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Items: 1 to 50 of 156

1.

Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors.

Ragnarsson L, Andersson Å, Thomas WG, Lewis RJ.

Sci Signal. 2019 Mar 12;12(572). pii: eaas9485. doi: 10.1126/scisignal.aas9485.

PMID:
30862702
2.

BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes.

O'Brien SL, Johnstone EKM, Devost D, Conroy J, Reichelt ME, Purdue BW, Ayoub MA, Kawai T, Inoue A, Eguchi S, Hébert TE, Pfleger KDG, Thomas WG.

Biochem Pharmacol. 2018 Dec;158:232-242. doi: 10.1016/j.bcp.2018.10.017. Epub 2018 Oct 19.

PMID:
30347205
3.

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.

Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodson MP, Ferguson C, Drowley L, Plowright AT, Needham EJ, Wang QD, Gregorevic P, Xin M, Thomas WG, Parton RG, Nielsen LK, Launikonis BS, James DE, Elliott DA, Porrello ER, Hudson JE.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8372-E8381. doi: 10.1073/pnas.1707316114. Epub 2017 Sep 15.

4.

Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity.

Kaakinen M, Reichelt ME, Ma Z, Ferguson C, Martel N, Porrello ER, Hudson JE, Thomas WG, Parton RG, Headrick JP.

Basic Res Cardiol. 2017 May;112(3):24. doi: 10.1007/s00395-017-0613-6. Epub 2017 Mar 25.

PMID:
28343262
5.

Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection.

Reichelt ME, O'Brien S, Thomas WG, Headrick JP.

Int J Biochem Cell Biol. 2017 Feb;83:97-110. doi: 10.1016/j.biocel.2016.12.014. Epub 2016 Dec 31. Review.

PMID:
28049018
6.

CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis.

Iyer S, Chhabra Y, Harvey TJ, Wang R, Chiu HS, Smith AG, Thomas WG, Pennisi DJ, Piper M.

J Mol Histol. 2017 Feb;48(1):53-61. doi: 10.1007/s10735-016-9702-3. Epub 2016 Nov 1.

PMID:
27803996
7.

Crim1 has cell-autonomous and paracrine roles during embryonic heart development.

Iyer S, Chou FY, Wang R, Chiu HS, Raju VK, Little MH, Thomas WG, Piper M, Pennisi DJ.

Sci Rep. 2016 Jan 29;6:19832. doi: 10.1038/srep19832.

8.

International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].

Karnik SS, Unal H, Kemp JR, Tirupula KC, Eguchi S, Vanderheyden PM, Thomas WG.

Pharmacol Rev. 2015 Oct;67(4):754-819. doi: 10.1124/pr.114.010454. Review. Erratum in: Pharmacol Rev. 2015 Oct;67(4):820.

9.

Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion.

Hirst DJ, Lee TH, Pattenden LK, Thomas WG, Aguilar MI.

Sci Rep. 2015 Jun 30;5:9972. doi: 10.1038/srep09972.

10.

Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation.

Roura E, Aldayyani A, Thavaraj P, Prakash S, Greenway D, Thomas WG, Meyerhof W, Roudnitzky N, Foster SR.

Chem Senses. 2015 Jul;40(6):427-35. doi: 10.1093/chemse/bjv024. Epub 2015 May 21.

PMID:
25999325
11.

Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation.

Foster SR, Porrello ER, Stefani M, Smith NJ, Molenaar P, dos Remedios CG, Thomas WG, Ramialison M.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Oct;388(10):1009-27. doi: 10.1007/s00210-015-1118-1. Epub 2015 May 20.

PMID:
25986534
12.

G protein-coupled receptors in cardiac biology: old and new receptors.

Foster SR, Roura E, Molenaar P, Thomas WG.

Biophys Rev. 2015 Mar;7(1):77-89. doi: 10.1007/s12551-014-0154-2. Epub 2015 Jan 13.

13.

Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2.

Clayton D, Hanchapola I, Thomas WG, Widdop RE, Smith AI, Perlmutter P, Aguilar MI.

Front Pharmacol. 2015 Jan 30;6:5. doi: 10.3389/fphar.2015.00005. eCollection 2015.

