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Modulatory Effect of Selected Dietary Phytochemicals on Delayed Rectifier K+ Current in Human Prostate Cancer Cells.

George K, Thomas NS, Malathi R.

J Membr Biol. 2019 Jun;252(2-3):195-206. doi: 10.1007/s00232-019-00070-9. Epub 2019 Jun 4.


Piperine blocks voltage gated K+ current and inhibits proliferation in androgen sensitive and insensitive human prostate cancer cell lines.

George K, Thomas NS, Malathi R.

Arch Biochem Biophys. 2019 May 30;667:36-48. doi: 10.1016/ Epub 2019 Apr 29.


Anticancer mechanism of troxerutin via targeting Nrf2 and NF-κB signalling pathways in hepatocarcinoma cell line.

Thomas NS, George K, Selvam AAA.

Toxicol In Vitro. 2019 Feb;54:317-329. doi: 10.1016/j.tiv.2018.10.018. Epub 2018 Oct 30.


Troxerutin subdues hepatic tumorigenesis via disrupting the MDM2-p53 interaction.

Thomas NS, George K, Selvam AAA.

Food Funct. 2018 Oct 17;9(10):5336-5349. doi: 10.1039/c8fo01111g.


Alcohol Metabolizing Polygenic Risk for Alcohol Consumption in European American College Students.

Thomas NS, Adkins A, Aliev F, Edwards AC, Webb BT, Tiarsmith EC, Kendler KS, Dick DM, Chartier KG.

J Stud Alcohol Drugs. 2018 Jul;79(4):627-634.


Seagulls of endoscopic ultrasound.

Pathak A, Shoukat A, Thomas NS, Mehta D, Sharma M.

Endosc Ultrasound. 2017 Jul-Aug;6(4):231-234. doi: 10.4103/2303-9027.190919. No abstract available.


Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis.

Siddique AI, Mani V, Arivalagan S, Thomas NS, Namasivayam N.

Toxicol Mech Methods. 2017 Feb;27(2):136-150. doi: 10.1080/15376516.2016.1273422. Epub 2017 Jan 11.


Interrelationship between family history of alcoholism and generational status in the prediction of alcohol dependence in US Hispanics.

Chartier KG, Thomas NS, Kendler KS.

Psychol Med. 2017 Jan;47(1):137-147. doi: 10.1017/S0033291716002105. Epub 2016 Sep 29.


Identification of 15 novel partial SHOX deletions and 13 partial duplications, and a review of the literature reveals intron 3 to be a hotspot region.

Benito-Sanz S, Belinchon-Martínez A, Aza-Carmona M, de la Torre C, Huber C, González-Casado I, Ross JL, Thomas NS, Zinn AR, Cormier-Daire V, Heath KE.

J Hum Genet. 2017 Feb;62(2):229-234. doi: 10.1038/jhg.2016.113. Epub 2016 Sep 8. Review.


The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects.

Thomas NS, George K, Arivalagan S, Mani V, Siddique AI, Namasivayam N.

Eur J Nutr. 2017 Oct;56(7):2353-2366. doi: 10.1007/s00394-016-1275-0. Epub 2016 Aug 3.


Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment.

Kordasti S, Costantini B, Seidl T, Perez Abellan P, Martinez Llordella M, McLornan D, Diggins KE, Kulasekararaj A, Benfatto C, Feng X, Smith A, Mian SA, Melchiotti R, de Rinaldis E, Ellis R, Petrov N, Povoleri GA, Chung SS, Thomas NS, Farzaneh F, Irish JM, Heck S, Young NS, Marsh JC, Mufti GJ.

Blood. 2016 Sep 1;128(9):1193-205. doi: 10.1182/blood-2016-03-703702. Epub 2016 Jun 8.


The role of romantic relationship status in pathways of risk for emerging adult alcohol use.

Salvatore JE, Thomas NS, Cho SB, Adkins A, Kendler KS, Dick DM.

Psychol Addict Behav. 2016 May;30(3):335-44. doi: 10.1037/adb0000145.


Radioprotective Effect of Carvacrol Against X-Radiation-Induced Cellular Damage in Cultured Human Peripheral Blood Lymphocytes.

Arivalagan S, Thomas NS, Kuppusamy T, Namashivayam N.

J Environ Pathol Toxicol Oncol. 2015;34(3):263-75.


Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.

Marson CM, Matthews CJ, Atkinson SJ, Lamadema N, Thomas NS.

