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Items: 1 to 50 of 129

1.

Identification and targeting of novel CDK9 complexes in acute myeloid leukemia.

Beauchamp EM, Abedin SM, Radecki SG, Fischietti M, Arslan AD, Blyth GT, Yang A, Lantz C, Nelson A, Goo YA, Akpan I, Eklund EA, Frankfurt O, Fish EN, Thomas PM, Altman JK, Platanias LC.

Blood. 2018 Dec 26. pii: blood-2018-08-870089. doi: 10.1182/blood-2018-08-870089. [Epub ahead of print]

PMID:
30587525
2.

The vermiform appendix impacts the risk of developing Parkinson's disease.

Killinger BA, Madaj Z, Sikora JW, Rey N, Haas AJ, Vepa Y, Lindqvist D, Chen H, Thomas PM, Brundin P, Brundin L, Labrie V.

Sci Transl Med. 2018 Oct 31;10(465). pii: eaar5280. doi: 10.1126/scitranslmed.aar5280.

PMID:
30381408
3.

Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria.

Fisher OS, Kenney GE, Ross MO, Ro SY, Lemma BE, Batelu S, Thomas PM, Sosnowski VC, DeHart CJ, Kelleher NL, Stemmler TL, Hoffman BM, Rosenzweig AC.

Nat Commun. 2018 Oct 15;9(1):4276. doi: 10.1038/s41467-018-06681-5.

4.

USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.

Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutierrez-Diaz BT, Wang KK, Johnson MR, Volk AG, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, Abshiru NA, Hijiya N, Peirs S, Vandamme N, Berx G, Goosens S, Marshall SA, Rendleman EJ, Takahashi YH, Wang L, Rawat R, Bartom ET, Collings CK, Van Vlierberghe P, Strikoudis A, Kelly S, Ueberheide B, Mantis C, Kandela I, Bourquin JP, Bornhauser B, Serafin V, Bresolin S, Paganin M, Accordi B, Basso G, Kelleher NL, Weinstock J, Kumar S, Crispino JD, Shilatifard A, Ntziachristos P.

Clin Cancer Res. 2019 Jan 1;25(1):222-239. doi: 10.1158/1078-0432.CCR-18-1740. Epub 2018 Sep 17.

PMID:
30224337
5.

Stability of histone post-translational modifications in samples derived from liver tissue and primary hepatic cells.

Gruppuso PA, Boylan JM, Zabala V, Neretti N, Abshiru NA, Sikora JW, Doud EH, Camarillo JM, Thomas PM, Kelleher NL, Sanders JA.

PLoS One. 2018 Sep 7;13(9):e0203351. doi: 10.1371/journal.pone.0203351. eCollection 2018.

6.

Drug prescription pattern of outpatients in a tertiary care teaching hospital in Tamil Nadu.

Shanmugapriya S, Saravanan T, Rajee SS, Venkatrajan R, Thomas PM.

Perspect Clin Res. 2018 Jul-Sep;9(3):133-138. doi: 10.4103/picr.PICR_86_17.

7.

The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins.

Riley NM, Sikora JW, Seckler HS, Greer JB, Fellers RT, LeDuc RD, Westphall MS, Thomas PM, Kelleher NL, Coon JJ.

Anal Chem. 2018 Jul 17;90(14):8553-8560. doi: 10.1021/acs.analchem.8b01638. Epub 2018 Jul 5.

PMID:
29924586
8.

The unique biomineralization transcriptome and proteome of Lytechinus variegatus teeth.

Alvares K, DeHart CJ, Thomas PM, Kelleher NL, Veis A.

Connect Tissue Res. 2018 Dec;59(sup1):20-29. doi: 10.1080/03008207.2017.1408605.

PMID:
29745816
9.

Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology.

Robey MT, Ye R, Bok JW, Clevenger KD, Islam MN, Chen C, Gupta R, Swyers M, Wu E, Gao P, Thomas PM, Wu CC, Keller NP, Kelleher NL.