14.

Capacity building among african american faith leaders to promote HIV prevention and vaccine research.

Alio AP, Lewis CA, Bunce CA, Wakefield S, Thomas WG, Sanders E, Keefer MC.

Prog Community Health Partnersh. 2014 Autumn;8(3):305-16. doi: 10.1353/cpr.2014.0050.

PMID:
25435557
15.

Extracellular surface residues of the α1B-adrenoceptor critical for G protein-coupled receptor function.

Ragnarsson L, Andersson Å, Thomas WG, Lewis RJ.

Mol Pharmacol. 2015 Jan;87(1):121-9. doi: 10.1124/mol.114.094557. Epub 2014 Oct 28.

PMID:
25352041
16.

Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart.

Foster SR, Blank K, See Hoe LE, Behrens M, Meyerhof W, Peart JN, Thomas WG.

FASEB J. 2014 Oct;28(10):4497-508. doi: 10.1096/fj.14-256305. Epub 2014 Jul 1.

PMID:
25002118
17.

Extrasensory perception: odorant and taste receptors beyond the nose and mouth.

Foster SR, Roura E, Thomas WG.

Pharmacol Ther. 2014 Apr;142(1):41-61. doi: 10.1016/j.pharmthera.2013.11.004. Epub 2013 Nov 23. Review.

PMID:
24280065
18.

A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation.

George AJ, Purdue BW, Gould CM, Thomas DW, Handoko Y, Qian H, Quaife-Ryan GA, Morgan KA, Simpson KJ, Thomas WG, Hannan RD.

J Cell Sci. 2013 Dec 1;126(Pt 23):5377-90. doi: 10.1242/jcs.128280. Epub 2013 Sep 17.

19.

Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches.

George AJ, Hannan RD, Thomas WG.

FEBS J. 2013 Nov;280(21):5258-68. doi: 10.1111/febs.12509. Epub 2013 Sep 23. Review.

20.

Expression, regulation and putative nutrient-sensing function of taste GPCRs in the heart.

Foster SR, Porrello ER, Purdue B, Chan HW, Voigt A, Frenzel S, Hannan RD, Moritz KM, Simmons DG, Molenaar P, Roura E, Boehm U, Meyerhof W, Thomas WG.

PLoS One. 2013 May 15;8(5):e64579. doi: 10.1371/journal.pone.0064579. Print 2013.

21.

PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus.

Wang X, Wang L, Zhu L, Pan Y, Xiao F, Liu W, Wang Z, Guo F, Liu Y, Thomas WG, Chen Y.

Diabetes. 2013 Feb;62(2):444-56. doi: 10.2337/db12-0244. Epub 2012 Oct 18.

22.

Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function.

Callander GE, Ma S, Ganella DE, Wimmer VC, Gundlach AL, Thomas WG, Bathgate RA.

PLoS One. 2012;7(8):e42300. doi: 10.1371/journal.pone.0042300. Epub 2012 Aug 2.

23.

Angiotensin 1A receptors transfected into caudal ventrolateral medulla inhibit baroreflex gain and stress responses.

Palma-Rigo K, Bassi JK, Nguyen-Huu TP, Jackson KL, Davern PJ, Chen D, Elghozi JL, Thomas WG, Allen AM, Head GA.

Cardiovasc Res. 2012 Nov 1;96(2):330-9. doi: 10.1093/cvr/cvs252. Epub 2012 Aug 6.

PMID:
22869618
24.

Real-time measurement of F-actin remodelling during exocytosis using Lifeact-EGFP transgenic animals.

Jang Y, Soekmadji C, Mitchell JM, Thomas WG, Thorn P.

PLoS One. 2012;7(7):e39815. doi: 10.1371/journal.pone.0039815. Epub 2012 Jul 2.

25.

Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress.

Chen D, Jancovski N, Bassi JK, Nguyen-Huu TP, Choong YT, Palma-Rigo K, Davern PJ, Gurley SB, Thomas WG, Head GA, Allen AM.

J Neurosci. 2012 Feb 8;32(6):2051-61. doi: 10.1523/JNEUROSCI.5360-11.2012.

26.

Efferent projections of C3 adrenergic neurons in the rat central nervous system.

