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High-throughput custom capture sequencing identifies novel mutations in coloboma-associated genes: Mutation in DNA-binding domain of retinoic acid receptor beta affects nuclear localization causing ocular coloboma.

Kalaskar VK, Alur RP, Li LK, Thomas JW, Sergeev YV, Blain D, Hufnagel RB, Cogliati T, Brooks BP.

Hum Mutat. 2019 Dec 9. doi: 10.1002/humu.23954. [Epub ahead of print]


mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes.

Raybuck AL, Lee K, Cho SH, Li J, Thomas JW, Boothby MR.

FASEB J. 2019 Dec;33(12):13202-13215. doi: 10.1096/fj.201900069R. Epub 2019 Sep 18.


The National MDS Natural History Study: design of an integrated data and sample biorepository to promote research studies in myelodysplastic syndromes.

Sekeres MA, Gore SD, Stablein DM, DiFronzo N, Abel GA, DeZern AE, Troy JD, Rollison DE, Thomas JW, Waclawiw MA, Liu JJ, Al Baghdadi T, Walter MJ, Bejar R, Gorak EJ, Starczynowski DT, Foran JM, Cerhan JR, Moscinski LC, Komrokji RS, Deeg HJ, Epling-Burnette PK.

Leuk Lymphoma. 2019 Dec;60(13):3161-3171. doi: 10.1080/10428194.2019.1616186. Epub 2019 May 21.


DNA methylation in mice is influenced by genetics as well as sex and life experience.

Grimm SA, Shimbo T, Takaku M, Thomas JW, Auerbach S, Bennett BD, Bucher JR, Burkholder AB, Day F, Du Y, Duncan CG, French JE, Foley JF, Li J, Merrick BA, Tice RR, Wang T, Xu X; NISC Comparative Sequencing Program, Bushel PR, Fargo DC, Mullikin JC, Wade PA.

Nat Commun. 2019 Jan 18;10(1):305. doi: 10.1038/s41467-018-08067-z.


Molecular regulation of peripheral B cells and their progeny in immunity.

Boothby MR, Hodges E, Thomas JW.

Genes Dev. 2019 Jan 1;33(1-2):26-48. doi: 10.1101/gad.320192.118. Review.


Increased Reporting of Immune Checkpoint Inhibitor-Associated Diabetes.

Wright JJ, Salem JE, Johnson DB, Lebrun-Vignes B, Stamatouli A, Thomas JW, Herold KC, Moslehi J, Powers AC.

Diabetes Care. 2018 Dec;41(12):e150-e151. doi: 10.2337/dc18-1465. Epub 2018 Oct 10. No abstract available.


Certified Child Life Specialists Lessen Emotional Distress of Children Undergoing Laceration Repair in the Emergency Department.

Hall JE, Patel DP, Thomas JW, Richards CA, Rogers PE, Pruitt CM.

Pediatr Emerg Care. 2018 Sep;34(9):603-606. doi: 10.1097/PEC.0000000000001559.


Common genetic causes of holoprosencephaly are limited to a small set of evolutionarily conserved driver genes of midline development coordinated by TGF-β, hedgehog, and FGF signaling.

Roessler E, Hu P, Marino J, Hong S, Hart R, Berger S, Martinez A, Abe Y, Kruszka P, Thomas JW, Mullikin JC; NISC Comparative Sequencing Program, Wang Y, Wong WSW, Niederhuber JE, Solomon BD, Richieri-Costa A, Ribeiro-Bicudo LA, Muenke M.

Hum Mutat. 2018 Oct;39(10):1416-1427. doi: 10.1002/humu.23590. Epub 2018 Jul 26.


Anti-Insulin B Cells Are Poised for Antigen Presentation in Type 1 Diabetes.

Felton JL, Maseda D, Bonami RH, Hulbert C, Thomas JW.

J Immunol. 2018 Aug 1;201(3):861-873. doi: 10.4049/jimmunol.1701717. Epub 2018 Jun 27.


Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies.

Surrey E, Taylor HS, Giudice L, Lessey BA, Abrao MS, Archer DF, Diamond MP, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Singh SS, Rechberger T, Agarwal SK, Duan WR, Schwefel B, Thomas JW, Peloso PM, Ng J, Soliman AM, Chwalisz K.

Obstet Gynecol. 2018 Jul;132(1):147-160. doi: 10.1097/AOG.0000000000002675. Erratum in: Obstet Gynecol. 2018 Dec;132(6):1507-1508.


B Cell-Intrinsic mTORC1 Promotes Germinal Center-Defining Transcription Factor Gene Expression, Somatic Hypermutation, and Memory B Cell Generation in Humoral Immunity.