ACS Chem Biol. 2018 May 18;13(5):1142-1147. doi: 10.1021/acschembio.8b00024. Epub 2018 Apr 17.

PMID:
29631395
10.

Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids.

Martin RW, Des Soye BJ, Kwon YC, Kay J, Davis RG, Thomas PM, Majewska NI, Chen CX, Marcum RD, Weiss MG, Stoddart AE, Amiram M, Ranji Charna AK, Patel JR, Isaacs FJ, Kelleher NL, Hong SH, Jewett MC.

Nat Commun. 2018 Mar 23;9(1):1203. doi: 10.1038/s41467-018-03469-5.

11.

The biosynthesis of methanobactin.

Kenney GE, Dassama LMK, Pandelia ME, Gizzi AS, Martinie RJ, Gao P, DeHart CJ, Schachner LF, Skinner OS, Ro SY, Zhu X, Sadek M, Thomas PM, Almo SC, Bollinger JM Jr, Krebs C, Kelleher NL, Rosenzweig AC.

Science. 2018 Mar 23;359(6382):1411-1416. doi: 10.1126/science.aap9437.

PMID:
29567715
12.

Interrogation of Benzomalvin Biosynthesis Using Fungal Artificial Chromosomes with Metabolomic Scoring (FAC-MS): Discovery of a Benzodiazepine Synthase Activity.

Clevenger KD, Ye R, Bok JW, Thomas PM, Islam MN, Miley GP, Robey MT, Chen C, Yang K, Swyers M, Wu E, Gao P, Wu CC, Keller NP, Kelleher NL.

Biochemistry. 2018 Jun 12;57(23):3237-3243. doi: 10.1021/acs.biochem.8b00076. Epub 2018 Mar 20.

13.

Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains.

Davis RG, Park HM, Kim K, Greer JB, Fellers RT, LeDuc RD, Romanova EV, Rubakhin SS, Zombeck JA, Wu C, Yau PM, Gao P, van Nispen AJ, Patrie SM, Thomas PM, Sweedler JV, Rhodes JS, Kelleher NL.

Anal Chem. 2018 Mar 20;90(6):3802-3810. doi: 10.1021/acs.analchem.7b04108. Epub 2018 Feb 26.

PMID:
29481055
14.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.

Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.

PMID:
29443976
15.

PAI-1 is a critical regulator of FGF23 homeostasis.

Eren M, Place AT, Thomas PM, Flevaris P, Miyata T, Vaughan DE.

Sci Adv. 2017 Sep 13;3(9):e1603259. doi: 10.1126/sciadv.1603259. eCollection 2017 Sep.

16.

Truly unentangled photon pairs without spectral filtering.

Vernon Z, Menotti M, Tison CC, Steidle JA, Fanto ML, Thomas PM, Preble SF, Smith AM, Alsing PM, Liscidini M, Sipe JE.

Opt Lett. 2017 Sep 15;42(18):3638-3641. doi: 10.1364/OL.42.003638.

PMID:
28914921
17.

A synthetic biology approach to probing nucleosome symmetry.

Ichikawa Y, Connelly CF, Appleboim A, Miller TC, Jacobi H, Abshiru NA, Chou HJ, Chen Y, Sharma U, Zheng Y, Thomas PM, Chen HV, Bajaj V, Müller CW, Kelleher NL, Friedman N, Bolon DN, Rando OJ, Kaufman PD.

Elife. 2017 Sep 12;6. pii: e28836. doi: 10.7554/eLife.28836.

18.

Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain.

Wildburger NC, Esparza TJ, LeDuc RD, Fellers RT, Thomas PM, Cairns NJ, Kelleher NL, Bateman RJ, Brody DL.

Sci Rep. 2017 Aug 25;7(1):9520. doi: 10.1038/s41598-017-10422-x.

19.

A scalable platform to identify fungal secondary metabolites and their gene clusters.

Clevenger KD, Bok JW, Ye R, Miley GP, Verdan MH, Velk T, Chen C, Yang K, Robey MT, Gao P, Lamprecht M, Thomas PM, Islam MN, Palmer JM, Wu CC, Keller NP, Kelleher NL.