Sevigny CP, Bassi J, Williams DA, Anderson CR, Thomas WG, Allen AM.

J Comp Neurol. 2012 Aug 1;520(11):2352-68. doi: 10.1002/cne.23041.

PMID:
22237784
27.

PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus.

Jin T, Ding Q, Huang H, Xu D, Jiang Y, Zhou B, Li Z, Jiang X, He J, Liu W, Zhang Y, Pan Y, Wang Z, Thomas WG, Chen Y.

Cell Res. 2012 Apr;22(4):661-76. doi: 10.1038/cr.2011.161. Epub 2011 Oct 4.

28.

Regulation of angiotensinogen by angiotensin II in mouse primary astrocyte cultures.

O'Callaghan EL, Bassi JK, Porrello ER, Delbridge LM, Thomas WG, Allen AM.

J Neurochem. 2011 Oct;119(1):18-26. doi: 10.1111/j.1471-4159.2011.07406.x. Epub 2011 Aug 22.

29.

Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles.

Porrello ER, Pfleger KD, Seeber RM, Qian H, Oro C, Abogadie F, Delbridge LM, Thomas WG.

Cell Signal. 2011 Nov;23(11):1767-76. doi: 10.1016/j.cellsig.2011.06.011. Epub 2011 Jun 25.

PMID:
21740964
30.

Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors.

Bosnyak S, Jones ES, Christopoulos A, Aguilar MI, Thomas WG, Widdop RE.

Clin Sci (Lond). 2011 Oct;121(7):297-303. doi: 10.1042/CS20110036.

PMID:
21542804
31.

Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy.

Smith NJ, Chan HW, Qian H, Bourne AM, Hannan KM, Warner FJ, Ritchie RH, Pearson RB, Hannan RD, Thomas WG.

Hypertension. 2011 May;57(5):973-80. doi: 10.1161/HYPERTENSIONAHA.110.166710. Epub 2011 Mar 7.

PMID:
21383310
32.

A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function.

Jones ES, Del Borgo MP, Kirsch JF, Clayton D, Bosnyak S, Welungoda I, Hausler N, Unabia S, Perlmutter P, Thomas WG, Aguilar MI, Widdop RE.

Hypertension. 2011 Mar;57(3):570-6. doi: 10.1161/HYPERTENSIONAHA.110.164301. Epub 2011 Feb 7.

PMID:
21300665
33.

The renin-angiotensin system and cancer: old dog, new tricks.

George AJ, Thomas WG, Hannan RD.

Nat Rev Cancer. 2010 Nov;10(11):745-59. doi: 10.1038/nrc2945. Epub 2010 Oct 22. Review.

PMID:
20966920
34.

Ligand-supported purification of the urotensin-II receptor.

Du AT, Onan D, Dinh DT, Lew MJ, Ziogas J, Aguilar MI, Pattenden LK, Thomas WG.

Mol Pharmacol. 2010 Oct;78(4):639-47. doi: 10.1124/mol.110.065151. Epub 2010 Jul 20.

PMID:
20647393
35.

Expression of angiotensin type 1A receptors in C1 neurons restores the sympathoexcitation to angiotensin in the rostral ventrolateral medulla of angiotensin type 1A knockout mice.

Chen D, Bassi JK, Walther T, Thomas WG, Allen AM.

Hypertension. 2010 Jul;56(1):143-50. doi: 10.1161/HYPERTENSIONAHA.110.151704. Epub 2010 May 10.

PMID:
20458002
36.

Glucocorticoids suppress growth in neonatal cardiomyocytes co-expressing AT(2) and AT(1) angiotensin receptors.

Porrello ER, Meeker WF, Thomas WG, Widdop RE, Delbridge LM.

Neonatology. 2010;97(3):257-65. doi: 10.1159/000253757. Epub 2009 Oct 30.

PMID:
19887855
37.

Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival.

Lattin JE, Greenwood KP, Daly NL, Kelly G, Zidar DA, Clark RJ, Thomas WG, Kellie S, Craik DJ, Hume DA, Sweet MJ.

Mol Immunol. 2009 Dec;47(2-3):340-7. doi: 10.1016/j.molimm.2009.09.012. Epub 2009 Sep 26.

