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Low-dose ladostigil for mild cognitive impairment: A phase 2 placebo-controlled clinical trial.

Schneider LS, Geffen Y, Rabinowitz J, Thomas RG, Schmidt R, Ropele S, Weinstock M; Ladostigil Study Group.

Neurology. 2019 Sep 6. pii: 10.1212/WNL.0000000000008239. doi: 10.1212/WNL.0000000000008239. [Epub ahead of print]


Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial.

Schneider LS, Thomas RG, Hendrix S, Rissman RA, Brewer JB, Salmon DP, Oltersdorf T, Okuda T, Feldman HH; Alzheimer’s Disease Cooperative Study TCAD Study Group.

JAMA Neurol. 2019 Jul 8. doi: 10.1001/jamaneurol.2019.1868. [Epub ahead of print]


Remote targeted implantation of sound-sensitive biodegradable multi-cavity microparticles with focused ultrasound.

Su X, Thomas RG, Bharatula LD, Kwan JJ.

Sci Rep. 2019 Jul 3;9(1):9612. doi: 10.1038/s41598-019-46022-0.


Corrigendum to "Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles" [Int. J. Biol. Macromol. 74 (2015) 249-262].

Rejinold NS, Thomas RG, Muthiah M, Chennazhi KP, Manzoor K, Park IK, Jeong YY, Jayakumar R.

Int J Biol Macromol. 2019 Aug 15;135:1274-1275. doi: 10.1016/j.ijbiomac.2019.06.071. Epub 2019 Jun 26. No abstract available.


The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease.

Lopez Lopez C, Tariot PN, Caputo A, Langbaum JB, Liu F, Riviere ME, Langlois C, Rouzade-Dominguez ML, Zalesak M, Hendrix S, Thomas RG, Viglietta V, Lenz R, Ryan JM, Graf A, Reiman EM.

Alzheimers Dement (N Y). 2019 Jun 12;5:216-227. doi: 10.1016/j.trci.2019.02.005. eCollection 2019. Review.


Biomedical Applications for Gas-Stabilizing Solid Cavitation Agents.

Thomas RG, Jonnalagadda US, Kwan JJ.

Langmuir. 2019 Aug 6;35(31):10106-10115. doi: 10.1021/acs.langmuir.9b00795. Epub 2019 May 13.


A randomized clinical trial to evaluate home-based assessment of people over 75 years old.

Sano M, Zhu CW, Kaye J, Mundt JC, Hayes TL, Ferris S, Thomas RG, Sun CK, Jiang Y, Donohue MC, Schneider LS, Egelko S, Aisen PS, Feldman HH; Alzheimer Disease Cooperative Study Investigators.

Alzheimers Dement. 2019 May;15(5):615-624. doi: 10.1016/j.jalz.2019.01.007. Epub 2019 Mar 11.


Memantine and Acetylcholinesterase Inhibitor Use in Alzheimer's Disease Clinical Trials: Potential for Confounding by Indication.

Huisa BN, Thomas RG, Jin S, Oltersdorf T, Taylor C, Feldman HH.

J Alzheimers Dis. 2019;67(2):707-713. doi: 10.3233/JAD-180684.


Hexa-functional tumour-seeking nano voyagers and annihilators for synergistic cancer theranostic applications.

Ramachandra Kurup Sasikala A, Unnithan AR, Thomas RG, Batgerel T, Jeong YY, Park CH, Kim CS.

Nanoscale. 2018 Nov 7;10(41):19568-19578. doi: 10.1039/c8nr06116e. Epub 2018 Oct 16.


The Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical PSEN1 E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal-dominant Alzheimer's disease, including a placebo-treated noncarrier cohort.

Tariot PN, Lopera F, Langbaum JB, Thomas RG, Hendrix S, Schneider LS, Rios-Romenets S, Giraldo M, Acosta N, Tobon C, Ramos C, Espinosa A, Cho W, Ward M, Clayton D, Friesenhahn M, Mackey H, Honigberg L, Sanabria Bohorquez S, Chen K, Walsh T, Langlois C, Reiman EM; Alzheimer's Prevention Initiative.