J Med Chem. 2015 Sep 10;58(17):6803-18. doi: 10.1021/acs.jmedchem.5b00545. Epub 2015 Aug 27.


Molecular aspects and chemoprevention of dimethylaminoazobenzene-induced hepatocarcinogenesis: A review.

Thomas NS, George K, Namasivayam N.

Hepatol Res. 2016 Jan;46(1):72-88. doi: 10.1111/hepr.12569. Epub 2015 Sep 21. Review.


Combined therapeutic efficacy of carvacrol and X-radiation against 1,2-dimethyl hydrazine-induced experimental rat colon carcinogenesis.

Arivalagan S, Thomas NS, Chandrasekaran B, Mani V, Siddique AI, Kuppsamy T, Namasivayam N.

Mol Cell Biochem. 2015 Dec;410(1-2):37-54. doi: 10.1007/s11010-015-2536-6. Epub 2015 Aug 12.


JAK inhibition induces silencing of T Helper cytokine secretion and a profound reduction in T regulatory cells.

Keohane C, Kordasti S, Seidl T, Perez Abellan P, Thomas NS, Harrison CN, McLornan DP, Mufti GJ.

Br J Haematol. 2015 Oct;171(1):60-73. doi: 10.1111/bjh.13519. Epub 2015 Jun 15.


Bridging topological and functional information in protein interaction networks by short loops profiling.

Chung SS, Pandini A, Annibale A, Coolen AC, Thomas NS, Fraternali F.

Sci Rep. 2015 Feb 23;5:8540. doi: 10.1038/srep08540.


A patient with hepatitis C virus infection and inflammatory polyarthritis.

Thomas NS, Kerr G, Benator D, Lichy JH.

Arthritis Care Res (Hoboken). 2013 Nov;65(11):1885-91. doi: 10.1002/acr.22075. Review. No abstract available.


DNA methylation profiling in X;autosome translocations supports a role for L1 repeats in the spread of X chromosome inactivation.

Bala Tannan N, Brahmachary M, Garg P, Borel C, Alnefaie R, Watson CT, Thomas NS, Sharp AJ.

Hum Mol Genet. 2014 Mar 1;23(5):1224-36. doi: 10.1093/hmg/ddt553. Epub 2013 Nov 1.


The STAT3-DNMT1 connection.

Thomas NS.

JAKSTAT. 2012 Oct 1;1(4):257-60. doi: 10.4161/jkst.22436.


Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.

Marson CM, Matthews CJ, Yiannaki E, Atkinson SJ, Soden PE, Shukla L, Lamadema N, Thomas NS.

J Med Chem. 2013 Aug 8;56(15):6156-74. doi: 10.1021/jm400634n. Epub 2013 Jul 23.


Diagnostic screening identifies a wide range of mutations involving the SHOX gene, including a common 47.5 kb deletion 160 kb downstream with a variable phenotypic effect.

Bunyan DJ, Baker KR, Harvey JF, Thomas NS.

Am J Med Genet A. 2013 Jun;161A(6):1329-38. doi: 10.1002/ajmg.a.35919. Epub 2013 May 1.


8p23.1 duplication syndrome; common, confirmed, and novel features in six further patients.

Barber JC, Rosenfeld JA, Foulds N, Laird S, Bateman MS, Thomas NS, Baker S, Maloney VK, Anilkumar A, Smith WE, Banks V, Ellingwood S, Kharbutli Y, Mehta L, Eddleman KA, Marble M, Zambrano R, Crolla JA, Lamb AN.

Am J Med Genet A. 2013 Mar;161A(3):487-500. doi: 10.1002/ajmg.a.35767. Epub 2013 Jan 23.


The effects of 5-azacytidine on the function and number of regulatory T cells and T-effectors in myelodysplastic syndrome.

Costantini B, Kordasti SY, Kulasekararaj AG, Jiang J, Seidl T, Abellan PP, Mohamedali A, Thomas NS, Farzaneh F, Mufti GJ.

Haematologica. 2013 Aug;98(8):1196-205. doi: 10.3324/haematol.2012.074823. Epub 2012 Dec 14.


Detailed clinical and molecular study of 20 females with Xq deletions with special reference to menstruation and fertility.

Mercer CL, Lachlan K, Karcanias A, Affara N, Huang S, Jacobs PA, Thomas NS.