Raybuck AL, Cho SH, Li J, Rogers MC, Lee K, Williams CL, Shlomchik M, Thomas JW, Chen J, Williams JV, Boothby MR.

J Immunol. 2018 Apr 15;200(8):2627-2639. doi: 10.4049/jimmunol.1701321. Epub 2018 Mar 12.


Prediction of Vancomycin Dose for Recommended Trough Concentrations in Pediatric Patients With Cystic Fibrosis.

Amin RW, Guttmann RP, Harris QR, Thomas JW.

J Clin Pharmacol. 2018 May;58(5):662-665. doi: 10.1002/jcph.1061. Epub 2018 Jan 10.


Somatic mosaicism of an intragenic FANCB duplication in both fibroblast and peripheral blood cells observed in a Fanconi anemia patient leads to milder phenotype.

Asur RS, Kimble DC, Lach FP, Jung M, Donovan FX, Kamat A, Noonan RJ, Thomas JW, Park M, Chines P, Vlachos A, Auerbach AD, Smogorzewska A, Chandrasekharappa SC.

Mol Genet Genomic Med. 2018 Jan;6(1):77-91. doi: 10.1002/mgg3.350. Epub 2017 Nov 30.


A comprehensive approach to identification of pathogenic FANCA variants in Fanconi anemia patients and their families.

Kimble DC, Lach FP, Gregg SQ, Donovan FX, Flynn EK, Kamat A, Young A, Vemulapalli M, Thomas JW, Mullikin JC, Auerbach AD, Smogorzewska A, Chandrasekharappa SC.

Hum Mutat. 2018 Feb;39(2):237-254. doi: 10.1002/humu.23366. Epub 2017 Nov 22.


Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50.

Chandrasekharappa SC, Chinn SB, Donovan FX, Chowdhury NI, Kamat A, Adeyemo AA, Thomas JW, Vemulapalli M, Hussey CS, Reid HH, Mullikin JC, Wei Q, Sturgis EM.

Cancer. 2017 Oct 15;123(20):3943-3954. doi: 10.1002/cncr.30802. Epub 2017 Jul 5.


Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist.

Taylor HS, Giudice LC, Lessey BA, Abrao MS, Kotarski J, Archer DF, Diamond MP, Surrey E, Johnson NP, Watts NB, Gallagher JC, Simon JA, Carr BR, Dmowski WP, Leyland N, Rowan JP, Duan WR, Ng J, Schwefel B, Thomas JW, Jain RI, Chwalisz K.

N Engl J Med. 2017 Jul 6;377(1):28-40. doi: 10.1056/NEJMoa1700089. Epub 2017 May 19.


B Cell Receptor Affinity for Insulin Dictates Autoantigen Acquisition and B Cell Functionality in Autoimmune Diabetes.

Packard TA, Smith MJ, Conrad FJ, Johnson SA, Getahun A, Lindsay RS, Hinman RM, Friedman RS, Thomas JW, Cambier JC.

J Clin Med. 2016 Nov 8;5(11). pii: E98.


Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system.

Cho SH, Raybuck AL, Stengel K, Wei M, Beck TC, Volanakis E, Thomas JW, Hiebert S, Haase VH, Boothby MR.

Nature. 2016 Sep 8;537(7619):234-238. doi: 10.1038/nature19334. Epub 2016 Aug 8.


Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.

Wan X, Thomas JW, Unanue ER.

J Exp Med. 2016 May 30;213(6):967-78. doi: 10.1084/jem.20151869. Epub 2016 May 2.


Design, Synthesis, and Evaluation of Novel Auxin Mimic Herbicides.

Do-Thanh CL, Vargas JJ, Thomas JW, Armel GR, Best MD.

J Agric Food Chem. 2016 May 11;64(18):3533-7. doi: 10.1021/acs.jafc.6b00675. Epub 2016 Apr 27.


Genes located in a chromosomal inversion are correlated with territorial song in white-throated sparrows.

Zinzow-Kramer WM, Horton BM, McKee CD, Michaud JM, Tharp GK, Thomas JW, Tuttle EM, Yi S, Maney DL.

Genes Brain Behav. 2015 Nov;14(8):641-54. doi: 10.1111/gbb.12252. Epub 2015 Oct 14.


Targeting Anti-Insulin B Cell Receptors Improves Receptor Editing in Type 1 Diabetes-Prone Mice.

Bonami RH, Thomas JW.

J Immunol. 2015 Nov 15;195(10):4730-41. doi: 10.4049/jimmunol.1500438. Epub 2015 Oct 2.


