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Items: 43

1.

Time-kill kinetics of cadazolid and comparator antibacterial agents against different ribotypes of Clostridium difficile.

Skinner K, Birchall S, Corbett D, Thommes P, Locher HH.

J Med Microbiol. 2018 Sep;67(9):1402-1409. doi: 10.1099/jmm.0.000808. Epub 2018 Jul 27.

PMID:
30052178
2.

How, When, and Where? Assessing Renewable Energy Self-Sufficiency at the Neighborhood Level.

Grosspietsch D, Thömmes P, Girod B, Hoffmann VH.

Environ Sci Technol. 2018 Feb 20;52(4):2339-2348. doi: 10.1021/acs.est.7b02686. Epub 2018 Jan 23.

PMID:
29304276
3.

Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin.

Warn P, Thommes P, Sattar A, Corbett D, Flattery A, Zhang Z, Black T, Hernandez LD, Therien AG.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6471-6482. doi: 10.1128/AAC.00974-16. Print 2016 Nov.

4.

SMT19969 for Clostridium difficile infection (CDI): in vivo efficacy compared with fidaxomicin and vancomycin in the hamster model of CDI.

Sattar A, Thommes P, Payne L, Warn P, Vickers RJ.

J Antimicrob Chemother. 2015;70(6):1757-62. doi: 10.1093/jac/dkv005. Epub 2015 Feb 3.

5.

Hydrophobic and charged residues in the C-terminal arm of hepatitis C virus RNA-dependent RNA polymerase regulate initiation and elongation.

Cherry AL, Dennis CA, Baron A, Eisele LE, Thommes PA, Jaeger J.

J Virol. 2015 Feb;89(4):2052-63. doi: 10.1128/JVI.01106-14. Epub 2014 Nov 26.

6.

Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.

Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, Böttger EC.

MBio. 2014 Sep 30;5(5):e01827-14. doi: 10.1128/mBio.01827-14.

7.

4'-O-substitutions determine selectivity of aminoglycoside antibiotics.

Perez-Fernandez D, Shcherbakov D, Matt T, Leong NC, Kudyba I, Duscha S, Boukari H, Patak R, Dubbaka SR, Lang K, Meyer M, Akbergenov R, Freihofer P, Vaddi S, Thommes P, Ramakrishnan V, Vasella A, Böttger EC.

Nat Commun. 2014;5:3112. doi: 10.1038/ncomms4112.

8.

1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.

Cano C, Saravanan K, Bailey C, Bardos J, Curtin NJ, Frigerio M, Golding BT, Hardcastle IR, Hummersone MG, Menear KA, Newell DR, Richardson CJ, Shea K, Smith GC, Thommes P, Ting A, Griffin RJ.

J Med Chem. 2013 Aug 22;56(16):6386-401. doi: 10.1021/jm400915j. Epub 2013 Aug 1.

PMID:
23855836
9.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

Maynard A, Crosby RM, Ellis B, Hamatake R, Hong Z, Johns BA, Kahler KM, Koble C, Leivers A, Leivers MR, Mathis A, Peat AJ, Pouliot JJ, Roberts CD, Samano V, Schmidt RM, Smith GK, Spaltenstein A, Stewart EL, Thommes P, Turner EM, Voitenleitner C, Walker JT, Waitt G, Weatherhead J, Weaver K, Williams S, Wright L, Xiong ZZ, Haigh D, Shotwell JB.

J Med Chem. 2014 Mar 13;57(5):1902-13. doi: 10.1021/jm400317w. Epub 2013 May 29.

PMID:
23672667
10.

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.

Foote KM, Blades K, Cronin A, Fillery S, Guichard SS, Hassall L, Hickson I, Jacq X, Jewsbury PJ, McGuire TM, Nissink JW, Odedra R, Page K, Perkins P, Suleman A, Tam K, Thommes P, Broadhurst R, Wood C.

J Med Chem. 2013 Mar 14;56(5):2125-38. doi: 10.1021/jm301859s. Epub 2013 Mar 1.