Eur J Med Genet. 2013 Jan;56(1):1-6. doi: 10.1016/j.ejmg.2012.08.012. Epub 2012 Oct 8.


Mimicking the tumour microenvironment: three different co-culture systems induce a similar phenotype but distinct proliferative signals in primary chronic lymphocytic leukaemia cells.

Hamilton E, Pearce L, Morgan L, Robinson S, Ware V, Brennan P, Thomas NS, Yallop D, Devereux S, Fegan C, Buggins AG, Pepper C.

Br J Haematol. 2012 Sep;158(5):589-99. doi: 10.1111/j.1365-2141.2012.09191.x. Epub 2012 Jun 19.


Evaluation of PRDM9 variation as a risk factor for recurrent genomic disorders and chromosomal non-disjunction.

Borel C, Cheung F, Stewart H, Koolen DA, Phillips C, Thomas NS, Jacobs PA, Eliez S, Sharp AJ.

Hum Genet. 2012 Sep;131(9):1519-24. doi: 10.1007/s00439-012-1180-4. Epub 2012 May 30.


Novel Tandem Duplication in Exon 1 of the SNURF/SNRPN Gene in a Child with Transient Excessive Eating Behaviour and Weight Gain.

Naik S, Thomas NS, Davies JH, Lever M, Raponi M, Baralle D, Temple IK, Caliebe A.

Mol Syndromol. 2012 Jan;2(2):76-80. Epub 2012 Jan 4.


Proteomic and protein interaction network analysis of human T lymphocytes during cell-cycle entry.

Orr SJ, Boutz DR, Wang R, Chronis C, Lea NC, Thayaparan T, Hamilton E, Milewicz H, Blanc E, Mufti GJ, Marcotte EM, Thomas NS.

Mol Syst Biol. 2012 Mar 13;8:573. doi: 10.1038/msb.2012.5.


Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.

Upadhyaya M, Spurlock G, Thomas L, Thomas NS, Richards M, Mautner VF, Cooper DN, Guha A, Yan J.

Hum Mutat. 2012 Apr;33(4):763-76. doi: 10.1002/humu.22044. Epub 2012 Mar 5.


A functional assay for microRNA target identification and validation.

Gäken J, Mohamedali AM, Jiang J, Malik F, Stangl D, Smith AE, Chronis C, Kulasekararaj AG, Thomas NS, Farzaneh F, Tavassoli M, Mufti GJ.

Nucleic Acids Res. 2012 May;40(10):e75. doi: 10.1093/nar/gks145. Epub 2012 Feb 9.


A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse.

Carlin LM, Evans R, Milewicz H, Fernandes L, Matthews DR, Perani M, Levitt J, Keppler MD, Monypenny J, Coolen T, Barber PR, Vojnovic B, Suhling K, Fraternali F, Ameer-Beg S, Parker PJ, Thomas NS, Ng T.

Sci Signal. 2011 Nov 29;4(201):ra81. doi: 10.1126/scisignal.2001729.


Exploring the somatic NF1 mutational spectrum associated with NF1 cutaneous neurofibromas.

Thomas L, Spurlock G, Eudall C, Thomas NS, Mort M, Hamby SE, Chuzhanova N, Brems H, Legius E, Cooper DN, Upadhyaya M.

Eur J Hum Genet. 2012 Apr;20(4):411-9. doi: 10.1038/ejhg.2011.207. Epub 2011 Nov 23.


De novo deletions and duplications detected by array CGH: a study of parental origin in relation to mechanisms of formation and size of imbalance.

Sibbons C, Morris JK, Crolla JA, Jacobs PA, Thomas NS.

Eur J Hum Genet. 2012 Feb;20(2):155-60. doi: 10.1038/ejhg.2011.182. Epub 2011 Sep 28.


Prostate-derived sterile 20-like kinases (PSKs/TAOKs) are activated in mitosis and contribute to mitotic cell rounding and spindle positioning.

Wojtala RL, Tavares IA, Morton PE, Valderrama F, Thomas NS, Morris JD.

J Biol Chem. 2011 Aug 26;286(34):30161-70. doi: 10.1074/jbc.M111.228320. Epub 2011 Jun 24.


Single base-pair substitutions at the translation initiation sites of human genes as a cause of inherited disease.

Wolf A, Caliebe A, Thomas NS, Ball EV, Mort M, Stenson PD, Krawczak M, Cooper DN.