Importance of dispersal routes that minimize open-ocean movement to the genetic structure of island populations.

Harradine EL, Andrew ME, Thomas JW, How RA, Schmitt LH, Spencer PB.

Conserv Biol. 2015 Dec;29(6):1704-14. doi: 10.1111/cobi.12555. Epub 2015 Jul 14.


Reversing Tolerance in Isotype Switch-Competent Anti-Insulin B Lymphocytes.

Williams JM, Bonami RH, Hulbert C, Thomas JW.

J Immunol. 2015 Aug 1;195(3):853-64. doi: 10.4049/jimmunol.1403114. Epub 2015 Jun 24.


A randomized double-blind, placebo-, and active-controlled study of T-type calcium channel blocker ABT-639 in patients with diabetic peripheral neuropathic pain.

Ziegler D, Duan WR, An G, Thomas JW, Nothaft W.

Pain. 2015 Oct;156(10):2013-20. doi: 10.1097/j.pain.0000000000000263.


Genomic resources for the endangered Hawaiian honeycreepers.

Callicrate T, Dikow R, Thomas JW, Mullikin JC, Jarvis ED, Fleischer RC; NISC Comparative Sequencing Program.

BMC Genomics. 2014 Dec 12;15:1098. doi: 10.1186/1471-2164-15-1098.


Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae.

Conlan S, Thomas PJ, Deming C, Park M, Lau AF, Dekker JP, Snitkin ES, Clark TA, Luong K, Song Y, Tsai YC, Boitano M, Dayal J, Brooks SY, Schmidt B, Young AC, Thomas JW, Bouffard GG, Blakesley RW; NISC Comparative Sequencing Program, Mullikin JC, Korlach J, Henderson DK, Frank KM, Palmore TN, Segre JA.

Sci Transl Med. 2014 Sep 17;6(254):254ra126. doi: 10.1126/scitranslmed.3009845.


A methodological review of meditation research.

Thomas JW, Cohen M.

Front Psychiatry. 2014 Jul 1;5:74. doi: 10.3389/fpsyt.2014.00074. eCollection 2014.


Factors affecting costs in Medicaid populations with behavioral health disorders.

Freeman E, McGuire CA, Thomas JW, Thayer DA.

Med Care. 2014 Mar;52 Suppl 3:S60-6. doi: 10.1097/MLR.0000000000000075.


NFATc2 (NFAT1) assists BCR-mediated anergy in anti-insulin B cells.

Bonami RH, Wolfle WT, Thomas JW, Kendall PL.

Mol Immunol. 2014 Dec;62(2):321-8. doi: 10.1016/j.molimm.2014.01.003. Epub 2014 Feb 6.


Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes.

Horton BM, Hudson WH, Ortlund EA, Shirk S, Thomas JW, Young ER, Zinzow-Kramer WM, Maney DL.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1443-8. doi: 10.1073/pnas.1317165111. Epub 2014 Jan 13.


Requirement for Rictor in homeostasis and function of mature B lymphoid cells.

Lee K, Heffington L, Jellusova J, Nam KT, Raybuck A, Cho SH, Thomas JW, Rickert RC, Boothby M.

Blood. 2013 Oct 3;122(14):2369-79. doi: 10.1182/blood-2013-01-477505. Epub 2013 Aug 19.


B cell-intrinsic and -extrinsic regulation of antibody responses by PARP14, an intracellular (ADP-ribosyl)transferase.

Cho SH, Raybuck A, Wei M, Erickson J, Nam KT, Cox RG, Trochtenberg A, Thomas JW, Williams J, Boothby M.

J Immunol. 2013 Sep 15;191(6):3169-78. doi: 10.4049/jimmunol.1301106. Epub 2013 Aug 16.


B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic mice.

Henry-Bonami RA, Williams JM, Rachakonda AB, Karamali M, Kendall PL, Thomas JW.

J Immunol. 2013 Jun 15;190(12):5992-6003. doi: 10.4049/jimmunol.1201359. Epub 2013 May 15.


Adulteration of purported herbal and natural sexual performance enhancement dietary supplements with synthetic phosphodiesterase type 5 inhibitors.

Campbell N, Clark JP, Stecher VJ, Thomas JW, Callanan AC, Donnelly BF, Goldstein I, Kaminetsky JC.

J Sex Med. 2013 Jul;10(7):1842-9. doi: 10.1111/jsm.12172. Epub 2013 May 1.


Tolerant anti-insulin B cells are effective APCs.

Kendall PL, Case JB, Sullivan AM, Holderness JS, Wells KS, Liu E, Thomas JW.