PMID:
23394205
11.

Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives.

Clapham KM, Rennison T, Jones G, Craven F, Bardos J, Golding BT, Griffin RJ, Haggerty K, Hardcastle IR, Thommes P, Ting A, Cano C.

Org Biomol Chem. 2012 Sep 7;10(33):6747-57. doi: 10.1039/c2ob26035b. Epub 2012 Jul 19.

PMID:
22814419
12.

Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K.

Munck JM, Batey MA, Zhao Y, Jenkins H, Richardson CJ, Cano C, Tavecchio M, Barbeau J, Bardos J, Cornell L, Griffin RJ, Menear K, Slade A, Thommes P, Martin NM, Newell DR, Smith GC, Curtin NJ.

Mol Cancer Ther. 2012 Aug;11(8):1789-98. doi: 10.1158/1535-7163.MCT-11-0535. Epub 2012 May 10.

13.

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.

Li X, Zhang YK, Liu Y, Ding CZ, Zhou Y, Li Q, Plattner JJ, Baker SJ, Zhang S, Kazmierski WM, Wright LL, Smith GK, Grimes RM, Crosby RM, Creech KL, Carballo LH, Slater MJ, Jarvest RL, Thommes P, Hubbard JA, Convery MA, Nassau PM, McDowell W, Skarzynski TJ, Qian X, Fan D, Liao L, Ni ZJ, Pennicott LE, Zou W, Wright J.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5695-700. doi: 10.1016/j.bmcl.2010.08.022. Epub 2010 Aug 10.

PMID:
20801653
14.

Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.

Li X, Zhang YK, Liu Y, Ding CZ, Li Q, Zhou Y, Plattner JJ, Baker SJ, Qian X, Fan D, Liao L, Ni ZJ, White GV, Mordaunt JE, Lazarides LX, Slater MJ, Jarvest RL, Thommes P, Ellis M, Edge CM, Hubbard JA, Somers D, Rowland P, Nassau P, McDowell B, Skarzynski TJ, Kazmierski WM, Grimes RM, Wright LL, Smith GK, Zou W, Wright J, Pennicott LE.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3550-6. doi: 10.1016/j.bmcl.2010.04.129. Epub 2010 May 20.

PMID:
20493689
15.

Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo.

Griffin S, Trowbridge R, Thommes P, Parry N, Rowlands D, Harris M, Bright H.

J Hepatol. 2008 Dec;49(6):908-15. doi: 10.1016/j.jhep.2008.07.020. Epub 2008 Sep 15.

16.

Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity.

Burton G, Ku TW, Carr TJ, Kiesow T, Sarisky RT, Lin-Goerke J, Hofmann GA, Slater MJ, Haigh D, Dhanak D, Johnson VK, Parry NR, Thommes P.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):1930-3. Epub 2007 Jan 19.

PMID:
17270443
17.

Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.

Slater MJ, Amphlett EM, Andrews DM, Bravi G, Burton G, Cheasty AG, Corfield JA, Ellis MR, Fenwick RH, Fernandes S, Guidetti R, Haigh D, Hartley CD, Howes PD, Jackson DL, Jarvest RL, Lovegrove VL, Medhurst KJ, Parry NR, Price H, Shah P, Singh OM, Stocker R, Thommes P, Wilkinson C, Wonacott A.

J Med Chem. 2007 Mar 8;50(5):897-900. Epub 2007 Feb 2.

PMID:
17269759
18.

Development of cell-based assays for in vitro characterization of hepatitis C virus NS3/4A protease inhibitors.

Chung V, Carroll AR, Gray NM, Parry NR, Thommes PA, Viner KC, D'Souza EA.

Antimicrob Agents Chemother. 2005 Apr;49(4):1381-90.

19.
20.

Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor.

Mahbubani HM, Chong JP, Chevalier S, Thömmes P, Blow JJ.

J Cell Biol. 1997 Jan 13;136(1):125-35.

21.

The DNA replication licensing system.

Thömmes P, Blow JJ.

Cancer Surv. 1997;29:75-90. Review.