Hum Mutat. 2011 Oct;32(10):1137-43. doi: 10.1002/humu.21547. Epub 2011 Sep 8.


Large de novo deletion of 7p15.1 to 7p12.1 involving the imprinted gene GRB10 associated with a complex phenotype including features of Beckwith Wiedemann syndrome.

Naik S, Riordan-Eva E, Thomas NS, Poole R, Ashton M, Crolla JA, Temple IK.

Eur J Med Genet. 2011 Jan-Feb;54(1):89-93. doi: 10.1016/j.ejmg.2010.09.006. Epub 2010 Oct 8.


Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription.

Buggins AG, Pepper C, Patten PE, Hewamana S, Gohil S, Moorhead J, Folarin N, Yallop D, Thomas NS, Mufti GJ, Fegan C, Devereux S.

Cancer Res. 2010 Oct 1;70(19):7523-33. doi: 10.1158/0008-5472.CAN-10-1634. Epub 2010 Aug 24.


A de novo duplication of Xp11.22-p11.4 in a girl with intellectual disability, structural brain anomalies, and preferential inactivation of the normal X chromosome.

Holden ST, Clarkson A, Thomas NS, Abbott K, James MR, Willatt L.

Am J Med Genet A. 2010 Jul;152A(7):1735-40. doi: 10.1002/ajmg.a.33457.


Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycle.

Orr SJ, Gaymes T, Ladon D, Chronis C, Czepulkowski B, Wang R, Mufti GJ, Marcotte EM, Thomas NS.

Oncogene. 2010 Jul 1;29(26):3803-14. doi: 10.1038/onc.2010.138. Epub 2010 May 3.


Lck is a key target of imatinib and dasatinib in T-cell activation.

Lee KC, Ouwehand I, Giannini AL, Thomas NS, Dibb NJ, Bijlmakers MJ.

Leukemia. 2010 Apr;24(4):896-900. doi: 10.1038/leu.2010.11. Epub 2010 Feb 11. No abstract available.


De novo apparently balanced translocations in man are predominantly paternal in origin and associated with a significant increase in paternal age.

Thomas NS, Morris JK, Baptista J, Ng BL, Crolla JA, Jacobs PA.

J Med Genet. 2010 Feb;47(2):112-5. doi: 10.1136/jmg.2009.069716. Epub 2009 Jul 27.


Epigenetics of human T cells during the G0-->G1 transition.

Smith AE, Chronis C, Christodoulakis M, Orr SJ, Lea NC, Twine NA, Bhinge A, Mufti GJ, Thomas NS.

Genome Res. 2009 Aug;19(8):1325-37. doi: 10.1101/gr.085530.108. Epub 2009 Jun 22.


Clinical and molecular characterization of duplications encompassing the human SHOX gene reveal a variable effect on stature.

Thomas NS, Harvey JF, Bunyan DJ, Rankin J, Grigelioniene G, Bruno DL, Tan TY, Tomkins S, Hastings R.

Am J Med Genet A. 2009 Jul;149A(7):1407-14. doi: 10.1002/ajmg.a.32914.


A complex medical phenotype in a patient with triplication of 2q12.3 to 2q13 characterized with oligonucleotide array CGH.

Mercer CL, Browne CE, Barber JC, Maloney VK, Huang S, Thomas NS, Foulds N, MacLachlan N.

Cytogenet Genome Res. 2009;124(2):179-86. doi: 10.1159/000207526. Epub 2009 May 5. Erratum in: Cytogenet Genome Res. 2009;126(4):367. MacLachlan, N [added].


Identification and molecular characterization of six novel mutations in the UDP-N-acetylglucosamine-1-phosphotransferase gamma subunit (GNPTG) gene in patients with mucolipidosis III gamma.

Persichetti E, Chuzhanova NA, Dardis A, Tappino B, Pohl S, Thomas NS, Rosano C, Balducci C, Paciotti S, Dominissini S, Montalvo AL, Sibilio M, Parini R, Rigoldi M, Di Rocco M, Parenti G, Orlacchio A, Bembi B, Cooper DN, Filocamo M, Beccari T.

Hum Mutat. 2009 Jun;30(6):978-84. doi: 10.1002/humu.20959.


The Human Gene Mutation Database: 2008 update.

Stenson PD, Mort M, Ball EV, Howells K, Phillips AD, Thomas NS, Cooper DN.

Genome Med. 2009 Jan 22;1(1):13. doi: 10.1186/gm13.

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