J Immunol. 2013 Mar 15;190(6):2519-26. doi: 10.4049/jimmunol.1202104. Epub 2013 Feb 8.


The C-terminal putative nuclear localization sequence of breast cancer metastasis suppressor 1, BRMS1, is necessary for metastasis suppression.

Hurst DR, Xie Y, Thomas JW, Liu J, Edmonds MD, Stewart MD, Welch DR.

PLoS One. 2013;8(2):e55966. doi: 10.1371/journal.pone.0055966. Epub 2013 Feb 4.


Behavioral characterization of a white-throated sparrow homozygous for the ZAL2(m) chromosomal rearrangement.

Horton BM, Hu Y, Martin CL, Bunke BP, Matthews BS, Moore IT, Thomas JW, Maney DL.

Behav Genet. 2013 Jan;43(1):60-70. doi: 10.1007/s10519-012-9574-6. Epub 2012 Dec 21.


Autoantigen-specific B-cell depletion overcomes failed immune tolerance in type 1 diabetes.

Henry RA, Kendall PL, Thomas JW.

Diabetes. 2012 Aug;61(8):2037-44. doi: 10.2337/db11-1746. Epub 2012 Jun 14.


Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.

Gilbert MR, Wagner NJ, Jones SZ, Wisz AB, Roques JR, Krum KN, Lee SR, Nickeleit V, Hulbert C, Thomas JW, Gauld SB, Vilen BJ.

J Immunol. 2012 Jul 15;189(2):711-20. doi: 10.4049/jimmunol.1102973. Epub 2012 Jun 6.


Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire.

Briney BS, Willis JR, Hicar MD, Thomas JW 2nd, Crowe JE Jr.

Immunology. 2012 Sep;137(1):56-64. doi: 10.1111/j.1365-2567.2012.03605.x.


Physician Cost Profiling-Reliability and Risk of Misclassification: Detailed Methodology and Sensitivity Analyses.

Adams JL, Mehrotra A, Thomas JW, McGlynn EA, Adams JL, Mehrotra A, McGlynn EA.

Rand Health Q. 2012 Mar 1;2(1):3. eCollection 2012 Spring.


BAC-based sequencing of behaviorally-relevant genes in the prairie vole.

McGraw LA, Davis JK, Thomas PJ; NISC Comparative Sequencing Program, Young LJ, Thomas JW.

PLoS One. 2012;7(1):e29345. doi: 10.1371/journal.pone.0029345. Epub 2012 Jan 6.


PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse.

Keebaugh AC, Mitchell HA, Gaval-Cruz M, Freeman KG, Edwards GL, Weinshenker D, Thomas JW.

PLoS One. 2011;6(7):e22381. doi: 10.1371/journal.pone.0022381. Epub 2011 Jul 27.


A genetic linkage map and comparative mapping of the prairie vole (Microtus ochrogaster) genome.

McGraw LA, Davis JK, Young LJ, Thomas JW.

BMC Genet. 2011 Jul 7;12:60. doi: 10.1186/1471-2156-12-60.


Haplotype-based genomic sequencing of a chromosomal polymorphism in the white-throated sparrow (Zonotrichia albicollis).

Davis JK, Mittel LB, Lowman JJ, Thomas PJ, Maney DL, Martin CL; NISC Comparative Sequencing Program, Thomas JW.

J Hered. 2011 Jul-Aug;102(4):380-90. doi: 10.1093/jhered/esr043. Epub 2011 May 25.


Genome-wide analysis of copy number variation in type 1 diabetes.

Grayson BL, Smith ME, Thomas JW, Wang L, Dexheimer P, Jeffrey J, Fain PR, Nanduri P, Eisenbarth GS, Aune TM.

PLoS One. 2010 Nov 15;5(11):e15393. doi: 10.1371/journal.pone.0015393.


Contrasting population genetic patterns within the white-throated sparrow genome (Zonotrichia albicollis).

Huynh LY, Maney DL, Thomas JW.

BMC Genet. 2010 Oct 28;11:96. doi: 10.1186/1471-2156-11-96.


Low costs of defensive medicine, small savings from tort reform.

Thomas JW, Ziller EC, Thayer DA.

Health Aff (Millwood). 2010 Sep;29(9):1578-84. doi: 10.1377/hlthaff.2010.0146.


Follicular B cell trafficking within the spleen actively restricts humoral immune responses.

Hoek KL, Gordy LE, Collins PL, Parekh VV, Aune TM, Joyce S, Thomas JW, Van Kaer L, Sebzda E.

Immunity. 2010 Aug 27;33(2):254-65. doi: 10.1016/j.immuni.2010.07.016. Epub 2010 Aug 5.

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