PMID:
19783052
38.

Immunoprecipitation and phosphorylation of G protein-coupled receptors.

Thomas WG.

Methods Mol Biol. 2009;552:359-71. doi: 10.1007/978-1-60327-317-6_26.

PMID:
19513663
39.

Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy.

Porrello ER, D'Amore A, Curl CL, Allen AM, Harrap SB, Thomas WG, Delbridge LM.

Hypertension. 2009 Jun;53(6):1032-40. doi: 10.1161/HYPERTENSIONAHA.108.128488. Epub 2009 May 11.

PMID:
19433781
40.

Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor.

Huynh J, Thomas WG, Aguilar MI, Pattenden LK.

Mol Cell Endocrinol. 2009 Apr 29;302(2):118-27. Review.

PMID:
19418628
41.

Development and optimization of microRNA against relaxin-3.

Callander GE, Thomas WG, Bathgate RA.

Ann N Y Acad Sci. 2009 Apr;1160:261-4. doi: 10.1111/j.1749-6632.2008.03816.x.

PMID:
19416200
42.

High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus.

Drew BG, Duffy SJ, Formosa MF, Natoli AK, Henstridge DC, Penfold SA, Thomas WG, Mukhamedova N, de Courten B, Forbes JM, Yap FY, Kaye DM, van Hall G, Febbraio MA, Kemp BE, Sviridov D, Steinberg GR, Kingwell BA.

Circulation. 2009 Apr 21;119(15):2103-11. doi: 10.1161/CIRCULATIONAHA.108.843219. Epub 2009 Apr 6.

PMID:
19349317
43.

Differential participation of angiotensin II type 1 and 2 receptors in the regulation of cardiac cell death triggered by angiotensin II.

Aránguiz-Urroz P, Soto D, Contreras A, Troncoso R, Chiong M, Montenegro J, Venegas D, Smolic C, Ayala P, Thomas WG, Lavandero S, Díaz-Araya G.

Am J Hypertens. 2009 May;22(5):569-76. doi: 10.1038/ajh.2009.32. Epub 2009 Mar 19.

PMID:
19300422
44.

Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of beta-arrestin recruitment.

Callander GE, Thomas WG, Bathgate RA.

Am J Physiol Cell Physiol. 2009 May;296(5):C1058-66. doi: 10.1152/ajpcell.00581.2008. Epub 2009 Mar 11.

45.

The angiotensin II type 2 (AT2) receptor: an enigmatic seven transmembrane receptor.

Porrello ER, Delbridge LM, Thomas WG.

Front Biosci (Landmark Ed). 2009 Jan 1;14:958-72. Review.

PMID:
19273111
46.

Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL.

Ballinger ML, Ivey ME, Osman N, Thomas WG, Little PJ.

Atherosclerosis. 2009 Aug;205(2):451-7. doi: 10.1016/j.atherosclerosis.2009.01.024. Epub 2009 Jan 24.

PMID:
19217622
47.

Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction.

Porrello ER, Bell JR, Schertzer JD, Curl CL, McMullen JR, Mellor KM, Ritchie RH, Lynch GS, Harrap SB, Thomas WG, Delbridge LM.

Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R672-80. doi: 10.1152/ajpregu.90919.2008. Epub 2009 Jan 7.

48.

UBF levels determine the number of active ribosomal RNA genes in mammals.

Sanij E, Poortinga G, Sharkey K, Hung S, Holloway TP, Quin J, Robb E, Wong LH, Thomas WG, Stefanovsky V, Moss T, Rothblum L, Hannan KM, McArthur GA, Pearson RB, Hannan RD.

J Cell Biol. 2008 Dec 29;183(7):1259-74. doi: 10.1083/jcb.200805146. Epub 2008 Dec 22.

50.

Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor.

Vivar R, Soto C, Copaja M, Mateluna F, Aranguiz P, Muñoz JP, Chiong M, Garcia L, Letelier A, Thomas WG, Lavandero S, Díaz-Araya G.

J Cardiovasc Pharmacol. 2008 Aug;52(2):184-90. doi: 10.1097/FJC.0b013e318181fadd.

PMID:
18670360

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