Alzheimers Dement (N Y). 2018 Mar 8;4:150-160. doi: 10.1016/j.trci.2018.02.002. eCollection 2018.


Implantable chemothermal brachytherapy seeds: A synergistic approach to brachytherapy using polymeric dual drug delivery and hyperthermia for malignant solid tumor ablation.

Aguilar LE, Thomas RG, Moon MJ, Jeong YY, Park CH, Kim CS.

Eur J Pharm Biopharm. 2018 Aug;129:191-203. doi: 10.1016/j.ejpb.2018.06.003. Epub 2018 Jun 4.


Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial.

Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer JB, Rissman RA, Siffert J, Aisen PS; AAV2-NGF Study Team.

JAMA Neurol. 2018 Jul 1;75(7):834-841. doi: 10.1001/jamaneurol.2018.0233.


MHI-148 Cyanine Dye Conjugated Chitosan Nanomicelle with NIR Light-Trigger Release Property as Cancer Targeting Theranostic Agent.

Thomas RG, Moon MJ, Surendran SP, Park HJ, Park IK, Lee BI, Jeong YY.

Mol Imaging Biol. 2018 Aug;20(4):533-543. doi: 10.1007/s11307-018-1169-z.


Do patients with p16-positive oropharyngeal squamous cell carcinoma get more bone metastasis than p16-negative patients?

Harris AS, Thomas RG, Passant CD.

J Laryngol Otol. 2018 May;132(5):429-433. doi: 10.1017/S0022215118000051. Epub 2018 Feb 12.


Electromagnetic manipulation enabled calcium alginate Janus microsphere for targeted delivery of mesenchymal stem cells.

Thomas RG, Unnithan AR, Moon MJ, Surendran SP, Batgerel T, Park CH, Kim CS, Jeong YY.

Int J Biol Macromol. 2018 Apr 15;110:465-471. doi: 10.1016/j.ijbiomac.2018.01.003. Epub 2018 Jan 31.


Conjugation of nitrated acetaminophen to Der p1 amplifies peripheral blood monocyte response to Der p1.

Thomas RG, Rivera Reyes BM, Gaston BM, Rivera Acosta NB, Bederman IR, Smith LA, Sutton MT, Wang B, Hunt JF, Bonfield TL.

PLoS One. 2017 Dec 11;12(12):e0188614. doi: 10.1371/journal.pone.0188614. eCollection 2017.


The Alzheimer's Prevention Initiative Generation Program: Evaluating CNP520 Efficacy in the Prevention of Alzheimer's Disease.

Lopez Lopez C, Caputo A, Liu F, Riviere ME, Rouzade-Dominguez ML, Thomas RG, Langbaum JB, Lenz R, Reiman EM, Graf A, Tariot PN.

J Prev Alzheimers Dis. 2017;4(4):242-246. doi: 10.14283/jpad.2017.37.


Anti-legal attitude toward abortion among abortion patients in the United States.

Thomas RG, Norris AH, Gallo MF.

Contraception. 2017 Nov;96(5):357-364. doi: 10.1016/j.contraception.2017.07.166. Epub 2017 Aug 1.


NIRF Heptamethine Cyanine Dye Nanocomplexes for Multi Modal Theranosis of Tumors.

Thomas RG, Jeong YY.

Chonnam Med J. 2017 May;53(2):83-94. doi: 10.4068/cmj.2017.53.2.83. Epub 2017 May 25. Review.


Randomized controlled trials in mild cognitive impairment: Sources of variability.

Petersen RC, Thomas RG, Aisen PS, Mohs RC, Carrillo MC, Albert MS; Alzheimer's Disease Neuroimaging Initiative (ADNI) and Foundation for NIH (FNIH) Biomarkers Consortium AD MCI Placebo Data Analysis Project Team.