PMID:
9338097
22.

Characterization of the Xenopus replication licensing system.

Chong JP, Thömmes P, Rowles A, Mahbubani HM, Blow JJ.

Methods Enzymol. 1997;283:549-64. No abstract available.

PMID:
9251047
23.

The role of MCM/P1 proteins in the licensing of DNA replication.

Chong JP, Thömmes P, Blow JJ.

Trends Biochem Sci. 1996 Mar;21(3):102-6. Review.

PMID:
8882583
25.

Purification and characterisation of a DNA helicase, dheI I, from Drosophila melanogaster embryos.

Thömmes P, Marton RF, Cotterill S.

Nucleic Acids Res. 1995 Nov 11;23(21):4443-50.

26.

Mitochondrial single-stranded DNA-binding protein from Drosophila embryos. Physical and biochemical characterization.

Thömmes P, Farr CL, Marton RF, Kaguni LS, Cotterill S.

J Biol Chem. 1995 Sep 8;270(36):21137-43.

27.

Synthesis of the tomato golden mosaic virus AL1, AL2, AL3 and AL4 proteins in vitro.

Thömmes PA, Buck KW.

J Gen Virol. 1994 Aug;75 ( Pt 8):1827-34.

PMID:
8046385
28.
29.
30.

TGMV replication protein AL1 preferentially binds to single-stranded DNA from the common region.

Thömmes P, Osman TA, Hayes RJ, Buck KW.

FEBS Lett. 1993 Mar 15;319(1-2):95-9.

31.

Eukaryotic DNA helicases: essential enzymes for DNA transactions.

Thömmes P, Hübscher U.

Chromosoma. 1992 Jun;101(8):467-73. Review.

PMID:
1330454
32.

Four different DNA helicases from calf thymus.

Thömmes P, Ferrari E, Jessberger R, Hübscher U.

J Biol Chem. 1992 Mar 25;267(9):6063-73.

33.

Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein.

Thömmes P, Fett R, Schray B, Burkhart R, Barnes M, Kennedy C, Brown NC, Knippers R.

Nucleic Acids Res. 1992 Mar 11;20(5):1069-74.

34.

DNA polymerase epsilon: in search of a function.

Hübscher U, Thömmes P.

Trends Biochem Sci. 1992 Feb;17(2):55-8. Review.

PMID:
1566327
35.

Biochemical and functional comparison of DNA polymerases alpha, delta, and epsilon from calf thymus.

Weiser T, Gassmann M, Thömmes P, Ferrari E, Hafkemeyer P, Hübscher U.

J Biol Chem. 1991 Jun 5;266(16):10420-8.

36.

Eukaryotic DNA replication. Enzymes and proteins acting at the fork.

Thömmes P, Hübscher U.

Eur J Biochem. 1990 Dec 27;194(3):699-712. Review.

37.
38.
39.

Eukaryotic DNA helicases.

Thömmes P, Hübscher U.

FEBS Lett. 1990 Aug 1;268(2):325-8. Review.

40.

Efficient production of chicken egg yolk antibodies against a conserved mammalian protein.

Gassmann M, Thömmes P, Weiser T, Hübscher U.

FASEB J. 1990 May;4(8):2528-32.

PMID:
1970792
41.

[The chicken egg as a supply of polyclonal antibodies].

Gassmann M, Weiser T, Thömmes P, Hübscher U.

Schweiz Arch Tierheilkd. 1990;132(6):289-94. Review. German.

PMID:
2205000
42.

The core region of human glutaminyl-tRNA synthetase homologies with the Escherichia coli and yeast enzymes.

Thömmes P, Fett R, Schray B, Kunze N, Knippers R.

Nucleic Acids Res. 1988 Jun 24;16(12):5391-406.

43.

Synthesis of DNA polymerase alpha analyzed by immunoprecipitation from synchronously proliferating cells.

Thömmes P, Reiter T, Knippers R.

Biochemistry. 1986 Mar 25;25(6):1308-14.

PMID:
3964677

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