Nat Chem Biol. 2017 Aug;13(8):895-901. doi: 10.1038/nchembio.2408. Epub 2017 Jun 12.

20.

Proteoforms in Peripheral Blood Mononuclear Cells as Novel Rejection Biomarkers in Liver Transplant Recipients.

Toby TK, Abecassis M, Kim K, Thomas PM, Fellers RT, LeDuc RD, Kelleher NL, Demetris J, Levitsky J.

Am J Transplant. 2017 Sep;17(9):2458-2467. doi: 10.1111/ajt.14359. Epub 2017 Jun 27.

21.

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer.

Cleland TP, DeHart CJ, Fellers RT, VanNispen AJ, Greer JB, LeDuc RD, Parker WR, Thomas PM, Kelleher NL, Brodbelt JS.

J Proteome Res. 2017 May 5;16(5):2072-2079. doi: 10.1021/acs.jproteome.7b00043. Epub 2017 Apr 19.

22.

Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite.

DeHart CJ, Fellers RT, Fornelli L, Kelleher NL, Thomas PM.

Methods Mol Biol. 2017;1558:381-394. doi: 10.1007/978-1-4939-6783-4_18.

23.

Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein.

Schroeter ER, DeHart CJ, Cleland TP, Zheng W, Thomas PM, Kelleher NL, Bern M, Schweitzer MH.

J Proteome Res. 2017 Feb 3;16(2):920-932. doi: 10.1021/acs.jproteome.6b00873. Epub 2017 Jan 23.

24.

Identification and Characterization of Human Proteoforms by Top-Down LC-21 Tesla FT-ICR Mass Spectrometry.

Anderson LC, DeHart CJ, Kaiser NK, Fellers RT, Smith DF, Greer JB, LeDuc RD, Blakney GT, Thomas PM, Kelleher NL, Hendrickson CL.

J Proteome Res. 2017 Feb 3;16(2):1087-1096. doi: 10.1021/acs.jproteome.6b00696. Epub 2016 Dec 12.

25.

EphA2 proteomics in human keratinocytes reveals a novel association with afadin and epidermal tight junctions.

Perez White BE, Ventrella R, Kaplan N, Cable CJ, Thomas PM, Getsios S.

J Cell Sci. 2017 Jan 1;130(1):111-118. doi: 10.1242/jcs.188169. Epub 2016 Nov 4.

26.
27.

Characterization of Methanobactin from Methylosinus sp. LW4.

Kenney GE, Goering AW, Ross MO, DeHart CJ, Thomas PM, Hoffman BM, Kelleher NL, Rosenzweig AC.

J Am Chem Soc. 2016 Sep 7;138(35):11124-7. doi: 10.1021/jacs.6b06821. Epub 2016 Aug 26.

28.

Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status".

LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, Shi X, Doud EH, Krivtsov AV, Chung YR, Khodos I, de Stanchina E, Ouerfelli O, Adusumilli PS, Thomas PM, Kelleher NL, Luo M, Keilhack H, Abdel-Wahab O, Melnick A, Armstrong SA, Levine RL.

Nat Med. 2016 Jun 7;22(6):578-9. doi: 10.1038/nm.4094. No abstract available.

PMID:
27270773
29.

Comparative top down proteomics of peripheral blood mononuclear cells from kidney transplant recipients with normal kidney biopsies or acute rejection.

Savaryn JP, Toby TK, Catherman AD, Fellers RT, LeDuc RD, Thomas PM, Friedewald JJ, Salomon DR, Abecassis MM, Kelleher NL.

Proteomics. 2016 Jul;16(14):2048-58. doi: 10.1002/pmic.201600008.

30.

Reducing protein oxidation in low-flow electrospray enables deeper investigation of proteoforms by top down proteomics.

Kim K, Compton PD, Toby TK, Thomas PM, Wilkins JT, Mutharasan RK, Kelleher NL.

EuPA Open Proteom. 2015 Sep;8:40-47. Epub 2015 Jun 5.