Neurology. 2017 May 2;88(18):1751-1758. doi: 10.1212/WNL.0000000000003907. Epub 2017 Apr 5.


A phase 3 trial of IV immunoglobulin for Alzheimer disease.

Relkin NR, Thomas RG, Rissman RA, Brewer JB, Rafii MS, van Dyck CH, Jack CR, Sano M, Knopman DS, Raman R, Szabo P, Gelmont DM, Fritsch S, Aisen PS; Alzheimer's Disease Cooperative Study.

Neurology. 2017 May 2;88(18):1768-1775. doi: 10.1212/WNL.0000000000003904. Epub 2017 Apr 5.


Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease.

Gelmont D, Thomas RG, Britt J, Dyck-Jones JA, Doralt J, Fritsch S, Brewer JB, Rissman RA, Aisen P.

Alzheimers Dement (N Y). 2016 Jun 21;2(2):131-139. doi: 10.1016/j.trci.2016.06.003. eCollection 2016 Jun.


Breast Tumor Targetable Fe3O4 Embedded Thermo-Responsive Nanoparticles for Radiofrequency Assisted Drug Delivery.

Rejinold NS, Thomas RG, Muthiah M, Lee HJ, Jeong YY, Park IK, Jayakumar R.

J Biomed Nanotechnol. 2016 Jan;12(1):43-55.


Phospholipid End-Capped Acid-Degradable Polyurethane Micelles for Intracellular Delivery of Cancer Therapeutics.

John JV, Thomas RG, Lee HR, Chen H, Jeong YY, Kim I.

Adv Healthc Mater. 2016 Aug;5(15):1874-83. doi: 10.1002/adhm.201600126. Epub 2016 Jun 1.


Longitudinal decline in mild-to-moderate Alzheimer's disease: Analyses of placebo data from clinical trials.

Thomas RG, Albert M, Petersen RC, Aisen PS.

Alzheimers Dement. 2016 May;12(5):598-603. doi: 10.1016/j.jalz.2016.01.002. Epub 2016 Feb 23.


Multifunctional Nanocarpets for Cancer Theranostics: Remotely Controlled Graphene Nanoheaters for Thermo-Chemosensitisation and Magnetic Resonance Imaging.

Ramachandra Kurup Sasikala A, Thomas RG, Unnithan AR, Saravanakumar B, Jeong YY, Park CH, Kim CS.

Sci Rep. 2016 Feb 4;6:20543. doi: 10.1038/srep20543.


Effectiveness of Losartan-Loaded Hyaluronic Acid (HA) Micelles for the Reduction of Advanced Hepatic Fibrosis in C3H/HeN Mice Model.

Thomas RG, Moon MJ, Kim JH, Lee JH, Jeong YY.

PLoS One. 2015 Dec 29;10(12):e0145512. doi: 10.1371/journal.pone.0145512. eCollection 2015.


Response to Rojo and Bueno: "Analysis of the impact of high resolution monitors in digital pathology".

Randell R, Ruddle RA, Thomas RG, Treanor D.

J Pathol Inform. 2015 Oct 28;6:58. doi: 10.4103/2153-3539.168522. eCollection 2015. No abstract available.


A smart magnetic nanoplatform for synergistic anticancer therapy: manoeuvring mussel-inspired functional magnetic nanoparticles for pH responsive anticancer drug delivery and hyperthermia.

Sasikala AR, GhavamiNejad A, Unnithan AR, Thomas RG, Moon M, Jeong YY, Park CH, Kim CS.

Nanoscale. 2015 Nov 21;7(43):18119-28. doi: 10.1039/c5nr05844a.


A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease.

Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS; Alzheimer's Disease Cooperative Study.

Neurology. 2015 Oct 20;85(16):1383-91. doi: 10.1212/WNL.0000000000002035. Epub 2015 Sep 11.


