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Items: 13


Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.

Thomenius MJ, Totman J, Harvey D, Mitchell LH, Riera TV, Cosmopoulos K, Grassian AR, Klaus C, Foley M, Admirand EA, Jahic H, Majer C, Wigle T, Jacques SL, Gureasko J, Brach D, Lingaraj T, West K, Smith S, Rioux N, Waters NJ, Tang C, Raimondi A, Munchhof M, Mills JE, Ribich S, Porter Scott M, Kuntz KW, Janzen WP, Moyer M, Smith JJ, Chesworth R, Copeland RA, Boriack-Sjodin PA.

PLoS One. 2018 Jun 1;13(6):e0197372. doi: 10.1371/journal.pone.0197372. eCollection 2018.


EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL.

Brach D, Johnston-Blackwell D, Drew A, Lingaraj T, Motwani V, Warholic NM, Feldman I, Plescia C, Smith JJ, Copeland RA, Keilhack H, Chan-Penebre E, Knutson SK, Ribich SA, Raimondi A, Thomenius MJ.

Mol Cancer Ther. 2017 Nov;16(11):2586-2597. doi: 10.1158/1535-7163.MCT-16-0840. Epub 2017 Aug 23.


The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis.

Yang CS, Sinenko SA, Thomenius MJ, Robeson AC, Freel CD, Horn SR, Kornbluth S.

Cell Death Differ. 2014 Apr;21(4):604-11. doi: 10.1038/cdd.2013.184. Epub 2013 Dec 20.


Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability.

Horn SR, Thomenius MJ, Johnson ES, Freel CD, Wu JQ, Coloff JL, Yang CS, Tang W, An J, Ilkayeva OR, Rathmell JC, Newgard CB, Kornbluth S.

Mol Biol Cell. 2011 Apr 15;22(8):1207-16. doi: 10.1091/mbc.E10-07-0567. Epub 2011 Feb 16.


Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc.

Yang CS, Thomenius MJ, Gan EC, Tang W, Freel CD, Merritt TJ, Nutt LK, Kornbluth S.

EMBO J. 2010 Sep 15;29(18):3196-207. doi: 10.1038/emboj.2010.191. Epub 2010 Aug 10.


Mitochondrial localization of Reaper to promote inhibitors of apoptosis protein degradation conferred by GH3 domain-lipid interactions.

Freel CD, Richardson DA, Thomenius MJ, Gan EC, Horn SR, Olson MR, Kornbluth S.

J Biol Chem. 2008 Jan 4;283(1):367-79. Epub 2007 Nov 12.


Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.

Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, Hahn WC, Virshup DM, Kornbluth S.

Cell. 2006 Nov 17;127(4):759-73.


Transition state stabilization by six arginines clustered in the active site of creatine kinase.

Jourden MJ, Geiss PR, Thomenius MJ, Horst LA, Barty MM, Brym MJ, Mulligan GB, Almeida RM, Kersteen BA, Myers NR, Snider MJ, Borders CL Jr, Edmiston PL.

Biochim Biophys Acta. 2005 Aug 10;1751(2):178-83.


Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance.

Thomenius MJ, Distelhorst CW.

J Cell Sci. 2003 Nov 15;116(Pt 22):4493-9. Review.


Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals.

Wang Z, Malone MH, Thomenius MJ, Zhong F, Xu F, Distelhorst CW.

J Biol Chem. 2003 Jul 18;278(29):27053-8. Epub 2003 May 7.


Asparagine 285 plays a key role in transition state stabilization in rabbit muscle creatine kinase.

Borders CL Jr, MacGregor KM, Edmiston PL, Gbeddy ER, Thomenius MJ, Mulligan GB, Snider MJ.

Protein Sci. 2003 Mar;12(3):532-7.


Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins.

Thomenius MJ, Wang NS, Reineks EZ, Wang Z, Distelhorst CW.

J Biol Chem. 2003 Feb 21;278(8):6243-50. Epub 2002 Dec 10.


Unreliability of the cytochrome c-enhanced green fluorescent fusion protein as a marker of cytochrome c release in cells that overexpress Bcl-2.

Unkila M, McColl KS, Thomenius MJ, Heiskanen K, Distelhorst CW.

J Biol Chem. 2001 Oct 19;276(42):39132-7. Epub 2001 Aug 6.

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