 10.1517/17425255.2016.1108406. Epub 2015 Nov 11. Review.


ALDH1B1 links alcohol consumption and diabetes.

Singh S, Chen Y, Matsumoto A, Orlicky DJ, Dong H, Thompson DC, Vasiliou V.

Biochem Biophys Res Commun. 2015 Aug 7;463(4):768-773. doi: 10.1016/j.bbrc.2015.06.011. Epub 2015 Jun 15.


ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways.

Singh S, Arcaroli J, Chen Y, Thompson DC, Messersmith W, Jimeno A, Vasiliou V.

PLoS One. 2015 May 7;10(5):e0121648. doi: 10.1371/journal.pone.0121648. eCollection 2015.


Crowdsourcing in pharma: a strategic framework.

Bentzien J, Bharadwaj R, Thompson DC.

Drug Discov Today. 2015 Jul;20(7):874-83. doi: 10.1016/j.drudis.2015.01.011. Epub 2015 Jan 27. Review.


Epidemiology of bicycle injuries and risk factors for serious injury. 1997.

Rivara FP, Thompson DC, Thompson RS.

Inj Prev. 2015 Feb;21(1):47-51. doi: 10.1136/injprev-00002-0038rep.


Transgenic mouse models for alcohol metabolism, toxicity, and cancer.

Heit C, Dong H, Chen Y, Shah YM, Thompson DC, Vasiliou V.

Adv Exp Med Biol. 2015;815:375-87. doi: 10.1007/978-3-319-09614-8_22.


Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers.

Singh S, Arcaroli J, Thompson DC, Messersmith W, Vasiliou V.

Adv Exp Med Biol. 2015;815:281-94. doi: 10.1007/978-3-319-09614-8_16. Review.


Human ALDH1B1 polymorphisms may affect the metabolism of acetaldehyde and all-trans retinaldehyde--in vitro studies and computational modeling.

Jackson BC, Reigan P, Miller B, Thompson DC, Vasiliou V.

Pharm Res. 2015 May;32(5):1648-62. doi: 10.1007/s11095-014-1564-3. Epub 2014 Nov 21.


Zinc finger nuclease-mediated gene knockout results in loss of transport activity for P-glycoprotein, BCRP, and MRP2 in Caco-2 cells.

Sampson KE, Brinker A, Pratt J, Venkatraman N, Xiao Y, Blasberg J, Steiner T, Bourner M, Thompson DC.

Drug Metab Dispos. 2015 Feb;43(2):199-207. doi: 10.1124/dmd.114.057216. Epub 2014 Nov 11.


Improved drug therapy: triangulating phenomics with genomics and metabolomics.

Monte AA, Brocker C, Nebert DW, Gonzalez FJ, Thompson DC, Vasiliou V.

Hum Genomics. 2014 Sep 1;8:16. doi: 10.1186/s40246-014-0016-9. Review.


Modulation of electrocortical brain activity by attention in individuals with and without tinnitus.

Paul BT, Bruce IC, Bosnyak DJ, Thompson DC, Roberts LE.

Neural Plast. 2014;2014:127824. doi: 10.1155/2014/127824. Epub 2014 Jun 12.


Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity.

Jang JH, Bruse S, Liu Y, Duffy V, Zhang C, Oyamada N, Randell S, Matsumoto A, Thompson DC, Lin Y, Vasiliou V, Tesfaigzi Y, Nyunoya T.

Free Radic Biol Med. 2014 Mar;68:80-6. doi: 10.1016/j.freeradbiomed.2013.11.028. Epub 2013 Dec 4.


Update of the human and mouse SERPIN gene superfamily.

Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V.

Hum Genomics. 2013 Oct 30;7:22. doi: 10.1186/1479-7364-7-22. Review.


Glutathione defense mechanism in liver injury: insights from animal models.

Chen Y, Dong H, Thompson DC, Shertzer HG, Nebert DW, Vasiliou V.

Food Chem Toxicol. 2013 Oct;60:38-44. doi: 10.1016/j.fct.2013.07.008. Epub 2013 Jul 12. Review.


The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system.

Heit C, Dong H, Chen Y, Thompson DC, Deitrich RA, Vasiliou VK.

Subcell Biochem. 2013;67:235-47. doi: 10.1007/978-94-007-5881-0_8. Review.


ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein-protein interactions with HPRT1.

Vasiliou V, Sandoval M, Backos DS, Jackson BC, Chen Y, Reigan P, Lanaspa MA, Johnson RJ, Koppaka V, Thompson DC.

Chem Biol Interact. 2013 Feb 25;202(1-3):22-31. doi: 10.1016/j.cbi.2012.12.018. Epub 2013 Jan 21.


Crowd computing: using competitive dynamics to develop and refine highly predictive models.

Bentzien J, Muegge I, Hamner B, Thompson DC.

Drug Discov Today. 2013 May;18(9-10):472-8. doi: 10.1016/j.drudis.2013.01.002. Epub 2013 Jan 19.


Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.

Jackson BC, Holmes RS, Backos DS, Reigan P, Thompson DC, Vasiliou V.

Chem Biol Interact. 2013 Feb 25;202(1-3):11-21. doi: 10.1016/j.cbi.2012.11.022. Epub 2012 Dec 13.

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