Hyaluronic acid conjugated superparamagnetic iron oxide nanoparticle for cancer diagnosis and hyperthermia therapy.

Thomas RG, Moon MJ, Lee H, Sasikala AR, Kim CS, Park IK, Jeong YY.

Carbohydr Polym. 2015 Oct 20;131:439-46. doi: 10.1016/j.carbpol.2015.06.010. Epub 2015 Jun 16.


Biomedical Applications of Magnetically Functionalized Organic/Inorganic Hybrid Nanofibers.

Lee HJ, Lee SJ, Uthaman S, Thomas RG, Hyun H, Jeong YY, Cho CS, Park IK.

Int J Mol Sci. 2015 Jun 15;16(6):13661-77. doi: 10.3390/ijms160613661. Review.


Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer's disease.

Doody RS, Raman R, Sperling RA, Seimers E, Sethuraman G, Mohs R, Farlow M, Iwatsubo T, Vellas B, Sun X, Ernstrom K, Thomas RG, Aisen PS; Alzheimer’s Disease Cooperative Study.

Alzheimers Res Ther. 2015 Jun 10;7(1):36. doi: 10.1186/s13195-015-0121-6. eCollection 2015.


Mussel-Inspired Electrospun Nanofibers Functionalized with Size-Controlled Silver Nanoparticles for Wound Dressing Application.

GhavamiNejad A, Rajan Unnithan A, Ramachandra Kurup Sasikala A, Samarikhalaj M, Thomas RG, Jeong YY, Nasseri S, Murugesan P, Wu D, Hee Park C, Kim CS.

ACS Appl Mater Interfaces. 2015 Jun 10;7(22):12176-83. doi: 10.1021/acsami.5b02542. Epub 2015 May 29.


Regulation of correlative inhibition of axillary bud outgrowth by basal branches varies with growth stage in Trifolium repens.

Thomas RG, Hay MJ.

J Exp Bot. 2015 Jul;66(13):3803-13. doi: 10.1093/jxb/erv184. Epub 2015 Apr 28.


A Hyaluronic Acid-Conjugated Gadolinium Hepatocyte-Specific T1 Contrast Agent for Liver Magnetic Resonance Imaging.

Moon M, Thomas RG, Heo SU, Park MS, Bae WK, Heo SH, Yim NY, Jeong YY.

Mol Imaging Biol. 2015 Aug;17(4):497-503. doi: 10.1007/s11307-014-0819-z.


Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles.

Sanoj Rejinold N, Thomas RG, Muthiah M, Chennazhi KP, Manzoor K, Park IK, Jeong YY, Jayakumar R.

Int J Biol Macromol. 2015 Mar;74:249-62. doi: 10.1016/j.ijbiomac.2014.11.044. Epub 2014 Dec 17. Erratum in: Int J Biol Macromol. 2019 Aug 15;135:1274-1275.


Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials.

Donohue MC, Moghadam SH, Roe AD, Sun CK, Edland SD, Thomas RG, Petersen RC, Sano M, Galasko D, Aisen PS, Rissman RA.

Alzheimers Dement. 2015 Sep;11(9):1069-79. doi: 10.1016/j.jalz.2014.07.156. Epub 2014 Oct 7.


Paclitaxel loaded hyaluronic acid nanoparticles for targeted cancer therapy: in vitro and in vivo analysis.

Thomas RG, Moon M, Lee S, Jeong YY.

Int J Biol Macromol. 2015 Jan;72:510-8. doi: 10.1016/j.ijbiomac.2014.08.054. Epub 2014 Sep 16.


Effect of display resolution on time to diagnosis with virtual pathology slides in a systematic search task.

Randell R, Ambepitiya T, Mello-Thoms C, Ruddle RA, Brettle D, Thomas RG, Treanor D.

J Digit Imaging. 2015 Feb;28(1):68-76. doi: 10.1007/s10278-014-9726-8.