31.

Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis.

Cleland TP, Schroeter ER, Zamdborg L, Zheng W, Lee JE, Tran JC, Bern M, Duncan MB, Lebleu VS, Ahlf DR, Thomas PM, Kalluri R, Kelleher NL, Schweitzer MH.

J Proteome Res. 2015 Dec 4;14(12):5252-62. doi: 10.1021/acs.jproteome.5b00675. Epub 2015 Nov 23.

32.

Value conditioning modulates visual working memory processes.

Thomas PM, FitzGibbon L, Raymond JE.

J Exp Psychol Hum Percept Perform. 2016 Jan;42(1):6-10. doi: 10.1037/xhp0000144. Epub 2015 Nov 2.

33.

Integrated Bottom-Up and Top-Down Proteomics of Patient-Derived Breast Tumor Xenografts.

Ntai I, LeDuc RD, Fellers RT, Erdmann-Gilmore P, Davies SR, Rumsey J, Early BP, Thomas PM, Li S, Compton PD, Ellis MJ, Ruggles KV, Fenyö D, Boja ES, Rodriguez H, Townsend RR, Kelleher NL.

Mol Cell Proteomics. 2016 Jan;15(1):45-56. doi: 10.1074/mcp.M114.047480. Epub 2015 Oct 26.

34.

Top Down Proteomics Reveals Mature Proteoforms Expressed in Subcellular Fractions of the Echinococcus granulosus Preadult Stage.

Lorenzatto KR, Kim K, Ntai I, Paludo GP, Camargo de Lima J, Thomas PM, Kelleher NL, Ferreira HB.

J Proteome Res. 2015 Nov 6;14(11):4805-14. doi: 10.1021/acs.jproteome.5b00642. Epub 2015 Oct 28.

35.

Loss of BAP1 function leads to EZH2-dependent transformation.

LaFave LM, Béguelin W, Koche R, Teater M, Spitzer B, Chramiec A, Papalexi E, Keller MD, Hricik T, Konstantinoff K, Micol JB, Durham B, Knutson SK, Campbell JE, Blum G, Shi X, Doud EH, Krivtsov AV, Chung YR, Khodos I, de Stanchina E, Ouerfelli O, Adusumilli PS, Thomas PM, Kelleher NL, Luo M, Keilhack H, Abdel-Wahab O, Melnick A, Armstrong SA, Levine RL.

Nat Med. 2015 Nov;21(11):1344-9. doi: 10.1038/nm.3947. Epub 2015 Oct 5.

36.

Serious Drug-Drug Interactions in the Prescriptions of Diabetic Patients.

Sankar V, Saaed Y, Joseph RM, Azizi H, Thomas PM.

Med Sci (Basel). 2015 Oct 1;3(4):93-103. doi: 10.3390/medsci3040093.

37.

Defining the Neuropeptidome of the Spiny Lobster Panulirus interruptus Brain Using a Multidimensional Mass Spectrometry-Based Platform.

Ye H, Wang J, Zhang Z, Jia C, Schmerberg C, Catherman AD, Thomas PM, Kelleher NL, Li L.

J Proteome Res. 2015 Nov 6;14(11):4776-91. doi: 10.1021/acs.jproteome.5b00627. Epub 2015 Oct 5.

38.

Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.

Zheng Y, Fornelli L, Compton PD, Sharma S, Canterbury J, Mullen C, Zabrouskov V, Fellers RT, Thomas PM, Licht JD, Senko MW, Kelleher NL.

Mol Cell Proteomics. 2016 Mar;15(3):776-90. doi: 10.1074/mcp.M115.053819. Epub 2015 Aug 13.

39.

Fungal artificial chromosomes for mining of the fungal secondary metabolome.

Bok JW, Ye R, Clevenger KD, Mead D, Wagner M, Krerowicz A, Albright JC, Goering AW, Thomas PM, Kelleher NL, Keller NP, Wu CC.

BMC Genomics. 2015 Apr 29;16:343. doi: 10.1186/s12864-015-1561-x.

