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Items: 22


Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a non-cell-autonomous fashion.

El Ouaamari A, O-Sullivan I, Shirakawa J, Basile G, Zhang W, Roger S, Thomou T, Xu S, Qiang G, Liew CW, Kulkarni RN, Unterman TG.

J Biol Chem. 2019 Jan 18;294(3):1059-1069. doi: 10.1074/jbc.RA118.006031. Epub 2018 Nov 20.


Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors.

Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ.

EMBO J. 2018 Dec 14;37(24). pii: e100409. doi: 10.15252/embj.2018100409. Epub 2018 Nov 16.


Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues.

Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR.

Nature. 2017 May 10;545(7653):252. doi: 10.1038/nature22319. No abstract available.


Adipose-derived circulating miRNAs regulate gene expression in other tissues.

Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR.

Nature. 2017 Feb 23;542(7642):450-455. doi: 10.1038/nature21365. Epub 2017 Feb 15. Erratum in: Nature. 2017 May 10;545(7653):252.


Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice.

Reis FC, Branquinho JL, Brandão BB, Guerra BA, Silva ID, Frontini A, Thomou T, Sartini L, Cinti S, Kahn CR, Festuccia WT, Kowaltowski AJ, Mori MA.

Aging (Albany NY). 2016 Jun;8(6):1201-22. doi: 10.18632/aging.100970.


PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts.

Khamaisi M, Katagiri S, Keenan H, Park K, Maeda Y, Li Q, Qi W, Thomou T, Eschuk D, Tellechea A, Veves A, Huang C, Orgill DP, Wagers A, King GL.

J Clin Invest. 2016 Mar 1;126(3):837-53. doi: 10.1172/JCI82788. Epub 2016 Jan 25.


Dysfunctional Subcutaneous Fat With Reduced Dicer and Brown Adipose Tissue Gene Expression in HIV-Infected Patients.

Torriani M, Srinivasa S, Fitch KV, Thomou T, Wong K, Petrow E, Kahn CR, Cypess AM, Grinspoon SK.

J Clin Endocrinol Metab. 2016 Mar;101(3):1225-34. doi: 10.1210/jc.2015-3993. Epub 2016 Jan 12.


ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.

Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR.

Sci Transl Med. 2014 Jul 30;6(247):247ra103. doi: 10.1126/scitranslmed.3008490.


Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy.

Mori MA, Thomou T, Boucher J, Lee KY, Lallukka S, Kim JK, Torriani M, Yki-Järvinen H, Grinspoon SK, Cypess AM, Kahn CR.

J Clin Invest. 2014 Aug;124(8):3339-51. doi: 10.1172/JCI73468. Epub 2014 Jul 1.


Mechanisms and metabolic implications of regional differences among fat depots.

Tchkonia T, Thomou T, Zhu Y, Karagiannides I, Pothoulakis C, Jensen MD, Kirkland JL.

Cell Metab. 2013 May 7;17(5):644-656. doi: 10.1016/j.cmet.2013.03.008. Epub 2013 Apr 11. Review.


Role of microRNA processing in adipose tissue in stress defense and longevity.

Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR.

Cell Metab. 2012 Sep 5;16(3):336-47. doi: 10.1016/j.cmet.2012.07.017.


Role of substance P in the regulation of glucose metabolism via insulin signaling-associated pathways.

Karagiannides I, Bakirtzi K, Kokkotou E, Stavrakis D, Margolis KG, Thomou T, Giorgadze N, Kirkland JL, Pothoulakis C.

Endocrinology. 2011 Dec;152(12):4571-80. doi: 10.1210/en.2011-1170. Epub 2011 Oct 18.


Concerted action of aldehyde dehydrogenases influences depot-specific fat formation.

Reichert B, Yasmeen R, Jeyakumar SM, Yang F, Thomou T, Alder H, Duester G, Maiseyeu A, Mihai G, Harrison EH, Rajagopalan S, Kirkland JL, Ziouzenkova O.

Mol Endocrinol. 2011 May;25(5):799-809. doi: 10.1210/me.2010-0465. Epub 2011 Mar 24.


Sex- and depot-dependent differences in adipogenesis in normal-weight humans.

Tchoukalova YD, Koutsari C, Votruba SB, Tchkonia T, Giorgadze N, Thomou T, Kirkland JL, Jensen MD.

Obesity (Silver Spring). 2010 Oct;18(10):1875-80. doi: 10.1038/oby.2010.56. Epub 2010 Mar 18.


Aging and regional differences in fat cell progenitors - a mini-review.

Sepe A, Tchkonia T, Thomou T, Zamboni M, Kirkland JL.

Gerontology. 2011;57(1):66-75. doi: 10.1159/000279755. Epub 2010 Jan 29. Review.


Aging, depot origin, and preadipocyte gene expression.

Cartwright MJ, Schlauch K, Lenburg ME, Tchkonia T, Pirtskhalava T, Cartwright A, Thomou T, Kirkland JL.

J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):242-51. doi: 10.1093/gerona/glp213. Epub 2010 Jan 27.


Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways.

Gross K, Karagiannides I, Thomou T, Koon HW, Bowe C, Kim H, Giorgadze N, Tchkonia T, Pirtskhalava T, Kirkland JL, Pothoulakis C.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1012-9. doi: 10.1152/ajpgi.90351.2008. Epub 2009 Mar 12.


Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis.

Tchkonia T, Pirtskhalava T, Thomou T, Cartwright MJ, Wise B, Karagiannides I, Shpilman A, Lash TL, Becherer JD, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1810-9. Epub 2007 Oct 2.


Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity.

Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1041-51. Epub 2006 Dec 5.


Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns.

Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, Pirtskhalava T, Cartwright A, Cartwright M, Flanagan J, Karagiannides I, Gerry N, Forse RA, Tchoukalova Y, Jensen MD, Pothoulakis C, Kirkland JL.

Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E298-307. Epub 2006 Sep 19.


Fat depot-specific characteristics are retained in strains derived from single human preadipocytes.

Tchkonia T, Giorgadze N, Pirtskhalava T, Thomou T, DePonte M, Koo A, Forse RA, Chinnappan D, Martin-Ruiz C, von Zglinicki T, Kirkland JL.

Diabetes. 2006 Sep;55(9):2571-8.


Increased CUG triplet repeat-binding protein-1 predisposes to impaired adipogenesis with aging.

Karagiannides I, Thomou T, Tchkonia T, Pirtskhalava T, Kypreos KE, Cartwright A, Dalagiorgou G, Lash TL, Farmer SR, Timchenko NA, Kirkland JL.

J Biol Chem. 2006 Aug 11;281(32):23025-33. Epub 2006 Jun 5.

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