Diagnosis of major cancer resection specimens with virtual slides: impact of a novel digital pathology workstation.

Randell R, Ruddle RA, Thomas RG, Mello-Thoms C, Treanor D.

Hum Pathol. 2014 Oct;45(10):2101-6. doi: 10.1016/j.humpath.2014.06.017. Epub 2014 Jul 2.


The preclinical Alzheimer cognitive composite: measuring amyloid-related decline.

Donohue MC, Sperling RA, Salmon DP, Rentz DM, Raman R, Thomas RG, Weiner M, Aisen PS; Australian Imaging, Biomarkers, and Lifestyle Flagship Study of Ageing; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Cooperative Study.

JAMA Neurol. 2014 Aug;71(8):961-70. doi: 10.1001/jamaneurol.2014.803.


Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease.

Galasko D, Bell J, Mancuso JY, Kupiec JW, Sabbagh MN, van Dyck C, Thomas RG, Aisen PS; Alzheimer's Disease Cooperative Study.

Neurology. 2014 Apr 29;82(17):1536-42. doi: 10.1212/WNL.0000000000000364. Epub 2014 Apr 2.


Estimating long-term multivariate progression from short-term data.

Donohue MC, Jacqmin-Gadda H, Le Goff M, Thomas RG, Raman R, Gamst AC, Beckett LA, Jack CR Jr, Weiner MW, Dartigues JF, Aisen PS; Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement. 2014 Oct;10(5 Suppl):S400-10. doi: 10.1016/j.jalz.2013.10.003. Epub 2014 Mar 20.


Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease.

Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS, Siemers E, Liu-Seifert H, Mohs R; Alzheimer's Disease Cooperative Study Steering Committee; Solanezumab Study Group.

N Engl J Med. 2014 Jan 23;370(4):311-21. doi: 10.1056/NEJMoa1312889.


Differential bud activation by a net positive root signal explains branching phenotype in prostrate clonal herbs: a model.

Thomas RG, Li FY, Hay MJ.

J Exp Bot. 2014 Feb;65(2):673-82. doi: 10.1093/jxb/ert427. Epub 2014 Jan 7.


Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, Buckles VD, Cairns NJ, Clifford D, Danek A, Fagan AM, Farlow M, Fox N, Ghetti B, Goate AM, Heinrichs D, Hornbeck R, Jack C, Jucker M, Klunk WE, Marcus DS, Martins RN, Masters CM, Mayeux R, McDade E, Morris JC, Oliver A, Ringman JM, Rossor MN, Salloway S, Schofield PR, Snider J, Snyder P, Sperling RA, Stewart C, Thomas RG, Xiong C, Bateman RJ.

Rev Neurol (Paris). 2013 Oct;169(10):737-43. doi: 10.1016/j.neurol.2013.07.017. Epub 2013 Sep 6. Review.


A phase 3 trial of semagacestat for treatment of Alzheimer's disease.

Doody RS, Raman R, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, He F, Sun X, Thomas RG, Aisen PS; Alzheimer's Disease Cooperative Study Steering Committee, Siemers E, Sethuraman G, Mohs R; Semagacestat Study Group.

N Engl J Med. 2013 Jul 25;369(4):341-50. doi: 10.1056/NEJMoa1210951.


Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly.

Salmon DP, Ferris SH, Thomas RG, Sano M, Cummings JL, Sperling RA, Petersen RC, Aisen PS.

Neuropsychology. 2013 Jul;27(4):391-401. doi: 10.1037/a0032707.


Relationships between brain and body temperature, clinical and imaging outcomes after ischemic stroke.

Karaszewski B, Carpenter TK, Thomas RG, Armitage PA, Lymer GK, Marshall I, Dennis MS, Wardlaw JM.

J Cereb Blood Flow Metab. 2013 Jul;33(7):1083-9. doi: 10.1038/jcbfm.2013.52. Epub 2013 Apr 10.

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