40.

ProSight Lite: graphical software to analyze top-down mass spectrometry data.

Fellers RT, Greer JB, Early BP, Yu X, LeDuc RD, Kelleher NL, Thomas PM.

Proteomics. 2015 Apr;15(7):1235-8. doi: 10.1002/pmic.201570050.

41.

Deep and quantitative top-down proteomics in clinical and translational research.

Kelleher NL, Thomas PM, Ntai I, Compton PD, LeDuc RD.

Expert Rev Proteomics. 2014 Dec;11(6):649-51. doi: 10.1586/14789450.2014.976559. Epub 2014 Oct 28.

42.

The C-score: a Bayesian framework to sharply improve proteoform scoring in high-throughput top down proteomics.

LeDuc RD, Fellers RT, Early BP, Greer JB, Thomas PM, Kelleher NL.

J Proteome Res. 2014 Jul 3;13(7):3231-40. doi: 10.1021/pr401277r. Epub 2014 Jun 12.

43.

Site-specific human histone H3 methylation stability: fast K4me3 turnover.

Zheng Y, Tipton JD, Thomas PM, Kelleher NL, Sweet SM.

Proteomics. 2014 Oct;14(19):2190-9. doi: 10.1002/pmic.201400060. Epub 2014 Jul 9.

44.

Applying label-free quantitation to top down proteomics.

Ntai I, Kim K, Fellers RT, Skinner OS, Smith AD 4th, Early BP, Savaryn JP, LeDuc RD, Thomas PM, Kelleher NL.

Anal Chem. 2014 May 20;86(10):4961-8. doi: 10.1021/ac500395k. Epub 2014 May 7.

45.

Top-down proteomics with mass spectrometry imaging: a pilot study towards discovery of biomarkers for neurodevelopmental disorders.

Ye H, Mandal R, Catherman A, Thomas PM, Kelleher NL, Ikonomidou C, Li L.

PLoS One. 2014 Apr 7;9(4):e92831. doi: 10.1371/journal.pone.0092831. eCollection 2014.

46.

Fragmentation of integral membrane proteins in the gas phase.

Skinner OS, Catherman AD, Early BP, Thomas PM, Compton PD, Kelleher NL.

Anal Chem. 2014 May 6;86(9):4627-34. doi: 10.1021/ac500864w. Epub 2014 Apr 17.

47.

The first pilot project of the consortium for top-down proteomics: a status report.

Dang X, Scotcher J, Wu S, Chu RK, Tolić N, Ntai I, Thomas PM, Fellers RT, Early BP, Zheng Y, Durbin KR, Leduc RD, Wolff JJ, Thompson CJ, Pan J, Han J, Shaw JB, Salisbury JP, Easterling M, Borchers CH, Brodbelt JS, Agar JN, Paša-Tolić L, Kelleher NL, Young NL.

Proteomics. 2014 May;14(10):1130-40. doi: 10.1002/pmic.201300438. Epub 2014 Apr 14.

48.

Ultraviolet photodissociation for characterization of whole proteins on a chromatographic time scale.

Cannon JR, Cammarata MB, Robotham SA, Cotham VC, Shaw JB, Fellers RT, Early BP, Thomas PM, Kelleher NL, Brodbelt JS.

Anal Chem. 2014 Feb 18;86(4):2185-92. doi: 10.1021/ac403859a. Epub 2014 Jan 29.

49.

Fosfomycin trometamol (3,000 mg) in perioperative antibiotic prophylaxis of healthcare-associated infections after endourological interventions: a narrative review.

Wagenlehner FM, Thomas PM, Naber KG.

Urol Int. 2014;92(2):125-30. doi: 10.1159/000355103. Epub 2013 Sep 13. Review.

50.

Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence.

Catherman AD, Durbin KR, Ahlf DR, Early BP, Fellers RT, Tran JC, Thomas PM, Kelleher NL.

Mol Cell Proteomics. 2013 Dec;12(12):3465-73. doi: 10.1074/mcp.M113.030114. Epub 2013 Sep 10.

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